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Compressible Parabolized Stability Equation in Curvilinear Coordinate System and integration
Gao, Bing,Park, S.O. The Korean Society for Aeronautical and Space Scie 2006 International Journal of Aeronautical and Space Sc Vol.7 No.2
Parabolized stability equations for compressible flows in general curvilinear coordinate system are derived to deal with a broad range of transition prediction problems on complex geometry. A highly accurate finite difference PSE code has been developed using an implicit marching procedure. Compressible and incompressible flat plate flow stability under two-dimensional and three¬dimensional disturbances has been investigated to test the present code. Results of the present computation are found to be in good agreement with the multiple scale analysis and DNS data. Stability calculation results by the present PSE code for compressible boundary layer at Mach numbers ranging from 0.02 to 1.5 are also presented and are again seen to be as accurate as the spectral method.
Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives
Gao, Jing,Xie, Li,Yang, Wan-Shui,Zhang, Wei,Gao, Shan,Wang, Jing,Xiang, Yong-Bing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Hepatocellular carcinoma is a common disorder worldwide which ranks 5th and 7th most common cancer among men and women. In recent years, different incidence trends have been observed in various regions, but the reasons are not completely understood. However, due to the great public efforts in HCC prevention and alternation of lifestyle, the roles of some well documented risk factors played in hepatocarcinogenesis might have changed. This paper summarizes both the environmental and host related risk factors of hepatocellular carcinoma including well established risk factors such as hepatitis virus infection, aflatoxin and alcohol, as well as possible risk factors such as coffee drinking and other dietary agents.
Compressible Parabolized Stability Equation in Curvilinear Coordinate System and Integration
Bing Gao,S. O. Park 한국항공우주학회 2006 International Journal of Aeronautical and Space Sc Vol.7 No.2
Parabolized stability equations for compressible flows in general curvilinear coordinate system are derived to deal with a broad range of transition prediction problems on complex geometry. A highly accurate finite difference PSE code has been developed using an implicit marching procedure. Compressible and incompressible flat plate flow stability under two-dimensional and three¬dimensional disturbances has been investigated to test the present code. Results of the present computation are found to be in good agreement with the multiple scale analysis and DNS data. Stability calculation results by the present PSE code for compressible boundary layer at Mach numbers ranging from 0.02 to 1.5 are also presented and are again seen to be as accurate as the spectral method.
High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis
Gao Ya-chen,Jiang Nan-nan,Qin Xiu-juan,Jiang Hui,Wei Liang-bing,Gao Jia-rong 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Circular RNAs (circRNAs), a unique novel type of RNA, have been widely reported to be involved in physiologic and pathologic processes in humans. However, the exact molecular pathogenesis of circRNAs in chronic glomerulonephritis (CGN) is far from clear. Objective This paper aims to evaluate the specific expression profile of circRNAs in renal cortex tissues from Adriamycin-induced CGN rats. Methods CircRNAs were screened in renal cortex tissues from 3 CGN rats and 3 control rats by using high-throughput sequencing (HTS). Then, 4 circRNAs were selected randomly for verification by quantitative real-time polymerase chain reaction (qRT-PCR). In addition, the differentially expressed (DE) circRNAs were analyzed by bioinformatics methods. Results In total, 31 significantly DE circRNAs were identified, which revealed their potential roles in CGN; in particular, we found that 4 confirmed altered circRNAs (rno-circ-RNAs 689, 3217, 1327, and 5001) might play important roles in the development of CGN. Conclusion This study reveals a cluster of circRNAs that are DE in Adriamycin-induced CGN rats, which brings us closer to understanding the pathogenic mechanisms and may provide new potential targets for clinical treatment.
Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53
Ri Zhe Zhu Bing Si Li Shang Shang Gao Jae Ho Seo Byung-Min Choi 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.4
Luteolin, a sort of flavonoid, has been reported to be involved in neu-roprotective function via suppression of neuroinflammation. In this study, we in-vestigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H2O2)-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated β-galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H2O2-induced cellular senescence by upregulation of sirtuin 1 (SIRT1). In contrast, the inhibitory effect of luteolin on cellular senescence under oxidative stress was abolished by silencing of SIRT1. This study indicates that luteolin effectively protects against oxidative stress-induced cellular senescence through p53 and SIRT1. These results suggest that luteolin possesses therapeutic potentials against age-related hearing loss that are induced by oxidative stress.
Hydrodynamic cavitation and its application in water treatment combined with ozonation: A review
Bing Wang,Yunxian Liu,Huan Zhang,Wen Shi,Mingyang Xiong,Chunyang Gao,Mingcan Cui 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Advanced oxidation processes (AOPs) such as cavitation and ozonation have been used as an alternativeand effective option for the treatment of wastewater with difficult to biodegrade compounds. In thisreview, the necessity and advantages of combining hydrodynamic cavitation with ozonation (HC/O3)were initially discussed. The discussion of the mechanism of the HC/O3 process revealed the presenceof both mechanical and chemical effects. Overviews of earlier work with HC/O3 technology were thensummarised to show the positive synergies and the HC devices in different wastewater treatments. Recommendations were given for parameter selection by analysing the impact of important operatingparameters on process performance. Energy efficiency and cost comparisons indicated that the HC/O3process was more cost effective than the individual process. Overall, the HC/O3 process with optimisedconditions is able to increase the degradation rate of refractory pollutants by more than 40% comparedto the HC process alone.
Gao, Fei,Ma, Shuren,Zhang, Ning,Zhang, Yingchun,Ai, Meina,Wang, Bing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Objective: This study was conducted to investigate the efficacy of pancreatic drainage for pain relief in advanced pancreatic cancer. Method: Seventy-one patients with pancreatic carcinoma were divided into two groups: dilated and non-dilated pancreatic ducts. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP), endoscopic biliary stenting and pancreatic stenting. Visual Analog Scale (VAS) scores, pain remission rates and survival time were evaluated during follow-up. Results: The post-ERCP VAS score of the dilated group was lower than that of the non-dilated group at 1 and 3 months post-ERCP. There was no difference at 6 months. The pain remission rate in the dilated duct group was significantly higher than that in non-dilated duct group in 1 and 3 months post-ERCP. The median survival times were 8.17 and 8.22 months respectively. Conclusion: Endoscopic pancreatic drainage can relieve pain of advanced pancreatic cancer accompanied by safe dilation of the pancreatic duct.