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삼릉(三稜)이 자궁경부암세포(子宮頸部癌細胞)(HeLa cell)의 Apoptosis에 미치는 영향(影響)
홍기철 ( Ki Cheul Hong ),김주연 ( Joo Yeon Kim ),공복철 ( Bok Cheul Kong ),최창민 ( Chang Min Choi ),유심근 ( Sim Keun Yoo ) 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.4
Purpose: This study is to examine the ability of Rhizoma Scirpi (RS) to induce HeLa cell viability. Methods: We culture HeLa cell which is human metrocarcinoma cell in D-MEM included 10% fetal bovine serum(Hyclone Laboratories) below 37℃, 5% CO2. Then we observed apoptosis of log phage cell which is changed cultivation liquid 24 Hours periodically. Results: 1. RS induces mitochondria membrane potential collapse. 2. P38 MAPK is involved in RS-induced death in HeLa cells. 3. P38 MAPK is involved in RS-induced apoptosis in HeLa cells. 4. P38 MAPK reguates RS-induced caspase-3, -8 and -9 activation in HeLa cells. 5. The inhibition of caspase regulates RS-induced cell death in HeLa cells. 6. RS induces mitochondria membrane potential collapse in HeLa cells. 7. P38 MAPK is involved in the regulation of Bcl-2 and Bax in HeLa cells. 8. RS regulates the expression of Bcl-2 and Bax in HeLa cells. 9. SR induces p38 MAPK activation in HeLa cells. Conclusion: RS induces apoptosis in HeLa cells via p38 MAPK activation.