성인에서 장기간 Furosemide오용과 연관된 신수질 석회화

김윤구,이윤하,이규백,장세호,김대중,오하영,김보현,김미경,조윤숙 대한신장학회 1996 대한신장학회잡지 Vol.15 No.4

정면에서 평가한 한국인 여성 입술의 심미성과 전방 분절 골절단술 후 입술의 평가

이범석,강윤구,윤태호,국윤아 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.5

이 연구는 한국인 여자 유명 모델과 일반인의 정면입술의 차이점을 비교하여 아름다운 입술의 특징을 규명하며 양악 전방 분절골절단술을 시행한 환자에서 정면입술의 변화를 측정하고 그 수술 결과를 한국인 모델과 비교하여 차이점을 알아보고자 하였다. 한국인 유명 모델 30명, 일반인 26명과 양악 전방 분절골절단술을 받은 환자의 10명을 대상으로 정면입술 부위의 12개의 선 길이, 홍순의 5개의 각도와 둘레 및 면적을 측정하였고, 통계분석은 unpaired & paired t-test를 이용하였다. 한국인 유명 모델 군과 일반인 군의 비교에서 하안면 얼굴 폭경, 하안면 수직길이, 상홍순의 높이, 하순의 길이, 상홍순의 구각부 각도와 central bow의 각도는 의미 있는 차이로 일반인 군보다 유명 모델 군에서 작았다. 그러나, 입술의 폭, 하홍순의 높이, Cupid's bow tip간 거리와 하홍순의 구각부 각도는 유명 모델 군에서 컸고 입술의 둘레와 전체 면적에서도 일반인 군보다 컸다. 양악 전방 분절골절단술을 받은 환자의 정면입술에서는 하안면 얼굴 폭경, 상홍순의 높이, Cupid's bow tip에서 구각부까지의 길이와 상홍순의 면적이 통계적으로 의미 있는 변화를 보였고 한국인 유명 모델과의 비교에서 비슷한 수치를 나타내었지만 상순의 길이는 반대로 증가하였다. 연구의 결과는 교정치료 혹은 양악 전방 분절골절단술을 계획할 때 정면 입술 심미성을 평가하는 데 도움이 될 것으로 생각된다. Objective: The aim of this study was to determine firstly the characteristics of esthetic lips in Korean females and secondly to measure the changes of the lips before and after anterior segmental osteotomy in bimaxillary protruded patients. Methods: Samples consisted of 30 models and 26 nonmodels, and 10 patients who had received anterior segmental osteotomy. Twelve linear measurements, 5 angular measurements, and the lip perimeter and area were measured. These results were compared for each group using unpaired and paired t-tests. Results: Full face width, nose to chin, upper vermilion height and angle, lateral heights at the point of the tips of Cupid's bow, central bow angle, and the lower lip to chin lengths were significantly greater in nonmodels than in models. However, overall lip width, lower vermilion height and angle, tip-to-tip of Cupid's bow lip perimeter, and lower vermilion area were greater in models than in nonmodels. Comparison of before and after anterior segmental osteotomy revealed that the values for the upper vermilion and lateral heights, the angle to Cupid's bow tip lengths, and upper vermilion area of post-operative patients had become similar to those of Korean female models. Our findings demonstrated that Korean female models have a fuller lower vermilion & thinner upper vermilion compared with nonmodel controls, as determined by the vermilion heights, angles, and areas. Conclusions: It will be helpful for clinicians to use these measurements as guidelines for improving patients' facial esthetics.

삼차동맥존속증을 동반한 정중엽 다리뇌경색

하윤석,김명국,유봉구 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Persistent trigeminal artery (PTA) is the most frequently observed fetal anastomosis between the carotid and vertebrobasilar circulations. PTA is usually associated with hypoplasia or aplasia of the vertebrobasilar artery. A 56-year-old woman presented with right hemiparesis and dysarthria. Brain MRI showed acute infarction in the right paramedian pons. CT angiogram revealed right persistent trigeminal artery and hypoplasia of the proximal basilar artery

라운드 리클라이너 개발을 위한 정적 강도 해석 및 안전성 평가

정윤구,임재규,김형종 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

Seat is one of the most important part of an automobile for passenger's safety especially when an accident happens. A recliner is a part of the seat assembly, having the function of adjusting the back-plate angle of a seat. Recently, many kinds of vehicles have adopted the round recliner module rather than the conventional types of recliners because of its broad compatibility and structural simplicity. In this study a two-dimensional finite element strength analysis has been performed using a commercial code ABAQUS/Standard for the purpose of developing a new round recliner model. The loading condition for the analysis is the same as the FMVSS 301 regulation. The finite element result for the round recliner has been compared with that for the conventional type.

Mondor씨병 1례

김윤성,구본길,차종식,박장규,이영 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1

Mondor's disease has been regarded as an obliterative phlebitis usually affecting superficial vein of the chest wall. It is characteristic that the cord-like thrombosed vein which is red and tender at first changes into painless fibrous band. In the past, it was confused with lymphatic spread of carcinoma but it was confirmed that it was benign and related with the systemic diseases or cancer. The authors observed a 57-year-old female with Mondor's disease. 15 days ago, she notified the cord-like lesion on the right chest well, from right axillar fold to right iliac crest. 1. month later, the skin lesion much improved without special treatment.

Crouzon씨병 교정치료를 위한 개선된 Frontofacial monobloc advancement와 Cranial vault remodeling 병행수술 방법

문구현,이윤호 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.6

Crouzon's disease characterized by exorbitism, retromaxillism, inframaxillism, and paradoxic retrogenia, was first described by Crouzon in 1912. Premature fusion of cranial sutures results in a variety of calvarial deformities, but oxycephaly and brachycephaly are most often observed.¹ According to the severity of deformity and patient's age, the method of surgical correction should be selected. In adults, for reasons of safety, staged operation, first, limited frontocranial remodeling if necessary and facial advancement later, is generally favored. Combined orbitofacial monobloc advancement and frontal repositioning was popularized by Oritz-Monasterio(1978) but this technique has been reserved only for child. Persistent intracranial dead space, increased risk of ascending infection via nasofrontal communication, possibility of frontal bone flap resorption, and some technical difficulties rendered monobloc advancement to be not indicated in adults. We thought that modification and improvement of original monobloc procedure combined with cranial vault remodeling could overcome above mentioned disadvantages. Authors' combined procedure can correct deformities of midface, forehead and cranial vault simultaneously in one stage. We performed our combined surgical procedures of modified frontofacial monobloc advancement and cranial vault remodeling in 22 year-old female patient and obtained successful without complication. Through our limited experience, this new methods probably can be safely applied to the adult patients of Crouzon's disease with calvarial deformities and correct not only front-orbito-facial region but also whole cranial vault deformity in one stage.

인도메타신의 투여가 치아 맹출 시 기질금속단백분해 효소의 분포에 미치는 영향

강윤구,남종현,이기수 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구는 치낭과 그 주위 조직 세포에서 matrix metalloproteinase (MMP)-3과 -9의 발현에 대한 인도메타신의 영향을 관찰하여 인도메타신이 치아의 맹출에 미치는 영향의 일단을 규명하기 위해 시행되었다. 생후 10-12주된 10마리의 개를 실험군 8마리와 대조군 2마리로 나누고 실험군은 인도메타신을 체중에 대하여 통상적 복용량인 인도메타신 2㎎/㎏/day을 7일간 및 14일간 투여한 군과 과량의 8㎎/㎏/day을 7일간 및 14일간 투여한 군으로 나누고 대조군은 빈 캅셀을 placebo로 투여한 후 희생하고 맹출 중인 영구치 치배를 적출하여 조직 처리하고 H-E 염색 및 MMP-3과 -9에 대한 면역염색 시행 후 광학현미경으로 검경하였다. 관찰결과 대조군에서는 파골세포, 조골세포, 치주인대 세포, 법랑모세포 및 상아모세포에서 모두 MMP-3과 -9의 발현이 뚜렷하게 관찰되었다. 대조군에 비해 인도메타신 투여군에서 파골세포, 조골세포, 치주인대 세포는 MMP-3과 -9의 발현이 억제된 소견이 관찰되었으며 인도메타신의 투여기간이 길수록 투여량이 많을수록 더 뚜렷하게 관찰되었다. 법랑모세포와 상아모세포는 대조군과 실험군의 MMP-3과 -9의 발현의 차이가 관찰되지 않았다. 이상의 결과에 의하면 prostaglandin (PG) 생합성 억제제인 인도메타신은 치낭의 파골세포, 조골세포 및 치주인대 세포에서 MMP-3과 -9의 발현을 억제하였으며 이는 인도메타신 투여로 치아 맹출이 억제될 수 있음을 시사한다. Tooth eruption requires remodeling of surrounding tissues. This study was aimed to investigate the effect of indomethacin on the dental follicle and paradental tissues during tooth eruption by observing the distribution and expression of MMP by the immunohistochemical method. Ten mongrel dogs of ten to twelve weeks old were divided into 5 groups: four experimental groups administered indomethacin 2㎎/㎏/day 8㎎/㎏/day and orally 2 times a day for 14 days and 7 days respectively, and the control group was administered a placebo. Permanent teeth before eruption and their surrounding tissues were selected and excised. H & E staining and immunohistochemical stainings of MMP-3 and -9 were performed and examined under the light microscope. Osteoclasts, osteoblasts, periodontal ligament cells, ameloblasts and odontoblasts of the control group all expressed MMP-3 and -9. In the experimental group, osteoclasts, osteoblasts and periodontal ligament cells showed reduced expression of MMP-3 and -9. Magnitude of MMP reduction in the experimental group showed a time and dose of indomethacin administration dependent manner. These results show that indomethacin inhibited MMP-3 and -9 expression in the dental follicle and surrounding tissues and suggest that when indomethacin is administered for long periods, tooth eruption could be delayed.

갑상선 여포선암 진단시 HBME-1 면역염색법의 유용성

신영구,이기범,정윤석,김현만 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

경희대학교 수원 캠퍼스의 교문디자인 연구

김동찬,이윤수,박중구,황세현,김명기 경희대학교 디자인연구원 2000 예술· 디자인학연구 Vol.3 No.1

The Suwon Campus of Kyunghee University was decided to rebuild a university gate to make new image of the university for a new millenium. The purpose of this study is to design a university gate not only for a gate but also for a commemorative environmental model which presents a spirit and idea of the Kyunghee University. The entire design of the gate has a renaissance style, the design of it's center has a triumphal arch form which cars can go through, and the design of it's side has a corridor form which pedestrians can walk. The gate is designed to present the spirit for human and world peace which Kyunghee University intends.

인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예

이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2

저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.