한강하구지역에서 월동하는 재두루미(Grus vipio)의 개체군 감소

이화수(Hwa-Su Lee),신주열(Ju-Yeol Shin),이시완(Si-Wan Lee),강태한(Tae-Han Kang),윤순영(Soon-Young Yoon),김정수(Jungsoo Kim) 한국조류학회II 2012 한국조류학회지 Vol.19 No.4

김포시와 고양시 일대의 한강하구 지역은 우리나라에서 재두루미의 가장 중요한 월동지 및 중간기착지로 알려져 있지만, 이 지역의 조류 서식환경은 심각한 개발압력과 인간의 간섭으로 인해 지속적으로 나빠지고 있다. 따라서 본 연구에서는 2007-2008년과 2011-2012년의 월동시기에 본 지역에 도래하는 재두루미를 대상으로 월동 개체군 크기 변화와 월동지역 내에서 과거와 현재의 취식지역 이용 현황 등을 조사하여 개발행위가 이들의 서식에 미치는 영향을 확인하였다. 본 지역에서 월동하는 재두루미 개체군은 평균 124.9개체(2007-2008년)에서 59.0개체(2011-2012년)로 감소하였으며, 주요 취식지역에서 확인된 개체수는 평균 77.7개체에서 24.1개체로 감소하여 월동개체군의 감소폭에 비해 주요 취식지역의 이용 개체수의 감소폭이 더 크게 나타났다. 유형별 분석에서는 가족군에 비해 무리군의 개체수가 많이 감소한 것으로 나타났으나, 홍도평 지역의 가족군 이용 개체수는 변화가 나타나지 않았다(Mann-Whitney test. Z=-0.26, p=0.979). 그리고 과거 다수의 재두루미가 주요 취식지역으로 이용하였던 송포동과 평동지역은 2012-2013년 조사에서는 거의 이용하지 않는 것으로 나타났다. 이는 위 지역의 개발행위(예: 제 2자유로 건설 등)와 깊은 연관성이 있는 것으로 생각된다. Han-river estuary in Gimpo and Goyang city is well known as one of the most important wintering and stopover sites for migrating White-naped Crane (Grus vipio) in Korea. Nowadays, habitat quality of this area is getting worse due to serious development pressure and high human disturbances. So, we wanted to know whether development actions affected total wintering population change in Han-river estuary and feeding group pattern of White-naped Crane in main feeding habitats between the 2007-2008 and 2011-2012 wintering period. Average wintering population was decreased 124.9 to 59.0 and population of main feeding site also decreased 77.7 to 24.1. But decrease rate of main feeding site population was higher than total wintering population. Non-family feeding population was more decrease than family feeding population in the flock type analysis. But family feeding population of Hongdopyong was maintained from past and present (Mann-Whitney test. Z=-0.26, p=0.979). However, almost all White-naped Crane din not use both feeding sites, Pyong-dong and Songpo-dong, where were deteriorated habitat quality by human act.

정상 성인에 경구 투여한 Cefixime 두 정제의 생물학적 동등성 비교

강진양,서성훈,이경태,문창훈,강진한,이동건,최정현,신완식 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

목적 : 식품의약안전청 고시 제 1998-86호(1998. 8.26) "생물학적 동등성 시험 기준"에 의하여 섹심 캅셀(시험약, 한국유나이트제약)과 슈프락스 캅셀(대조약, 동아제약)의 생물학적 동등성을 비교 검토하였다. 방법 : 2×2 라틴 방격법에 따라 건강한 성인 남성 지원자 20명에게 cefixime 100㎎씩 경구투여하였다. 약제투여 후 12시간까지 일정간격으로 채혈하였고 각 피험자들의 혈중약물농도 데이터로부터 구한 Area under the concentration (AUC), C_(max), T_(max) 등의 생체이용률 파라미터에 대해 통계학적으로 고찰하여 두 제제간의 생물학적 동등성을 평가하였다. 결과 : AUC, C_(max), T_(max)에 대한 평균값의 차가 각각 1.26%, 3.73%, 6.21%로서 모두 대조약의 20% 이내에 들어 생물학적 동등성 판정기준의 전제조건을 만족하였다. 분산분석 결과 AUC, C_(max), T_(max)의 각 비교 항목에 있어서 모두 유의수준 α=0.05의 군/순서효과 검정에서 F비가 F 분석표의 한계값보다 작아 교차시험이 제대로 이루어졌음을 확인할 수 있었으며, AUC, C_(max), T_(max) 각 비교항목에 있어서 유의수준 α=0.05에서 대조약에 대한 최소검출차(Δ)가 각각 17.74%, 17.05%, 15.67%로 모두 20% 이내이었으며, 검출력(1-β)도 모두 0.8 이상으로 나타나 생물학적 동등성 판정기준을 만족시켰다. 또 AUC, C_(max), T_(max) 각 비교항목에 있어서 대조약에 대한 생체이용률 차이의 신뢰한계(δ)가 ±20% 이내이어야 한다는 생물학적 동등성 판정기준을 모두 만족시켰다. 결론 : 이상의 실험결과로 시험약은 대조약에 대하여 생물학적 동등성 평가항목인 AUC, C_(max), T_(max)에서 모두 판정기준을 만족시켜 시험약은 대조약과 생물학적으로 동등하다고 사료된다. Background : The study was designed to compare the bioeqivalence between the test (CEXIME®. United Korea. Co., Ltd) and control (SUPRAX®. Dong-a Pharm. Co.. Ltd) capsules of cefixime. Methods : Twenty. healthy, male volunteers completed the study Each subject ingested single dose (100 ㎍) of the control and test drugs in 2?2 crossover design with a week drug-free interval between the doses. Blood samples were collected serially up to 12 hours and plasma concentrations of cefixime were measured by high-performance liquid chromatography with UV detection. A non-compartmental approach was used for analysis of the concentration-time data. Results : The area under the curve (AUC), the maximum concentration of drug (C_(max)). and time to reach C_(max)(T_(max)) did not show any significant difference between the two preparations by ANOVA. The mean differences of AUC, C_(max), and T_(max) were within 20% of the control drug, those were 1.26%. 3.73%. and 6.21%. respectively. The confidence limits of three parameters were satisfied the bioeqivalence criteria. Conclusion : These results suggest that the test drug was bioequivalent with the control drug.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

황색포도구균의 균혈증에서 초기 항생제 치료가 예후에 미치는 영향

김성한,박완범,이기덕,강철인,최영주,김홍빈,박상원,김의석,오명돈,김의종,최강원 대한감염학회 2002 감염 Vol.34 No.5

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

항나제복합치료(MDT)후 재발문제 : report of three cases

김한욱,강광숙,임철완 大韓癩學會 1989 癩學 會誌 Vol.22 No.1

골수이식 후 골밀도 및 골대사의 변화 : 2년 추적관찰 2-Year Prospective Study

이원영,강무일,오은숙,오기원,한제호,손현식,윤건호,차봉연,이광우,손호영,강성구,신완식,민우성,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

사과 열과(裂果)의 원인과 그 방지에 관한 연구

권병규,강영호,이우승,성민웅,한강원 경북대학교 1971 生産技術 Vol.5 No.-

On the basis of our hypothesis about the causes of cracking has obtained in our 1969's study, we investigated the relations among the cracking and the microelements, the environmental factors, and the treatment of IAA and GA in two selected orchards. We analyzed and compared with the contents of microelements (Mn, B, zn, and Cu) in leaves and soils of two test orchards (Taegu and Yungju). The results of the study which the causes of cracking of apples are examined through the above three procedures, are as follows: 1. The contents of Mn in soil of Taegu test orchard were total Mn 435.9 ppm, soil sol'n Mn 6.2ppm, and total Mn 284.6 pm in leaves. That of Yungju test orchard were total Mn 595.1ppm, soil sol'n Mn 6.2ppm and total Mn 144.2ppm in leaves. Comparing with Mn optimum contents in leaves Mn contents of Taegu test orchard were higher than the optimum concentration, while those of Yungju were approximately satis-factory. 2. The contents of B in leaves were 3.7ppm in Taegu and 4.6ppm in Yungju. These contents were lower ten times than the optimum contents and were the same deficiency in both test orchards. 3. The contents of Zn in leaves were 5.7ppm in Taegu and 3.8ppm in Yungju. Those contents were both the same deficiency as comparing with the optimum contents. 4. The contents of Cu in leaves were 29.3ppm in Taegu test orchard and 10.6ppm in Yungju test orchard. Comparing with the optimum contents, the contents of Cu were excess in Taegu test orchard, while that of Cu were approximately satisfactory in Yungju 5. The diameter of Ralls apple fruits were increased 1.1% in IAA spraying treatment and 3.1% in GA spraying treatment as comparing with control group 6. The thickness of cuticle layer of Ralls apple fruits were highest and the cuticle treated with IAA and GA was thinner than the control group. 7. New branches of tree with higher cracking rate tended to decrease in length, in figure and size of leaves. 8. The change of diameter in fruits were decreased in higher cracking fruits during day and night. The change of that in IAA and GA group were increased 6.1% and 1.2% respectively compared with the control group. 9. The application of IAA and GA solution slowed the cracking rate by 2.2 and 0.8% respectively compared with the control group 10. In 1970 year the cracking rate of Ralls apple fruit were 6.53% in Taegu and 4.31% in Yungju test orchard. 11. We obtained linear regression of rate of cracking and the summation of temperature during May to August in Taegu area. The summation of temperature was 2428.1℃ during June to August in 1970. When the summation of temperature was increased more than above that of tempera ture, we could expect that it was possible to increase the rate of cracking Ralls apple. An equation in the summation of temperature and the rate of cracking fruits during May to August were obtained y=0.074x-157.50. 12. The investigation indicates that a method of preventing the cracking of Ralls apple is: a. to spray at the optimum time growth hormone which increases the elasticity and elongation of cell wall. b. to alter the composition of soil by putting the organic fertilizer deeply in the ground. c. to replace Ralls apples with new varieties which is strong against cracking and have high quality and economical productivity.

Staphylococcus aureus와 Coagulase-Negative Staphylococcus Species에 대한 Arbekacin의 시험관내 항균력

위성헌,강진한,허동호,이동건,김상일,김양리,최정현,김종현,유진흥,허재균,신완식,강문원 대한감염학회 2001 감염 Vol.33 No.4

Background : Most strains of methicillin-resistant Staphylococcus aureus (MRSA) now exhibit high-level resistance to various antibiotics, such as β -lactam antibiotics, aminoglycosides, macrolides, tetracyclines and quinolones. Recent reports describing the therapeutic failure of vancomycin for MRSA infections have arisen considerable concerns regarding the emergence of MRSA strains, which will require new therapeutic agents. Arbekacin, an aminoglycoside antibiotic, has antibacterial activity against both gram-positive and gram-negative bacteria and is stable in the presence of aminoglycoside inactivating enzymes produced by S. aureus. In this study, we compared the antibacterial activity of arbekacin with those of vancomycin, gentamicin, and amikacin against Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CNS). Methods : For a collection of 549 S. aureus and 251 CNS isolates from three Catholic University Hospitals in Korea, minimum inhibitory concentrations (MICs) of arbekacin, vancomycin, amikacin and gentamicin were determined by agar dilution method using Mueller-Hinton agar according to NCCLS (National Committee for Clinical Laboratory Standards, USA)criteria. Results : Among 549 S. aureus isolates, 278 isolates were MRSA and 271 isolates were methicil sensitive S. aureus (MSSA). MIC50 & MIC90 of arbekacin against 549 S. aureus were 0.5 & 1 ㎍/mL, and MIC50 & MIC90 of vancomycin were 1 & 1 ㎍/mL. MIC of arbekacin against 549 S. aureus isolates ranges from 0.03 to 4 ㎍/mL, and MIC of vancomycin against 549 S. aureus ranges from 0.25 to 2 ㎍/mL. MIC90 of amikacin against 549 S. aureus was 32㎍/mL, and that of gentamicin was 128 ㎍/mL. MICs of amikacin and gentamicin were variable, ranging from 0.125 to 256, and otherwise arbekacin and vancomycin revealed relatively narrow range of MICs. MIC90 of arbekacin against 278 MRSA isolates & 271 MSSA were 1 & 0.5 ㎍/mL, and those of vancomycin against MRSA & MSSA were 1 & 1 ㎍/mL. MIC90 of amikacin against 278 MRSA & 271 MSSA isolates were 32 & 4 ㎍/mL, and that of gentamicin against MRSA & MSSA isolates were 128 & 32 ㎍/mL respectively. Among 251 CNS isolates, 122 isolates were MRCNS and 129 were MSCNS. MICSO & MIC90 of arbekacin against 251 CNS isolates were 0.25 & 2 ㎍/mL, and those of vancomycin were 1 & 2 ㎍/mL. MIC of arbekacin against 251 CNS isolates ranges from 0.015 to 32 ㎍/mL, and that of vancomycin isolates ranges from 0.25 to 2 ㎍/mL, MIC90 of arbekacin against 122 MRCNS & 129 MSCNS isolates were 2&0.3 ㎍/ML, and those of vancomycin were 2&s ㎍/ML. MIC90 of amikacin against 251 CNS isolates was 32 ㎍/ML, and that of gentamicin was 128 ㎍/ML for CNS. MIC90 of amikacin against 122 MRCNS & 129 MSCNS isolates were 128 & 8㎍/mL, and those of gentamicin ere 256 & 32 ㎍/mL. Conclusion : Considering above results, arbekacin can be useful agent against most strains of MRSA and MRCMS, which exhibit high-level resistance to amikacin and gentamicin. (Korea J Infect Dis 33:254~260, 2001)