1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

건강인에서 결핵균 30-kDa항원이 말초혈액 임파구증식에 미치는 영향

최대경,고석신,김화중,조은경,백태현,신철식 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

T lymphocytes are thought to play a central role in cell mediated immune response. To Study the T lymphocyte proliferative response to 30-kDa antigen purified from Mycobacterium tuberculosis H37Rv, peripheral blood lymphocytes isolated from healthy subjects were stimulated with the 30kDa antigen, crude antigen or PHA. Healthy subjects were divided into three groups so that PPD(+), PPD(±) and PPD(-). The proliferations of lymphocytes were measured by the incroporation of ^3H-thyrnidine. The results were summarized as follows: 1. For the PPD(+) person, at concentration of < 1 ㎍/ml, the proliferative response to 30-kDa antigen resulted in a mild reduction but crude antigen showed relatively rapid reduction. For the PPD(-) person, decreasing the concentration of the both antigens showed rapid reduction of proliferation 2. The lymphocytes proliferations to 30-kDa antigen and crude antigen were significantly increased in PPD(+) group when compared to those in PPD(-) group, but PHA response was no significant difference. 3. The sensitivity and specificity of lymphocyte proliferation assay to 30-kDa antigen and crude antigen when compared with skin test results were 92.3%, 100% and 76.9%, 50%, respectively.

다약물 내성기전으로서 ABC transporter와 화학감작제의 개발

최철혁,권대승,최석민 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Anticancer resistance is one of the major problems in the clinical cancer chemotherapy. Of resistance mechanisms are ATP (ATP-binding cassette) transporters including P-glycoprotein. In this paper, ABC transporters with respect to the physiological functions and multidrug resistance mechanisms as well as the development of chemosensitizers for their reversal have been reviewed.

Methotrexate 치료를 받고 있는 활동성 류마티스 관절염 환자에서 etanercept의 유효성과 안전성에 관한 연구

최병렬,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 류마티스 관절염을 앓고 있는 한국인 중에 기존 DMARDs로 치료 실패하였고, 고정용량의 MTX를 복용하고 있는 환자들에 있어서 etanercept의 유효성과 안전성을 평가하고자 하였다. 방법 : 기존 DMARDs로 치료 실패한 활동성 류마티스 관절염 환자 76명을 대상으로 하여 단일군, 공개시험을 하였다. 대상 환자들은 고정용량의 MTX를 복용하면서 etanercept 25 mg을 1주일에 두 번 피하 주사하였으며 12주간 투여하였다. 유효성은 ACR 20, ACR 50,조조강직 시간으로 평가하였고, 약제의 안전성은 이상반응 등으로 평가하였다. 결과 : 대상 환자는 총 76명으로 평균 연령은 45.2세, 남자 5명, 여자 71명이었다. 84.4%인 54명이 12주째에 ACR 20을 만족하였고, 53.1%인 34명이 12주째에 ACR 50을 만족하였다. 조조 강직 시간은 치료 전 203.3분에서 치료 12주째 42.6분을 평균 74.5% 호전되었다. 가장 흔한 이상반응은 주사부위 반응이었다. 이외에도 상기도 감염, 오심, 안면부종 등이 발생하였으나 심각한 부작용은 없었다. 결론 : etanercept는 효과적이고, 안전한 류마티스 관절염 치료 방법이며 특히 MTX치료에도 불구하고 활동성인 류마티스 관절염에 기대되는 치료라고 할 수 있다. Background : This study was performed to investigate the efficacy and safety of etanercept in active rheumatoid arthritis patients with stable dose of methotrexate in Korean. Methods : In a 12 week, single arm, open trial, we assigned 76 patients with active rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs. Patients received twice-weekly subcutaneous injections of etanercept 25 ㎎ while containing to receive methotrexate at a stable dose of 7.5~25 ㎎ per week. The clinical response was defined as the percent improvement in disease activity according to the criteria of the American Collage of Rheumatology (ACR) at 12 weeks. Results : Etanrecept led to significant improvements in disease activity and was safe and well tolerated. At 12 week, 84.4% of the patients receiving 25 ㎎ of etanercept achieved a 20% ACR response, and 53.1% of those receiving etanercept achieved a 50% ACR response. The most common adverse event was injection-site reaction. Other advanse events were upper respiratory infection, nausea, and facial edema, but there were no serious adverse events associated with etanercept. Conclusion : In active rheumatoid arthritis patients, etanercept was safe, well tolerated, and provided rapid clinical improvements.

정상교합인의 두부위치변화에 따른 교합접촉점의 변화에 과한 연구

최희철,이성복,최대균,박남수 慶熙大學校 齒科大學 1994 慶熙齒大論文集 Vol.16 No.1

The understanding the nature of occlusal tooth contacts of natural dentition is important for correct diagnosis and treatment of diseases developed in stomatognatic system. Several investigator have studied the distribution of tooth contacts in maximum intercuspation and have repored contact locations with respect to the tooth position. However, there are few report the variation of the occlusal contact point with change in each head position. This study analysed the number of occlusal contact point with change in each head position. 30 subject(male 17, female 13), who had natural occlusion and no symptoms of temporomandibular disorder, were selected. The numbers and patterns of tooth contact were recorded by silicone bite registration on stone model at four different head positions with head anguration gauge(from the supine to the upright position). The results obtained were as follows: 1. The numbers of total occlusal contact point on teeth increased to average 25, 29, 35, 42 points as head angulation was changed from the supine to the upright position against the ala-tragus line, and there was significant difference (P<0.05) 2. In the 19 subject(65%) of total 30 subject, the perforated point of the silicone bite indicated that the locus for the prime contact point moved mesially as the head angulation was changed from the supine to the upright position. 3. On the basis of the fact that the anterior occlusal contact point increase as head angulation changed from the supine to the upright position,we could find that the mandibular position is moved anteriorly.

웨이블릿 변환과 독립성분분석을 이용한 디지털 워터마킹

차성철,김대성,최훈,손상욱,배현덕 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.2

디지털 워터마크는 디지털 자료를 모사로부터 보호하는 방법이다. 그르므로 디지털 워터마크는 파일변환, 컬러변환, 약간의 몽롱화, 압축과 같은 치리에서 뿐 아니라 인쇄, 복사, 스캐닝에 대해서도 강인해야한다. 본 논문은 워터마크 추출을 위한 키 데이터와 독립성분분석을 이용하는 알고리즘을 제안한다. 이 기법에서는 워터마크는 사람의 눈에 덜 민감한 원 영상의 웨이블릿변환 계수에 삽입된다. 그리고 독립성분분석 알고리즘은 서로 확률 분포가 다른 워터마크와 계수를 분리한다. 실험결과 워터마크가 워터마크 영상에서 사람 눈으로 인지할 수 없음을 보였으며, 워터마크 영상으로부터 키 데이터를 이용 영상이 일부 제거된 경우, 잡음이 첨가된 경우, JPEG 압축에서 워터마크의 추출이 가능함을 보였다. A digital watermark is a method to protect digital material from counterfeit. Therefore, it must be robust to withstand any processing, such as file format conversions, color conversions, slight blurring, sharpening color adjustment and compression as well as printing, copying and scanning. This paper proposed a method using key data and ICA algorithm for extraction of watermark. In this Method, we embed the watermark to the wavelet transform coefficients of original image which located in less sensitive subband to human eyes. ICA algorithm separated between watermark and coefficient that differs with probability distribution function each other. The experiment results have shown that the watermark is invisible to human eyes in watermarked image, and it is possible for watermarked image to extract the watermark with key data in various environment, such as removing, mixed noises and JPEG compressions.

로자탄 대 포시노프릴의 고혈압 환자들에서 항고혈압 효과, 안전성 및 내약성의 비교

박대균,이명묵,채인호,이무용,이홍자,김효수,김철호,손대원,오병희,박영배,최윤식 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

Destructive Encephalopathy를 보인 Incontinentia Pigmenti 1예

한진규,최재철,박민규,박건우,은백린,정지태,이대희 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.

자기베어링 런아웃의 적응제어

김재실,배철용,이재환,안대균,최헌오 창원대학교 산업기술연구소 2001 産技硏論文集 Vol.15 No.-

자기베어링의 회전정밀도에 영향을 미치는 인자로 PWM 전력증폭기, 위치 센서 등과 같은 자기베어링 구성 장치의 동특성 및 정밀도, 시스템의 정확한 모델링, 제어기법, 런아웃 등이 있다. 본 연구에서는 능동 자기베어링을 제어하기 위해 자기베어링의 PWM 전력증폭기와 회전축을 모델링하고 이를 바탕으로 능동 자기베어링 제어를 위한 PID 제어기를 구성하였으며, 변위 센서의 부착위치 및 회전축의 진원도의 영향으로 발생하는 주기적인 런아웃 요소를 첨가하여 런아웃의 영향을 확인하였으며, 런아웃(Runout)에 의해 발생하는 에러(Error)를 효과적으로 제어하여 자기베어링의 제어 정밀도를 향상시키기 위한 방법으로 기본적인 PID 제어기에 최소평균자승(Least Mean Square, LMS) 알고리즘을 적용한 적응 피드포워드 제어기를 구성하여 자기베어링의 능동 제어에서 발생하는 주기적인 런아웃을 효과적으로 제어할 수 있음을 MATLAB을 통한 시뮬레이션을 통해 확인하였다.