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성인에서 발견된 Albright 선천성 골이형성증을 동반하지 않은 가성부갑상선기능저하증 1예
이윤범,노정민,유정선,한정우,남지선,조민호,박종숙,안철우,김경래 대한내분비학회 2009 Endocrinology and metabolism Vol.24 No.2
Pseudohypoparathyroidism is a rare disease caused by resistance to parathyroid hormone, and is associated with typical clinical typical symptoms such as tetany and seizures, hypocalcemia, hyperphosphatemia and increased parathyroid hormone levels. Pseudohypoparathyroidism is classified to Type Ia, Ib, Ic and II according to the clinical and biochemical manifestations. Type Ia and Ic have morphological characteristics called Albright's hereditary osteodystrophy. Type Ib differs from type II for the pathogenesis. Type Ib may~ receptors and type II may~ pathway, but the pathophysiology of type II is not clear yet. Administration of parathyroid hormone extract may help to distinguish between the two types. We report a case of a pseudohypoparathyroidism type Ib or II patient who had tetany, hypocalcemia and hyperphosphatemia with normal morphologic features.
커뮤니티 개념을 적용한 도시하천 수변공간 정비방안에 관한 연구
김형태,이윤남,장준호 안양대학교 산업기술연구소 2002 自然科學硏究 Vol.9 No.-
급속한 도시화의 과정에서 기존의 도시하천정비는 공공의 논리로 이수, 치수목적에 큰 비중을 두었다. 그 결과 도시하천의 생태계 파괴는 물론, 획일적인 개발형태로 인하여 경관에 많은 문제점을 지니게 되었고, 특히 대도시 내에서의 하천은 그 경향이 심각하게 나타나게 됨에 따라 도시민에게 외면당하고 있는 실정이다. 따라서 본 연구에서는 이러한 문제점 해결방안으로 커뮤니티 개념을 적용한 접근 방법을 시도함으로써 새로운 문화와 상징을 창출하고 해당지역 주민에게 정비사업에의 참여를 통한 지역애와 지역공동체성을 함양시킬 수 있는 새로운 방안을 모색해보고자 한다. During the rapid urbanizing period, consolidating the urban waterfront system was likely to be regarded to leave the water or to regulate waterfront by the public logic. According to this research as a result, we have a lot of problems not only about the destruction of ecosystem but also about their appearance by the exact same development forms. As the problem is being more serious in the metropolitan areas, the residents don't care any more. So here, we are trying to solve this problem by approaching the concept of the community planning, so that we can creat the new cultural symbol and also we can make the fascinating space that people can feel their place more like home and give them comfortable through citizen participation.
급성 Respiratory syncytial virus 세기관지염 환아의 비인두흡인액에서 혈관내피세포 성장인자의 증가
라경숙,남효경,Siegfried Bauer,김지은,최익선,이윤,박상희,정지태,유영 대한 소아알레르기 호흡기학회 2010 Allergy Asthma & Respiratory Disease Vol.20 No.3
목 적:급성 respiratory syncytial virus (RSV) 세기관지염으로 입원한 2세 이하 환아에서 천명의 지속 기간과 혈청 또는 비인두흡인액 VEGF 농도와의 관계를 알아보고자 하였다. 방 법:2008년 11월부터 2009년 4월까지 고려대학교 안암병원 소아청소년과에 급성 바이러스성 세기관지염으로 입원한 2세 이하 환아 94명을 대상으로 혈액의 알레르기 염증 지표를 검사하고 의무기록지를 토대로 발열, 천명, 입원 기간 등의 임상 소견을 분석하고, 비인두흡인액과 혈청 VEGF 농도를 측정하였다. 결 과:대상 환아 94명 중 비인두흡인액 바이러스 배양에서 RSV가 검출된 RSV 양성군 51명과 RSV 음성군 43명에서 입원 기간은 각각 6.9±2.1일과 5.5±1.8일로 차이가 없었으나, 천명의 지속기간은 RSV 양성군이 3.8±2.7일로 RSV 음성군의 2.4±1.8일에 비해 유의하게 길었다. 혈청 VEGF 농도의 평균값은 RSV 양성군이 240.3±113.2 pg/mL로 RSV 음성군의 194.4±119.3 pg/mL 보다 약간 높았으나 통계적인 유의성은 없었고 (P=0.134), 비인두흡인액 VEGF 농도는 RSV 양성군이 331.8±197.8 pg/mL로 RSV 음성군의 204.5±97.0 pg/mL 보다 유의하게 높았다(P=0.002). 결 론:RSV 양성 세기관지염 환아군에서 RSV 음성 환아군에 비해 비인두흡인액 VEGF 농도가 높았고, 천명의 지속 기간도 길게 나타났다. 이는 RSV 세기관지염에서 증가된 VEGF가 기관지벽의 투과도 증가와 부종을 유발하고 기류제한을 초래하여 천명이 오래 지속되는 것에 일부 관계 있을 것으로 생각해 볼 수 있다. Purpose:Viral infection is known as one of the dominant risk factors for wheezing in children hospitalized before 2 years of age. Although the major viral pathogen associated with wheezing is respiratory syncytial virus (RSV), the mechanisms of wheezing remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability. The aim of this study was to evaluate the relationship between VEGF concentration and wheezing in children with acute RSV bronchiolitis. Methods:Ninety-four children with acute bronchiolitis who were admitted to Korea University Anam Hospital were enrolled in this study. Based on the proven viral agents, children with bronchiolitis were divided into 2 groups: those who were infected with RSV (RSV (+) group, n=51) and those who were not (RSV (–) group, n=43). A complete history taking, physical examination and routine laboratory tests were performed on all children. VEGF levels in serum and nasopharyngeal aspirates (NPA) were determined by ELISA. Results:NPA VEGF levels were significantly higher in the RSV (+) group than in the RSV (-) group (331.8±197.8 vs. 204.5±97.0 pg/mL, P=0.002). The duration of wheezing is significantly longer in the RSV (+) group than in the RSV (-) group (3.8±2.7 days vs. 2.4±1.8 days, P=0.037). Conclusion:The results of this study suggest that children with RSV bronchiolitis may have significantly higher NPA VEGF levels than those without, which may be associated with a longer duration of wheezing in those with RSV bronchiolitis.
AFLP 분석에 의한 멸종위기어류 미호종개, Iksookimia choii의 유전 다양성
이일로,이윤아,신현철,남윤권,김우진,방인철 한국하천호수학회 2008 생태와 환경 Vol.41 No.1
Genetic diversity and population genetic structure within or among three stream populations (Gab, Baekgok and Ji streams) of Korean endangered natural monument fish, Iksookimia choii, were assessed by amplified fragment length polymorphism (AFLP). AFLP analysis using three primer combinations generated 104 to 106 AFLP bands, and percent polymorphic bands were similar in those three populations ranging 21.5 to 24.5%. Heterozygosity and genetic diversity within or among populations were quite low for all of these populations with average values ranging from 0.067 to 0.084 and from 0.076 to 0.087, respectively. Analyses of pairwise distance and genetic similarity among three populations of I. choii also revealed the similar results with very low genetic differentiation one another. Although pairwise Fst values were very low, our data clearly indicated distinct genetic differentiation among the three populations. This is the first report concerning the genetic diversity and differentiation of this species, and provides basic genetic information that should facilitate attempts to conserve this species. Genetic diversity and population genetic structure within or among three stream populations (Gab, Baekgok and Ji streams) of Korean endangered natural monument fish, Iksookimia choii, were assessed by amplified fragment length polymorphism (AFLP). AFLP analysis using three primer combinations generated 104 to 106 AFLP bands, and percent polymorphic bands were similar in those three populations ranging 21.5 to 24.5%. Heterozygosity and genetic diversity within or among populations were quite low for all of these populations with average values ranging from 0.067 to 0.084 and from 0.076 to 0.087, respectively. Analyses of pairwise distance and genetic similarity among three populations of I. choii also revealed the similar results with very low genetic differentiation one another. Although pairwise Fst values were very low, our data clearly indicated distinct genetic differentiation among the three populations. This is the first report concerning the genetic diversity and differentiation of this species, and provides basic genetic information that should facilitate attempts to conserve this species.