Comparison Different Methods of Intraoperative and Intraperitoneal Chemotherapy for Patients with Gastric Cancer: A Meta-analysis

Huang, Jin-Yu,Xu, Ying-Ying,Sun, Zhe,Zhu, Zhi,Song, Yong-Xi,Guo, Peng-Tao,You, Yi,Xu, Hui-Mian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Purpose: To investigate the efficacy and safety of intraperitoneal chemotherapy (IPC) for patients with gastric cancer and to compare effects between different regimens of IPC. Method: Randomized controlled trials comparing the effects of surgery plus intraperitoneal chemotherapy with surgery alone or comparing the efficacy between different regimens of intraperitoneal chemotherapy were searched for in Medline, Embase, Pubmed, the Cochrane Library and the Chinese BioMedical Disc and so on by two independent reviewers. After quality assessment and data extraction, data were pooled for meta-analysis using RevMan5.16 software. Tests of interaction were used to test for differences of effects among subgroups grouped according to different IPC regimens. Results: Fifteen RCTs with a total of 1713 patients with gastric cancer were included for quality assessment and data extraction. Ten studies were judged to be of fair quality and entered into meta-analysis. Hyperthermic intraoperative intraperitoneal chemotherapy (HR=0.60, P<0.01), hyperthermic intraoperative intraperitoneal chemotherapy plus postoperative intraperitoneal chemotherapy (HR=0.47, P<0.01) and normothermic intraoperative intraperitoneal chemotherapy (HR=0.70, P=0.01) were associated with a significant improvement in overall survival. Tests of interaction showed that hyperthermia and additional postoperative intraperitoneal chemotherapy did not impact on its effect. Further analysis revealed that intraperitoneal chemotherapy remarkably decrease the rate of postoperative hepatic metastasis by 73% (OR=0.27, 95% CI=0.12 to 0.67, P<0.01). However, intraperitoneal chemotherapy increased risks of marrow depression (OR=5.74, P<0.01), fever (OR=3.67, P=0.02) and intra-abdominal abscess (OR=3.57, P<0.01). Conclusion: The present meta-analysis demonstrates that hyperthermic intraoperative intraperitoneal chemotherapy and normothermic intraoperative intraperitoneal chemotherapy should be recommended to treat patients with gastric cancer because of improvement in overall survival. However, it is noteworthy that intraperitoneal chemotherapy can increase the risks of marrow depression, intra-abdominal abscesses, and fever.

중국의 식품안전사고 관리정책

규지혜 ( Zhi Hui Liu ),김성철 ( Cheng Zhe Jin ),이병호 ( Byung Oh Lee ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2009 강원 농업생명환경연구 Vol.21 No.-

In this paper, we focus on the Food Safety Incident Management Issues in China. Facing with a series of food safety incidents in recent years, Chinese government does make a lot of effort to solve problems, ensure food safety and protect consumers from dangers. But still the areas in which further improvement might be considered as follows: First is to reduce the number of food safety incidents by improving the overall food safety level. Second is that the local administrative departments should continue to set up food safety publicity, improve the public ability to identify toxic plants and animals, increase public awareness of food safety according to the local diets, living habits and climatic characteristics. Third is to emphasize on prevention and control of food safety incidents. Fourth is that enterprises or related producers must at least have a moral bottom line as production progress is the first basic step of all manufactures. The last most important reform would be to allow the effective operation of the existing system of private civil litigation and bankruptcy that would allow injured parties to take action independent of the government, giving the producers a warning to act legally.

Investigation into performance enhancements of Li–S batteries via oxygen-containing functional groups on activated multi-walled carbon nanotubes using Fourier transform infrared spectroscopy

Yu Hai Wang,Zhe Dai,Chao Yue Zhang,Guo Wen Sun,Zhong Wei Lu,Xiu Ping Gao,Geng Zhi Sun,Wei Lan,Zhen Xing Zhang,Xiao Jun Pan,Jin Yuan Zhou 한국물리학회 2020 Current Applied Physics Vol.20 No.9

It was demonstrated that the electrochemical performance enhancements in KOH-activated carbon materials should be mainly due to the created polar oxygen-containing functional groups (OFGs, such as such as C–O, C–– O, –OH, and O–C–– O), while the role of each OFGs on the electrochemical enhancements is still unclear. In this work, KOH activation treatments were systematically conducted on carbon nanotubes (CNTs) to explore the role of each OFG on the performance enhancements of Li–S batteries (LSBs). Results showed that the capacity of activated-CNT-sulfur (a-CNT-S) cathodes is 33% higher than that of the pristine CNT-S cathodes, and their rate capability and cycling stability are also enhanced. And the electrochemical analysis combining with Fourier transform infrared spectroscopy indicated that the formed C–O bonds are the real factor for the enhanced electrochemical performances of a-CNT-S cathodes. Furthermore, the optimal activation conditions on CNTbased cathodes for LSBs were optimized to be 10 min at 700 ℃.

Efficacy and Safety of Autologous Fibroblast (FB) Seeded Biodegradable Scaffold for Rabbit Penile Girth Enlargement

( Yi Guang Wu ),( Zhe Jin ),( Zhong Cheng Xin ),( Wei Dong Song ),( Jing Peng ),( Zhi Chao Zhang ),( Bing Gao ),( Ze Long Kim ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.4

The purpose of this experiment is to construct an in vitro model of rabbit penis enlargement using tissue engineering method, and to investigate the efficacy and safety of autologous fibroblast cell seeded to biodegradable scaffold and also to provide a new perspective of clinical application. We observed the growth of GFP transgenic fibroblast cell from SD mouse after transplantation with the biodegradable scaffold by fluorescence microscope. At the second hand, 160 male New Zealand rabbits were divided into four groups; Group A for control; Group B for acellular matrix implanted; Group C for scaffold implanted only; Group D for autologous cultured fibroblast seeded scaffold. Rabbit scrotal skin (4×4 mm) was detached under general anesthesia, and fibroblast (FB) was cultured and proliferated for 2weeks. Cultured cells were seeded into the scaffold and inserted on the between buck`s and dartos fascia of rabbit penis. To assess the efficacy and safety of the cells, we observed for 4months. The FB of rabbit were successfully cultured and confirmed by immunohistochemistry method. In the results of group D, dermal cell seeding group, the penile girth was significantly increased to 22.3% compared to other groups (Group A 0.3%, Group B 12.7%, Group C 14.6% and Group D 22.3%). We checked the results in 2~4 months later. We observed that moderate penile girth increase was gained using the biodegradable scaffold without other side-effects. Therefore, we carefully suggest a new guidance for penile augmentation by the tissue engineering method.

Use of In Vivo-Induced Antigen Technology to Identify In Vivo-Expressed Genes of Campylobacter jejuni During Human Infection

( Yuan Qing Hu ),( Jin Lin Huang ),( Qiu Chun Li ),( Yu Wei Shang ),( Fang Zhe Ren ),( Yang Jiao ),( Zhi Cheng Liu ),( Zhi Ming Pan ),( Xin An Jiao ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.3

Campylobacter jejuni is a prevalent foodborne pathogen worldwide. Human infection by C. jejuni primarily arises from contaminated poultry meats. Genes expressed in vivo may play an important role in the pathogenicity of C. jejuni. We applied an immunoscreening method, in vivo-induced antigen technology (IVIAT), to identify in vivo-induced genes during human infection by C. jejuni. An inducible expression library of genomic proteins was constructed from sequenced C. jejuni NCTC 11168 and was then screened using adsorbed, pooled human sera obtained from clinical patients. We successfully identified 24 unique genes expressed in vivo. These genes were implicated in metabolism, molecular biosynthesis, genetic information processing, transport, and other processes. We selected six genes with different functions to compare their expression levels in vivo and in vitro using real-time RT-PCR. The results showed that the selected six genes were significantly upregulated in vivo but not in vitro. In short, these identified in vivo-induced genes may contribute to human infection of C. jejuni, some of which may be meaningful vaccine candidate antigens or diagnosis serologic markers for campylobacteriosis. IVIAT may present a significant and efficient method for understanding the pathogenicity mechanism of Campylobacter and for finding targets for its prevention and control.

Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats

Huan-Jun Lu,Mei-Han Li,Mei-Zhi Li,박상언,김민선,Yuan-Zhe Jin,박병림 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

다변량 기온확률모형을 이용한 날씨보험의 가격결정 및 리스크 평가에 대한 연구

이창수 ( Chang Soo Lee ),김철식 ( Zhe Zhi Jin ),송창길 ( Chang Gil Song ) 한국계리학회 2011 계리학연구 Vol.3 No.1

날씨위험은 기온, 강수량, 바람 등의 일상적 날씨 변수의 변동에 의한 기업이나 개인의 재무적 손실 위험을 의미한다. 해외의 경우 날씨 변화 리스크에 대한 인식이 높아지면서 날씨 리스크를 관리하기 위한 날씨파생상품, 날씨보험 등의 상품들이 개발되었다. 국내에도 날씨보험 상품이 도입되었지만 과도한 보험료 등의 이유로 시장이 활성화되지 못하고 있는 실정이다. 보험료 결정 모형의 타당성이 낮은 것이 과도한 보험료의 주요 원인이라 할 수 있다. 본 논문에서는 여름철 이상저온 현상을 담보하는 날씨보험에 대해 보다 합리적인 보험료 산출 방안을 제시하고 있다. 먼저, 기후온난화 추세와 지역간 기온의 상관관계를 반영한 다변량 기온확률모형을 제시하여 기존의 접근방법을 개선하고자 하였다. 또한 제시된 모형에 기반한 몬테카를로 시뮬레이션을 통해, 날씨보험의 가격을 결정하고 날씨보험 지역 포트폴리오에 대한 통합적 리스크를 평가하였다. Weather risk refers to uncertainty of financial losses caused by change of weather variables. Global market for the management of weather risk expanded significantly and financial instruments such as weather derivatives and weather insurance are being traded. Recently, a weather insurance product was introduced to Korean market also but its trading volume was very limited. One of main reasons of limited market size in Korea is unreasonably excessive premium level. In this paper a multivariate temperature model is suggested to improve adequacy of pricing model for weather insurance. Suggested model reflects correlations among different geographical areas and increasing trend in temperature. Results of pricing and evaluation of risk are provided using Monte Carlo simulation based on the suggested model

Research on the Development of College Student Education Based on Machine Learning ---Take the Physical Education of Yanbian University as an Example

Yu Quan,Wei-Jie Guo,Lin He,Zhe-Zhi Jin 영남수학회 2022 East Asian mathematical journal Vol.38 No.1

This paper is based on Yanbian University's physical test data, and uses statistical analysis methods to study the relationship between college students' physical test scores to promote college physical education. Firstly, using gender as categorical variables, we conduct a general analysis of students in different majors and different grades, and obtain the advantages and disadvantages of male and female college students; then we use Decision Trees and Random Forest algorithms to conduct modeling analysis to provide valuable suggestions for relevant departments of the university. the aiming of this research analyzing about the undergraduates physical test is that giving universities the targeted suggestions to improve the college graduate rate and promote the overall development of higher education, lay the foundation for achieving universal health.

Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats

Lu, Huan-Jun,Li, Mei-Han,Li, Mei-Zhi,Park, Sang Eon,Kim, Min Sun,Jin, Yuan-Zhe,Park, Byung Rim The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

RESEARCH ON SENTIMENT ANALYSIS METHOD BASED ON WEIBO COMMENTS

Li, Zhong-Shi,He, Lin,Guo, Wei-Jie,Jin, Zhe-Zhi The Youngnam Mathematical Society 2021 East Asian mathematical journal Vol.37 No.5

In China, Weibo is one of the social platforms with more users. It has the characteristics of fast information transmission and wide coverage. People can comment on a certain event on Weibo to express their emotions and attitudes. Judging the emotional tendency of users' comments is not only beneficial to the monitoring of the management department, but also has very high application value for rumor suppression, public opinion guidance, and marketing. This paper proposes a two-input Adaboost model based on TextCNN and BiLSTM. Use the TextCNN model that can perform local feature extraction and the BiLSTM model that can perform global feature extraction to process comment data in parallel. Finally, the classification results of the two models are fused through the improved Adaboost algorithm to improve the accuracy of text classification.