터어키안 종양의 경접형골 수술례에 대한 임상분석

신동익,고영초,조맹기,황도윤 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.1

The most common severe cervical spine injury involving the posterior elements is subluxation or dislocation in which the posterior ligamentus complex is completely tom. Late instability is more common than previously realized, because ligamentous structures do not reconstitute normally. even with prolonged external rigid fixation. Subluxation of the cervical vertebrae in a flexion injury can be reduced by skeletal traction ; however, they usually require posterior stabilization. Unilateral and bilateral facet dislocation freqently require open reduction and posterior stabilization. The authors have used interlaminar clamps for the stabilization of thirty cases of unstable cervical spine. Advantages of this method are 1) immediate and rigid stabilization without cord injury. 2) early ambulation and prevention of respiratory complication and pressure sore. And also, posterior cervical stabilization with Halifax clamps is an easier, safer and faster technology in treatment of unstable spine.

傳染性單核球增加症 1例 報告

金相仁,高光昱,趙漢翊,崔玲姬,崔勇,李在英 대한의학협회 1972 대한의학협회지 Vol.15 No.6

폐환기기능검사성적의 개체내 기술적 변이성

고영일(Young Il Koh),최인선(In Seon Choi),정익주(Ik Joo Jung),강유호(Rhoo Ho Kang),박상선(Sang Seon Park),이민수(Min Soo Lee),김영철(Young Chul Kim),박경옥(Kyung Ok Park),정은택(Eun Taek Jung),김헌남(Hun Nam Kim) 대한내과학회 1995 대한내과학회지 Vol.48 No.3

N/A Objectives: In the consideration of the variabilities of the test results related to the technical or the biologic factors, the standardized methods performing the ventilatory lung function test by spirometry were recommended by American Thoracic Society (ATS). However, even though most of the modern pulmonary function laboratories perform the lung function tests using the computerized standard spirometers and the standard performing methods, it is necessary to evaluate the intraindividual technical variabilities of the spirometric test results; in addition, there is no article about it published in Korea. Methods : The lung function tests of 13 normal subjects were performed in each laboratories of Chonnam University Hospital, Wonkwang University Hospital, and Kwangju Christian Hospital. Results: 1) The interlaboratory variability of the spirometric test results was significantly larger than the intralaboratory(Coefficients of Variation, CV: 7.25 ±5.33% vs 2.79±1.59%, p<0.05 in FVC; 7.23±5.22% vs 2.26±1.70%, p<0.05 in FEV₁). 2) The mean lung function test results measured by one machine were significantly larger than those by another(4.29±0.89L vs 4.13±0.90L, p<0.05 in FVC; 3.71±0.81L vs 3.51±0.80L, p<0.05 in FEV ,). However, the intermachine variability was not significantly different from the intramachine. 3) The intertechnician variability of spirometric test results measured by three different technicians was not significantly different from the intratechnician. 4) The significance level of intraindividual difference in spirometric test results were 12% in FVC and 12% in FEY, between the different laboratories, 5% in FVC and 6% in FEV₁, between the different machines, 3% in FVC and 4% in FEV₁, between the different technicians. Conclusion : These results suggest that the spirometric test must be interpreted cautiously under the consideration of such a variability, and that it is necessary to adhere strictly to the recommended methods of the equipment quality control and the maneuver performance, and to check regularly the inter and intralaboratory variabilities,

Taurine 및 ß-alanine이 고양이 척수후각세포의 Activity에 미치는 효과

고영익(Koh, Young-Ik),강석한(Kang, Sok-Han),김진혁(Kim, Jin-Hyuk),신홍기(Shin, Hong-Kee),김기순(Kim, Kee-Soon) 대한생리학회 1990 대한생리학회지 Vol.24 No.1

In 19 cats anesthetized with α-chloralose effects of taurine and β-alanine on the responses of wide dynamic range (WDR) cells to mechanical, chemical and thermal stimuli were investigated in the lumbar spinal cord of the cat. Also studied was an interaction of strychnine with taurine in affecting the activities of WDR cells. Following intravenous administration of taurine, the responses of WDR cells to all types of mechanical stimuli were markedly enhanced, demonstrating that the response to pressure was most sensitive to taurine action. When the receptive field was exposed to thermal stimuli (50℃) for 20 sec. taurine increased activity of WDR cell to 169.5% of the control value. The K⁺-induced activation of WDR cells was invariably suppressed after taurine administration. Intravenously administered strychnine remarkably reduced the enhanced response of WDR cell to natural stimuli resulting from intravenous administration of taurine. Also β-alanine markedly activated the response of spinal dorsal horn cell to natural mechanical stimuli. These findings suggest that neutral amino acid and its derivative such as β-alanine and taurine can enhance the response of WDR cells to different stimuli in cats.

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

Koh, Young Jun,Kim, Hak-Zoo,Hwang, Seong-Ik,Lee, Jeung Eun,Oh, Nuri,Jung, Keehoon,Kim, Minah,Kim, Kyung Eun,Kim, Homin,Lim, Nam-Kyu,Jeon, Choon-Ju,Lee, Gyun Min,Jeon, Byeong Hwa,Nam, Do-Hyun,Sung, Hoo Elsevier 2010 CANCER CELL Vol.18 No.2

<P><B>Summary</B></P><P>Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.</P> <P><B>Highlights</B></P><P>► DAAP simultaneously binds VEGF-A and angiopoietins, and blocks their actions ► DAAP effectively suppresses tumor angiogenesis, metastasis and vascular leakage ► DAAP is superior to VEGF-Trap plus Tie2-Fc in blocking tumor growth and metastasis ► Ang-2 is a therapeutic target to control tumor angiogenesis and vascular leakage</P>

A Choroidal Schwannoma Confirmed by Surgical Excision

Young Jae Cho,Jung Bin Won,Suk Ho Byeon,Woo Ik Yang,Hyoung Jun Koh,Oh Woong Kwon,Sung Chul Lee 대한안과학회 2009 Korean Journal of Ophthalmology Vol.23 No.1

Schwannomas rarely present as intraocular tumors and are often misdiagnosed as malignant melanoma. We describe a choroidal schwannoma confirmed by sclerouvectomy. A 30-year-old woman presented with a large nonpigmented intraocular mass of the choroid in the right eye and underwent surgical excision by sclerouvectomy. Histologically, the tumor was composed of a mixture of cellular solid components (Antoni A) and loose myxoid components (Antoni B). The tumor was eventually diagnosed as a schwannoma. Currently available ancillary studies are still of little value in definitively differentiating schwannomas from other choroidal tumors. In the case of atypical findings for a malignant melanoma, a benign neoplasm should be included in the differential diagnosis. This patient avoided enucleation by first having the mass excised. We are unaware of previous reports in which a choroidal schwannoma was diagnosed by surgical excision.

호흡곤란 평가지표들의 비교

정익주(Ik Joo Chung),최인선(In Seon Choi),박상선(Sang Seon Park),고영일(Young Il Koh),이민수(Min Su Lee),강유호(Yu Ho Kang),이신석(Shin Seok Lee),박재희(Jae Hi Park),박경옥(Kyung Ok Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.5

N/A Background: Although the pulmonary function tests have been widely used as the methods to investigate the dyspneic patients with respiratory disease, it has often been found that the correlation between the lung function and the degree of subjective sense of dyspnea is not so good. And so, various methods of categorizing subjective assessment of dyspnea severity have been developed, and this study was conducted to determine the usefulness of these methods in the evaluation of dyspneic patients with respiratory diseases. Methods: Clinical or psychophysical dyspnea indices {modified Medical Research Council (MRC) scale, Oxygen-Cost Diagram (OCD), Baseline Dyspnea Index (BDI), modified Borg category scale (Borg) and the distance walked in 12 minutes (12MW)} and pulmonary function were measured in 29 consecutive patients with respiratory diseases, who were referred to the clinical pulmonary function laboratory of Chonnam University Hospital from June 1991 to September 1992. Results: The ratings for the modified MRC, OCD, BDI, and Borg, and 12 MW were related significantly each other. However, the relationship between lung function and dyspnea indices were weak. The correlation between the results of two attempts of 12 minute walking test in individual patients was high(r=0.94, p<0.001) but the distance walked on the second occasion was significantly greater(p<0.05). In 10 patients rested at least once during their attemt the distance to the first stop correlated well with the total distance covered in 12 minutes(r=0.91, p<0.005). Conclusion: These resu1ts suggest that the various methods for rating dyspnea are interrelated and reproducible, but those were related weakly to lung function and may yield the independent useful information. And the use of the distance to the first stop in 12 minute walking test may not compromise the value of the test in patients with severe disability.

Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia

Jung, Young Ju,Koh, Younsuck,Hong, Sang-Bum,Chung, Joo Won,Choi, Sang Ho,Kim, Nam Joong,Kim, Mi-Na,Choi, Ik Su,Han, Song Yi,Kim, Won-Dong,Yun, Sung-Cheol,Lim, Chae-Man by the Society of Critical Care Medicine and Lippi 2010 Critical care medicine Vol.38 No.1

OBJECTIVE:: To investigate whether adding rifampicin to vancomycin could cure more patients with nosocomial methicillin-resistant Staphylococcus aureus pneumonia compared with vancomycin-only. DESIGN:: Prospective randomized open-label study. SETTING:: Medical intensive care unit in Seoul, Korea. PATIENTS:: Ninety-three of 183 patients with Gram-positive nosocomial pneumonia. INTERVENTIONS:: The enrolled patients with subsequently documented methicillin-resistant Staphylococcus aureus pneumonia (modified intention-to-treat population) were treated with vancomycin (1 g intravenous every 12 hrs) plus rifampicin (300 mg twice daily by mouth) (n = 41) or with vancomycin-only (n = 42). The intended treatment (at least 5 days) was completed in 30 patients in the vancomycin plus rifampicin group and 34 patients in the vancomycin-only group (per protocol population). MEASUREMENTS AND MAIN RESULTS:: The primary outcome was the clinical cure rate on day 14 of treatment. The secondary outcomes were intensive care unit mortality on days 28 and 60, and microbiological eradication on day 14. The clinical cure rate in the modified intention-to-treat population was 53.7% (22 of 41) in the vancomycin plus rifampicin group, and 31.0% (13 of 42) in the vancomycin-only group (p = .047), and the respective rates in the per protocol population were 63.3% (19 of 30) and 38.2% (13 of 34) (p = .079). The respective mortality rates were nine (22.0%) of 41 and 16 (38.1%) of 42 on day 28 (p = .151), and 11 (26.8%) of 41 and 21 (50.0%) of 42 on day 60 (p = .042). The microbiological eradication rate did not differ between groups (p = .472). CONCLUSIONS:: Vancomycin plus rifampicin seems to be more effective than vancomycin alone in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia.

성인에서 진단된 Bruton 형 무감마글로불린혈증 1 예

김영철,박경옥,최인선,양동욱,이민수,정익주,고영일,박상선,강유호 대한내과학회 1994 대한내과학회지 Vol.47 No.5

We report a 22 year old male with Bruton's agammaglobulinemia. He had been suffered from repeated pyogenic infections - sinusitis, osteomyelitis, meningitis, pneumonia - since about 6 months of his age. He was admitted due to pneumonia with parapneumonic effusion, and Hemophilus influenzae was isolated from the pleural fluid. In peripheral blood, there was no B cells found and showed panhypogammaglobulinemia, but in his bone marrow we could detect pre B cells in normal range (19q of bone marrow lymphoid cells) with immunophenotyping (CD10, Flowcytometry). He has apparently healthy mother and two sisters, and no history suggesting X linked inheritance, which is reflecting the possibility of first expression of a new mutation. He was successfully treated with antibiotics and chest tube drainage with monthly IV globulin infusions, and now he is being followed with periodic IV globulin replacements and prophylactic antibiotics. We are sorry about our inexperience in methods of detecting carriers and genetic analysis, which are ongoing in some laboratories.

重複子宮의 妊娠과 分娩 : 4例 報告 Report of 4 Cases

權寧朝,金性心,金榮哲,高根翼 大韓産婦人科學會 1965 大韓産婦人科學會雜誌 Vol.8 No.10