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정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구
이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6
연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.
Hyeong-Geun Yu,Whimin Kim,Dong-Jo Park,Dong Eui Chang,Hyunwoo Nam 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
The passive hyperspectral imaging system (HIS) is widely used in various fields since it enables not only remote sensing but also visualization of detection results. One of the simple and powerful chemical agent (CA) detection algorithms is the algorithm, which removes background signatures from the measured spectrum and estimates the similarity between the background-removed spectrum and the reference CA spectrum. A general concern of this algorithm is that the detection performance suffers from the modeling error that occurs by the inaccurate background removal. Therefore, we suggest a cooperative background removal process to minimize the modeling error. We also propose the cooperative CA detection algorithm based on the cooperative background removal process. Experimental results based on the real CA measurement data demonstrate that the proposed cooperative CA detection algorithm achieves better performance than the existing cooperative algorithms.
Design of Optimal Hard Decision for Spectrum Sensing under Noise Uncertainty
Hyeong-Geun Yu,Yong-Chan Kim,Dong-Jo Park 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.1
In cognitive radio networks, efficient and reliable spectrum sensing plays a critical role. However, there is noise uncertainty in spectrum sensing which significantly degrades the detection performance. In this paper, we propose an optimal hard decision algorithm with two thresholds. The thresholds divide the whole range of the local test statistic into three regions called the presence, uncertainty and absence regions, instead of the conventional two regions. A fusion center makes a final decision with a weighted combination of local decisions. The key idea is finding proper weights for the local decision. In this work, the weights were optimized by a log-likelihood ratio test to minimize the Bayes risk under Rayleigh fading channel conditions. Simulation results demonstrate that the proposed algorithm can significantly improve the detection performance, and is robust to noise uncertainty than the existing algorithms.
Genotoxicity Test on 3,9-Diferuloyl-6-oxopterocarpen, a New Agent Candidate for Anti-aging Material
Yu-Ri Jung,Sung-Min Park,Nam-Jin Lee,Hyeong-Bae Pyo,Geun Soo Kim,Jong-Hun You,Chun-Mei Lin,Zheng Mei Shu,Jong-Koo Kang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
To perform the safety studies on 3,9-diferuloyl-6-oxopterocarpen (DFO), we accomplished the reverse mutation assay in Salmonella typhimurium and Escherichia coli, in vitro chromosomal aberration assay on Chinese hamster lung cell and in vivo bone marrow micronucleus test in male ICR mice. In the reverse mutation assay, this material treatment at the dose range up to 5,000 ㎍/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA-with and without metabolic activation. In the in vitro chromosomal aberration assay, this material did not increase the number of cells having structural or numerical chromosome aberration. In the in vivo bone marrow micronucleus assay, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in male ICR mice administered this material. In conclusion, we suggested that DFO have no genotoxicity in reverse mutation assay, in vitro chromosomal aberration assay and in vivo bone marrow micronucleus test.
송형근 ( Hyeong-geun Song ),조유성 ( Yu-sung Cho ),양현주 ( Hyun-joo Yang ),서민경 ( Min-kyoung Seo ),이지훈 ( Ji-hoon Lee ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-
It is well known that the rhizosphere microbial communities are closely associated with plant roots. The rhizosphere microbiota can be harmful or beneficial to the host plants. In this study, to know whether pathogen-caused plant diseases would lead changes of rhizosphere microbiota or not, pathogenic bacteria were added to the plants through leaf stomata and the soils to induce the diseases and the rhizosphere microbial communities were analyzed using multiplex sequencing. The plant pathogen Xanthomonas euvesicatoria 173-1 causing bacterial spots was applied to Korean chili peppers (Capsicum annuum) and the plant pathogen Erwinia carotovora SCC1 causing bacterial soft rot was applied to Chinese cabbage (Brassica rapa). The pot soils were collected before and after the pathogen applications and disease occurrences and analyzed for v4 region of bacterial 16S rRNA gene using Illumina iSeq 100 system. In the bacterial spot disease peppers, soil bacterial diversity was larger than in the normal pepper soils in terms of both species richness and evenness. Although it was not easy to indicate the responsible taxa for the differentiation, the communities were found to have diverged in both the cases of the control and disease plants, supported by NMDS and PCoA analyses on distance metrics of the communities. From the Chinese cabbage soils, there was less differentiation of microbiota between the normal and disease plants, than in the pepper soils. In the further study, it would be also interesting to investigate the important factors for divergence of results between pepper and cabbage.