프로스타글란딘 E₁에칠에스테르의 외용 리오겔 제제 설계

양성운,이진교,이지은,김희규,박혜숙,김종석,최한곤,용철순,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

External lyogels containing prostaglandin E₁ethyl ester(PGE₁-EE), a produrg of prostaglandin E₁(PGE₁) as a therapeutic agent for erectile dysfunction, were formulated to overcome the aqueous instability and enhance the percutaneous absorption. Lyogels of PGE₁-EE were prepared with ethanol (EtOH)/proplyene glycol (PG) cosolvent system as a vehicle, cineol as an enhancer, and hydroxypropylcellusose as a gelling agent. In vitro percutaneous absorption studies were performed to determine the rate of PGE₁ absorption through rat or hairless mouse skin. The permeability of PGE₁-EE lyogel with enhancer was 16-fold greater than that of lyogel without enhancer. Cosolvent produced 9-fold increase in percutaneous absorption. Pharmacodynamic effects of lyogels were evaluated in mature male cats in terms of intracavernosal pressure (ICP). Lyogles containing 0.01% of PGE₁-EE showed higher ICP compared to intraurethral preparation of PGE₁(1%) and enhancer-free control lyogel. The shelf-life (t_(10%) of lyogel at refrigerated condition (4℃) was calculated as 928 days, which is 4.2 times longer than that of control hydrogel. As a result, PGE₁-EE was formulated successfully to a lyogel system with a selective enhancer and cosolvent system for the topical delivery of PGE₁.

숙명여자대학교 학위예복 디자인 개발에 관한 연구

양숙희,손휘순,박진영,양희영,위혜정 숙명여자대학교 건강·생활과학연구소 2004 生活科學硏究誌 Vol.- No.21

Academic costume is a ceremonial dress represented authority and formality. This indicates a degree in a viewpoint of personality, and symbolizes academic authority and well matched social responsibility. Besides, it emblematizes separately university's identity and tradition, and could be utilized useful culturaltools visualized national culture and tradition. That is to say, academic costume is most effect visual medium, which symbolizes our subjective culture and academic authority and phase. Accordingly, creative academic costume's development is a link of active and positive efforts to be satisfied with various needs of spearhead information society in 21C. Academic costume designing development had been progressed a public opinion survey, theoretical examination, and research on the actual condition through various actual materials. Based on the above examination, this study performs designing development of a bachelor, master, and doctor's academic costumes. Designing development of academic costumes intend to be enlarged and developed academic costume's function as a symbolic cultural tool, which includes Sookmyung women's spirit as a beginningof the racial education. Moreover, this aims at active utilizing of academic costumes as a symbolic medium expressed Sookmyung Women's University's identity, which intends to realization of the racial education establishing women's education, racial identity, and subjectivity, and represents educational objectives planning to the ruling women's bringing up.

골육종에서 p53단백발현에 대한 면역조직화학적 연구 : Osteosarcoma

양경무,홍순원,조미연,정순희,정우희 연세대학교 원주의과대학 1994 원주의대논문집 Vol.7 No.1

다발성 치아우식증 소아에서 타액 단백질의 특성

장희순,최병재,양호정,이승일 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

As a part of host factors of dental caries,salliva has been well known for its important role in relation to dental caries.The studies on its physical and chemical charaterisitics on development and progress of dental caries has been condected.Recently,various comparisons between saliva of caries-susceptable individuals and caries-free individuals has been done and the efforts to understand the machanisms of salivary intervention of development and progress of dental caries is actively in progress.In this study,15 children with rampant dental caries and 15 caries free children without any systemic diseases from the ages of 2 to 5 were chosen for the experiment and the whole saliva and parotid saliva from each individuals were collected and protein compared using polyacrylamide gel electophyoresis(PAGE). As results of this study,in parotid saliva,there was no difference in protein compositions between the rampant dental caries and caries free children.While electrophoresis was done with the whole saliva,protein with 120 KDa was found in children with rampant dental caries.However,this protein was not found or unclear,if any for the caries free group.(Exceptionally,clear protein band was present for one person.)Protein compositions of whole saliva rampant dental caries group was compared before and after the caries control and thick and clear protein bands of about 120 KDa were found in both cases.Protein compositions of caries free children and adults were indentical.Quantitative analysis of protein was done for the rampant dental caries group and the control group and no significant difference was found. Taken all together,protein with molecular weight of 120 KDa,found in rampant dental caries group,was still present when the treatment for the dental caries was done so it can be assumed that this protein has no interrelation with the presence of active carious lesions during saliva collecting.It can also be presumed that this specific salivary protein with the molecular weight of 120 KDa found in rampant dental caries group has effect on development and progress of dental caries.Identification on this protein with the molecular-weight of 120 KDa and the role of this protein against dental caries remain to be solved.

킬레이트 수지에 의한 금속이온 흡착에 관한 연구

정순량,양희태,오해범 又石大學校 1981 論文集 Vol.3 No.-

The selective adsorption of metal ions by chelating agent-treated resin was studied in aqueous media. The resin was prepared by the treated conventional anion exchange resin, Dowex 1-X8(48 to 80 mesh) with chelating agent containing sulfonic groups such as 1, 2 -dihydroxy benzene- 3, 5 disulfonate(Tiron). The stability of the resin was markedly influenced by the pH of the media. The optimum conditions for the adsorption of metal ions were determined with respect to the pH, shaking time and mixture solution of metal ions. Under the optimum condition the other of the adsorption of metal ions is as follows: Fe(Ⅲ), Cu(Ⅱ), Ca(Ⅱ), Mg(Ⅱ), Ni(Ⅱ), and Zn(Ⅱ) are little. The total capacities of the resins in Fe(Ⅲ) were found 37. 98㎎/gr in the condition of pH 3 and in Cu 6.86㎎/gr in the condition of pH 3.5.

제올라이트(NaA형, NaX형)의 이온교환성에 관한 연구

정순희,김복련,금경호,서양곤,안주현 경상대학교 환경보전연구소 2001 環境保全硏究所報 Vol.9 No.-

A study has been made of the exchange of Ag^+, Li^+, and Ba^++, Ca^++, Sr^++ ion by using synthetic zeolite-13X and zeolite-NaA. The zeolite used in this work was supplied as beads by Aldrich Chemical Company, Inc., and the formula of unit cell is M_x/n[AlO₂)_x(SiO₂)_y]zH₂O. X-ray diffraction analysis and Fourier transform infrared spectroscopy indicated that the crystallinity of zeolites was retained though sodium ion in zeolite exchanged with the cation. The amount of ion exchanged was measured by the determining of the amount of cation remained in solution by Inductively coupled plasma, and surface area, adsorption isotherm, Ion exchange kinetics. The selectivity of ions was in the order Ag^+>Li^+>Sr^++>Ca^++>Ba^++.

일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.

빌트인 모터를 이용한 2축 제어 미세 가공기 개발

김건희,김효식,양순철,이상용,국명호,이선규,김윤중,홍권희 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

This paper describes development of low cost precision machine that has combined the Build-in Motor with a vacuum chuck. This study mainly aims to find out a cutting condition for maintaining optimum surface condition and to examine cutting characteristics of the precision machine that is equipped by diamond bites. The cutting materials is Al alloy. Several experiments were carried out to find out the main factors that affect the surface roughness such as principal axis RPM(rotation per minute), feeding speed, and cutting depth. As a result, we obtain The optimum cutting condition of the developed precision machine.

강원도 지역 여자고등학생들의 식생활 행동과 체중 조절 태도에 관한 연구

김경희,임양순 한국 가정과 교육 학회 1995 한국가정과교육학회지 Vol.7 No.1

The purpose of this study was to investigate eating behavior and the attitude about weight control of the High School Girls. The questionnaires were completed by 519 girls'high school students.(lived in city ; 269, in mine region ; 250) The results were as follows; 1. The average stature of them was 159.01±6.76kg. 2. In the present body structure of them, the underweight structure was 26.2%, the normal weight structure was 58.4%, the over weight structure was 15.4%. The present body structure was very different from the recognition of their own body structure. 3. The average point of the eating behavior was 52.07 and that of city953.62 point) was higher than mine region(50.01 point). They had a significant difference(p<0.01) between two regions. 4. The rate of going without breakfast(p<0.05), the frequency of snsck(p<0.01), the eating rate of stimulus foods(p<0.05), the interest healthy food life(p<0.05) in two regions showed the significant difference. 5. The point of eating behavior in two regions showed the positive correlation in the economic level, the contentment degree of the present body structure, the conscious healthy condition. But it showed the vegative correlation in the rate of going without of breakfast. On observing the difference of the two regions, it showed the positive correlation to mether's education career on the negative relation to the experience of the weight control in the city. In the other hand, it showed the negative correlation to the recognition on degree of the present body structure in the mine region. 6. The contentment degree of the present body structure showed the negative correlation to the experience of the weight control. Also, it showed the vegative correlation to the rate of going without breakfast in the city.

인터넷 고퍼에 의한 교내정보시스템의 설계

이남순,양희재 慶星大學校 1995 論文集 Vol.16 No.3

This paper presents the design of a campus-wide information system (CWIS) using the Internet Gopher???, which was originally developed at the University of Minnesota in 1991 for providing an online mechanism for publishing hints on computing services at the university. Because of its simplicity and efficiency. Gopher is considered as one of the promising ways for CWIS with a large population number of users in a campus. However, Gopher lacks some important features which must be provided in order for it to be really suitable as a CWIS. To support these features we added several new protocols to the original Gopher protocol, while maintaining its basic structures so that the compatibility still holds. The system was actually implemented in Kyungsung University and the result says that our modified Gopher system is excellently suitable as a CWIS.