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신현철,황혜정,Kee Jung Kang,이봉호 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.2
Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. Phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as Ecklonia and Eisenia families. Phlorotanninrich extracts of Ecklonia cava including LAD103 showed significant antioxidant activities such as DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation, indicating their possible antioxidative interference both in onset and downstream consequences of osteoarthritis. LAD103 also showed significant down regulation of PGE2 generation in LPS-treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-1α-induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation. Since LAD103 showed strong therapeutic potentials in arthritic treatment through several in vitro experiments, it is highly encouraged to perform further mechanistic and efficacy studies.
신현철 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1
본 논문에서는 집적회로 설계에 있어서 지적 재산권 (Intellectual Property, IP)을 재사용하는 최근의 경향과 설계 기술을 설명한다 IP 재사용을 활성화시키기 위하여 VSIA, RAPID 및 VCX와 같은 여러 기관들이 설립되었으며, IP 산업을 위하여 CAD 업체들이 재구성되고 있다. IP는 소프트 IP, 펌 IP 및 하드 IP의 세 가지로 구분될 수 있다. 본 논문에서는 IP를 위한 설계 과정과 설계 기법들을 조사하였다. 효과적이고 효율적인 IP 재사용을 위해서는 설계 초기에서부터 DSM 영향을 고려할 수 있는 상위 수준의 floorplanning 틀을 개발하여야 한다. This paper describes recent trends and design technologies for Intellectual Property reuse in integrated circuit design. Several organizations, such as VSIA, RAPID and VCX, have been established to activate IP reuse, and CAD industries have been reorganized for IP business. IPs can be classified into 3 types: Soft IP, Firm IP, and Hard IP Design process for IPs and design technologies for IP reuse are studied. For efficient and effective IP reuse, high-level floorplanning tools which can consider DSM effects from the beginning of the design should be developed.
6-Azaumcil 내성을 지닌 Corynebacterium glutamicum 변이주에 의한 L-Lysine의 생산
신현철,김성준전영중이재흥 한국생물공학회 1994 KSBB Journal Vol.9 No.4
To improve L-lysine yield, pyrimidine base analogue(6-azauracil)-resistant mutants were isolated from Corynebacterium glutamicum KFCC10672 Among them the best producer, C. glutamicum CH0516, was selected and tested for L-lysine production in a $7\ell$ fermentor. It was found that the product yield obtained with C. glutamicum CH0516 was higher than that of the parent strain by 3%. In order to elucidate the gain in productivity with the 6-azauracil-resistant mutant enzymatic kinetic parameters such as aspartokinase(AKase) and aspartate carbamoyltransferase (ATCase) were measured. The Km values of AKase with C. glutamicum KFCC10672 and CH0516 were 200.0 mM and 166.7 mM and those of ATCase were 0.13 mM and 0.27 mM, respectively. However, the specific enzyme activities of AKase of C. glutamlcum KFCC10672 and CH0516 were $3.89{\times}10^{-1}$ units/mg and $4.78{\times}10^{-1}$ units/mg, and those of ATCarse were 2.20 units/mg and 1.84 units/mg, respectively. It appears that some increase in product yield with C. gluramicum CH0516 is likely due to the increased Akase activity and decreased ATCase activity. L-Lysine 고역가 생산균주를 개발하기 위해 공지의 균주인 C. glutamicum KFCCI0672를 인공 돌연변이시켜 pyrimidine analouge인 6-azauraciI($4\ell$) 내성을 부여한 결과 모균주에 비해 L-Lysine 생산성이 3% 증가된 C. glutamicum CH0516을 획득할 수있었다. L-Lysine 생산성 향상의 원인을 규명하고자 C. glutamicum KFCCI0672 및 CH0516의 aspartokir nase(AKase)와 aspartate carbamoyltrasferase ( ATCase)의 aspartate에 대한 $K_m$값을 측정한 결 과 AKase의 $K_m$값은 200.0ruM, 166.7mM이었고 A TCase의 $K_m$값은 0.13ruM, O.27mM이었다. 한편 C. glutamicum KFCC10672와 CH0516의 AKase 비효소활성은 각각 $3.89{\times}1^{-1}$ Iunits/mg, $4.78{\times}10^{-1}$ lunits/mg이었고 A TCase의 경우는 각각 2.20units/mg, 1.84units/mg이었다. C C. glutamicum CH0516이 KFCCl0672에 비해 세포의 성장도가 낮고 L-Lysine 생산성이 높은 이 유로셔는 CH0516의 A TCase의 aspartate에 대한 K Km값이 KFCC10672의 값에 비해 크고 비효소활성 이 낮은 점에셔 찾을 수 있다. 즉 CH0516 A TCase 의 aspartate 사용량이 KFCC10672에 비해 낮기 때문에 여분의 aspartate가 AKase에 의해 L-Lys sme이 합성됩으로써 L-Lysine 생산성 증가가 얻어 진 것으로 사료된다. 이러한 사실은 CH0516 A AKase의 Km값이 KFCC10672에 비해 낮고 비효 소활성이 높은 점에셔도 뒷받침된다.
곰페르츠형 형상모수에 근거한 소프트웨어 신뢰성모형에 대한 비교연구
신현철,김희철 (사)디지털산업정보학회 2014 디지털산업정보학회논문지 Vol.10 No.2
Finite failure NHPP software reliability models presented in the literature exhibit eitherconstant, monotonic increasing or monotonic decreasing failure occurrence rates per fault. Inthis paper, proposes the Gompertz distribution reliability model, which made out efficiencyapplication for software reliability. Algorithm to estimate the parameters used to maximumlikelihood estimator and bisection method, model selection based on mean square error(MSE) and coefficient of determination(R²), for the sake of efficient model, was employed. Analysis of failure using real data set for the sake of proposing fixed shape parameter of theGompertz distribution was employed. This analysis of failure data compared with theGompertz distribution model of shape parameter. In order to insurance for the reliability ofdata, Laplace trend test was employed. In this study, the proposed Gompertz model is more efficient in terms of reliability in thisarea. Thus, Gompertz model can also be used as an alternative model. From this paper,software developers have to consider the growth model by prior knowledge of the softwareto identify failure modes which can was helped
한국형모델(KIM) 기반 확률예측시스템 개발 현황 및 향후 계획
신현철,김은정,손주형,장한별,윤숙경,강현석 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
수치예보기술의 발달과 함께 미래의 대기 상태에 대한 다양한 예측시나리오를 제공해 주는 앙상블 모델에 대한 연구가 각광을 받고 있다. 수치예보모델은 100% 정확할 수 없기 때문에 단 하나의 예측 시나리오만 제공하는 결정론적 모델은 항상 예보가 틀릴 수 있다는 risk를 가질 수밖에 없으며, 이를 극복하기 위한 대안으로서 앙상블모델이 활용되고 있다. 앙상블모델은 미래에 가능한 여러 개의 시나리오를 제공함으로써 모델 user 들이 다양한 시나리오에 입각해 합리적인 결정을 내릴 수 있도록 도와준다. 이런 장점 때문에 전지구모델을 운영하는 대부분의 기상센터에서는 전지구모델과 함께 앙상블모델을 병행 운영하고 있다. 기상청은 9년간의 연구개발사업을 통해 자체 기술로 개발한 한국형 전지구모델(KIM)을 2020년 4월부터 현업으로 운영하고 있다. 또한 한국형모델 기반으로 구축된 앙상블모델을 2020년부터 준현업 운영해 오고 있다. 한국형모델 기반의 앙상블예측시스템은, 멤버 수 증가(14개 멤버에서 26개 멤버로) 등을 반영하여 2021년 말부터 현업운영될 예정이다. 현업화 될 한국형앙상블모델은 32 km 수평해상도에 91개의 연직층으로 구성되어 있으며 26개 멤버로부터 하루 2번 12일까지의 예측장을 생산한다. 한국형앙상블모델은 4차원 앙상블 변분자료동화시스템(4DEnVAR)를 통해 전지구모델과 연동되어 전 지구모델에 앙상블배경오차공분산 정보를 제공한다. 앙상블배경오차정보 산출용으로 사용되는 앙상블 멤버는 50개이고, 각 멤버모델들은 배경오차를 제공할 목적으로 하루 4번(00,06,12,18 UTC) 12시간 예측을 수행한다. 앙상블모델에 관측자료를 입력하고 섭동을 산출하기 위한 앙상블 자료동화체계는 LETKF (Local Ensemble Transform Kalman Filter)를 사용한다. 본 연구에서는 한국형앙상블모델의 개발 현황 및 향후 개선계획에 대해 설명하고 개발된 한국형앙상블모델의 예측성능을 전지구모델 및 기존 현업 앙상블모델의 예측성능과 비교 평가하여 그 결과를 제시하고자 한다.
삼국유사에 실려있는 식물들의 분류학적 실체와 민족식물학
신현철 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.2
“Samgukyusa”, written by Ilyeon, is one of the oldest books presenting the history of the period of Three Kingdom in Korea. The plants described in this book are very important in Ethnobotanical aspects in Korea. So, the purpose of this study is to compile the list of the plants appeared in the book, and to examine the scientific names of them texonomically as well as the utilities of them ethnobotanically. As the result, 62 plant names were compiled in the list, among which 45 names were identified taxonomically and hence could be given proper scientific names. The plants were also found to be used for food, industry, garden and religion.
역-레일리와 레일리 분포 특성을 이용한 유한고장 NHPP모형에 근거한 소프트웨어 신뢰성장 모형에 관한 비교연구
신현철,김희철 (사)디지털산업정보학회 2014 디지털산업정보학회논문지 Vol.10 No.3
The inverse Rayleigh model distribution and Rayleigh distribution model were widelyused in the field of reliability station. In this paper applied using the finite failure NHPPmodels in order to growth model. In other words, a large change in the course of thesoftware is modified, and the occurrence of defects is almost inevitable reality. Finite failure NHPP software reliability models can have, in the literature, exhibit eitherconstant, monotonic increasing or monotonic decreasing failure occurrence rates per fault. Inthis paper, proposes the inverse Rayleigh and Rayleigh software reliability growth model,which made out efficiency application for software reliability. Algorithm to estimate theparameters used to maximum likelihood estimator and bisection method, model selectionbased on mean square error (MSE) and coefficient of determination(R²), for the sake ofefficient model, were employed. In order to insurance for the reliability of data, Laplacetrend test was employed. In many aspects, Rayleigh distribution model is more efficient than the reverse-Rayleighdistribution model was proved. From this paper, software developers have to consider thegrowth model by prior knowledge of the software to identify failure modes which can helped.
의료급여 수급권자 확대정책이 예방가능한 입원율에 미친 영향
신현철,김세라 한국보건행정학회 2010 보건행정학회지 Vol.20 No.1
The objective of this study were to examine the impact of medicaid coverage expansion policy aimed at improving access to primary care. The case-control study was conducted to compare preventable hospitalization(PH) rate in new medicaid recipients versus national health insurance(NHI) enrollees form 1996 to 2001. Rates of preventable hospitalization associated with ambulatory care sensitive conditions(ACSC) were calculated and standardized by age and sex. Multinomial logit regression model was used to control the confounding factors such as age,gender and charlson comorbidity index Annual PH rates in the new medicaid increased 1.64 times after medicaid expansion, with controling confounding factors. Meanwhile, annual PH rate in the NHI increased 1.68 times during the sameperiod, with adjusting confounding factors. Current findings suggest that the new medicaid PH rate was less likely to rise than NHI PH rate after implementing medicaid expansion. This study is expected to provide policy-relevant evidence of medicaid expansion to include population with low income.