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강금석,남천석,김인덕,권륜희,이동찬,허예영,하배진 신라대학교 자연과학연구소 2007 自然科學論文集 Vol.16 No.-
The effects of Laminaria japonica fucoidan extract (LJFE) on the biochemical parameters of lipid-related function were investigated in liver and serum of CCl_(4)-treated rats. LJFE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 14 days. On the day 15, 3.3 ml/kg of CCl_(4) dissolved in olive oil (1:1) was injected 12 hours before anesthetization. We examined the lipid-related functions and enzyme activitys by measuring the levels of total cholesterol (TC), triglyceride (TG), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum. The results showed that CCl_(4) treatment increased the high values of TG, LDH and ALP decreased the low values of TC but LJFE pretreatment decreased the high values of TG, LDH and ALP to the low values, increased the TC. It was suggested that LJFE can be used as the potential candidate for the lipid-metabolism natural supplement.
Threshold-asymmetric volatility models for integer-valued time series
Kim, Deok Ryun,Yoon, Jae Eun,Hwang, Sun Young The Korean Statistical Society 2019 Communications for statistical applications and me Vol.26 No.3
This article deals with threshold-asymmetric volatility models for over-dispersed and zero-inflated time series of count data. We introduce various threshold integer-valued autoregressive conditional heteroscedasticity (ARCH) models as incorporating over-dispersion and zero-inflation via conditional Poisson and negative binomial distributions. EM-algorithm is used to estimate parameters. The cholera data from Kolkata in India from 2006 to 2011 is analyzed as a real application. In order to construct the threshold-variable, both local constant mean which is time-varying and grand mean are adopted. It is noted via a data application that threshold model as an asymmetric version is useful in modelling count time series volatility.
최근 국내 유입 Vibrio cholerae균 및 1995년도 국내 집단 발생 콜레라의 역학적 양상
김호훈,신영학,강연호,유천권,박미선,김동술,유재연,전정훈,이복권,박기덕,김동진,정태화,이종구,박기동,김상순,이동모,김문식,조병륜 대한감염학회 1996 감염 Vol.28 No.6
목적 : 1992년 이후 국내에 유입, 확인되는 V. cholerae 균은 현격한 증가 추세를 보이고 있으며, 1995년도 국내 집단 발생 콜레라의 역학적 양상이 종래의 경우와 상이한 바 있어 최근의 콜레라균 유입상황과 국내 역학적 특성을 정리하여 향후의 방역 대책에 참고로 하기 위하여 본 연구를 시행하였다. 방법 : 국내 유입 V. cholerae 균은 세균학적 방법에 의해 1986-1995년 사이에 확인된 균주를 대상으로 분석하였고, 국내 집단발생 콜레라는 1995년도에 내국인 거주자에게서 진성 콜레라 환자로 구명된 환자를 대상으로 역학적 양상을 살펴보았다. 결과 : 국내 유입 V. cholerae균은 1992년 이후 1995년 사이에 계절과 무관하게 뚜렷한 증가 추세를 보였다. 1995년도 콜레라 국내 집단 발생의 역학적 양상은 초발 환자가 인지되면서 단기간 사이에 지역적 연고가 없는 다양한 지역에서 콜레라 환자 발생이 확인되었다. 환자 발생 지역 내에서는 비교적 소규모 환자 발생에 그쳤고 진성 콜레라 환자로 확인된 환자 중 사망자는 없었으며 남성에서 여성보다 발병율이 높았다. 결론 : V.cholerae O1균의 국내 유입이 최근 현격히 증가되었고, 1994년에는 V. cholerae O139균의 국내유입이 처음으로 확인되었다. 콜레라 환자의 국내 집단 발생 위험은 1992년 이후 증가되었으며 1995년도의 집단 환자 발생은 지역적 연고가 없는 다양한 지역에서 비교적 단기간에 사망자 없이 소규모의 환자 발생양상을 보였다. Background: Imported Vibrio cholerae strains have increasingly been found since 1992 and the pattern of recent cholera epidemic outbreak in Korea showed a little difference from that of former epidemic outbreak. Methods: We had collected suspected V. cholerae isolates from Quarantine Stations or Public Health Laboratories, which were identified as V. cholerae O1 or O139. Epide miological analysis was made on the base of field surveys. Results: During the period from 1986 through 1995, 138 V. cholerae strains were imported. Nearly 85.5% of the strains (118 strains) were imported within recent 4 years from 1992 to 1995. One hundred and twenty-eight strains were E1 Tor-Ogawa type V. cholerae O1, 6 strains were V. cholerae O139 and 4 strains were E1 Tor-Inaba type V. cholerae O1. Of 138 strains, 71 strains were isolated from the airplane toilet swab and 67 strains from the passengers who entered into Korea after international travel. From 1993 to 1995, 101 strains were imported from the Southeast Asian countries; including Thailand(65), Indonesia(17), Philippines(10), Hongkong(6) Singapore(2) and Vietnam(1). During the cholera epidemic in 1995, 68 patients with V. cholerae O1 (E1 Tor-Ogawa) were found. Oneset of the index-case occurred on August 26th and the last on September 13th. Geographically it occurred in Incheon city(25), Chungcheongnam do(25), Kangwon do(6), Kyungsangbuck do(5), Kyunggi do(4), Daejeon city(2) and Pusan city(1). Of total 68 cases, 39 were male. Cases were found in all age groups, but it was more common in elderly groups. During the epidemic, E1 Tor-Ogawa type V. cholerae O1 strains were also isolated from the coastal sea water of Kanghwa kun where the epidemic outbreak occurred. Conclusions: In Korea, the imported V. cholerae O1 and V. cholerae O139 strains have increasingly been found without seasonal variation since 1992. Cholera epidemic outbreak in 1995, occurred simultaneously at many different local areas within a short period without mortality.
Forecasting evaluation via parametric bootstrap for threshold-INARCH models
Kim, Deok Ryun,Hwang, Sun Young The Korean Statistical Society 2020 Communications for statistical applications and me Vol.27 No.2
This article is concerned with the issue of forecasting and evaluation of threshold-asymmetric volatility models for time series of count data. In particular, threshold integer-valued models with conditional Poisson and conditional negative binomial distributions are highlighted. Based on the parametric bootstrap method, some evaluation measures are discussed in terms of one-step ahead forecasting. A parametric bootstrap procedure is explained from which directional measure, magnitude measure and expected cost of misclassification are discussed to evaluate competing models. The cholera data in Bangladesh from 1988 to 2016 is analyzed as a real application.
Sang-Yeoup Kim,Hae-Ryun Choi,Ye-Seul Kim,Joo-Hee Lee,Hyunwook Kim,Jae Deok Son,Bong-Kyu Byun 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
최근 변화하는 기후로 인해 외래해충의 유입이 증가하였으며 발달된 교통수단 등으로 인해 새로운 지역으로 확산이 가속화되는 추세(Bale, 2002)이므로 그 중요성이 증대하고 있다. 본 연구는 우리나라의 최근에 침입한 대표적인 흡즙성 해충인 미국선녀벌레를 대상으로 충청지역의 발생분포를 파악하기 위해 수행되었다. 이를 위해 2018년 5월부터 8월까지 충남북 관내 주요 행정구역을 대상으로 미국선녀벌레 발생여부와 피해정도를 중심으로 조사하였다.
Saponin Modification by Enzyme for Ginseng Standard and Functional Products
Deok-Chun Yang,Min-Ju Park,Ho-Bin Kim,Se-Hwa Kim,Ju-Ryun Na,Le-Qin Cheng 한국작물학회 2007 한국작물학회 학술발표대회 논문집 Vol.2007 No.11
Introduction The ginseng saponin (ginsenoside) is one of the most important secondary metabolites in ginseng and hasvarious pharmacological activities. To date about 38 kinds of ginsenosides have been isolated and identified from Panax ginseng C. A. Meyer. Among these ginsenosides, Rg3 is a precursor for ginsenoside Rh2, which has a very strong antitumor effect. and has many pharmaceutical activities. However, Rg3 is extremely low in normal ginseng. Thus production of ginsenoside Rg3 would be very important and many studies have aimed to convert major ginsenosides to the more active minor ginsenoside Rg3. The enzymatic conversion through sugar hydrolysis at a specific position is desirable for the production of active minor ginsenoside Rg3. Material and Method The isolation of β-glucosidase-producing microorganisms was performed according to a previously published method. Each microbialsuspension cultured in nutrient broth was added to the same volume of 1 mM ginsenoside Rb1 solution and then incubated on a rotary shaker at 30°C for 48 h. The reaction mixture was extracted with butanol saturated with H2O and then analyzed by thin layer chromatography (TLC). 8 μl of the ginseng extract solution was spotted on a TLC plate and developed to 5.5 cm distance in a chamber with chloroform/methanol/water as the mobile phase. Bands on the TLC plates were detected by spraying 10% H2SO4, followed by heating. Result and Discussion Ginseng(the root of Panax ginseng C. A. Meyer, Araliaceae) is frequently used as a crude substance taken orally in Korea, China and Japan, as well as other Asian countries, as a traditional medicine. Ginsenosides are the principal components having pharmacological and biological activities. More than 38 different ginsenosides so far have been isolated and identified from ginseng saponins. Among them, deglycosylated ginsenosides are known to be more effective in vivo physiological action and to act as active compounds. A lactic acid bacteria, which have β-glucosidase activity, were isolated from soil and kimchi using a MRS-Esculin agar. These strains were identified on the basis of phylogenetic inference based on 16S rDNA sequences. TLC and HPLC were used to analysis transformed ginsenosides. Ginsenosides are main pharmacoactive component in ginseng. When ginseng was orally administered, the absorption of ginsenosides from the gastrointestinal tract are extremely low. In order to improve oral bioavailability, transforming major ginsenosides into more active minor ginsenoside is very important. Caulobacter leidyia GP45 and Micro- bacterium esteraromaticum GS514 were isolated from ginseng field for converting major ginsenosides into minor ginsenosides. In the co-culture of strain GP45 and GS514 with ginsenoside Rb1, produced compound K and ginsenoside Rg3 individually. The transformation pathway of ginsenoside Rb1 were confirmed Rb1⟶Rd⟶F2⟶compound K and Rb1⟶Rd⟶Rg3.