조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

주폐자충 폐렴으로 발현된 Felty 증후군 1예

김성호,남대근,문재현,김지홍,김보석,안진광,문태건,안병재,김성일 全南大醫大 2001 전남의대학술지 Vol.37 No.3

KSDeN^TM process의 영양염류 제거 특성

김도군,천상욱,김병군,서인석,박철휘,김성준,류수현 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

Intermittent aeration processes have been much of interest as an excellent alternative for nutrients removal for upgrading secondary wastewater treatment plants, with minimum modification. Also, operational flexibility of those proposes a good opportunity for newly planed plants. Here, a pilot study was conducted to evaluate the performance of a continuous flow intermittent aeration process (KSDeN^TM process). The influent was collected at the effluent channel of the grit chamber of a large sewage treatment plant. The influent characteristics with standard deviation were 243.2±170.9mg/L for TCOD_cr, 47.5 13.9mg/L for T-N, 8.4±8.3mg/L for T-P and 5.2±1.8 for C/N ratio. Effluent of 1^st sedimentation tank was 208.2±87.6mg/L for TCOD_cr, 35.0±10.3mg/L for T-N, 4.8±1.9mg/L for T-P and 6.1±2.3 for C/N ratio. The average removal efficiencies of TCOD_cr, T-N and T-P were 93.6, 77.0 and 86.4% and effluent TCOD_cr, T-N and T-P concentrations were 12.5, 9.2 and 0.7mg/L respectively, satisfying regulatory limits. Alkalinity deficiency was not observed during the oxic periods, which is one of the special features of an intermittent aeration process. The results showed higher COD, T-N and T-P removal efficiencies and stability with varying influent conditions, compared to other conventional fixed phase nutrients removal processes.

KSDeNTM 공정에서 C/P 비, SRT, 온도 및 질산염 농도가 인 제거에 미치는 영향

김병군,서인석,홍성택,김도군,천상욱 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

In this study, the effects of C/P ratio, SRT, temperature and nitrate concentration on the phosphorus removal efficiency of KSDeN™ process (KOWACO-Ssangyong DeNutrient process) was investigated with a pilot plant, which is fed with the grit chamber effluent of 'J' MWWTP (Municipal Wastewater Treatment Process). During the operating period, T-P removal efficiency was more than 80% at C/P ratio (TCOD_Cr/T-P ratio) of 35 or above, and it was higher at relatively low temperature and high C/P ratio. At SRT (Sludge Retention Time)'s of 3-28 days, phosphorus removal efficiency increased up to 90% until the SRT reached 20 days. The phosphorus removal efficiency decreased rapidly with more than 20 days of SRT, which showed that the optimal SRT is 20 days for the T-P removal of KSDeN™ process. Effluent T-P concentration increased with increasing temperature. It is considered that the competition on organic compounds between PAOs (Phosphorus Accumulating Organisms) and denitrifiers resulted in lowering T-P removal by activating nitrifiers at 15℃ or above. The release of phosphorus was influenced by nitrate concentration in anaerobic/anoxic tank. When the nitrate concentration was higher than 2 ㎎/L, the release of phosphorus was disturbed by denitrifiers. SCOD and PO^3-_4-P profile with each reactors of KSDeN™ process showed typical behavior of phosphorus release and luxury uptake by PAOs.

저사이클 피로수명에 영향을 미치는 구상흑연주철의 흑연입자수의 영향

김민건,이병현,유병호 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

Low cycle fatigue life of spheroidal graphite cast iron is determined by the morphological parameters of internal graphite. The aim of this study is to clarify the effect of the number of nodular grain of spheroidal graphite cast iron on low cycle fatigue life. Two specimens that have identical average nodular grain size by changing nodular grain volume fraction and different number of nodular grain count was tested. In this paper, the parameter governing fatigue life through fatigue test, the number of nodular grain seriously affect fatigue life and nodular grain size is no longer governing parameter of it.

EPRCA 스위치의 성능 개선 연구

김종근,천성권,강병욱 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.1

Latest, requirements of service of high speed traffics have increased, because these traffics are difficult to predict owing to its bursty occurrence. ATM(Asynchronous Transfer Mode) serves ABR(Available Bit Rate) service for these traffics. When concentrated high speed traffics are arrived, cell loss and cell transfer delay are occurred because statistical multiplexing of ATM raise states of congestion on network. To minimize these influence of congestion, reactive control scheme which takes advantage of feedback information should be used, in this case using preventive control scheme is insufficient. In this paper, we applied variable threshold to determine the congestion in switch node, controled transmission rate dynamically. We simulated our model and analyzed to compare our schemes to the previous ones. The results show that the average transmission rate increased up respectively. The ramp-up time that is the amount of time from the idle state to the balance state is shorter, the maximum number of cells which is much related to cell loss is less, and the control cycle of transmission rate is shorter compared to the previous methods.

이족 보행 로봇의 견실 보행제어

김준홍,심병균,한성현 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

The research presents the robot which aims in walking as person. The human gait will be analyzed and what kind of biped robot will be stabilized naturally and will be able to apply. To connects the data which acquires from ZMP in gait, the front continuous pattern in order to guarantee a stability of walking robot that are considered a wheel track and combined the walking pattern of this robot.

마이크로홀 드릴링 머신의 개발 및 절삭성능 평가

김민건,유병호 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.5

In this paper, drill feed mechanism, cutting depth measuring device and sensing buzzer of drill contact were investigated in order to develop the micro-hole drilling machine. Also, measuring device of cutting resistance was developed in order to estimate cutting resistance from change of cutting condition. The results show that extremely-low feed rate(less then 17㎛/s) can be done and cutting depth can be measured by up to 1㎛ with develope drilling machine. Accordingly we could assemble a very cheap micro-hole drilling machine(ø0.05∼0.5mm). Also we got the some properties of cutting performance i.e. under the same condition, cutting torque decreases as increase of spindle speed and rapid feed of drill brings about the inferior cutting state under low spindle speed.

북한학 강좌 교재연구

김용대,이병희,김대군 경상대학교 1998 民族統一論集 Vol.14 No.1

골다공증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이남수,이상건,이상범,이상우,이선정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : As the average lifespan of human increases, osteoporosis and osteoporosis-related fractures have become major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis in general adults. This study examined the recognition of osteoporosis and analyzed the relating factors. Method : A population-based sample of 1086 adults in Asan-city, Korea was investigated with questionnaires and height, weight, Information regarding the general characteristics(gender, age, economic state), lifestylef exercise, smoking, alcohol),medical history(progestin, GH, steroid, calcitonin, PTH), demographic parameter, obesity, stress, and family history was collected through an interview using a structural questionnaire. The level of obesity was measured by the body mass index(BMI). BMD(Bone mineral density) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry. Osteoporosis was considered to be T-score below -2.5. Results : The prevalence of osteoporosis increased progressively with age, decreased with BMI and predominant in women by the result of x^(2) -test, T-test. Age, weight, BMI were significantly correlated with osteoporosis by the result of Pearson correlation ana1ysis(P<0.05). And age, gender, BMI, family history of osteoporosis were proved to be significant risk factors of osteoporosis by the result of multiple logistic regression(P<0.05). Conclusion : These results suggest that age, gender, BMI might be the most important risk factors of osteoporosis. And the history taking about family history of osteoporosis is helpful for diagnosing osteoporosis.