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Wearing-off 현상을 경험하는 파킨슨병 환자에서 엔타카폰의 효과 및 안정성: 다기관 무작위 위약비교 이중맹검 연구
임주혁,이종균,정선주,전범석,조진환,이명식,조은경,이원용,이은아,김재우,이명종 대한신경과학회 2005 대한신경과학회지 Vol.23 No.2
Background: The purpose of this study was to assess the efficacy and safety of entacapone, a catechol-O- methyltransferase (COMT) inhibitor in Parkinson's disease (PD) patients with wearing-off phenomenon. Methods: A total of 197 PD patients were included in this 2-month multi-center, randomized, placebo-controlled, double blind, parallel-group study. After a 2-week screening period, each patient was randomly allocated to receive either entacapone (n=98) or placebo (n=99) as an adjunct to levodopa. The efficacy was evaluated with the changes of “on” and “off” time percentage while awake, the reduction of the levodopa dose, Unified Parkinson's Disease Rating Scale (UPDRS), and the clinical global impression (CGI) by the examiner. Results: The percentage of “on” time increased by 9.4±18.0% in the entacapone group, 7.4±15.6% in the placebo group. The percentage of “off” time was reduced by 8.6±16.9% in the entacapone group, 6.6±18.2% in the placebo group. These parameters did not show a statistical significance between the two groups. However, the levodopa dose was significantly reduced in the entacapone group (51.6±154.5 mg/day) compared with the placebo group (0.7±130.0 mg/day) (p=0.009). The total and motor scores of the UPDRS were significantly decreased in the entacapone group (p=0.039, p=0.017, respectively). The most common adverse drug reactions in the entacapone group were urine discoloration (22%), dyskinesia (13%), dizziness (7%). Conclusions: Entacapone was a safe and well-tolerated drug. Although the changes of “on” and “off” time were not significant, entacapone showed an overall significant beneficial effect in the PD patients with wearing-off phenomenon. Background: The purpose of this study was to assess the efficacy and safety of entacapone, a catechol-O- methyltransferase (COMT) inhibitor in Parkinson's disease (PD) patients with wearing-off phenomenon. Methods: A total of 197 PD patients were included in this 2-month multi-center, randomized, placebo-controlled, double blind, parallel-group study. After a 2-week screening period, each patient was randomly allocated to receive either entacapone (n=98) or placebo (n=99) as an adjunct to levodopa. The efficacy was evaluated with the changes of “on” and “off” time percentage while awake, the reduction of the levodopa dose, Unified Parkinson's Disease Rating Scale (UPDRS), and the clinical global impression (CGI) by the examiner. Results: The percentage of “on” time increased by 9.4±18.0% in the entacapone group, 7.4±15.6% in the placebo group. The percentage of “off” time was reduced by 8.6±16.9% in the entacapone group, 6.6±18.2% in the placebo group. These parameters did not show a statistical significance between the two groups. However, the levodopa dose was significantly reduced in the entacapone group (51.6±154.5 mg/day) compared with the placebo group (0.7±130.0 mg/day) (p=0.009). The total and motor scores of the UPDRS were significantly decreased in the entacapone group (p=0.039, p=0.017, respectively). The most common adverse drug reactions in the entacapone group were urine discoloration (22%), dyskinesia (13%), dizziness (7%). Conclusions: Entacapone was a safe and well-tolerated drug. Although the changes of “on” and “off” time were not significant, entacapone showed an overall significant beneficial effect in the PD patients with wearing-off phenomenon.
프리스트레스트 중공 슬래브와 현장타설된 토핑콘크리트의 수평전단성능 평가
임주혁,박민국,이득행,서수연,김강수 한국콘크리트학회 2014 콘크리트학회논문집 Vol.26 No.6
프리스트레스트 중공(PHC) 슬래브는 장경간에 적합하도록 경량화된 효율적인 프리캐스트 부재이며, 국내·외에서 많이사용되고 있다. 특히, 국내에서는 현장타설콘크리트와 같이 사용되는 합성슬래브 형태로 주로 적용되고 있다. 그러나, 압출성형방식으로 제작되는 PHC 슬래브 부재는 매우 낮은 슬럼프의 콘크리트로 제작되어 타설 직후에도 표면경도가 높기 때문에 계면의거친면 처리 및 전단연결재 배치가 어려운 단점이 있다. 이 연구에서는 PHC slab 부재와 토핑콘크리트 사이의 합성성능을 고찰하기 위하여 다양한 계면상태를 변수로 직접전단실험을 수행하였으며, 기존 실험결과를 수집하여 국내·외 수평전단강도 설계기준을 평가하였다.
원산지별 홍삼투여에 따른 백서의 자연살해세포 활성도 변화에 대한 연구
임주혁,조인영,민경윤,이혜영,김슬지,박영주,류재환,이범준,김성욱,주일우,Im, Ju-Hyuk,Cho, In-Young,Min, Kyoung-Yoon,Lee, Hae-Yong,Kim, Seul-Ji,Park, Young-Ju,Lew, Jae-Hwan,Lee, Beom-Joon,Kim, Sung-Wook,Joo, Il-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : The purpose of this experiment is comparing the difference on natural killer cell activity through Korean red ginseng and Chinese red ginseng by $^{51}Cr$ release assay. Methods : Thirty rats were equally divided into a Korean red ginseng group, a Chinese red ginseng group and a control group. Korean and Chinese red ginseng were administrated to the rats at 200mg daily for a weak, while 0.9% normal saline was given to the control. Percent specific lysis (PSL) and lytic units (LU) were calculated from spleen cells by $^{51}Cr$ release assay. Results : Percent specific lysis of the Korean red ginseng group was significantly higher than that of the control in the ratio of 100:1, effector cell:target cell (p<0.05). Percent specific lysis of Korean red ginseng group was also significantly higher than that of the Chinese red ginseng group in the ratio of 25:1, effector cell:target cell (p<0.05). Chinese red ginseng showed no effect on NK cell activity. Conclusions : These findings suggest that Korean red ginseng improves immunologic function and shows superior effects than Chinese red ginseng.
임주혁,박민국,이득행,김강수,서수연 대한건축학회지회연합회 2014 대한건축학회연합논문집 Vol.16 No.5
PHC 슬래브는 제작특성상 전단철근을 배치할 수 없기 때문에 복부전단에 매우 취약하다. 이에 현행 기준에서는 기존에 수행된 실험적 연구에 근거하여 최소전단철근량이 배치되지 않은 두께 315 mm 이상의 중공을 갖는 부재에 대해 전단강도를 산정할 때 기준에 의해 산정된 전단강도의 1/2 값 이하로 설계하중을 제한하도록 규정하고 있다. 이는 PHC 슬래브의 적용확대에 큰 걸림돌이 되고 있다. 따라서, 이 연구에서는 315 mm 이상의 두께를 갖는 PHC 슬래브의 전단강도 성능실험을 수행하였으며, 이와 더불어 여러 문헌으로부터 실험결과들을 수집하여 현행기준의 전단강도식을 평가하였다. Prestressed hollow-core (PHC) slab is disadvantageous in web-shear strength because it is very difficult to provide shear reinforcement due to its unique production method. In current shear design provisions, it is newly regulated that the web-shear capacity of PHC slab members exceeding 315 mm in depth without minimum shear reinforcement should be reduced by half based on recent experimental studies. This new limitation on the PHC slab member becomes an obstacle for the application of PHC slabs in market. Therefore, in this study, the web-shear tests on the PHC slabs with thickness over 315 mm were conducted, and a large number of shear test results on the PHC slab units were collected from literature, by which the shear strength equations in design codes were evaluated.