내경동맥 지배 영역의 급성 허혈성 뇌졸중 환자에서 초 선택적 국소적 Urokinase주입술

김인규,김명규,김재규,조기현,김세종 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

다발성 말초신경병증의 조기진단 : 적외선 체열촬영검사와 전류지각역치검사의 조합진단 Combination Diagnosis Using by Digital Infrared Thermogram and Current Perception Threshold

이삼규,김재형,최인성,이소영,한재영,조성렬,김재휴,노성만,정민영,정동진,김현성 全南大醫大 2001 전남의대학술지 Vol.37 No.3

食用油脂類에 對한 免疫生物學的 硏究

朴炳哲,文宰奎,朴榮吉,金杏順,安年衡,金度勳,金正勳,安榮根,李相根,鮮于演 圓光大學校 1990 論文集 Vol.24 No.2

食用油脂는 健康維持에 必須的인 營養素이다. 그러나 食用油脂는 脂肪을 構成하는 脂肪酸의 種類와 攝取하는 量에 따라 健康을 保衛하는 必須的인 食品의 成分이 되기도 하고 有害한 影響을 끼칠 수도 있어서 脂質代謝와 關連된 疾病 뿐만아니라 老化를 促進하고, 乳房癌, 大腸癌等의 癌發生과도 關連된 것으로 밝혀져 있다. 本 硏究는 우리生活環境에서 食用으로 接할 수 있는 10種의 油脂에 對한 免疫生物學的인 活性에서 究明한 結果 對照群인 참기름食餌群에 比해 올리브유食用群은 全般的으로 體液性 및 細胞性免疫을 有意性있게 增加시켰으나, 大食細胞의 活性과 末梢循環白血球數는 有意性없는 減少를 보였고, 動物性 油脂인 牛脂食餌群과 植物性 油脂인 옥수수기름食餌群, 들기름食餌群, 米糠油食餌群, 大豆油食餌群, 菜種油食餌群 및 고추씨기름食餌群에서는 全般的으로 體液性 및 細胞性免疫, 大食細胞의 活性 및 末梢循環白血球數를 有意性있게 減少시켰다. This study was performed to investigate the effects of edible oils and fats on the immunobiological responses in ICR male mice. Ten groups of experimental diets, such as sesame oil diet, beef tallow diet, lard oil diet, olive oil diet, corn oil diet, perilla oil diet, rice polishing oil diet, soybeen oil diet, rape seed oil diet, and red pepper seed oil diet were fed adlibitum to the ICR male mice for 27 days. The results of this study were summarized as followings. 1. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes in sesame oil group were increased. However, the increasing rate of body weight and the weight retios of spleen and thymus to body were generally decreased. 2. Hemagglutination titer(HA) and rosette forming cell(RFC) of the beef tallow group and the lard group were significantly lower than the sesame oil group(P<0.01), but the lard group significantly increased Arthus reaction and delayed type hypersensitivity(DTH)(P<0.01). 3. Arthus reaction, DTH, and RFC of the olive oil group were significantly higher than the sesame oil group(P<0.01). 4. DTH of the corn oil group was significantly higher than the sesame oil group(P<0.01) whereas phagochyte activity was significantly lower(P<0.01). But no statistically significant differences were found between the two groups in the humoral immune response. 5. HA, PFC, DTH, RFC, phagocyte activity, and number of leukocytes of the perilla oil group and the rice polishing oil group were significantly lower than the sesame oil group(P<0.01). 6. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes of the soybeen oil group, the rape seed oil group, and the red pepper oil group were significantly lower than the sesame oil group(P<0.01).

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

CCA 처리재로부터 방부제 유효성분의 용제추출

김규혁,공일곤,나종범,조재성,김재진 한국목재공학회 2003 목재공학 Vol.31 No.4

본 연구는 CCA 처리재로부터 방부제 유효성분을 추출하기 위한 적정 용제를 선정하고, 선정된 용제의 최적추출조건을 평가하기 위 해 수행되었다. 추출수율과 용제의 사용 및 환경 안전성을 고려할 때, 과산화수소가 CCA유효성분을 추출하는 데 가장 적절한 용제로 선정되었다. 과산화수소를 이용한 추출 결과. 추출온도, 추출용제농도, 추출시간 간에 상호작용이 존재하였으나 추출온도와 추출용제의 농도가 높을수록, 그리고 추출시간이 연장될수록 CCA유효성분의 추출수율은 증가되었다. 경제적인 측면을 고려할 때 가능하면 낮은 농도의 추출용제를 사용하여 저온에서 추출하여야 하나, 이 경우에는 필요한 추출수율을 달성하기 위한 추출시간이 상당히 길어지기 때문에 40℃ 이상의 온도에서 추출이 바람직하며 사용할 추출용제의 농도는 추출시간을 고려하여 최종적으로 결정하여야 된다고 사료된다. This research was performed to select an appropriate agent to extract preservative components from CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and extracting time on the removal of chrome, copper, and arsenic from treated wood. Hydrogen peroxide was selected as the best extracting agent when considered extraction yield as well as use and environmental safety. Its extraction yield was dependent on extracting variables (temperature, concentration, and time), and a highly significant interaction existed among variables. It should be possible to optimize extraction by manipulating these extracting variables. The results may suggest that the required temperature conditions for the reasonable removal of CCA components are at least above 40℃ because extracting time is too long at low temperature (20℃). Reagent concentrations for extracting at above 40℃ should be decided by considering the extracting time.

보일러 플랜트 제어계통 모델링 및 시뮬레이션에 관한 연구

김재화,장태규 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

본 연구에서는 보령화력 1,2호기 500MW급 드럼형 보일러 및 제어 시스템을 대상으로 보일러 플랜트의 dynamics 모델링과 운전 시뮬레이션을 수행하였으며 이를 실제 수행한 발전소 시험 데이터와 비교하여 높은 일치도를 보이는 것을 확인하였다. 본 연구를 통하여 얻은 결과는 추후 공장감지 신호처리 앨고리즘을 개발하는 과정에 여러 운전 패턴 및 고장 상황을 발생시켜 적용하여 볼수있도록 하여주는 개발환경으로 사용하고자한다. This paper presents the dynamics modeling and the operation simulation of the 500 MW drum-type boiler and its control system hosted in the Boryung Power Plant unit #1 and #2. The fidelity of the modeling and the operation simulation is well verified by their agreement with the actual data obtained form the plant operation. As a plant signal generator for the various operation patterns and fault situations, the simulation environment will be utilized to develope the fault detecting signal processing algorithms.

Pb의 노출에 따른 넙치, Paralichthys olivaceus, 치어의 생존, 성장 및 산소소비율의 변화

김성길,김재원,장석우,김상규,강주찬 한국어병학회 2002 한국어병학회지 Vol.15 No.3

Experiments were carried out to investigate the effects of lead exposure on survival, growth and oxygen consumption of juvenile oliver flounder, Paralichthys olivaceus. Survival rate of the oliver flounder was significantly affected above 150㎍/L. Growth of the olive flounder exposed to ≥ 150 ㎍/L of lead concentration was significantly lower than that of fish reared in normal condition. Metabolic rate of fish exposed to lead ≥ 80 ㎍/L concentration was significantly reduced with increasing lead concentration than that in normal condition. This study revealed that high lead concentration (≥ 80 ㎍/L) reduced growth and metabolic rates of juvenile olive flounder suggesting potential influence of lead on the natural mortality of olive flounder in the coastal areas.

소나무와 잣나무 원목에서 변재변색 발생

김규혁,김재진,나종범 한국목재공학회 2002 목재공학 Vol.30 No.2

본 연구는 동절기 (1월 중순)에 벌채된 후 목재집하장으로 운반되어 야적장에 저목 중인 소나무와 잣나무 원목을 대상으로 변재변색의 발생시기와 변색 특성을 조사하기 위하여 수행되었다. 벌채 후 3, 4, 5, 6, 8개월 경과시 변색 평가를 실시하였는데, 매 평가시 원목 3개를 임의로 선정하여 원목당 수축방향에 대해 일정 간격으로 7∼9개의 두께 3 ㎝ 원판을 채취하여 변색 원인균을 분리한 후 변재변색의 방사방향 최대 침투깊이와 % 변색율을 측정하였다. 변재변색은 전적으로 층형변색이었으며, 주요 변색원인균인 Ophiostomatoid 균을 매개하는 수피천공충은 소나무좀으로 확인되었다. 소나무와 잣나무 원목은 5월 이전까지는 변재변색의 위험없이 저목할 수 있으나 5월 이후부터는 원목의 변재변색이 급속하게 증가하였다. 변색의 정도는 소나무보다 잣나무에서 심하였으며, 장마철 저목 중에 소나무 원목에서 개떡버섯과 치마버섯의 자실체를 다수 관찰할 수 있었다. 본 연구를 통해 밝혀진 결과들은 앞으로 동절기에 벌채되어 저목 중인 소나무와 잣나무 원목에 발생하는 변재변색을 예방하기 위한 제반 조치를 취하는데 매우 중요한 자료로 사용될 것이다. This study was conducted to investigate the influence of storage time on the sapstain development of Japanese red pine and Korean pine logs during storage in log yard, and their stain characteristics. Japanese red pine and Korean pine trees were harvested and cut into logs in mid January of 2001. These logs were transported to the two local sawmills where they were closely stacked in remote parts of log yard. The logs were then sampled destructively by cutting seven to nine 3-㎝ long discs along the length of each log at intervals of 3, 4, 5, 6, and 8 month after felling. The stain coverage and maximal radial penetration of stain were measured from the discs of the sampled logs after the isolation of causal staining fungi. The sapstain was primarily infested by the attack of bark beetles and the species of bark beetle was identified as Tomicus piniperda. The main fungal species isolated from stained wood was Ophiostoma species. Based on the present study, the logs could be stored in log yard until May without stain; but stain development was rapid after May and the severity of stain increased proportionally with storage time. Korean pine was more susceptible to fungal stain than Japanese red pine. During summer storage, decay started to develop in logs and the main species were identified as Tyromyces sp. and Schizophyllum commune. Information provided in this paper would be very useful to develop more effective control strategies for sapstain prevention in Japanese red pine and Korean pine logs.

급성 세균성 부비강염에 대한 Cefpodoxime proxetil의 치료효과

김춘관,이혁,김성민,백경란,동헌종,나동규,송재훈 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.4

목적 Cefpodoxime proxetil은 새로이 개발된 제3세대 경구용 세팔로스포린 항균제이다. 그람양성과 그람음성균에 넓은 항균력을 가지고 있으며 특히 페니실린 내성 폐렴구균에 중등도로 효과가 있다. 이에 저자들은 시험관 내에서 폐렴구균에 대한 cefpodoxime의 감수성 여부를 조사하고, 급성 세균성 부비강염에 대한 cefopdoxime proxetil의 임상적 효과 및 안전성을 검토하기 위해 이 연구를 시행하였다. 방법 임상 검체에서 분리되어 보관하고 있는 폐렴구균 100 균주를 대상으로 cefodoxime 디스크를 이용하여 항균제 감수성 여부를 조사하였다. 또한 1996년 9월부터 1996년 12월 까지 삼성의료원에 내원한 33명의 급성 세균성 부비강염 환자를 대상으로 cefpodoxime proxetil 200mg을 14 일간 부여하였다. 환자들은 치료를 전후하여 임상 증상 및 증후를 비교하고, 세균검사, 임상 검사, 방사선학적 검사를 시행하였다. 결과 페니실린 감수성 폐렴구균 24균주와 페니실린 중등도 내성 26 균주 모두 cefpodoxime에 감수성이 있었다. 페니실린 내성 폐렴구균 50 균주중 78% 에서 감수성이 있었고 나머지 22%는 내성을 보였다. 임상적 호전을 보인 환자는 전체의 96%였다. 단순 방사선 촬영과 CT를 기초로 판단한 방사선학적 호전율은 69%였다. 약제 부작용은 전체 33명 중 관찰되었고 소화기계 증상과 두통이 각각 2명에서 관찰되었으며, 두통이 발생한 2명은 그 정도가 심하여 투약을 중지하였다. Background : Cefpodoxime proxetil is a new third-generation cephaiosporin. It has 2 broad antibacterial spectrum and shornrs potent antibacterial activity against respiratory pathogens, including Huemophilus in fluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis. Moreover, it has inoderate activity to penicillin-resistant Streptococcus pneumoniue, the incidence of which is increasing worldwidely. Therefore, cefpodoxirne proxetii can be recommended as an empirical antibiotic for treatment of acute bacterial sinusitis. The aim of this study is to reassure In vitro antimicrobial activity of cefpodoxirne to Streptococcus pneumoniae including penicillin-resistant strains and to evaluate the therapeutic efficacy and the safety of cefpodoxiine proxetii in acute bacterial sinusitis. Method : In vitro antimicrobial activities of cefpodoxime to 100 S. pneumoniae isolates from clinical specimens were investigated by disk diffusion method. Clinically. cefpodoxime proxetil mas admmmstered 200 mg twice a day orally for 14 days in 33 patients with acute bacterial smus~tis. The therapeutic efficacy was evaluated by patient's clinical s tom and signs, and by radiologic frndings of simple X-ray of paranasal sinuses and CT. Results : In vitro, penicillin sensitrve(n= 26) and intermediately resistant(n=26) S. pneumontae were all susceptible to cefpodoxime. Among 50 isolates of penicillin resistant s. pneumoruae, 39 strains(78%) were cefpodoxime sensitive and 11 strains(22%) were intermediately resistant to cefodoxime. Clinical symptoms and signs were improved in 32 patients(96%) of the patients. Radiological improvernent were found in 23 patients(69%). During treatment, headache and abdominal discomfort were developed in 2 patients, respectively. Conclusion : Cefpodoxime proxetil was highly effective and safe in treating acute bacterial sinusitis.