http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
문치숙,김선희,기현균,오원섭,백경란,이남용,송재훈 대한감염학회 2006 Infection and Chemotherapy Vol.38 No.3
Background : To evaluate urinary tract infections (UTI) in renal transplant recipients in setting where TMP-SMX resistance is quite common. Materials and Methods : All patients underwent renal transplantation at Samsung Medical Center from January 1998 to August 2002 were included with the completion of 2 year-follow-up. TMP- SMX was prophylactically administered during 12 months after renal transplantation. Their medical records and microbiologic data were reviewed, retrospectively. Results : A total of 336 patients were enrolled (male to female ratio, 191 : 145; mean age, 39±10 years). 146 episodes of UTI were observed in 104 patients (31.0%) within 2 years after renal transplantation. 52 episodes (35.6%) developed during post-transplantation 30 days, and 87 episodes (59.6%) within post-transplantation 6 months. There was no difference in the incidence of UTI with regard to the type of immunosuppressants (P=0.371) or graft rejections (P=0.291). Among the isolated strains, Escherichia coli (E. coli) (51.4%) was the most common, followed by Enterococcus species (12.3%), Pseudomonas species (6.8%), Enterobacter species (6.1%), Coagulase-negative staphylococci (5.5%), and Klebsiella species (5.5%). Among 75 E. coli isolates, rates of resistance to TMP-SMX, ciprofloxacin, ampicillin-sulbactam and ceftriaxone were 62.7%, 34.7%, 33.3%, and 1.0%, respectively. There was no difference in mortality rate related with the occurrence of UTI (P= 0.754). Conclusion : Despite high prevalence of TMP-SMX resistance, post-transplantation UTI is usually mild and does not seem to predispose to increase graft rejection or patient mortality. Nevertheless, because most common episodes of UTI occur within 1 or 6 months of transplantation, further studies are warranted to evaluate if additional preventive strategies during early period are needed. 목 적 : 최근의 신이식에서 강력한 면역억제요법의 도입과 예방적 항균요법에 쓰이는trimethoprim-sulfamethoxazole (TMP-SMX)의 내성률 증가는 이식 후 발생하는 요로감염 양상의 변화를 유도할 가능성이 있다. 이에 저자들은 신이식 후 요로감염의 발생과 임상 양상에 대하여 알아보고자 하였다.재료 및 방법 : 1998년 1월에서 2002년 8월까지 삼성서울병원에서 신이식을 받은 336명의 환자를 대상으로 이식 후 2년 동안의 의무기록과 배양 검사 결과를 후향적으로 조사하였다. 모든 대상 환자는 이식 후 12개월까지 TMP- SMX의 예방요법을 받았다.결 과 : 대상 환자의 평균 연령은 39±10세(15-78세)였으며 남녀 비는 191 : 145이었다. 이식 후 2년간 추적 관찰하는 동안 104명(31.0%)의 환자에서 146예의 요로감염이 발생하였고, 요로감염의 35.6%는 이식 후 첫 1개월 이내, 59.6%가 이식 후 6개월 이내에 발생하였다. 요로감염은 통계학적으로 유의하게 여자 환자에서 흔히 나타났다(124 episodes, P=0.0001). 면역억제제의 종류(P=0.371)와 이식신의 거부반응(P=0.291)은 요로감염의 발생과 유의한 상관관계를 보이지 않았다. 요로감염의 원인 균주로 146균주가 분리되었고, Escherichia coli (E. coli) (51.4%), Enterococcus species (12.3%), Pseudomonas species (6.8%), Enterobacter species (6.1%), coagulase-negative staphylococci (5.5%), Klebsiella species (5.5%)의 순서로 나타났다. 75개의 E. coli 균주에서 TMP-SMX의 내성률은 62.7%이었고, ciprofloxacin, ampicillin-sulbactam, ceftriaxone에 대해서 각각 34.7%, 33.3%, 1.0%의 내성률을 보였다. 신이식 환자의 사망률은 1.2%(4명)이었고, 요로감염으로 인한 사망례는 없어서 이식 후 요로감염과 환자의 사망은 유의한 상관관계를 보이지 않았다(P= 0.754).
우리나라 임신부에서 대유행 인플루엔자(H1N1) 2009 감염
김백남,문치숙,곽이경,김연숙,이꽃실,이창섭,허지안,김의석 대한감염학회 2011 Infection and Chemotherapy Vol.43 No.1
Background: Pregnant women are at an increased risk for severe illness and complications associated with pandemic (H1N1) 2009. This study was conducted to identify the severity of pandemic (H1N1) 2009 in pregnant Korean women. Materials and Methods: The demographic and clinical data from pregnant women with laboratory confirmed pandemic (H1N1) 2009 during September to December 2009 were retrospectively collected from 8 hospitals in Korea. Results: A total of 150 pregnant women with pandemic (H1N1) 2009 were identified. The median age was 30 years (range: 22-39 years), and the median gestational age (n=114) was 20 weeks (range: 1-39 weeks). All but one patient with secondary bacterial pneumonia had influenza without complication. Although 12 pregnant women needed hospitalization, there were no patients who needed admission to the intensive care unit or who died. Only one hospitalized patient had elective cesarean section because of oligohydamnios. No maternal or fetal complications directly related to the pandemic (H1N1) 2009 were identified among the 67 pregnant women who were followed up for 1 to 185 days after their influenza illness, including 6 women who delivered during the study period. Conclusions: In contrast with the reports from Western countries, pandemic (H1N1)2009 among pregnant Korean women was mild.
김태희,문치숙,이상민,이현성,정수룡,이영민,조길현,김대경,김두일,김동수 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
This malformation of the heart entirely lacks atrial septum due to lack of formation of the septum primum and septum secundum. The main anatomical feature is the existence of a large, common cavity behaving as a single atrium. Hemodynamics are quite similar to the one of a large atrial septal defect. Treatment is no significant difference with ASD. A large prosthesis is usually necessary to obliterate the large defect. We report a case of patient with single atrium treated with patch closure.
서우선,문치숙,허민영,이현성,이상민,이재호,이상봉,정수룡,조길현,김대경,김두일,김동수 한국심초음파학회 2003 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.11 No.1
Primary cardiac tumors in infancy and childhood are rare, with fibromas being the second most common tumor after rhabdomyomas. Although cardiac fibromas are characteristically benign intramural tumors, they may exhibit expansile growth resulting in obstruction, valvular dysfunction, as well as other problems so early diagnosis and successful surgical excision are important. We experienced a case of cardiac fibroma in right ventricle that diagnosed by transthoracic echocardiography, chest CT, open heart tissue biopsy etc. 저자등은 흉부 불쾌감을 주소로 내원한 16세 여자환자에서 심장에 발생한 원발성 섬유종 1예를 경험하여 임상경과 및 문헌고찰과 함께 보고하는 바이다.
이영민,문치숙,염호기,박성근,최석진,김주인 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
Interstitial lung disease is a frequent and important clinical manifestation of drug toxicity. Drug-induced lung disease has no pathognomonic signs, symptoms, laboratory tests, or pathologic findings. Thus, the diagnosis of drug-induced pulmonary toxicity always rests on the exclusion of such processes as neoplasm, infection, pulmonary thromboembolism, and congestive heart failure. In most cases, the mainstay of ther apy consists of drug withdrawal, and a trial of corticosterois is warranted if gas exchange abnormalities are severe. Bucillamine is a disease modifying antirheumatic drug(DMARD) which is used for the treatment of rheumatoid arthritis(RA) and shows clinical efficacy in RA. Since the chemical structure of bucillamine is similar to that of D-penicillamine, side effects of bucillamine may be similar to those of D-penicillamine. Various side effects have been associated with bucillamine, but to our knowledge, until recently there has been no report on an association between pulmonary fibrosis and bucillamine. We experienced a patient with RA who developed pulmonary fibrosis during the treatment of bucillamine and reported with review of the literature.