흉부 X-Ray 영상개선을 위한 신경망 적용에 관한 연구

이주원,이한욱,이종회,신태민,김영일,이건기,Lee, Ju-Won,Lee, Han-Wook,Lee, Jong-Hoe,Shin, Tae-Min,Kim Young-Il,Lee, Gun-Ki 대한전자공학회 2000 電子工學會論文誌-SC (System and control) Vol.37 No.1

흉부의 병변을 진단하기 위해 주로 사용되고 있는 흉부 X-선 촬영은 최근 컴퓨터 기술의 발달에 힘입어 디지털화 되고 있다. 디지털화된 흉부 영상을 방사선과 전문의가 모니터 상에서 관찰할 때 흉부 영상의 품질이 고르지 못하여 병변을 검출하기가 어려울 뿐만 아니라 이로 인하여 많은 진단 시간이 소요된다. 따라서 본 연구에서는 디지털 흉부 영상을 개선하기 위해 신경망을 이용하여 흉부 X-선 영상의 등화 방법을 제안하고 그 결과를 히스토그램 등화 방법과 비교하여 제시하였다. Recently, X-ray chest rediography is showing a tendency to take an image of digital radiography so as to diagnose the pathology of chest in a usual. When the radiologist observes the chest image derived from digital radiography system on the monitor, he feels difficult to find out the pathological pattern because the quality of chest radiography is unequal. It takes amount of time to adjust the proper image for diagnosis. Therefore, we propose the method of the chest image equalization using neural networks and provide the compared result with histogram equalization method.

퍼지 알고리즘을 이용한 관상동맥의 협착부위 검출

이주원,김성후,김주호,이한욱,정원근,이건기,Lee, Ju-Won,Kim, Sung-Hu,Kim, Joo-Ho,Lee, Han-Wook,Jung, Won-Geun,Lee, Gun-Ki 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.9

관상동맥 성형술과 관상동맥 우회술은 심근경색의 치료를 위해서 널리 이용되고 있는 방법이다. 특히 이 시술을 위해서 혈관의 협착 부위를 정확히 진단하는데 많은 어려움이 있다. 이러한 문제점을 개선하기 위해서 여러 연구자들에 의해서 에지 추출을 이용한 혈관의 협착부위를 검출하는 연구가 진행되고 있다. 그러나 이러한 방법들은 혈관의 구조나 영상의 질에 따라 그 성능의 차이가 발생한다. 따라서 본 연구는 이러한 문제점을 개선하기 위해 새로운 알고리즘을 제안한다. 제안된 알고리즘은 다중 샘플링과 쓰레쉬홀드, 퍼지 알고리즘을 이용한 혈관의 분기점과 끝점, 협착 부위를 검출하는 방법으로 구성되어 있다. 제안된 알고리즘의 성능을 평가하기 위해 다양한 혈관조영영상을 사용하였으며 그 결과 제안된 알고리즘에 의한 혈관의 분기점 및 끝점, 협착 부위 검출에 효과적이었다. Coronary angioplasty and coronary artery bypass graft, both are for the treatment of myocardial infarction widely used methods. For these procedures, there are especially difficulties in stenosis of blood vessels to diagnose accurately. To remedy this problem, by several researchers by using edge detection to detect stenosis of blood vessels has been studying. However, the results of using these methods vary defend on the vascular structure and the quality of the image. In this study, to improve these problems, the new algorithm is proposed. The proposed algorithm consists of methods to detect bifurcation of blood vessels and its ending point by using multi sampling, threshold and fuzzy algorithm. To evaluate the performance of the proposed algorithm, angiography was used for the different results of the blood vessels of the proposed algorithm, and the result was effective in detecting bifurcation of blood vessels and its ending point.

U-헬스케어를 위한 퍼지추론과 다중 하위대역 필터를 기반한 맥파 최대치 검출

이주원,이병로,Lee, Ju-Won,Lee, Byeong-Ro 한국정보통신학회 2008 한국정보통신학회논문지 Vol.12 No.12

Ubiquitous healthcare system is system that monitors and manages user's health information, and most important in the healthcare system is accuracy of the measured health data. But, the accuracy changes remarkably according to user's motion artifacts in real life. To elevate accuracy of health data, we proposed new algorithm to detect maximum point of pulse wave for heart rate extraction. and the proposed algorithm is to detect maximum points detect of pulse wave in photo-plethysmography signal included motion artifacts by fuzzy inference and multi sub-band filters. In results of experiment to evaluate the performance of the proposed algorithm, we could verify the proposed algorithm extracted maximum point of pulse wave in complex motion artifacts. 유비쿼터스 헬스케어 시스템은 사용자의 건강 정보를 감독하고 관리하는 시스템이며, 이 헬스케어 시스템에서 가장 중요한 점은 측정된 건강 데이터의 정확성이다. 그러나 실생활에서는 사용자의 움직임 에 따라 그 정확성이 현저하게 달라진다. 따라서 건강 정보 정확성을 향상시키기 위해 본 연구에서는 심박수 추출에 있어 새로운 맥파 최대점 검출 알고리즘을 제안하였고, 제안된 알고리즘은 다중 하위 대역 필터와 퍼지 추론기를 이용하여 동잡음이 포함된 PPG 신호에서 맥파의 최대점을 검출하기 위한 것이다. 제안된 알고리즘에 대한 성능평가 실험에서 복잡한 동잡음에서도 맥파 최대점 추출이 가능함을 보였다.

의료보험(醫療保險) 의약품(醫藥品)의 요양취급기관(療養取扱機關) 종별(種別), 약효군별(藥效群別), 상병별(傷病別) 사용(使用)에 관(關)한 조사연구(調査硏究)

이주원,한오석,Lee, Chu-Won,Hahn, Oh-Surk 대한예방의학회 1989 Journal of Preventive Medicine and Public Health Vol.22 No.2

To grasp the idea about how drugs are used under Medical Insurance Scheme, the amount and share of drug cost in the total medical fee have been reviewed and analyzed for different types of patients (in-patient out-patient), medical institutions and frequently seen diseases and following findings were revealed. In 1986, drug cost took 32.78% of total medical fee for in-patients and 32.98% for out-patients averaged over 30% share as a whole. When drug cost per case in 1980 be indexed to 100, it has shown steady growth to become 200 for in-patients and about 150 for out-patients in 1986. The contribution of drug cost to the total medical fee is, regardless of patient type-in-patients and out-patients, the highest in University hospitals and followed by General hospitals, Hospitals and Clinics in decending order That for the most frequent 10 diseases came out the highest,79 a with the essential benign hypertension of out-patients in the General hospitals, 61% for the gastric ulcer of out-patients in Hospitals and 33% for the female genital diseases of out-patients in Clinics. The drug cost of oral formula was contributed the most, 7.93% by cardiovascular agents followed by hepatic detoxicants(5.47%) and out-patients(4.93%), and that of injectable formula was contributed the most by antibiotics(24.17%), followed by protein amino-acid preparations(6.19%). The order of drug usage by specialty for the in-patients was the highest with internal medicine followed by general surgery and E.N.T, and that for the out-parients was in the order of Internal medicine, neuropsychology and Ob/Gy. This study revealed that the drug dependency was characteristically different to specialty. In view of the fact that drug cost on average exceeds over 30% of total medical fee, proper drug administration appears to be vitally important for the stabilization of the financial standing of the Medical Insurance Scheme. As a consequence, drug usage guidelines including antibiotics usage shall be established first of all and the voluntary participation for the regulation of drug usage and propagation of the guidelines to medical institutions are strongly coerced.

집합 유사 시퀀스 매칭의 성능 향상을 위한 인덱스 기반 검색 방법

이주원,임효상,Lee, Juwon,Lim, Hyo-Sang 한국정보처리학회 2017 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.6 No.11

집합 유사 시퀀스 매칭 방법은 유사한 정도를 나타내는 척도로 교집합을 기반으로 한 유사도를 사용한다. 그러나 교집합 크기를 계산하는 과정에 시간이 오래 걸릴 뿐만 아니라, 유사한 시퀀스를 찾기 위해서 수많은 집합 간 교집합 크기를 구해야 하므로 수행 시간이 오래 걸리는 성능상의 문제가 있다. 본 논문에서는 이러한 성능상의 문제를 해결하기 위해 인덱스 기반의 검색 방법을 사용하여 집합 기반 유사 시퀀스 매칭을 빠르게 수행하는 방법을 제안한다. 제안하는 방법은 크게 두가지로 구분된다. 첫 번째로 집합 시퀀스 유사도 문제를 교집합의 크기 비교 문제로 정형적으로 변환하고, 교집합의 크기를 빠르게 찾을 수 있는 인덱스 구조를 제안한다. 두 번째로 제안한 인덱스 구조를 사용하여 집합 기반 유사 시퀀스 매칭을 효율적으로 수행할 수 있는 방법을 제안한다. 성능 평가 결과, 제안하는 방법이 기존 방법에 비해 최대 30배에서 50배의 수행 시간 단축이 있음을 보인다. 또한 데이터 시퀀스의 개수가 증가할수록 수행시간의 차이가 점점 커지므로, 대용량 데이터 처리에 적절함을 보인다. The set-based similar sequence matching method measures similarity not for an individual data item but for a set grouping multiple data items. In the method, the similarity of two sets is represented as the size of intersection between them. However, there is a critical performances issue for the method in twofold: 1) calculating intersection size is a time consuming process, and 2) the number of set pairs that should be calculated the intersection size is quite large. In this paper, we propose an index-based search method for improving performance of set-based similar sequence matching in order to solve these performance issues. Our method consists of two parts. In the first part, we convert the set similarity problem into the intersection size comparison problem, and then, provide an index structure that accelerates the intersection size calculation. Second, we propose an efficient set-based similar sequence matching method which exploits the proposed index structure. Through experiments, we show that the proposed method reduces the execution time by 30 to 50 times then the existing methods. We also show that the proposed method has scalability since the performance gap becomes larger as the number of data sequences increases.

Plate theory 를 이용한 Deoxyribonucleosides 의 분배 계수의 계산

이주원,소명섭,정성택,노경호 ( Ju Weon Lee,Myong Seup So,Sung Taik Chung,Kyung Ho Row ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

Step - Gradient Mode 를 이용한 인지질의 분리

이주원,노경호 ( Ju Weon Lee,Kyung Ho Row ) 한국공업화학회 1997 공업화학 Vol.8 No.4

대두에 포함된 유용 인지질 PE, PI, PC를 분리하기 위해서 정상 HPLC를 이용하였다. 이동상으로 hexane, isopropanol, methanol을 사용하였고 일정용매조성법으로는 세 물질을 분리할 수 없었기 때문에 구배용매조성법을 적용하였다. 최적 분리조건을 구하기 위해서 단 이론과 step-gradient mode에서의 용량인자를 계산하는 식으로부터 농도분포곡선을 계산하였다. 계산 결과에 의하면 PE는 일정용매조성법(hexane/ isopropanol / methanol=90/5/5 vol.%)에서 분리하고 PI와 PC를 분리하기 위해서는 10분의 구배시간과 두번째 이동상을 hexane /isopropanol/methanol =50/20/30(vol.%)으로 계단함수의 구배용매조성법을 사용하는 것이다. 계산된 최적 분리조건을 실험 data와 비교한 결과 잘 일치하였고 이 제시된 방법은 구배용매조성법에서 최적 분리조건을 구하는데 이용될 수 있었다. Normal-phase HPLC was used to separate the useful phospholipids, PE, PI and PC in soybean lecithin. The mobile phase used in this experiments were hexane, isopropanol and methanol, the gradient mode was applied as the three components could not be separated by the isocratic mode. To find the optimum separation condition, the concentration profiles of effluents were calculated from the plate theory and the capacity factor in step-gradient mode. From the calculated results, PE was separated with hexane /isopropanol/methanol = 90 / 5 / 5 vol.% in isocratic mode and PI and PC were resolved in the conditions of lOmin gradient time and the second mobile phase of hexane / isopropanol / methanol = 50 / 20 / 30 vol.% in step-gradient mode. The agreement between the calculated concentration profile and experimental data was good, so the methodology developed in this work can be used to obtain the optimum separation condition in gradient mode.

우리나라 유행성뇌염(流行性腦炎)의 역학적(疫學的) 및 혈청학적(血淸學的) 조사연구(調査硏究)

이주원,김경호,김인달,Lee, Chu-Won,Kim, Kyung-Ho,Kim, In-Dal 대한예방의학회 1974 Journal of Preventive Medicine and Public Health Vol.7 No.2

The author has investigated epidemiological features of human cases of epidemic encephalitis (E. E.) in the Republic of Korea and the status of antibody requisition in pre-and post-epidemic time. And virological and serological studies with regarding the relationship of E. E. infection between human and piglet, and field survey against its vector by means of virus isolation from mosquitoes were carried out. Finally, vaccine field trial against human population has also been evaluated in order to confirm its effectiveness. The results of the studies are summarized as follows : 1. The annual incidence of reported cases during the past 25 years (1949-1973) in the Republic of Korea has shown two patterns, one was typical cyclic incidence and the other one was irregular. Annual average morbidity and mortality rate per 100,000 population were 5.7 and 2.1 and fatality rate was 34.6% in typical cyclic years. 2. With regard to the geographical distribution of E. E., the province of Jeolla-Bug-Do illustrated the highest incidence regardless of the epidemic size. 3. The main epidemic period was between mid-August and mid-September (above 90% of the total number of cases). The first case was reported in middle of July and the epidemic ceased in late of October. 4. An analysis of the age distribution of cases of E. E., has shown that above 90% of the total cases occurred in the age groups under 14 years and it was noted that about its 54% were occurred in the age groups between 5-9 years group. 5. Through the Haemagglutination Inhibition (H-I) test for the laboratory diagnosis of E. E., it was found that higher H-I antibody titer was usually detected in the convalescent phase, 15 days after onset. 6. The H-I antibody survey against 563 healthy population by age groups during the pre-epidemic season showed that 422(75%) were less than H-I titer, 1:20 and 122(21.7%) were positive H-I titer, 1:20. Among the 94 American in Seoul who had not been in E. E. endemic area previously only one person had appeared sero-conversion as a H-I titer of 1:80 after post-epidemic season. 7. The E. E. virus could be isolated from the mosquitos pools-C, tritaeniorhyncus which were caught between late July and middle August. 8. E.E. Virus was also isolated from piglet blood on early August and H-I antibody conversion was occurred mostly on middle of August. 9. H-I antibody sero-conversion rate reached to high level when vaccine purified by mouse brain tissue inoculated, showing 98.9%. Higher antibody titer was acquired when booster inoculation was performed, Four fold rise of H-I add N-T antibodies was confirmed with 93.2% and 82.1% respectively.

콩 발아 중 isoflavone malonylglucosides의 함량 변이

이주원,이유정,이주희,조민식,최도진,마무현,김홍식,김대옥,윤홍태,김용호,Lee, Ju-Won,Yi, Yoo-Jung,Lee, Ju-Hee,Jo, Min-Sik,Choi, Do-Jin,Ma, Mu-Hyun,Kim, Hong-Sik,Kim, Dae-Ok,Yun, Hong-Tae,Kim, Yong-Ho 한국작물학회 2018 한국작물학회지 Vol.63 No.3

Soybean produces three major types of isoflavones, daidzein, genistein, and glycitein aglycones and their glucosides and malonylglucosides. It has been known that malonylated glucosides are rapidly converted to their corresponding aglycones due to the unstable thermolabile glucoside malonates; therefore, the analytical study of malonylated glucosides has been insufficient. In this study, we analyzed the malonylglucoside content in soybean seeds. Isoflavone analysis of three soybean cultivars revealed that 81.5~90.0% of the total isoflavones were malonylglucosides, whereas aglycones were rarely detected. Moreover, the total isoflavone content increased during a 5-day germination period where growth regulators and coumaric acid treatments tended to yield higher isoflavone content than the normal germination treatment, however the differences were not significant; notably, the isoflavone accumulation trend continued with additional germination days. The content of malonylglucoside was higher than that of other isoflavones, which was 83.7~86.6% of the total isoflavone content in seeds with a 3-day germination period. Furthermore, isoflavones were significantly accumulated in the hypocotyl of seedlings with a 5-day germination period. The content of isoflavone in the hypocotyl of the Pungsannamul-kong was 10,240 ug/g when treated with coumaric acid, which was considerably higher than that of other cultivars and treatments. Additionally, soybean seeds heated at $60^{\circ}C$ for 1 hour produced higher isoflavone content than non-heated soybean seeds. Our results show that it is possible to increase the isoflavone content in soybean seeds through various treatments.

흉부 심음을 기반한 u-헬스케어용 RF-Tag설계

이주원,이병로,Lee, Ju-Won,Lee, Byeong-Ro 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.4

본 논문은 유비쿼터스 헬스케어 시스템을 위하여 생체 정보 단말기 개발에 있어 심음 신호를 기반한 RF-Tag의 하드웨어 구조와 신호처리 방법을 제안한 것이다. 본 연구에서의 RF-Tag는 체온 센서와 심음 검출을 위한 다이나믹 마이크로폰, 측정된 헬스정보를 전송하기 위한 블루투스 통신, 적응 이득제어기로 이루어진 심박 주기 검출 알고리즘으로 구성되어 있다. RF-Tag의 성능 분석을 위해 잡음환경에서 실험하였으며, 그 결과 우수한 성능을 보였다. 본 연구에서 제안한 방법을 u-헬스케어 단말기에 적용한다면, 모바일 환경에서도 실시간적으로 정확한 헬스 정보를 얻을 수 있을 것이라 사료된다. This paper is proposed the hardware structure and signal processing method of the RF-Tag based on heart sound to develop the mobile biomedical information device for the u-healthcare system. The RF-Tag in this study is consisted of a skin temperature sensor, a dynamic microphone for heart sound detection, Bluetooth communication to transmute healthcare data, and pulse period detection algorithm with adaptive gain controller. We experimented to evaluate performance of the RF-Tag in noisy environments. In addition, the RF-Tag has shown the good performance in the results of experiment. If the proposed methods in this study apply to design the u-healthcare device, we will be able to get the exact health data on real time in mobile environments.