대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

Organic Solar Cells: Solution‐Processable Reduced Graphene Oxide as a Novel Alternative to PEDOT:PSS Hole Transport Layers for Highly Efficient and Stable Polymer Solar Cells (Adv. Mater. 42/2011)

Yun, Jin‐,Mun,Yeo, Jun‐,Seok,Kim, Juhwan,Jeong, Hyung‐,Gu,Kim, Dong‐,Yu,Noh, Yong‐,Jin,Kim, Seok‐,Soon,Ku, Bon‐,Cheol,Na, Seok‐,In WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.42

<P>Solution‐processable reduced graphene oxide as a hole‐transporting layer for highly efficient and stable organic solar cells is reported on page 4923 by Dong‐Yu Kim, Seok‐In Na, and co‐workers. Introduction of a newly reduced graphene oxide by simple solution processing into solar cells dramatically raises the cell efficiency and cell life‐time. The results will allow full use of chemically reduced graphene and will advance the realization of carbon‐based printable optoelectronic devices. </P>

설계변경의 경향 및 원인 분석을 통한 설계 품질향상 방안

석성재,김재근,이철우,홍순구,유춘번 한국품질경영학회 2000 품질혁신 Vol.1 No.1

This study is prepared to introduce design quality improvement measures by the trend and cause analysis of design changes which have been made during operations of construction project for power plant. In this study, two types of analysis tool have mainly taken for the use of the improvement measures. One tool is the trend analysis to identify which action should be taken to cut down design changes. This is also useful to monitor whether project participant's endeavour for the action taken is effective or not, to the project performance and design quality improvement. The other is the cause analysis, by using cause and effect diagram, which is useful to identify main causes of the design changes and to establish the measures to reduce recurrence of the design changes.

인체 방광암에서 p33^ING1의 발현 변화

이석영,신관희,한광희,이상철,김용태,김원재 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

철원산 현무암을 이용한 폴리머 콘크리트의 물리·역학적 특성

연규석,이윤수,김철영 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-

이 연구는 철원지역에 분포하는 현무암을 대상으로 부가가치를 향상시킬 수 있는 상품을 개발하기 위한 기초자료를 얻기 위하여 현무암에 대한 암석학적 및 물리적. 화학적 특성을 규명하고자 하였다. 철원지역의 현무암은 크게 대다공상 조직과 소다공상 조직을 갖는 2가지 암상으로 구분할 수 있으며, 주로 사장석과 휘석류, 감람석, 불투명 광물 등으로 구성되어 있고, 일부 기공속에서는 석영과 방해석이 발견된다. 현무암의 비중(참비중)은 2.89∼2.94, 공극률과 흡수율은 각각 9.96∼13.7%, 4.01∼6.53% 값의 범위를 보였고, 마모감량은 24.7∼30.5wt.%, 일축 압축강도와 인장강도는 각각 536∼875㎏f/㎠, 53.7∼69.1㎏f/㎠의 값이므로, 강도의 경우 기공이 적은 현무암이 많은 현무암보다 약간 더 강한 것으로 나타났다. 현무암의 미량원소 함량중 Co, Cr, Ni 등의 함량은 KIoke(1979)가 제시한 농작물에 독성을 줄 수 있는 토양중의 최대 허용한계값 (Co 50 ppm, Cr 100 ppm, Ni 100 ppm) 보다 더 높은 값을 보여, 철원현무암을 석제품으로 가공할 때 생기는 미석분을 처리할 때에는 이러한 점을 충분히 고려하는 것이 바람직할 것이며, 현무암의 분말시료에 대한 양이온 교환 용량 값에 의하면 대다공상 현무암 (5.81meq/100g)의 경우 중금속 흡착제로 활용할 수 있는 가능성이 충분히 있어, 이에 대한 차후의 면밀한 연구가 필요할 것으로 판단된다. Feasibility of chulwon basalt as a coarse aggregate for polymer concrete was investigate to solve the environmental problems associated with the waste. Basalt aggregates were prepared and used to produce basalt polymer concrete. The concrete was tested for physical and mechanical properties. The tested properties of basalt polymer concrete were not different from those of normal polymer concrete. It was concluded that chulwon basalt could be used as an aggregate for polymer concrete production. However, the long-term behavior, thermal extension and durability of basalt polymer concrete were suggested to be further explored.

여성요도구협착의 수술적 교정

오범석,김도완,오철규,노안식,박석산 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Objective: We describe various clinical presentations of female urethral meatal stricture, which may mimic other pelvic floor disorders and result in diagnostic delay. Diagnosis, management, and outcome results are reported Materials and Methods: We reviewed retrospectively 26 consecutive cases of female urethral meatal stricture. Patient characteristics, history, clinical presentation, symptom score, maximal flow rate, residual urine, diagnosis, management and short-term follow up are reported. Results: Mean patient age plus or minus standard deviation was 54 years. Most 21 (81%) cases were referred as diagnostic dilemmas with symptoms present for 1 month to 30 years. Mean interval between onset of symptoms to diagnosis was 5.8 years. The most common symptoms were residual urine sensation (77% of cases), frequency (54%), pelvic pain (46%), dysuria (46%), weak stream urine (27%), urgency (15%) and 17 patients (65%) have combined symptoms. 16 patients (62%) had been treated with oral and/or vaginal medication and/or psychotherapy. The female urethral meatal stricture was visible on physical examination in 21 patients (81%) and cystoscopy in 5 patients (19%). Of these visible urethral meatal stricture, 11 patients (45%) contained recurrent urinary tract infection, 9 patients (35%) contained urethral mucosal prolapse, 7 patients (27%) contained urethral diverticulum, and 3 patients (12%) contained stress urinary incontinence. 18 patients (69%) who has been treated with oral and/or vaginal medication or psychotherapy was not successfully improved. Treatment consist of urethral meatal excision and/or everted urethral mucosal excision and/or urethral diverticulum excision and/or anti-incontinence surgery when indicated. Subsequently 24 patients (92%) had improved symptom score, but 2 patient was not changed. In 9 patients new symptom developed. Conclusions: Female urethral meatal stricture have several urinary symptoms and may mimic other pelvic floor disorders. This condition should be considered in women with frequency, residual urine sensation, pelvic pain, dysuria and etc. Medical treatment is not sufficient but surgical treatment is usually simple, safe and effective in alleviation associated symptoms.

Canine juvenile cellulites의 진단과 치료 증례

황철용,유종현,강형석,윤화영,한홍율 한국임상수의학회 2002 한국임상수의학회지 Vol.19 No.4

Canine Juvenile cellulitis was diagnosed in 2 puppies hospitalized in Veterinary Medical Teaching Hospital of Seoul National University. Characterized dermatological problems were presents of scale, crust, purlent exudation and alopecia limited on their face. On cytologic examinations of direct impression smears for the lesions, numerous neutrophils and macrophagies were observed. No bacteria and fungus were noted. Treatments with administration of predinisolone and antibiotic orally combined with topical shampoo treatment had good results for the two puppies.

Neuropathic Pain의 동물모델에서 유발된 Thermal Hyperalgesia에 대한 Clonidine의 효과

윤석화,오세철,최세진 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

The effects of intraperitoneal injection(i.p.) of the alpha 2 adrenal receptive agonist, clonidine on the thermal hyperalgesia produced by unilateral patially tight ligation of the sciatic nerve was studied in rats. First in the preoperative and postoperative Mays, paw withdrawal latency of both hind paw(lesioned,unlesioned) with heat stimulant was tested. After that, each groups of rats injected saline, clonidine 10㎍/kg, or clonidine 50㎍/kg. I.p.10㎍/kg and 50㎍/kg clonidine, paw withdrawal latency of lesioned side significantly reduced than saline group. It is suggested systemical clonidine may be useful in treating neuropathic pain in humans.

생물계면활성제를 이용한 중금속 및 유기물 오염 토양의 정화

홍석정,현재혁,김영철 한국공업화학회 2002 응용화학 Vol.6 No.1

A study on the soil remediation was performed by using a biosurfactant. The surfactant solutions were applied to the soil flushing of the artificially contaminated soil with copper ion, cadmium ion and phenol. The optimal concentration of the surfactant was determined by the lab.-scale column tests using the solutions of various concentrations. The characteristic behavior of the contaminant removal was studied and the efficiencies of the soil flushing were determined for the contaminants.

적산온도법에 의한 에폭시 모르터의 초기강도 예측에 관한 연구

연규석,大濱嘉彦,이윤수,김철영 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-

에폭시 모르터를 보수용으로 사용할 경우 거푸집의 회전율을 높이고 완전한 시공관리 차원에서 초기강도의 예측은 매우 중요하다 할 수 있다. 이에 본 연구는 결합재로서 에폭시 수지를 사용한 폴리머 모르터를 제조하고 경화제의 첨가량에 따른 초기강도의 변화를 시멘트 콘크리트에 적용되어 온 적산온도 방법에 의해 예측하는데 목적이 있다. 에폭시 모르터 제조에 사용된 재료는 반응성 희석제로 변성한 저점도형 Bisphenol-A계 액상 에폭시를 사용하였으며, 경화제는 지방족 Amine 변성 경화제를 사용하였다. 실험결과 에폭시 모르터의 기준온도는 -3∼-11℃로 나타났고, 경화제 첨가량에 따른 적산온도와 압축강도 사이의 강도 추정식은 다음과 같이 구할 수 있었다. 30% : Y = 292.42 Ln(M) - 881.16 40% : Y = 386.64 LN(M) - 1223.1 50% : Y = 273.18 LN(M) - 1040.5 Epoxy mortar is widely used to repair cement concrete structure and predicting strength of the mortar is of importance in its application. The objectives of this study were to compare the development of compressive strength of epoxy mortar with respect to maturity and to propose a predictive model for strength development of epoxy mortar. A series of tests were carried out for the hardener contents of 30, 40 and 50 percentage of resin and compressive strengths were measured at the age of 6, 12, 24, 72, 120 and 168 hours respectively under the cure temperature of 0, 10, 20 and 30℃. The datum temperature was estimated by measured strength, and the maturity was calculated with the estimated datum temperature. It was shown that the compressive strength of epoxy mortar could be predicted by regression analysis from the maturity-compressive strength relationship.