파라콰트 중독에서의 항산화치료

권운용,조유환,송형곤,김명천,이중의,서길준,윤여규 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Paraquat causes severe tissue toxicity when ingested, but has no effective treatment modality. We have shown that high dose vitamin C has effective antioxidant activities against the paraquat intoxication in a previous animal experiment. This study was designed to evaluate the effect of antioxidant therapy with high dose vitamin C and vitamin E in human cases of paraquat intoxication. Methods: From August 1999 to August 2001, 19 paraquat intoxication patients who visited the emergency department of the Seoul National University Hospital and the Kyounghee University Hospital were enrolled to this study. They were devided into two groups, a control group(9 patients) and a study group(10 patients). The control group received only conservative managements including gastro-intestinal decontaminati-on. The study group received conservative managements plus the antioxidant therapy which was composed of vitamin C 24 gm/day intravenously and 20 gm/day orally, and vitamin E 1.6 gm/day orally. Results: In the study group, 5 of 10 patients(50%) survived, but all patients of the control group died(p=0.003). There were no significant differences in age, sex, and usage of gastric lavage and activated charcoal between the two groups. Difference in ingested amount of paraquat between the two groups could not be analyzed due to the inexact and subjective measuring methods based on patients' histories. Conclusion: Antioxidant therapy with high dose vitamin C and vitamin E is effective in vival rate in paraquat intoxicated patients.

초등과학 탐구수업 지도자료의 활용 실태

신영준,장명덕,배진호,권난주,여상인,이희순,노석구 한국초등과학교육학회 2005 초등과학교육 Vol.24 No.2

In this study, we had tried to present a plan for improving the actual conditions of practical utilization of teaching material for 6th grade science developed by Ministry of Education & Human Resources Development and distributed to all elementary schools in Korea. Also we presented ways of better utilization of the teaching material after investigating the actual conditions of practical utilization. A survey was made to investigate and collect all data in the major metropolitan cities, the Kangwon, Chungcheong, Honam, and Kyeongsang area, respectively. We surveyed 316 6th grader teachers to investigate the actual conditions of distribution and utilization of teaching material as a general research. In addition, we surveyed 46 teachers to investigate the organization and content of teaching material as a particular research. The results are as follows. First, the teaching material was not approximately transmitted and kept to 6th grader teachers. Second, the utilization guide was not made. Third, it was reported that the thematic divisions of teaching material was a strong point, but the less detailed experiment manual was a weak point. Fourth, the consideration of content difficulties and simplicity was necessary to improve the material. Fifth, additional items should be included in the introductory presentation, convenience of reorganization, activity material causing learning interest, guidance of substitution experiment, and more concrete notice of experiment activity. Finally, there were positive responses of more than 4.0 point of Likert scale (1 to 5 point scale) in detail investigations of thematic items, which could have possibility that the teaching material was helpful to elementary school science field.

High Incidence and Mortality of Out-of-Hospital Cardiac Arrest on Traditional Holiday in South Korea

Joon-myoung Kwon,전기현,Hyue Mee Kim,Min Jeong Kim,Sung-Min Lim,Kyung-Hee Kim,Pil Sang Song,Jinsik Park,Rak Kyeong Choi,Byung-Hee Oh 대한심장학회 2019 Korean Circulation Journal Vol.49 No.10

Background and Objectives: This study aimed to confirm the effects of traditional holidays on the incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in South Korea. Methods: We studied 95,066 OHCAs of cardiac cause from a nationwide, prospective study from the Korea OHCA Registry from January 2012 to December 2016. We compared the incidence of OHCA, in-hospital mortality, and neurologic outcomes between traditional holidays, Seollal (Lunar New Year's Day) and Chuseok (Korean Thanksgiving Day), and other day types (weekday, weekend, and public holiday). Results: OHCA occurred more frequently on traditional holidays than on the other days. The median OHCA incidence were 51.0 (interquartile range [IQR], 44.0–58.0), 53.0 (IQR, 46.0–60.5), 52.5 (IQR, 45.3–59.8), and 60.0 (IQR, 52.0–69.0) cases/day on weekday, weekend, public holiday, and traditional holiday, respectively (p<0.001). The OHCA occurred more often at home rather than in public place, lesser bystander cardiopulmonary resuscitation (CPR) was performed, and the rate of cessation of CPR within 20 minutes without recovery of spontaneous circulation was higher on traditional holiday. After multivariable adjustment, traditional holiday was associated with higher in-hospital mortality (adjusted hazard ratio [HR], 1.339; 95% confidence interval [CI], 1.058–1.704; p=0.016) but better neurologic outcomes (adjusted HR, 0.503; 95% CI, 0.281–0.894; p=0.020) than weekdays. Conclusions: The incidence of OHCAs was associated with day types in a year. It occurred more frequently on traditional holidays than on other day types. It was associated with higher in-hospital mortality and favorable neurologic outcomes than weekday.

Development and Validation of Deep-Learning Algorithm for Electrocardiography-Based Heart Failure Identification

Joon-myoung Kwon,Kyung-Hee Kim,Ki-Hyun Jeon,Hyue Mee Kim,Min Jeong Kim,Sung-Min Lim,Pil Sang Song,Jinsik Park,Rak Kyeong Choi,Byung-Hee Oh 대한심장학회 2019 Korean Circulation Journal Vol.49 No.7

Background and Objectives: Screening and early diagnosis for heart failure (HF) are critical. However, conventional screening diagnostic methods have limitations, and electrocardiography (ECG)-based HF identification may be helpful. This study aimed to develop and validate a deep-learning algorithm for ECG-based HF identification (DEHF). Methods: The study involved 2 hospitals and 55,163 ECGs of 22,765 patients who performed echocardiography within 4 weeks were study subjects. ECGs were divided into derivation and validation data. Demographic and ECG features were used as predictive variables. The primary endpoint was detection of HF with reduced ejection fraction (HFrEF; ejection fraction [EF]≤40%), and the secondary endpoint was HF with mid-range to reduced EF (≤50%). We developed the DEHF using derivation data and the algorithm representing the risk of HF between 0 and 1. We confirmed accuracy and compared logistic regression (LR) and random forest (RF) analyses using validation data. Results: The area under the receiver operating characteristic curves (AUROCs) of DEHF for identification of HFrEF were 0.843 (95% confidence interval, 0.840–0.845) and 0.889 (0.887–0.891) for internal and external validation, respectively, and these results significantly outperformed those of LR (0.800 [0.797–0.803], 0.847 [0.844–0.850]) and RF (0.807 [0.804–0.810], 0.853 [0.850–0.855]) analyses. The AUROCs of deep learning for identification of the secondary endpoint was 0.821 (0.819–0.823) and 0.850 (0.848–0.852) for internal and external validation, respectively, and these results significantly outperformed those of LR and RF. Conclusions: The deep-learning algorithm accurately identified HF using ECG features and outperformed other machine-learning methods.

능동텐던을 이용한 구조물의 내진 최적제어

권준명(Kwon Joon-Myoung),박문호(Park Moon-Ho),조창근(Cho Chang-Geun),김종수(Kim Jong-Soo) 대한토목학회 2002 대한토목학회 학술대회 Vol.2002 No.11

호중구감소증 환자에서의 기관-기관지 아스페르길루스증 1예

권재철,송명준,김기조,오유경,김성용,박선희,최수미,이동건,이석,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

저자들은 급성 림프구성 백혈병 환자에서 항암치료 후 호중구감소증이 지속되는 상태에서 침습성 아스페르길루스증의 드문 형태인 치명적인 아스페르길루스 기관기관지염을 경험하고 문헌고찰과 함께 증례를 보고하는 바이다. Tracheobronchial aspergillosis is an uncommon clinical form of invasive aspergillosis, particularly found in patients with AIDS and in lung transplant recipients than in other immunocompromised patients. The rapidity of the disease progression can result in fatal airway obstruction in a short period of time that the patient may need emergency tracheostomy without knowing the cause of the obstruction. We describe a case of fatal tracheobronchial aspergillosis which developed in a 43-year-old female patient with acute lymphoblastic leukemia. Dyspnea and stridor developed on the 20th day after 2nd consolidation chemotherapy, which was during the prolonged neutropenic period. Airway narrowing was observed on the computed tomograph scan of neck and emergency tracheostomy was performed. Infiltration with aspergillus hyphae was found in the tracheal ring and bronchial mucosa. Despite the use of amphotericin B, the patient died of bleeding and airway obstruction.

Sebaceous Carcinoma Arising from the Nevus Sebaceous

Myoung Soo Jo,Ki-Hyun Kwon,신혜경,Joon Choe,장태정 대한성형외과학회 2012 Archives of Plastic Surgery Vol.39 No.4

Isolation of Terpennoids from the Oleogum Resin of Boswellia carterii Birdwood

Joon Yeop Lee,Yun Ju Kwon,Soo Hyun, Kim,Eon Mi Kim,Jong Bum Kim,Myoung Lae Cho 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

클라우드 스토리지의 효율적인 이용과 자료에 대한 자기소유권 강화방안

장준언 ( Joon-un Jang ),정준권 ( Jun-kwon Jung ),정태명 ( Tai-myoung Chung ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.2

클라우드 서비스는 향후 IT 분야에 있어 중요한 기술이 되고 있다. 특히 모바일 네트워크 시장의 규모가 커감에 따라서 클라우드 서비스는 지금보다 더 부각되는 기술이 될 것이다. 하지만, 사용자의 정보가 제 3자에게 위탁된다는 점에서 보안 문제가 가장 큰 이슈가 되고 있다. 본 논문에서는 자료에 대한 암호화를 통해 개인의 정보소유권을 강화하면서 클라우드 스토리지를 효과적으로 이용할 수 있는 시스템을 제안한다.

신 자가 이식 : 증례 보고 A case report

김명수,김성순,이강영,오창권,김유선,홍성준,박기일 대한혈관외과학회 1995 Vascular Specialist International Vol.11 No.1

Renal autotransplantation is the sectioning of the kidney from the vascular pedicle and excretory tract so as to reimplant it into a different vascular territory in the same patient. We performed right kidney renal autotransplantation for renovascular hypertension. And we report it here as a case study. A 23-year-old man was found to be hypertensive at a routine medical examination. Bilateral selective renal arteriography revealed irregular narrowing of the right renal artery over a 0.9 cm length on the middle one third. We performed a right kidney autotransplantation with segmental resection of the narrowing segment. Blood pressure fell to 130/80 mmHg immediately following the operation and has remained at this level for the l0 months without further treatment. Vascular pathology revealed typical fibromuscular dysplasia of affecting artery.