KAL기 추락에 의한 대량재해의 개인식별

강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

흰쥐에서 출혈량에 따른 비장세포 증식력과 말초임파구 아형의 변화

이한식,정성필,김욱진,조영순,장석준 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Hemorrhage itself has been shown to produce abnormalities in immunity, particularly depression of the lymphocyte function. In order to better examine the amount of hemorrhage required to suppress the lymphocyte function, we determined the effect of graded fixed-volume hemorrhage on splenocyte proliferation and the lymphocyte subpopulation. Methods: Male Sprague-Dawley rats(weight,350∼400 g) were anesthetized, subjected to hemorrhages of 7.5 ㎖/㎏, 15 ㎖/㎏, and 22.5 ㎖/㎏ by percutaneous cardiac puncture with ㎖/㎏ needles, After 1, 2, 4, and 7 days, animals were killed to obtain the blood and spleen. The splenocyte proliferative capacity was measured by using the tritiated thymidine incorporation technique, and the peripheral lymphocyte subpopulation was determined using flow cytometry with the following monoclonal antibodies: T cell(CD3+), T helper cell(CD4+),7 cytotoxic cell(CD8+), and B cell(CD45RA+). Results: Hemorrhage of 7.5 ㎖/㎏ did not induce depression of splenocyte proliferation. However, for hemorrhage greater than 15 ㎖/㎏, the splenocyte proliferative capacity was significantly depressed at 2 days after hemorrhage and recovered at 4 days. Hemorrhage induced no changes in the relative percentage of lymphocyte subpopulations and in the number of each cell in peripheral blood. Conclusion: This study suggests that cellular immunity is depressed at 48 hrs after a hemorrhage greater than 15 ㎖/㎏ without any change in the peripheral lymphocyte subpopulation.

관광도시의 관광자원·상품연계 개발에 관한 연구 : 경상북도 3개 관광도시를 중심으로 article connection in tourist city

이장춘,남태석 한국관광정책학회 2003 觀光政策學硏究 Vol.9 No.1

As central cities of the provinces north of Gyongsang, Mungkyeong, Andong, Yeongju have to set up a strategic plan of attracting more international and domestic tourists for development of central districts broadly. In particular, Mungyeong city puts spurs to develop after foundation of Mungyeong Tourism and Leisure Town Inc., which the Ministry of Commerce, Industry and Energy, Kangwon land, Mungyeong city joint-found on April 2003. All citizens put their effort on developing the Mungyeong Tourism and Leisure Town Inc., which is invested of national (government) and private expenditure about 11hundred million won. There are several alternative plans that enabled balance-development of promoting tourism locality. However, secure of investment capital is more important in tourist attractions-article connection. The stable secure of financial support for tourism development is primarily based on local economic activity. Unfortunately, almost all Korea local authorities foundations have radical limitation of promoting to tourism development project, this is mainly due to weak economic situation with fragility in local financial. Therefore, it is significant to get the central government and a megalopolis governments intervention regarding tourism development project. At present, the tendency is toward increasing of participating in private sectors and coming under private management in all kinds of development project. In addition, there found some limitation of promoting relative management only in the public organization, thus it is important to induce active private departments participation. Basically, it is essential to find out key factors of overcoming the difficulties on attracting private sectors investment and their participation. At the same time, there need to seek solution of the difficulties and execute offering the incentives hence attract private investment. According to the results from confidence-analysis and factor-analysis, the infrastructure and the expansion of social indirect capital are urgent through active supporting of a central government, megalopolis government and connection of tourism system. Moreover, it is suggested that there need to promote establishing of effective information-system, and correctness in tourist information, which affect in decision of a tourism policy. Finally, it is vital to promote development of tourist attractions-article connection.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

Bacillus lentimorbus WJ5의 감마선유도 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자의 microarray 분석

이영근,장화형,장유신,허재호,형석원,정혜영 한국환경생물학회 2004 환경생물 : 환경생물학회지 Vol.22 No.3

본 연구에서는 감마선으로 유도된 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자들의 발현을 연구하기 위하여, B. lentimorbus WJ5의 방사선 유도 돌연변이체에서 발현되는 유전자를 DNA microarray로 동시에 탐색하였다. DNA microarray는 B. lentimorbus WJ5 genome을 무작위로 절단하여 2,000단편으로 구성하였으며, 감마선 (^(60)Co)으로 유도된 7돌연변이체의 발현을 정량적으로 관찰하였다. 클러스터 분석결과 발현된 408 유전자 중 27개가 감마선 유도 돌연변이체 모두에서 유의하게 발현이 증가되었다. 특히, 복구(mutL, mutM)에너지 대사 (acsA, sdhB, p하, yhjB, citB), protease(npr), 산화자극에 대한 환원 (HMM)관련 유전자들이 동시에 증가되었다. 이는 감마선 유도 돌연변이체들에서 자발적인 직/간접 복구 관련 유전자의 발현 증가는 방사선 노출 직후 보이는 stress response와는 다른 현상임을 나타내는 것으로 생각된다. To study the radiation related gene expression in mutants of Bacillus lentimorbus WJ5 induced by gamm radiation, the simultaneous gene expression was analyzed by DNA microarray. We constructed DNA chips including two thousand randomly digested genome spots of B. lentimorbus WJ5 and compared its quantitative aspect with seven mutants induced by gamma radiation (^(60)Co). From the cluster analysis of gene expression pattern, totally 408 genes were expressed and 27 genes were significantly upregulated by the gamma radiation in all mutants. Especially, genes involved in repair (mutL, mutM), energy metabolism (acsA, sdhB, pgk, yhjB, citB), protease (npr), and reduction response to oxidative stress (HMM) were simultaneously upregulated. It seems that the induction of the direct and/or indirect repair related genes in mutants induced by gamma radiation could be remarkably different from the adaptive responses against acute exposure to radiation.

The Rainbow에 나타난 Narrative Technique과 문체의 특징

李錫長 한국영어교육연구학회 2001 영어교육연구 Vol.- No.23

In The Rainbow, Lawrence extended the domain of Ursula's self-awareness by treating profoundly the analytical technique of modern consciousness. He also made use of a cyclic technique of image in order to describe the action and emotion of the main characters, of which the repetition and cumulation came into being from the imitation of the changing process in the natural world and of its rhythm. Lawrence's description of blood and flesh introduced the rhythmical cadence which was in accord with his syntax of artistic language, and this cadence arose from a variety of rhythm in the natural world. Lawrence frequently made use of physical and chemical images such as combustion and consummation in order to describe the non-human element or the element of process of characters. The technique which shows the actions streaming out of the language of process and down the surface of consciousness reaches the climax in the last moonlight scenes of the Ursula-Skrebensky story. The mimetic technique which describes the repetition of tension and release toward a certain apex is attended with a unique swelling cadence. The opposing terms such as the vertical and horizontal directions or the centrifugal and centripetal forces stand for the nature of polarity based on Lawrence's dualism.

정보시스템 감리의 모형설계와 개선에 관한 연구

이장형,박희석 大邱大學校 社會科學硏究所 2000 社會科學硏究 Vol.8 No.1

정보화 시대를 살아가면서 더 많은 조직들이 업무에 있어서 정보의 중요성을 인식하고, 대부분의 조직들은 정보시스템을 주된 기능으로 대체하는데 기초를 둔 컴퓨터 환경으로 변화시킬 계획들을 가지고 있다. 하지만 많은 조직들은 정보시스템의 효율성과 신뢰성을 조사할 필요가 있고 심지어 불평까지 하는 경우도 있다. 오늘날 정보시스템 감리에 대한 수요는 정보시스템의 성공적인 개발을 지원하기 위해 증대하고 있다. 감리의 목표는 정보시스템의 부작용을 막고, 예산의 효율적인 사용을 확신하며 조직의 내부 감리 능력과 인식을 제공하는 것이다. 이런 목표를 성취하고 감리 품질을 높이기 위하여 정보시스템 감리를 제도화하고 감리모형을 개발할 필요가 있다. 이 연구에서는 우선 감리, 모형, 사례등을 기술한다. 그리고 감리를 수행하기 위한 모형과 방법을 소개한다. 이 모형들은 시스템 개발자와 감리인에게 사용되어질 것이다. 감리의 증대되는 수요에 따라 새로운 모형의 개발은 필요하고 현장에서 응용도구와 다양한 기술 표준 및 모형이 고려되었다. 따라서 정보시스템 감리 모형에 관한 연구를 수행하였다. 정보시스템 감리의 모형 개발을 위한 하위 메뉴로는 정보시스템 계획을 위한 감리모형, 정보 시스템 관리를 위한 감리모형, 정보시스템 유지를 위한 감리모형, 정보시스템에서 품질관리를 위한 감리모형, 보안 및 통제를 위한 감리모형이다. 모형은 3가지 모형인데 모형1은 동등비중의 감리모형, 모형2는 점검표 항목수에 따른 감리모형이고 모형3은 이 둘의 혼합 감리모형이다. 개선되는 모형으로는 모형3을 제안한다.

電動機의 磁束分布特性의 微視的 解析

張錫明,李殷雄,權丙一 충남대학교 공업교육연구소 1984 論文集 Vol.7 No.2

In this paper, the magnetic flux distribution in and around slot-air gap-tooth region which be important fundamental data to the analysis and the design of electric machines, was microscopically studied and examined. First, Roth's method, one of classical methods, was applied to the inside region of a slot and its around was compared with the result by F.E.M which had been applied together with the development that result of two methods was very approximate. Second, It is expected that the presentation of the analysis which concerned with the characteristic of the leakage flux distribution at the region slot-airgap-tooth., of will be usable to the analysis and the design of electric machines.