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오매(烏梅)의 다성분동시분석 및 마우스를 이용한 경구 단회투여 급성독성시험
이인선,한창현,이철,황방연,정상혁,이영준,전원경,Lee, In-Sun,Han, Chang-Hyun,Lee, Chul,Hwang, Bang-Yeon,Jung, Sang-Hyeok,Lee, Young-Joon,Jeon, Won-Kyung 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.1
Objectives : Previous studies have shown that Fructus mume (FM) has anti-platelet effects. The present study was performed to determine the acute oral toxicity and quality control of a crude extract of FM in ICR mice. Methods : We investigated the in vivo single dose acute toxicity of FM 95% ethanol extract. This test was orally administered once by gavage to 20 male and 20 female mice at dose levels of 0 (control group), 1250, 2500 and 5000mg/kg body weight, respectively. Mortalities, clinical findings, autopsy findings and body weight changes were monitored daily for the 14 days following the administration. HPLC analysis was performed for the simultaneous determination of ursolic acid and p-hydroxycinnamic acid in FM. Reverse-phase chromatography using a C18 column and photodiode array detection at 211 nm was used for quantification of the two maker components. The mobile phase for gradient elution consists of water and acetonitrile. Results : We observed survival rates, general toxicity, change of body weight, and autopsy. The mice did not die after single oral administration of maximum dose of FM. Autopsy of animal revealed no abnormal gross finding. Therefore, $LD_{50}$ value of FM for ICR mice was more than 5000mg/kg on oral route. The HPLC analysis showed that ursolic acid and p-hydroxycinnamic acid amounts to 9.75- and 0.12% in the extract with the retention times of 47.99- and 15.38 minutes, respectively. Conclusions : These results suggest that no toxic dose level of FM in mice is considered to be more than 5000mg/kg. Consequently, it was concluded that FM have no effect on acute toxicity and side effect in ICR mice. For the quality control of FM extract, simultaneous determination of ursolic acid and p-hydroxycinnamic acid was established.
이인선,신호준,백민호,Lee,In-Sun,Shin,Ho-Joon,Baek,Min-Ho 한국방재학회 2012 한국방재학회논문집 Vol.12 No.5
인구증가 및 경제성장으로 인해 도시의 외적 규모가 급속히 확대되고 고층건물, 지하공간의 고도이용 등 도시공간이 복잡해져 있는 상황에서 도시지역에 자연재난 및 인적재난이 발생 할 경우 막대한 피해가 예상된다. 이에 피해지역의 도시탐색구조 역량강화는 중요한 과제라 할 수 있다. 우리나라는 도시탐색구조 분야의 개념 정립 및 인식이 미비한 단계이며, 전문적인 교육 및 훈련시설의 부족으로 체계적인 대응이 이루어지지 못하고 있는 상황이다. 이에 본 논문에서는 도시탐색구조의 개념을 정리하고 도시탐색구조를 위한 국내 외 조직현황을 분석하였으며 도시탐색구조업무를 담당하는 중앙 119구조대원에 의한 설문조사를 통하여 도시탐색구조의 문제점 및 개선방안을 제시하였다. Population and economic growth have caused the rapid external expansion of cities with high-rises in the metropolitan area, high-intensity utilization of underground space etc. As cities becoming more complex than ever, an outbreak of natural or manmade disaster would result in damages beyond imagination hence the enhancement of Urban Search and Rescue ability in the damaged area becomes crucial. Korea is in its very early stage as far as the concept and awareness of Urban Search and Rescue is concerned, and the lack of professional education and training facilities has prevented the associated bodies to take strategic responses. This paper defined the notion of Urban Search and Rescue, analyzed the status of national and international organizations, conducted surveys on National 119 Rescue Services team members responsible for the rescue operations to figure out problems of Urban Search and Rescue and proposed possible improvement measures.
한방진단시스템 DSOM의 진단결과에 따른 월경통 환자의 허실(虛實) 진단에 대한 연구
이인선,조혜숙,윤현민,정경근,김규곤,박지은,최선미,Lee, In-Sun,Cho, Hye-Sook,Youn, hyoun-Min,Jung, Kyoung-Keun,Kim, Kyu-Kon,Park, Ji-Eun,Choi, Sum-Mi 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.1
Purpose : This study was undertaken to make a diagnosis weakness and firmness (虛實) of Dysmenorrhea patients by diagnosis questionnaires system(Diagnosis System of Oriental Medicine-DSOM) Methods : The subjects were 58 volunteers who was suffering for dysmenorrhea, employed using Measure of Menstrual Pain (MMP) questionnaire. The had agreed to take part in this experiment, with didn't take any anodyne drugs. The MMP score by using 7 questions and the Menstrual Symptom Severity List(MSSL-D) was measured before and after menstruation cycle. Results and Conclusions : The findings of this study were as follows; 1. We examined Pathogenic Factor's frequency of DSOM, Coldness(寒) was 45 persons 80.36%, Damp(濕) was 40 persons 71.43%, Heart(心) was 37 persons 66.07%, Heat syndrom(熱) was 9 persons 16.07%, insufficiency of Yang(陽虛) was 6 persons 10.71%. 2. We divided Dysmenorrhea patients into two groups(weakness and firmness) by Results of DSOM, Firmness was 25 Persons 43.1%, Weakness was 23 persons 39.7%, Unknown was 10 persons 17.2%. 3. In estimation based on Measure of Menstrual Pain (MMP) questionnaire Severe menstrual pain is weakness, Mild menstrual pain is Firmness. 4. In estimation of coldness and heat syndrom, Coldness was 40 persons 69.0%, Heat syndrom, was 2 persons 3.5%, Possess both coldness and heat syndrom was 9 persons 15.5%.
이인선(In-Sun Lee),손진욱(Jin-Wook Sohn),배행자(Hang-Ja Bai) 한국중독정신의학회 2007 중독정신의학 Vol.11 No.1
Purpose:This study was to build up a detailed and structural substantive theory on the alcoholics’ hospital experience. Method:It was selected Creswell’s (2002) exploratory mixed method research design applying qualitative research and quantitative research sequentially, and then integrating two studies into one. In the qualitative research, 17 inpatient alcoholics participated. Qualitative data were collected and analyzed by the method of Strauss and Corbin (1998). In the quantitative study (survey), 172 inpatient alcoholics participated. Quantitative data were ana-lyzed with window’s SPSS 11.0 Version. Results:Through the qualitative research, 327 concepts, 81 subcategories, 23 categories, and a tentative conceptual framework were extracted. The tentative conceptual framework was composed with 23 categories including a core phenomenon (“Bridling”), emotional reactions (“Comfort”, “Bluntness”, “Boiling-Heart”), coping strategies (“Accepting”, “Dwindling”, “Standing-Against”), and de-bridling attitudes as result (“Recovering-Effort”, “Tinkering-Effort”, “Cling-Discharge”, “Depending-Hospital”, “Self-Despairing”). Through the quantitative research, significant factors (interventions and contextual conditions) which influence emotional reactions, coping strategies, and de-bridling attitudes of the inpatient alcoholics were founded. In the last phase of this study, the process of the alcoholics’ hospital experience was constructed. The process showed the steps and courses coming to the various de-bridling attitudes. Expecially the pathway to “recovering-effort”, one of the de-bridling attitudes, is expected to be desirable experience process for alcoholics during their hospitalization.
잘못된 Stent 삽입 치료 후 슬와 동맥 포착 증후군에서 발생한 슬와 동맥의 완전 폐쇄 1예
이인선 ( In Sun Lee ),최동훈 ( Dong Hoon Choi ),김은혜 ( Eun Hye Kim ),신상훈 ( Sang Hun Shin ),이도연 ( Do Yun Lee ),김승환 ( Seong Hwan Kim ),이택연 ( Taek Yeon Lee ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Entrapment of the popliteal artery is a rare cause of ischemia of the lower extremities in young males. The development of local occlusive or aneurysmal changes of the popliteal artery is caused by abnormal anatomical relationships between vascular and musculotendinous structures in the popliteal fossa. A 55-year-old male patient visited Yonsei University College of Medicine with the chief complaint of claudication in his right calf. He had undergone stent insertion in the right popliteal artery for peripheral artery occlusive disease 2 years earlier. Lower extremity CT angiography showed stent fracture and in-stent thrombosis. He underwent femoral-to-popliteal artery bypass surgery. Postoperative lower extremity CT angiography showed that the vein graft was compressed between the medial head of the gastrocnemius and the semimembranosus muscle. However, the blood flow was normal and his pain was relieved. (Korean J Med 2012;83:786-790)