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( Sung Won Lee ),( Hae Lim Lee ),( Jung Hyun Kwon ),( Jun Suh Lee ),( Young Chul Yoon ),( Yu Ri Shin ),( Hye Ji Kim ),( Eun Chung ),( Young Woon Kim ),( Jeong Won Jang ),( Soon Woo Nam ),( Nam Ik Han 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Intraoperative radiofrequency ablation (RFA) is one of the treatment options for hepatocellular carcinoma (HCC) patients with relatively poor liver function to undergo surgical resection or when percutaneous approach for RFA is not feasible due to the difficult location of the tumor. The aim of this study is to investigate the clinical outcomes of intraoperative RFA compared to surgical resection. Methods: A total of 76 consecutive patients who received either intraoperative RFA (n=23) or surgical resection (n=53) with curative intent at the Incheon St Mary``s hospital from June 2012 to September 2015 were enrolled. Disease free survival and overall survival rates were analyzed. Results: The median follow-up period was 20.1 months (range, 0.9-41.5). The mean baseline Model for End-Stage Liver Disease (MELD) score was higher in the RFA group compared to the resection group (11.5±4.7 vs. 7.8±1.5, p=0.001). The resection group consisted of larger tumors with the median diameter of 2.7cm (range, 1-16) compared to 2cm (range, 1-5) of the RFA group (p=0.002). However, there was no difference in the number of tumors and the tumor stage between the two groups. The disease free survival rates at 6 and 12 months were 81.6%, 74.8% in the RFA group and 92.2%, 86.2% in the resection group, respectively (p=0.256). The overall survival rates at one year were 91.3% in the RFA group and 94.3% in the resection group, respectively (p=0.635). In the RFA group, 5 patients (21.7%) received liver transplantation (LT) after median interval of 10.9 months (range, 9.2~26.4) since the intraoperative RFA. Conclusions: The patients who received intraoperative RFA presented with relatively poor liver function but the disease free survival and overall survival rates were non-inferior compared to the patients who underwent resection. Therefore, intraoperative RFA may be considered as a useful option for patients ineligible to percutaneous RFA and surgical resection, or as a bridge therapy before liver transplantation.
Basic : Drug interaction between Ginseng Extract (GE) and Sorafenib: modulation of pERK (초)
( Nam Hee Lee ),( Ki Tae Yoon ),( Ho Jae Park ),( Ja Sung Rho ),( Mi Kyung Kim ),( Yu Kyoung Lee ),( Eun A Cho ),( Jeong Heo ),( Tae Ho Hwang ),( Mong Cho ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
Yu, Song-Hee,Cho, Dae-Chul,Kim, Kyoung-Tae,Nam, Kyung-Hun,Cho, Hee-Jung,Sung, Joo-Kyung The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.4
Objective: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. Methods: Locomotor function was assessed according to the Basso-Beatlie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraperitoneal injections of 200 mg/kg VPA or the equivalent volume of normal saline for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation. Results: Basso-Beatlie-Bresnahan scale scores in rats receiving VPA were significantly higher than in the saline group (p<0.05). The cavity volume in the VPA group was Significantly reduced compared with the control (saline-injected) group (p<0.05). The level of histone acetylation recovered in the VPA group, while it was significantly decreased in the control rats (p<0.05). The macrophage level was significantly decreased in the VPA group (p<0.05). Conclusion: VPA influences the restoration of hyperacetylation and reduction of the inflammatory reaction resulting from SCI, and is effective for histology and motor function recovery.
Yu, Hyun-Ju,Shin, Ji-Ae,Yang, In-Hyoung,Won, Dong-Hoon,Ahn, Chi Hyun,Kwon, Hye-Jeong,Lee, Jeong-Sang,Cho, Nam-Pyo,Kim, Eun-Cheol,Yoon, Hye-Jung,Lee, Jae Il,Hong, Seong-Doo,Cho, Sung-Dae Elsevier 2017 Archives of oral biology Vol.84 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Caffeic acid phenethyl ester (CAPE), a natural honeybee product exhibits a spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant and antitumor actions. The purpose of this research was to investigate the anticancer potential of CAPE and its molecular mechanism in human oral cancer cell lines (YD15, HSC-4 and HN22 cells).</P> <P><B>Design</B></P> <P>To determine the apoptotic activity of CAPE and identify its molecular targets, trypan blue exclusion assay, soft agar assay, Western blot analysis, DAPI staining, and live/dead assay were performed.</P> <P><B>Results</B></P> <P>CAPE significantly suppressed transformation of neoplastic cells induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol 13-acetate (TPA) without inhibiting growth. CAPE treatment inhibited cell growth, increased the cleavages of caspase-3 and poly (ADP-ribose) polymerase (PARP), and augmented the number of fragmented nuclei in human oral cancer cell lines. CAPE activated Bax protein causing it to undergo a conformational change, translocate to the mitochondrial outer membrane, and oligomere. CAPE also significantly increased Puma expression and interestingly Puma and Bax were co-localized.</P> <P><B>Conclusion</B></P> <P>Overall, these results suggest that CAPE is a potent apoptosis-inducing agent in human oral cancer cell lines. Its action is accompanied by up-regulation of Bax and Puma proteins.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CAPE suppresses neoplastic cell transformation induced by EGF and TPA. </LI> <LI> CAPE has apoptotic effect via Puma and Bax activation in oral cancer. </LI> <LI> Possibility of CAPE as potent apoptosis-inducing agent in oral cancer is proposed. </LI> </UL> </P>
( Sung Eic Hong ),( Jin Koo Kim ),( Jeong Nam Yu ),( Keun Yong Kim ),( Chung Il Lee ),( Kwan Eui Hong ),( Kie Young Park ),( Moongeun Yoon ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.1
Genetic variation in the Asian shore crab Hemigrapsus sanguineus was determined from partial mitochondrial DNA (mtDNA) sequences of the cytochrome b (Cytb) gene. Samples included 143 crabs from six localities along three coastlines in South Korea. A nucleotide sequence analysis revealed 38 variable sites in a 470-bp sequence, which defined 37 haplotypes. The haplotypes were not associated geographically and had a shallow genealogy. Pairwise FST tests and a two-dimensional scaling analysis revealed no significant genetic differentiation among most of the populations. The low pairwise comparison values, but significant genetic differentiation of a northeastern population from all other populations, might have been influenced by a restriction in gene flow caused by hydrographic conditions such as ocean boundaries. The high haplotype diversity, low nucleotide diversity, and time since H. sanguineus expansion in Korean coastal waters indicate rapid population growth and a recent, sudden expansion in the Late Pleistocene.
Diagnostic accuracy of PET/CT in early stage ovarian cancer: comparison between PET/CT and CT or MRI
( Yu Bin Lee ),( Hyun Jong Park ),( Ga Won Yim ),( Sung Hoon Kim ),( Sang Wun Kim ),( Young Tae Kim ),( Jae Wook Kim ),( Eun Ji Nam ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
The purpose of this study was to compare the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT), abdomino-pelvic computed tomography (CT), and pelvic magnetic resonance imaging (MRI) for detection of early stage ovarian cancer. Medical record of 140 women who underwent PET/CT scanning with suspected early stage ovarian cancer (stage 1-2) from July 2005 to February 2012 was retrospectively reviewed. Preoperative CT, MRI, and PET/CT findings were compared with histopathologic results obtained from the surgery. The accuracy of each modality in detection of malignancy was evaluated by computing the relevant areas under a receiver operating characteristics(ROC) curve and comparisons of the area under the curve (AUC) according to the modality (MedCalc® version 9.6.3.0, Broekstraat 52, 9030 Mariakerke, Belgium). Histopathology showed 7 cases of benign tumors, 23 cases of borderline tumors, and malignant tumors in 110 cases. In detecting malignant lesions in the ovaries and the adnexa, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PET/CT were higher than the corresponding values of CT or MRI. In discriminating between cases of benign/borderline and malignant, the accuracy of PET/CT (0.760) trended higher than that of CT or MRI (0.585). PET/CT is more accurate than abdomino-pelvic CT or pelvic MRI in diagnosis of early stage ovarian cancer and in differentiating between cases of benign/borderline and malignant ovarian tumors.