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김광일,김동호,우상민,이석주,김홍성,조인성,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1
Spontaneous retroperitoneal hemorrhage due to hemophilia A with impaired coagulopathy is very rare. Spontaneous retroperitoneal hemorrhage has been recorded as having originated from many retroperitoneal organs and blood vessels, and it may be due to local and/or systemic factors. In the majority of the patients, kidney and adrenal gland were the major site of hemorrhage. The systemic causes of spontaneous retroperitoneal hemorrhage are anticoagulation therapy and chronic hemodialysis. During the course of these treatments, hemorrhagic complications may occur at many site, including the retroperitoneal space. Blood dyscrasias including leukemia, polycythemia, sickle cell trait and hemophilia have been reported associated with spontaneous retroperitoneal hemorrhage. We report a case of spontaneous retroperitoneal hemorrhage occurred in a gemophilia A patient with brief review of literature
Receiver Design for Satellite Navigation Signals using the Tiered Differential Polyphase Code
Jo, Gwang Hee,Noh, Jae Hee,Lim, Deok Won,Son, Seok Bo,Hwang, Dong-Hwan,Lee, Sang Jeong 항법시스템학회 2021 Journal of Positioning, Navigation, and Timing Vol.10 No.4
Modernized GNSS signal structures tend to use tiered codes, and all GNSSs use binary codes as secondary codes. However, recently, signals using polyphase codes such as Zadoff-Chu sequence have been proposed, and are expected to be utilized in GNSS. For example, there is Tiered Differential Polyphase Code (TDPC) using polyphase code as secondary code. In TDPC, the phase of secondary code changes every one period of the primary code and a time-variant error is added to the carrier tracking error, so carrier tracking ambiguity exists until the secondary code phase is found. Since the carrier tracking ambiguity cannot be solved using the general GNSS receiver architecture, a new receiver architecture is required. Therefore, in this paper, we describe the carrier tracking ambiguity and its cause in signal tracking, and propose a receiver structure that can solve it. In order to prove the proposed receiver structure, we provide three signal tracking results. The first is the differential decoding result (secondary code sync) using the general GNSS receiver structure and the proposed receiver structure. The second is the IQ diagram before and after multiplying the secondary code demodulation when carrier tracking ambiguity is solved using the proposed receiver structure. The third is the carrier tracking result of the legacy GPS (L1 C/A) signal and the signal using TDPC.
( Key Jo Lee ),( Gwang Ha Kim ),( Geun Am Song ),( Jeong Heo ),( Dong Uk Kim ),( Hyun Young Woo ),( Bong Eun Lee ),( Dong Hoon Baek ),( Hye Kyung Jeon ),( Hyun Jeong Lee ),( Joon Hyung Jhi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although endoscopic submucosal dissection (ESD) have been increasingly applied to undifferentiated type early gastric cancer (UD-EGC), its usefulness still remains controversial because of the lack of post-ESD long term follow-up data. The aim of this study was to investigate therapeutic outcomes of ESD for UD-EGC. Methods: Between February 2006 and December 2013, a total of 80 patients with UD-EGC were treated with ESD at the Pusan National University Hospital. Their medical records including clinicopathologic feature and therapeutic results were retrospectively reviewed. Results: 80 patients were treated with ESD and 41 patients (51.2%) met the expandedcriteria for ESD. In these 41 lesions meeting expanded criteria group, en bloc resection rate and curative resection rate were 92.6% (38/41) and 87.8% (36/41), respectively. These 36 patients who met the expanded criteria and underwent curative resection, no local recurrence or distant metastasis was detected during a mean follow-up period of 42 months (range 6-98 months). There were 5 patients who met the expanded criteria but non-curative resection was done. Two of them refuse surgical treatment. The other three patients were treated with gastrectomy and did not show local recurrence or distant metastasis. Among a total of 80 patients with UD-EGCs, delayed bleeding occurred 2 patients (2.5%), and there were no ESD-related complications like early bleeding or perforation except delayed bleeding. Conclusions: ESD could be a curative treatment for UD-EGC meeting expanded criteria if curative resection is achieved, and for more curative resection, technical advances are essential. Therefore, we should select appropriate patients with UD-EGC meeting expanded criteria before procedure, and to ensure the effi cacy of ESD for UDEGC, we need more long term follow-up results.
김광운 ( Gwang Un Kim ),예병덕 ( Byong Duk Ye ),변정식 ( Jeong Sik Byeon ),박환성 ( Hwan Sung Park ),옥태진 ( Tae Jin Ok ),양동훈 ( Dong Hoon Yang ),정기욱 ( Kee Wook Jung ),김경조 ( Kyung Jo Kim ),명승재 ( Seung Jae Myung ),양석 대한장연구학회 2011 Intestinal Research Vol.9 No.3
Background/Aims: With the growing volume of screening colonoscopies, the incidence of rectal carcinoids and the number of endoscopic resections for rectal carcinoids are also increasing. However, the prognosis including recurrence and metachronous lesions after endoscopic resection is unclear. Methods: The medical records of 255 patients who had undergone endoscopic resection for rectal carcinoids between October 1999 and April 2010 were retrospectively reviewed. Results: The number of males was 150 (58.8%), and the mean age was 54.1 years (range, 27-85 years). Mean tumor size was 6.9 mm. In total, 162 cases (63.5%) were treated with endoscopic mucosal resection and 93 (36.5%) were treated with endoscopic submucosal dissection. Although endoscopic complete resections were achieved in all cases, the histological examination showed 47 cases with a positive resection margin (18.4%) and three with lymphovascular invasion (1.2%). In the 54 patients with a free resection margin, who were followed for more than 12 months, abdominopelvic computed tomography and endoscopy did not show recurrence after a median of 30.5 and 36 months, respectively. Three patients with lymphovascular invasion did not show recurrence during follow-up period of 13, 30, and 37 months, respectively. Metachronous rectal carcinoids were detected in four patients at 23, 58, 61, and 89 months, respectively, after initial endoscopic resection, leading to a second endoscopic treatment. Conclusions: Small rectal carcinoids completely resected grossly and pathologically without lymphovascular invasion appear to have low probability of short-term recurrence. However, considering the slow growth rate of carcinoids, long-term follow-up for recurrence and metachronous carcinoids is required. (Intest Res 2011;9:217-224)
소독방법에 따른 실내수영장 수질 특성 -브롬산염, 클로레이트, 염소이온을 중심으로-
조광운 ( Gwang Un Jo ),이세행 ( Se Haeng Lee ),위환 ( Whan Wi ),윤상훈 ( Sang Hoon Yoon ),김난희 ( Nan Hee Kim ),안상수 ( Sang Soo An ),정숙경 ( Suk Kyeong Jung ),김동수 ( Dong Su Kim ),조영관 ( Young Gwan Cho ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.2
This study was carried out to investigate the characteristics of water quality parameters in the indoor swimming pool water according to the type of disinfection. The method of disinfection has a on-site oxidant generation, sodium hypochlorite and artificial seawater electrolysis that the salt was put in the pool directly. The on-site oxidant generation and sodium hypochlorite in the disinfectant contain high concentrations of bromate and chlorate. The bromate and chlorate containing the disinfectant is the cause of detection in a swimming pool. Maximum concentration of bromate in swimming pool waters was 1.365 mg/L at on-site oxidant generation and maximum concentration of chlorate was 36.00 mg/L at sodium hypochlorite. Therefore, to reduce the concentration of bromate and chlorate in swimming pool water, it is necessary to use the disinfectant containing the less quantity of bromate and chlorate and to exchange of swimming pool water frequently.
박동욱,김미란,이호준,박원일,김대운,조동제,김선영,박준영,김세광,권혁찬,한성원,홍서유 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.1
연구목적 : EEC-ESC-ECM의 3차원적 공배양 체계(three-dimensionally cultured endometrial cell)를 확립하고 성선 호르몬의 첨가에 따른 생체활성 물질(biological marker)의 발현 양상과 조직학적 양상을 관찰하여 착상기 자궁내막 조직과 동일한 분화 양상을 보이는지를 확인하고자 하였다. 연구방법 : 적출된 인간 자궁의 후저부에서 자궁내막세포를 채취하여 상피세포(EEC)와 기질세포(ESC)로 분리한 후에 collagen과 Matrigel을 이용하여 EEC-ESC-ECM 공 배양체계를 만들어 에스트로젠과 프로게스테론이 포함된 DMEM 배양액에 48시간 배양 한 후에 gelatin substrate zymography, electron microscopy, integrins, COX, MMPs에 대한 면역조직화학적 염색(immunohistochemistry)을 시행하여 관찰하였다. 결과 : 배양 48시간째 EEC-ESC-ECM 공 배양체계에서의 EEC의 미세구조는 극성을 갖고 있었으며 세포들 간에는 tight junction과 desmosome이 형성되어 있었다. 또한 일부 세포에서는 microvilli가 감소하면서 pinopode 형태의 돌기가 돌출 되어 있은 것을 관찰할 수 있었다. EEC 혹은 ESC 단층배양 체계 및 ESC-collagen 배양체제에서 면역조직화학적으로 발현되지 않던 MMP-1, -2, -3, -9 과 integrin α1, α4, β3이 강한 발현을 보였다. 결론 : 에스트로젠과 프로게스테론 존재하의 EEC-ESC-Matrigel/collagen의 3차원적 공 배양체계에서 EEC 혹은 ESC 단층배양 체계 및 ESC-collagen의 배양체계와 다르게 EEC와 ESC의 측분비 작용에 의해 in-vivo 에서 착상기 내막세포와 유사한 형태와 생체 활성 물질의 발현을 확인할 수 있었다. 이러한 체외 자궁내막 세포 배양 체계는 내막조직의 분화 및 배아의 착상기전 뿐 아니라 착상관련 질환의 병리학적 연구에 많은 도움이 될 것으로 사료된다. Objective : The aim of this study was to establish three-dimensionally cultured endometrial cell model containing endometrial stromal cell (ESC), endometrial epithelial cell (EEC) and extracellular matrix (ECM) and to compare the morphological and biomolecular expression patterns of this model with mid-luteal endometrium in vivo. Materials and Methods : The EEC and ESC was obtained from hysterectomy specimen and cultured separately. The EEC was overlayered in Matrigel layer on ESC embedded in collagen. The model had been cultured for 48 h in DMEM medium containing estrogen and progesterone. The ultrastructure was evaluated by electron microscopy. The expression of integrins, cyclooxygenases and matrix metalloproteinases were examined by immunohistochemistry and zymography. Results : EEC in three-dimensional culture model grew with polarity and tight junction and desmosome between cells were found. The formation of pinopodes was also detected. In three-dimensionally cultured endometrial cell model, the expression of integrin α1, α4, β3, MMP-1, -2, -3 and 9 was detected which was not expressed in monolayer culture of EEC, ESC or ESC embedded in collagen. Conclusion : The three-dimensionally cultured endometrial cell model possessed the morphological and biomolecular characteristics of in vivo endometrium of implantation period. These characteristics could be achieved by paracrine interactions between ESC and EEC. This model may contribute to the studies of differentiation of endometrium, process of implantation and pathophysiology of implantation-related diseases.
2 channel 보행성식도산도검사의 병적역류 환자에서의 상부식도의 역류와 식도내압검사와의 비교분석
조돈현 ( Jo Don Hyeon ),박수헌 ( Park Su Heon ),김형근 ( Kim Hyeong Geun ),정지성 ( Jeong Ji Seong ),손동균 ( Son Dong Gyun ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 위식도 역류질환에서의 병태생리학적 원인으로 저압성 하부식도괄약근, 일시적인 하부식도괄약근이완, 식도연동운동의 장애등의 식도운동질환이 생각되고 있다. 그러나 상부식도의 역류와 식도운동질환의 연관성에 대한 연구는 알려지지 않았다. 저자들은 2 channel 보행성 식도산도검사를 실시하여 하부 식도에서의 병적역류가 확진된 환자에서 상부식도의 병적역류여부와 식도내압검사의 결과를 비교 분석하고자 하였다. <방법> 하부식도의 역류를 보기 위한 원위부 탐침