항암화학요법을 받은 진행성 위암 환자에서 발생한 Trichosporon beigelii 진균혈증 1예

이충현,송서영,이혁,백경란,김성민,강원기,송재훈 대한감염학회 1999 감염 Vol.31 No.3

급성 림프구성 백혈병의 구제항암화학요법 후 골수부전기에 발생한 Trichosporon beigelii 폐렴 1례

정진태,백진호,김동환,곽동석,박소향,손상균,서장수,이규보 大韓血液學會 2000 大韓血液學會誌 Vol.35 No.2

토혈과 원통 모양의 토물을 주소로 내원한 Trichosporon beigelii 식도염 1례

박은정,황진복,안욱수,전창호,김용진,Park, Eun-Jung,Hwang, Jin-Bok,Ahn, Wook-Su,Jun, Chang-Ho,Kim, Yong-Jin 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.1

토혈과 함께 변성된 생체 조직의 일부로 보이는 토물을 주소로 내원한 소아에서 응급 상부위장관 내시경 시술을 이용하여 식도 부에서 유출된 토혈과 토물로 진단하고, 조직 검사를 이용하여 드문 원인 균인 T. beigelii에 의한 진균성 식도염으로 진단된 례를 경험하였다. 진균성 식도염에 의해 이미 형성되어 있던 가막성 조직은 변성된 식도 점막부의 상피 세포들로서 점막하 조직으로 부터 원통형으로 분리되었으며, 이때 발생한 구토에 의하여 토혈과 함께 토물로 배출된 희귀한 증례이다. We experienced a case of Trichosporon beigelii esophagitis in a 16-month-old boy who was presented with hematemesis with a large amorphous material. A spit-out material was silky, $10{\times}1.2\;cm$ in size and like a part of hollow viscus organ. Emergent gastrofiberscopy revealed that this silky material was teared up from upper and to lower esophagus and was threw with hematemesis. It was suggested that pseudomembrane on esophagus was peeled off followed by mucosal bleeding. Pathologic study revealed this material was pseudomembrane with esophageal mucosa of T. beigelii esophagitis and was teared at lamina propria level from submucosa.

Amphotericin B와 Fluconazole 병합요법으로 회복된 Trichosporon beigelii에 의한 파종성 감염증 1예

오봉준,신종희,신동현,정숙인,김형준,서순팔,양동욱 대한임상미생물학회 2005 Annals of clinical microbiology Vol.8 No.2

Trichosporon beigelii is often resistant to the fungicidal effect of amphotericin B and can cause fatal disseminated infections in immunocompromised patients. We report a case of a disseminated T. beigelii infection with a favorable outcome in a patient with acute erythroleukemia and neutropenia. The patient presented a persistent fever, multiple erythematous skin lesions, and pulmonary infiltrates. T. beigelii was isolated from blood cultures in four days and also from cultures of abdominal skin lesion, sputum, and stool. The isolate was resistant to amphotericin B (MIC, 2 μg/mL), and the respective fluconazole and itraconazole MICs were 4 and 1 μg/mL. The patient was successfully treated with fluconazole plus amphotericin B in combination with granulocyte colony stimulating factor and leukocyte transfusion. This case shows the importance of early diagnosis and treatment with combination of amphotericin B and fluconazole as a prognostic factor of disseminated T. beigeliiinfections.

급성골수성백혈병 환자에서Amphotericin B와 Fluconazole로 치료된 Trichosporon beigelii진균혈증 1례

장문주,이여경,한기철,홍성근,강명서,오도연,정소영 대한혈액학회 2004 Blood Research Vol.39 No.2

Trichosporon beigelii is a causative agent of white piedra, an superficial hair shaft infection in immunocompetent individuals, and rarely of disseminated trichosporonosis in immunocompromised patients especially in neutropenic patients with leukemia. Trichosporon infections in immunocompromised patients are frequently fatal despite therapy with amphotericin B. We describe an acute myelogenous leukemia patient with T. beigelii fungemia after remission induction chemotherapy who was successfully treated with amphotericin B and fluconazole.

Cecropin A-Magainin 2 유도체 펩티드의 Trichosporon beigelii에 대한 항진균 활성 및 인간 적혈구 세포에 대한 용혈활성

이동건,신송엽,이명규,함경수 한국미생물학회 1997 미생물학회지 Vol.33 No.3

강한 항진균 활성을 나타내며, 낮은 적혈구 용혈활성을 갖는 새로운 합성 펩티드를 얻기 위하여 cecropin A(1-8)-magainin 2(1-12) 및 이들의 유사체들을 설계하고 이들을 고상법에 의하여 합성하였다. 합성 펩티드의 항진균 활성은 Trichosporon beigelii에 대한 성장억제능에 의하여 측정하였으며, 세포독성은 인간의 적혈구 세포에 대한 용혈활성에 의하여 측정하였다. 펩티드의 양쪽 친매성의 증가는 항진균활성보다는 적혈구 용혈황성에 큰 영향을 미쳤다. Cecropin A(1-8)-magainin 2(1-12)의 12번 아미노산이 Lys을 Ala으로 치환시킨 유사체 펩티드(A2)는 가장 강한 항진균활성(minimum inhibitory concentration : 2.5.$\mu$g/ml)을 나타내며 비교적 낮은 적혈구 용혈활성(200.$\mu$g/ml의 펩티드 농도에서 0.5% hemolysis를 나타냄)을 나타내었다. 따라서 A2의 펩티드는 세포독성을 갖지 않으며 강한 항진균 활성을 가지는 모델로서 유용하게 사용될 것이다. In order to design a novel synthetic peptide with improved fungicidal activity but low hemolytic activity, a hybrid peptide, cecropin A(l-8)-magainin 2(1-12), and its analogue peptides were synthesized by the solid phase method. Antifungal and hemolytic activities of the synthetic peptides were assessed by the growth inhibition against Trichosporon beigelii and the cell membrane lysis against human red hlood cells, respectively. Analogue 2 in which Lys at position 12 in cecropin A(1-8)-magainin 2(1-12) was substituted with Ala showed most potent antifungal activity (MIC: 2.5.$\mu$g/ml) with minimal hemolytic activity (0.5% hemolysis at the (200.$\mu$g/ml peptide). This peptide (A2), therefore, could be useful as a model for further designing potent antifungal peptides without cytotoxicity.

지속성외래복막투석 환자에서 발생한 Trichosporon beigelii 복막염

양중일 ( Yang Jung Il ),김미애 ( Kim Mi Ae ),정은영 ( Jeong Eun Yeong ),백주은 ( Baeg Ju Eun ),하혜정 ( Ha Hye Jeong ),김현정 ( Kim Hyeon Jeong ),박동준 ( Park Dong Jun ),장세호 ( Jang Se Ho ),전은실 ( Jeon Eun Sil ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3

Fungal peritonitis is one of the leading causes of patients dropout from continuous ambluatory peritoneal dialysis (CAPD) therapy. Although the most causative agents of peritonits associated with CAPD are bacteria, fungi are implicated in up to 10% of cases. The most common organism of fungal peritonitis is Candida specises, but Trichosporon beigelii was reported as a rare causative agent of fungal peritonitis. We experienced a case of CAPD peritonitis by Trichosporon beigelii, which was treated with CAPD catheter removal, and antifungal agents with amphotericin B and fluconazole. Thus, we report our experience of CAPD peritonitis caused by Trichosporon beigelli and review of the literature. (Korean J Nephrol 2004;23(3):518-522)

하수처리장 근로자에서의 족부백선

김정애(Jeong Aee Kim),정승용(Seung Yong Jung),문상은(Sang Eun Moon),권석운(Seog Woon Kwon) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.1

Tinea pedis is frequently found in those people with poor hygine and in hot and humid environments. The authors investigated the clinical, epidemiologicol a id mycological characteristics of tinea pedis in 138 sewerage workers attending a sewerage plant in Seoul. Tinea pedis was found in 82, with a prevalence of 59.4%. The prevalence of tinea pedis increased with age and the period working at sewerage plant, however, there was no statistical significance. Also there was no difference in the prevalence of tinea pedis between the clerical workers and the field workers. Positive rate for KOH smear was 73.2%, and culture positive rates were 42.7%, producing 35 strains of dermatophytes. Twertyeight strains of Trichophyton Rubrum and 7 strains of Trichophyton mentagrophytes were isolated. Twentyseven yeast-form colonies were isolated, and Trichosporon beigelii was foungl in 19 samples. Most of the yeast forms were found mixed with dermatophytes and moulcis, However, 6 were isolated from direct smear positive cases and yieIded pure colonies of yeast. These included 4 cases of T. beigelii, 1 case of Candida parapsilosis, and 1 case of Candida hormicola. In view of the recent report of these fungi as pathogenic organism, these isolates, rspecially T. beigelii, were considered as a causative agent of tinea pedis in certain groups like sewerage workers. (Kor J Dermatol 1992; 30(1): 62-67)

쓰레기 처리장 근로자에서의 족부백선

김정애(Jeong Aee Kim),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3

Tinea pedis is frequently found in people with poor personal hygiene and in hot, humid environments. The authors investigated the clinical, epidemiological, and mycological characteristics of tinea pedis in 170 garbage workers(166 males and 4 females) employed in a garbage plant in Seoul, Korea. 40 were clerical workers and 130 were field workers. Tinea pedis was found in 134 with a prevalence rate of 78.8%. Of those 134, 61(45.5%) also had onychomycosis. The prevalence of tinea pedis increased with age and the period working in garbage plant. However, there was no difference in the prevalence of tinea pedis between clerical workers and field workers, mitigating against the conclusion that their tinea pedis may be of occupational origin. Clinically tinea pedis was classified into 4 types ; interdigital (41.8%), vesicular(23.1%), dry squamous(22.4%), and mixed(12.7%). KOH smear positivity and culture positivity was related to clinical types of the lesion the lowest in the interdigital type. In the interdigital type, the etiology of nonmycotic lesions could not be identified. Negative fungal cultures could have been due to secondary bacterial infections. 63 strains of dermatophytes were isolated; 54 strains of Trichophyton rubrem(85.7%), 8 strains of Trichophyton mentagrophytes(12.7%) and 1 mixed infection of T. rubrum and T. mentagrophytes. T. mentagrophytes was isolated only from the vesicular lesions. 8 strains of yeast forms, positive in KOH smears and yielding pure colonies, were also isolated, and repeated mycologic examination yielded the same results. Among them, at least 4 cases of Trichosporon beigelii, and 1 case of Candida parapsilosis were considered to be of pathogenic significance. (Kor J Dermatol 1992; 30(3): 340-346)