육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고

김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

원예치료가 정신 및 지체 장애인의 재활에 미치는 영향

손기철,고언희,엄수진,이상훈,송종은 建國大學校附設農業資源開發硏究所 2002 農資源開發論集 Vol.24 No.-

This study was to investigate the effect of horticulture therapy on the healing and rehabilitation of the mentally retarded (MR) and physical disorder (PD) persons. Horticultural therapy program was carried at S rehabilitation center located in Kyounggi-DO from Jun 29, 1999 to Oct 12, 1999. The participants in this program were 36 clients of MR and PD. They attended 14 times once a week for 1 hour at a time for horticultural therapy. Evaluation of horticultural activities and ADL (Activities of daily living) has been assessed two times, that is, before and after horticultural therapy program (HTP) whereas horticultural therapy group activity treatment procedure and horticulture task skill inventory have been assessed 3 times, that is, before HTP and after each 7 weeks. MR in the evaluation of horticultural activities showed statistically significant in participation, interest and assistance, verbal interaction during activity, self-concept and identity, need-drive adaptation, interpersonal and social relations, cognition and problem solving, exercise perceptivity, life-tasks skill and vocational adjustment. In activities group of MR also showed significant improvement in terms of physical perceptual abilities, cognitive ability, writing ability, social interaction (P<0.001). Additionally, their horticulture task skill were improved significantly in skill and efficiency factor (P<0.008) and their ADL were changed positively but not significant. On the other hand, PD in evaluation of horticultural activities showed significantly positive changes in self-concept and identity, interpersonal and social relations, life-tasks skill and vocational adjustment. However, physical perceptual abilities factor was proven to be effective in horticultural therapy group activities treatment procedure (P<0.002). Only grooming was significantly improved in ADL evaluation of PD (P<0.03). Putting these results together, it was found that horticultural therapy programs would be very useful for rehabilitation and healing method in both MR and PD.

Optode형 glucose 센서의 개발

강신원,고광락,이수미,김수진 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

인간의 미각은 단맛 (甘味, sweet taste), 신맛 (酸味, sour taste), 짠맛(鹽味, saline taste), 쓴맛 (苦味, bitter taste)의 4가지 기본요소와 우마미 (Umami)^1)로 이루어져 있다. 본 연구에서는 그 중 글루코오스를 감지할 수 있는 당도 (糖度)센서인 초보적인 미각센서의 개발을 위하여 광섬유를 이용한 optode형의 센서소자를 제작하여 glucose의 농도 1×10 exp (-7) ∼ 1×10 exp (-2) M의 범위에 대해 측정하였다. 본 센서의 측정원리는 광섬유를 통한 광의 전달시 감지막의 글루코오스에 대한 반응에 따른 흡광 특성에 의해 일어나는 출력광의 감소 즉, 소산파의 흡수를 측정하는 원리를 이용하였다. The taste is composed of five fundamental tastes, sweet, sour, saline, bitter taste and umami. This research purposed to develope a glucose sensor, sweet taste sensor. The glucose sensor device used five kinds of dye/PMMA polymer sensing membranes containing five dyes. All experiment processor is based on the pH 7.4, 0.05 M tris-HCl buffer solution and glucose concentration from 1×10 exp (-7) to 1×10 exp (-2) M range. The fiber optode of the sensor device is made of skipped cladding in the fiber's middle site and then coated by dye/PMMA membrane. The principle of the sensor is based on the absorbance change of the evanescent wave of the sensing membrane according to glucose concentration change. In this experiments, we made a response pattern of the glucose sensor system using the evanescent wave.

전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예 : Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET

서욱장,정선미,고수진,이창근,김재승,임주혁,유빈,문희범 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECt also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

코카콜라 경구 투여 및 내시경을 통한 코카콜라주입법으로 치료한 활동성 위궤양을 동반한 다발성 거대위석 1예

곽원건,박보라,강지훈,강현우,김재학,임윤정,이준규,고문수,이진호 동국대학교 의학연구소 2009 東國醫學 Vol.16 No.1

위석은 섭취된 이물질이 위내에서 응결된 덩어리로 일반적으로 내시경적 분쇄법 및 화학적 용해법이 치료방법으로 알려져 있다. 최근 코카콜라를 경구 또는 비위관을 통하여 주입하여 치료한 사례들이 보고되고 있으며 경구 투여 및 내시경을 이용하여 위석내 콜라를 주입하는 것이 치료기간 및 위석치료 성공률을 향상시킨다는 보고가 있다. 최근 저자들은 급성 위궤양이 확인된 환자의 거대위석을 코카콜라 경구 및 내시경 직접 주입법을 통하여 치료한 1예를 경험하였기에 보고하는 바이다. Gastric bezoars are concretions of foreign bodies found in the stomach, common method for the treatment was endoscopic fragmentation or chemical dissolution therapy, recently, there were reports on the treatment of bezoars by cola drinking or Coca-Cola gastric lavage, combination therapy with Coca.Cola drinking and endoscopic injection decreases duration of therapeutic time and increases dissolution rate, we report one case of active gastric ulcer with huge gastric Bezoars completely treated by drinking Coca.Cola with endoscopic injection

Sensitization of ionizing radiation-induced apoptosis by ursolic acid

Koh, Su Jin,Tak, Jean Kyoung,Kim, Seon Tae,Nam, Woo Suk,Kim, Sung Youl,Park, Kwon Moo,Park, Jeen-Woo Informa Healthcare 2012 Free radical research Vol.46 No.3

<P>Radiation therapy has been widely used for treating human cancers. However, cancer cells develop radioresistant phenotypes that decrease the efficacy of radiotherapy. Ionizing radiation (IR) induces the production of reactive oxygen species, which play an important role in apoptotic cell death. Therefore, radiation therapy combined with a sensitizer, which modulates cellular redox status, has the potential to enhance therapeutic efficacy in a variety of human cancers. Here, we investigated the radiosensitizing effects of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basil. IR-induced apoptosis in cancer cell lines such as DU145, CT26 and B16F10 was significantly enhanced by UA, as reflected by DNA fragmentation, cellular redox status, mitochondrial dysfunction and modulation of apoptotic marker proteins. Additionally, UA combined with IR was also effective for inhibiting tumorigenesis in B16F10 melanoma cells implanted into mice. Taken together, these results suggest that applying UA together with IR may be an effective combination modality for treating cancer.</P>

Clinical efficacy and safety of internal real-time thermosensing monopolar radiofrequency for face lifting and contouring

( Su Jin Oh ),( Won Seon Koh ),( Jae Min Shin ),( Eun Jin Kim ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: As demand for youthful appearance has increased, several techniques for face lifting and contouring by reducing excess fat and improving skin laxity have been introduced. Recently, radiofrequency (RF)-assisted lipolysis and liposuction (RFAL) has been successfully used as an alternative procedure for body and face contouring. Objectives: We aimed to evaluate the clinical improvement achieved with an internal real-time thermosensing monopolar RFAL device (APOLEX三, Chung Woo Medical, Seoul, Korea) for face lifting and contouring, and monitored its safety. Methods: A prospective study was conducted in 20 patients who underwent an internal real-time thermosensing monopolar RFAL procedure on the face and neck. Prior to treatment and 12 and 24 weeks after treatment, digital photographs were taken and skin elasticity was measured by a Cutometer三 CT575 (Courage and Khazaka三, Cologne, Germany). Safety was monitored by questioning for side effects at each visit. Results: All 20 patients showed clinical improvement. Although the changes in skin elasticity measured by the Cutometer三 were not statistically significant, all the treated regions showed a trend of improvement. Critical side effect was not occurred. Conclusion: After further studies with greater numbers of patients and longer follow-up periods, internal real-time thermosensing monopolar RF devices may become one of the popular treatment options for face lifting and contouring.

Serum β₂-Microglobulin Predicts Mortality in Peritoneal Dialysis Patients: A Prospective Cohort Study

Koh, Eun Sil,Lee, Kyungsoo,Kim, Su Hyun,Kim, Young Ok,Jin, Dong Chan,Song, Ho Chul,Choi, Euy Jin,Kim, Yong Lim,Kim, Yon Su,Kang, Shin Wook,Kim, Nam Ho,Yang, Chul Woo,Kim, Yong Kyun S. Karger AG 2015 American journal of nephrology Vol.42 No.2

<P>Abstract</P><P><B><I>Background/Aims:</I></B> β<SUB>2</SUB>-Microglobulin (β<SUB>2</SUB>-M) is a surrogate marker of middle-molecule uremic toxins and is associated with mortality in chronic hemodialysis patients. However, the impact of serum β<SUB>2</SUB>-M levels on mortality in peritoneal dialysis (PD) patients is uncertain. The purpose of this study was to examine the association of serum β<SUB>2</SUB>-M levels with all-cause mortality in PD patients. <B><I>Methods:</I></B> A total of 771 PD patients were selected from the Clinical Research Center registry for end-stage renal disease cohort in Korea. Patients were categorized into 3 groups by tertiles of serum β<SUB>2</SUB>-M levels. The primary outcome was all-cause mortality. <B><I>Results:</I></B> The median value of serum β<SUB>2</SUB>-M was 23.6 mg/l (interquartile range 14.8-33.4 mg/l), and the median follow-up period was 39 months. The Kaplan-Meier analysis showed that the all-cause mortality rate was significantly different according to tertiles of serum β<SUB>2</SUB>-M in PD patients (p = 0.03, log-rank). Multivariate Cox proportional analysis showed that the hazards ratio for all-cause mortality was 1.02 (95% CI 1.01-1.04, p = 0.006) per 1 mg/l increase in β<SUB>2</SUB>-M after adjustment for multiple confounding factors that relate to malnutrition and inflammation marker. However, serum β<SUB>2</SUB>-M was not associated with all-cause mortality after adjustment for residual renal clearance. <B><I>Conclusions:</I></B> These results are supportive of the potential role of the serum β<SUB>2</SUB>-M level as a predictor of mortality in PD patients.</P><P>© 2015 S. Karger AG, Basel</P>

Communication for end-of-life care planning among Korean patients with terminal cancer: A context-oriented model

Koh, Su Jin,Kim, Shinmi,Kim, Jinshil Cambridge University Press 2016 Palliative & supportive care Vol.14 No.1

<B>ABSTRACT</B><B>Objective:</B><P>In Korea, patients with terminal cancer are often caught out of the loop in end-of-life (EoL) care discussions. Healthcare professionals also have difficulty engaging in such communication in a variety of healthcare contexts. Therefore, the objective of our study was to develop a communication model for EoL care decision making compatible with the clinical environment in Korea.</P><B>Methods:</B><P>Using focus-group interview methodology, participants included eight doctors and five nurses who provide EoL care for terminal cancer patients in acute hospital settings or hospice care facilities in various provinces of Korea.</P><B>Results:</B><P>Five themes emerged regarding EoL care discussion, which included: (1) timing, (2) responsible professionals, (3) disclosure of bad news, (4) content areas of EoL care discussion, and (5) implementing strategies for EoL care discussions. These themes were based on development of a communication algorithm for EoL discussion among patients with terminal cancer. A structural communication step for delivery of a terminal prognosis was specified at the phase of disclosure of bad news: beginning with determination of a patient's decision-making capability, followed by a patient's perception of his/her condition, a patient's wish to know, family dynamics, and a patient's and/or family's readiness for EoL discussions.</P><B>Significance of Results:</B><P>The proposed context-oriented communication algorithm could provide a helpful guideline for EoL communication and, accordingly, facilitate meaningful improvements in EoL care in Korean clinical practice. The feasibility of this algorithm has not yet been determined, and its validation in a larger sample of patients with terminal cancers, using a quantitative research methodology, is a priority of research.</P>