Indomethacin으로 유발된 흰쥐의 위장장애에 ChondroT가 미치는 영향

김주일 ( Joo-il Kim ),김선길 ( Sun-gil Kim ),김지훈 ( Ji-hoon Kim ),윤찬석 ( Chan-suk Yoon ),최지민 ( Ji-min Choi ),최찬헌 ( Chan-hun Choi ),김선종 ( Seon-jong Kim ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3

Objectives The aim of this study was to investigate the inhibitory effect of ChondroT in indomethacin-induced gastric mucosal injury rat model. Methods Sprague-Dawley rats were randomly assigned to intact, control Joins, Celebrex, ChondroT50 and ChondroT200. Indomethacin (25 mg/kg) was used to induce damage to the gastric mucosal injury. ChondroT was administered by orally to inhibit the indomethacin-induced gastric mucosal injury. At the end of the experiment, pH level in stomach, stomach contents volume, tumor necrosis factor-α (TNF- α) level, interleukin-1β (IL-1β) level, prostaglandin E2 (PGE2) level, myeloperoxidase (MPO) activity, erythrocytes, and thrombocytes were measured. Ophthalmologic and histopathological examination was also analyzed. Results pH level in stomach and Stomach contents volume had no difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. TNF-α level was decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group and there were no significant difference. IL-1β level was decreased in PC-Joins group and ChondroT200 group compared to control group. PGE2 level had no significant difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. MPO level and complete blood count level were decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200. Symptom score of ophthalmologic examination was decreased in ChondroT50 and ChondroT200 group compared to control group. Conclusion Based on these results, It could be suggested that ChondroT was effective in reducing damage to the gastric mucosal injury. And further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):57-69)

최근 국내 유입 Vibrio cholerae균 및 1995년도 국내 집단 발생 콜레라의 역학적 양상

김호훈,신영학,강연호,유천권,박미선,김동술,유재연,전정훈,이복권,박기덕,김동진,정태화,이종구,박기동,김상순,이동모,김문식,조병륜 대한감염학회 1996 감염 Vol.28 No.6

목적 : 1992년 이후 국내에 유입, 확인되는 V. cholerae 균은 현격한 증가 추세를 보이고 있으며, 1995년도 국내 집단 발생 콜레라의 역학적 양상이 종래의 경우와 상이한 바 있어 최근의 콜레라균 유입상황과 국내 역학적 특성을 정리하여 향후의 방역 대책에 참고로 하기 위하여 본 연구를 시행하였다. 방법 : 국내 유입 V. cholerae 균은 세균학적 방법에 의해 1986-1995년 사이에 확인된 균주를 대상으로 분석하였고, 국내 집단발생 콜레라는 1995년도에 내국인 거주자에게서 진성 콜레라 환자로 구명된 환자를 대상으로 역학적 양상을 살펴보았다. 결과 : 국내 유입 V. cholerae균은 1992년 이후 1995년 사이에 계절과 무관하게 뚜렷한 증가 추세를 보였다. 1995년도 콜레라 국내 집단 발생의 역학적 양상은 초발 환자가 인지되면서 단기간 사이에 지역적 연고가 없는 다양한 지역에서 콜레라 환자 발생이 확인되었다. 환자 발생 지역 내에서는 비교적 소규모 환자 발생에 그쳤고 진성 콜레라 환자로 확인된 환자 중 사망자는 없었으며 남성에서 여성보다 발병율이 높았다. 결론 : V.cholerae O1균의 국내 유입이 최근 현격히 증가되었고, 1994년에는 V. cholerae O139균의 국내유입이 처음으로 확인되었다. 콜레라 환자의 국내 집단 발생 위험은 1992년 이후 증가되었으며 1995년도의 집단 환자 발생은 지역적 연고가 없는 다양한 지역에서 비교적 단기간에 사망자 없이 소규모의 환자 발생양상을 보였다. Background: Imported Vibrio cholerae strains have increasingly been found since 1992 and the pattern of recent cholera epidemic outbreak in Korea showed a little difference from that of former epidemic outbreak. Methods: We had collected suspected V. cholerae isolates from Quarantine Stations or Public Health Laboratories, which were identified as V. cholerae O1 or O139. Epide miological analysis was made on the base of field surveys. Results: During the period from 1986 through 1995, 138 V. cholerae strains were imported. Nearly 85.5% of the strains (118 strains) were imported within recent 4 years from 1992 to 1995. One hundred and twenty-eight strains were E1 Tor-Ogawa type V. cholerae O1, 6 strains were V. cholerae O139 and 4 strains were E1 Tor-Inaba type V. cholerae O1. Of 138 strains, 71 strains were isolated from the airplane toilet swab and 67 strains from the passengers who entered into Korea after international travel. From 1993 to 1995, 101 strains were imported from the Southeast Asian countries; including Thailand(65), Indonesia(17), Philippines(10), Hongkong(6) Singapore(2) and Vietnam(1). During the cholera epidemic in 1995, 68 patients with V. cholerae O1 (E1 Tor-Ogawa) were found. Oneset of the index-case occurred on August 26th and the last on September 13th. Geographically it occurred in Incheon city(25), Chungcheongnam do(25), Kangwon do(6), Kyungsangbuck do(5), Kyunggi do(4), Daejeon city(2) and Pusan city(1). Of total 68 cases, 39 were male. Cases were found in all age groups, but it was more common in elderly groups. During the epidemic, E1 Tor-Ogawa type V. cholerae O1 strains were also isolated from the coastal sea water of Kanghwa kun where the epidemic outbreak occurred. Conclusions: In Korea, the imported V. cholerae O1 and V. cholerae O139 strains have increasingly been found without seasonal variation since 1992. Cholera epidemic outbreak in 1995, occurred simultaneously at many different local areas within a short period without mortality.

초도의 마을어업에 관한 연구

최치훈 ( Chi Hoon Choi ) 한국도서(섬)학회 2010 韓國島嶼硏究 Vol.22 No.4

Chodo is located between Goheunggun and Geomundo, 92.4km southwest of Yeosu, and subject to Samsan-myeon, Yeosu Si, Jeollanamdo. Topographically it is more adjacent to Goheunggun rather than Yeosu Si. There have been numerous stow net fishing boats in Chodo even up till 1960. However, since then, the fishery industry has been in decline. These days the community-based fishery is playing a pivotal role in Chodo. In a community-based on fishery, the Eochongye tries to manage and utilize the fishery in the right direction, at which the fishery is restricted to the most adjacent region of the fishing village within water level of 5 m (7m in Gyeongsangbukdo and Gangwondo and Jejudo). There are three Eochongyes in Chodo; Daedong, Uiseong and Jinmak, and each tries to reserve their own community(based on fishery) rights. The capture and collection in the community(based on fishery) can be usually practiced in terms of handicraft fishery or skin diving fishery; however, in Chodo, skin diving fishery is most popular. Skin diving fishery involves woman divers, who capture and collect aquatic products under water without any oxygen supplying device. Today, 24 women divers are working in Chodo. The major aquatic products in a community(based on fishery) are abalones, top shells, sea mussels and oysters. These products are alloted to the woman divers and Eochongye, and the ratio of allotments depends on the circumstances of Eochongye. This research is based on the on-site survey and literally discussion on investigating how the community(based on fishery) in Chodo is utilized and managed, and also the features of it.

진주종상피에서 Apoptosis를 통한 세포의 사멸기전

박홍준,박기현,김보형,정연훈,정명현 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.4

Pediatric Cholecystectomy: Clinical Significance of Cases Unrelated to Hematologic Disorders

Kim, Hae-Young,Kim, Soo-Hong,Cho, Yong-Hoon The Korean Society of Pediatric Gastroenterology 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.2

Purpose: Cholecystectomy is rarely performed in the child and adolescent. However, it is associated with several conditions. This study was conducted to describe the characteristics of pediatric patient who underwent cholecystectomy unrelated to hematologic disorders, and then to suggest its clinical significance in management by comparing a simple and complicated gallbladder disease. Methods: We reviewed cases of cholecystectomy in pediatric patients (under 18 years old) at a single institution between January 2003 and October 2014. There were 143 cases during the study period and 24 were selected as the subject group. Results: There were 7 male (29.2%) and 17 female (70.8%) patients. The mean age was 13.1 years old, and 66.6% of patients were older than 12 years. Mean body weight was 52.7 kg, and body mass index was $21.7kg/m^2$, with 41.7% of patients being overweight or obese. We could identify a female predominance and high proportion of overweight or obesity in a complicated disease. There were also significantly increased levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin in this group. Most patients (87.5%) underwent laparoscopic cholecystectomy. Conclusion: Cholecystectomy for diseases unrelated to hematologic disorders is rarely performed in the child and adolescent. In general, female patients who are overweight or obese, and those older than 12 years old, require laparoscopic cholecystectomy owing to multiple gallstones. This condition has a tendency to show a complicated gallbladder disease and significantly increased levels of AST, ALT, ALP, and bilirubin.

Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes

( Jin Sung Park ),( Dong Kyu Kim ),( Hyun Dae Shin ),( Hyun Jae Lee ),( Ho Seung Jo ),( Jin Hoon Jeong ),( Young Lac Choi ),( Choong Jae Lee ),( Sun Chul Hwang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effects of apigenin. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription - polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), and ADAMTS-5. In rabbit articular chondrocytes, the effects of apigenin on IL-1β-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of apigenin on MMP-3 protein production was also examined in vivo. In rabbit articular chondrocytes, apigenin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5. Furthermore, apigenin inhibited the secretion and proteolytic activity of MMP-3 in vitro, and inhibited production of MMP-3 protein in vivo. These results suggest that apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.

최씨 훅을 이용한 복강경 버찌씨 수술

김영혜 ( Young Hye Kim ),박준선 ( Jun Seon Park ),최상준 ( Sang Joon Choi ),송창훈 ( Chang Hoon Song ),한세준 ( Sei Jun Han ),정혁 ( Hyuk Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6

목적: 버찌씨 수술은 복압성 요실금 수술에 효과적인 수술로 여겨져 왔다. 요실금의 원인이 내인성 요도 괄약근의 결손소견 없이 요도의 과운동성으로 인한 경우 버찌씨 수술이 일반적으로 추천되어진다. 본 연구에서는 복강경 버찌씨 수술에서 최씨 훅의 유용성에 대해 알아보고자 하였다. 연구방법: 2000년 10월부터 2005년 3월까지 본원에서 복강경 버찌씨 수술을 시행받은 47명의 환자를 대상으로 하였다. 27명은 고전적 복강경 버찌씨 수술을 시행하였고 20명은 내골반 근막을 Cooper 인대를 부착하는데 유용한 본원에서 고안한 최씨 훅을 이용하여 복강경 버찌씨 수술을 시행하였다. 결과: 고전적 복강경 버찌씨 수술을 시행한 군과 최씨 훅을 이용한 복강경 버찌씨 수술을 시행한 군의 평균 나이, 분만력, 폐경률, BMI는 두 군간에 통계학적으로 유의한 차이를 보이지 않았다 (p>0.05). 수술 시간은 고전적 복강경 버찌씨 수술은 90.52±15.32분, 최씨 훅을 이용한 복강경 버찌씨 수술은 38.50±10.14분으로 최씨 훅을 이용한 경우 수술시간이 통계적으로 유의하게 짧았다 (p<0.05). 두 군간에 재발률 및 합병증 발생은 통계적 유의성을 보이지 않았다 (p>0.05). 결론: 본 연구에서 본원에서 고안한 최씨 훅을 이용하여 복강경 버찌씨 수술을 시행한 결과 수술 시간을 단축시킬 수 있었으며 수술 효과는 기존 방법과 동일하게 관찰되었다. 이에 최씨 훅은 복강경 버찌씨 수술에서 사용할 때 집도자의 봉합 과정을 단순화시켜 수술 시간을 단축시키므로 복강경 버찌씨 수술에 용이한 기구이다. Objective: Burch operation has been effective method for the treatment of stress incontinence. Burch operation is a well-accepted procedure for treating stress urinary incontinence secondary to urethral hypermobility without intrinsic sphincter deficiency and is the reference standard with which other procedures are compared. This study is to evaluate the effectiveness of the Choi`s hook in laparoscopic Burch operation. Methods: This study included 47 patients who had undergone laparoscopic Burch operation from October 2000 through March 2005. Of these 47 patients, 27 patients underwent traditional laparoscopic Burch operation (Group 1) and 20 patients underwent laparoscopic Burch operation with Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament (Group 2). Results: The mean age of patients of Group 1 was 55.6±9.37 years of age and that of Group 2 was 56.0±5.93 years of age. There is no difference in the mean age of patients (P>0.05). The mean operating time was 90.5±15.32 minutes for Group 1 and 38.5±10.14 minute for Group 2. The mean operating time was shorter in Group 2 than Group 1 (P<0.05). There was no difference in recurrence rate and complication rate between Group 1 and Group 2 (P>0.05). Conclusion: We performed laparoscopic Burch operation with the Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament. When we compared traditional laparoscopic Burch operation with laparoscopic Burch operation with Choi`s Hook, we could shorten the operation time using the Choi`s Hook.

Interdigitated pixel electrodes with alternating tilts for fast fringe-field switching of liquid crystals

Choi, Tae-Hoon,Woo, Jae-Hyeon,Choi, Yeongyu,Yoon, Tae-Hoon The Optical Society 2016 Optics express Vol.24 No.24

Electro-optical characteristics of an in-plane-switching liquid crystal cell with zero rubbing angle: dependence on the electrode structure

Choi, Tae-Hoon,Choi, Yeongyu,Woo, Jae-Hyeon,Oh, Seung-Won,Yoon, Tae-Hoon The Optical Society 2016 Optics express Vol.24 No.14

Synthesis and characterization of novel germanium-containing poly(p-phenylenevinylene) derivatives

Cho, Hoon-Je,Hwang, Do-Hoon,Lee, Jong-Don,Cho, Nam-Sung,Lee, Sang-Kyu,Lee, Jonghee,Jung, Young Kwan,Shim, Hong-Ku Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of polymer science Part A, Polymer chemist Vol.46 No.3

<P>Novel blue-emitting germanium-containing poly(p-phenylenevinylene) (PPV) derivatives with well-defined conjugation lengths were synthesized via Wittig-condensation polymerizations. The polymers can be color-tuned by the introduction of various chromophores into the PPV-based polymer backbones. The photoluminescence (PL) spectra of the polymers, GePVK (containing carbazole moieties), GeMEH (containing dialkoxybenzene moieties), and GePTH (containing phenothiazine moieties), were found to exhibit blue, greenish blue, and green emissions, respectively. GePTH produces more red-shifted emission than GeMEH and GEPVK, resulting in green emission, and the solution and solid state PL spectra of GePVK consist of almost blue emission. The electroluminescence spectra of GeMEH and GePTH contain yellowy green and yellow colors, respectively. Interestingly, GePVK exhibits white emission with CIE coordinates of (0.33, 0.37) due to electroplex emission in the light-emitting diodes. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 979–988, 2008</P> <B>Graphic Abstract</B> <P>Three novel germanium-containing poly(p-phenylenevinylene) derivatives—GePVK, GeMEH, and GePTH—were successfully synthesized via Wittig-condensation polymerization. The polymers can be color-tuned by the introduction of various chromophores into the PPV-based polymer backbones. The photoluminescence spectra of the polymers, GePVK, GeMEH, and GePTH, were found to exhibit blue, greenish blue, and green emissions, respectively. <img src='wiley_img/0887624X-2008-46-3-POLA22441-gra001.gif' alt='wiley_img/0887624X-2008-46-3-POLA22441-gra001'> </P>