Ethyoene Oxide 폭로 근로자의 말초 임파구 자매염색분체 교환에 관한 연구

황천현,박종태,장성훈,김대성,이원진,김청식,김영환 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Operators of hospital sterilizers who use ethylene oxide(EtO) were studied to determine the exposure of EtO level and the frequency of sister chromatid exchanges(SCEs) from June 12 to July 20, 1997. To evaluate SCEs in the peripheral blood cells, we selected 22 workers at the central supply room of 4 university hospitals and 22 unexposed workers at the same hospitals according to match sex, age, and smoking habit and also did questionnaires. The mean air concentrations(8-hr TWA) of EtO at 4 university hospitals were less than 1 ppm. The SCE frequencies in exposed workers to EtO and controls were normally distributed. The SCE frequencies in exposed workers to EtO and controls were 6.42±0.63, 5.86±0.69, respectively and their differences were statistically significant(p=0.0093). But there were no statistically significant differences in smoking, alcohol intake, coffee drinking. Especially smokers who exposed to EtO were increased SCE statistically significant than the exposed group who did not smoke.

소아 삼출성 중이염이 약물 치료에 영향을 미치는 인자에 관한 연구

김영기,정현수,함태영 인제대학교 1994 仁濟醫學 Vol.15 No.2

삼출성 중이염의 예후와 관련된 인자를 알아보기 위하여 외래를 방문한 51명의 환자를 대상으로 난치성과 관련이 있는 요인을 조사해 본 결과, 과거의 중이수술 유무, 동반된 부비동염 등이 약물 치료에 대한 반응의 중요한 예후인자라고 생각되었다. It has been clarified that multiple factors are implicated in the otitis media with effusion which is common in children. This prospective study was performed to evaluate the factors related to the prognosis of the otitis media with effusion. History, physical examination, impedance audiometry, and radiologic examination were taken. Oral antibiotics (Augmentin or cefixime) were given to all patients orally for 3 months. Myringotomy and V -tube insertion was done in the patients who had no response after 3 months of medication. The factors implicated in the prognosis of otitis media with effusion were analysed. The significant risk factors were present inthose wish previous myringotomy or V-tube insertion, presence of mucopurulent rhinorrhea and total hazziness on PNS X-rays, but not to adenoid vegetaton, eardrum retraction, age, sex, bilaterality and presence of recurrence. Therefore, the presence of previous middle ear surgery and concomitant sinusitis were important prognostic factors in treatment of the otitis media with effusion medically.

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

위성 통신용 다대역 안테나

정치현(Chi-Hyun Cheong),정혜미(Hye-Mi Jeong),김건우(Kun-Woo Kim),배기형(Ki-Hyoung Bae),태현식(Hyun-Sik Tae),엡츄시킨겐나디(Evtyushkin Gennadiy) 한국항공우주학회 2010 韓國航空宇宙學會誌 Vol.38 No.12

본 논문에서 소개하는 위성 통신 안테나는 대용량 데이터 전송을 위한 위성 송수신 시스템에 응용되어 추가적인 급전부 교체나 다른 기구 형상 변경 없이 X, Ku와 Ka 3중 대역의 전파 신호를 통시에 송수신할 수 있다. 설계된 안테나는 오프셋 파라볼라 안테나 형태로 2중 대역(X/Ka 대역) 급전혼, 단일대역(Ku 대역) 급전혼, 주파수 선택막(FSS : frequency selective surface) 특성을 갖는 부반사판 및 파라볼라 주반사판으로 구성되어 있다. 주반사판의 초점에는 2중 대역 급전혼이 위치하며, FSS 부반사판으로 이미지 초점을 만들어 단일 대역 급전혼이 설치되어 운용된다. 본 안테나는 전기적 특성이 국내 위성 환경에 부합되도록 3차원 EM 시뮬레이터를 이용하여 설계하였고, 측정결과 X/Ku/Ka 대역에서 안테나 이득이 각각 31.6 dBi, 36.8 dBi, 40.8 dBi 이상, 교차편파는 각각 21.7 ㏈, 26.6 ㏈, 그리고 25.2 ㏈ 이상의 특성으로 목표 성능을 만족함을 확인하였다. The design is presented for a SATCOM antenna capable of simultaneous multi-band (X/Ku/Ka-Band) communications without replacement of feed horns or change of other parts in the application as a ground satellite terminal for large data transfer. The antenna is the offset configuration and consists of a dual-band(X/Ka-band) feed horn, a single-band(Ku-band) feed horn, a frequency selective surface(FSS) sub-reflector and a parabolic main-reflector. The antenna has a main reflector defining a prime focus and a frequency selective surface sub-reflector defining an image focus. A dual-band feed and a single-band feed are provided at each of the prime focus and image focus. The antenna is designed using 3D EM simulator and the gains measured in X/KulKa-band of the complete antenna assembly is more than 31.6dBi, 36.8dBi, 40.8dBi, and the cross polarization is 2l.7㏈, 26.6㏈, 25.2㏈, respectively.

Variance of The Bispectral Index Score (BIS) Among The Measurement Time in Patients with Brain Injuries

Kim, Se-Hun;Kim, Hyun-Tae;Cheong, Soon-Ho;Lee, Kun-Moo;Lee, Jeong-Han;Lim, Se-Hun;Cho, Kwang-Rae;Kim, Myoung-Hun;Kim, Se-Hun;Kim, Hyun-Tae;Cheong, Soon-Ho;Lee, Kun-Moo;Lee, Jeong-Han;Lim, Se-Hun;Cho, 인제대학교 2011 仁濟醫學 Vol.32 No.-

목적: 이중분광계수(Bispectral Index Score)는 중환자실에서 진정의 정도를 가하는 도구로 사용되고있다. 저자들은 뇌손상환자에서 진정척도를 사용하여 의식의 정도를 측정할 때 말이나 통중의 자극으로 인해 이중분광지수가 변할수 있다고 가정하였다. 방법: 42명의 뇌손상환자에서 진정척도를 사용하여 자극을 주기 5분전과 5분후에 이중편광계수를 측정하여 연관성을 확인하였다. 결과: 이중편광계수는 측정시간에 따라 차이가 없었다. 평균 이중편광계수는 Glasgow Coma Score (GCS), Richmond Agitation-Sedation Scale (RASS), Reaction Level Scale(RLS)와 연관성이 있었다. 결론: 진정척도와 이중편광지수와의 연관성은 자국의 유무에 의해 영향을 받지 않는 것으로 보인다.

Protective Effect of BOEC Co-Culture System against Nitric Oxide on Development of Bovine IVM/IVF Embryos

Hyun-Yong Jang,Yu-Sung Jung,Zheng-Yi Li,Hyoung-Jong Yoon,Hee-Tae Cheong,Jong-Taek Kim,Choon-Keun Park,Boo-Keun Yang 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.3

Somatic cells such as oviduct epithelial cell, uterine epithelial cell, cumulus-granulosa cell and buffalo rat river cell has been used to establish an effective culture system for bovine embryos produced in in vitro. But nitric oxide (NO) metabolites secreted from somatic cells were largely arrested the development of bovine in vitro matured/ in vitro fertilized (IVM/IVF) embryos, suggesting that NO was induced the embryonic toxic substance into culture medium. The objective of this study was to investigate whether BOEC co-culture system can ameliorate the NO-mediated oxidative stress in the culture of bovine IVM/IVF embryos. Therefore, we evaluated the developmental rate of bovine IVM/IVF embryos under BOEC co-culture system in the presence or absence of sodium nitroprusside (SNP), as a NO donor, and also detected the expression of growth factor (TGF-p , EGF and IGFBP) and apoptosis (Caspase-3, Bax and Bcl-2) genes. The supplement of SNP over 5 uM was strongly inhibited blastocyst development of bovine IVM/IVF embryos than in control and 1 uM SNP group (Table 2). The developmental rates beyond morulae stages of bovine IVM/IVF embryos co-cultured with BOEC regardless of SNP supplement (40.4% in 5 uM SNP+ BOEC group and 65.1% in BOEC group) were significantly increased than those of control (35.0%) and SNP single treatment group (23.3%, p<0.05: Table 3). The transcripts of Bax and Caspase-3 genes were detected in all experiment groups (1:Isolated fresh cell (IFC), 2:Primary culture cell (PCC), 3:PCC after using the embryo culture, 4: PCC containing 5 uM SNP and 5: PCC containing 5 uM SNP after using the embryo culture), but Bcl-2 gene was not detected in IFC and PCC (Fig. 1). In the expression of growth factor genes, TGF-p gene was found in all experimental groups, and EGF and IGFBP genes were not found in IFC and PCC (Fig. 2). These results indicate that BOEC co-culture system can increase the development beyond morula stages of bovine IVM/IVF embryos, possibly suggesting the alleviation of embryonic toxic substance like nitric oxide.

Antioxidative Effects of Curcumin on Development of IVM/IVF EmblYos and Viability of Semen Stored In vitro in Pig

Hyun-Yong Jang,Young-Han Kim,Han-Su Kim,Su-Jung Ji,Jong-Taek Kim,Choon-Keun Park,Hee-Tae Cheong,Boo-Keun Yang 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.2

In Vitro Developments of Bovine IVM/IVF Embryos under Bovine Oviduct Epithelial Cell (BOEC) Co-culture System and Gene Expression of BOEC Monolayers using or not for Embryo Culture

Hyun-Yong Jang,Yu-Sung Jung,Young-Han Kim,Su-Jung Ji,Jong-Taek Kim,Choon-Keun park,Hee-Tae Cheong,Boo-Keun Yang 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.2

Using genetic algorithm to support clustering-based portfolio optimization by investor information

Cheong, Donghyun,Kim, Young Min,Byun, Hyun Woo,Oh, Kyong Joo,Kim, Tae Yoon Elsevier 2017 Applied soft computing Vol.61 No.-

<P>A clustering-based portfolio optimization scheme that employs a genetic algorithm (GA) based on investor information for active portfolio management is presented. Whereas numerous studies have investigated trading behaviors, investor performance, and portfolio investment strategies, few works have developed investment strategies based on investor information. This study is conducted in two phases. First, a basket of portfolio (i.e., a collection of stocks held in individual portfolios) is developed through a cluster analysis of investor information. A GA is then employed to optimize the weights of the selected stocks. And the optimized portfolio is rebalanced to get excess return. It is concluded that the proposed multistage portfolio optimization scheme for active portfolio management generates superior results than previously proposed methods for the Korean stock market. (C) 2017 Elsevier B.V. All rights reserved.</P>