B형 삼중수소 운반용기 안정성 평가

이민수,백승우,김광락,안도희,임성팔,정홍석,최희주,최종원,손순환,송규민,Lee, Min-Soo,Paek, Seung-Woo,Kim, Kwang-Rag,Ahn, Do-Hee,Yim, Sung-Paal,Chung, Hong-Suk,Choi, Heui-Joo,Choi, Jeong-Won,Son, Soon-Hwan,Song, Kyu-Min 한국방사성폐기물학회 2007 방사성폐기물학회지 Vol.5 No.2

A transport container for a 500 kCi tritium storage vessel was developed, which could be used for the transport of metal tritide from Wolsong TRF facility to a disposal site. The structural, thermal, shielding, and confinement analyses were performed for the container in a view of Type B. As a result of structural analysis, the developed container sustained its integrity under normal and accidental conditions. The maximum temperature increase of the inner storage vessel by radiation was evaluated at $134.8^{\circ}C at room temperature. In $800^{\circ}C$ fire test, The thermal barrier of container sustained the inner vessel at $405^{\circ}C after 30 min, which temperature was allowable for the container integrity since maximum design temperature of inner vessel was $550^{\circ}C. In the evaluation of the shielding, the activity of radiation was nearly zero on the outer surface of inner vessel. Consequently the transport container for a 500 kCi tritium was evaluated to pass all the safety tests including accidental condition, so it was concluded that the designed transport container is proper to be used.

내외과계 환자의 정신과 약물치료에서 약물-약물 상호작용 - 고려대학교 부속병원의 자문조정의 경험을 통하여 -

이민수,이헌정,Lee, Min Soo,Lee, Heon-Jeong 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

Polypharmacotherapy, both psychotropic and nonpsychotropic, is widespread in various situations including psychiatric hospitals and general hospitals. As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. The objective of this review is evaluation for drug-drug interactions often encountered in psychiatric consultation. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In psychiatric consultation, these two subdivisions of drug interactions between psychotropic drugs and other drugs are likely to happen. We gathered informations of the drugs used in physically ill patients who are consulted to psychiatric department in Korea University Hospital. And we reviewed the related literatures about the drug-drug interactions between psychotropic drugs and other drugs.

SSRIs 이후의 항우울제

이민수,남종원,Lee, Min Soo,Nam, Jong Won 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

New antidepressants have become available for clinical use in the 1990s. Before this decade, the drugs available to treat depression consisted essentially of monoamine oxidase inhibitors, tricyclic antidepressants, and lithium. Following the introduction of SSRIs, the options have expanded and now include SSRIs, nefazodone, venlafaxine, mirtazapine, reboxetine, tianeptine. Newer antidepressants possess a variety of pharmacological characteristics that are relevant to the choice of an antidepressant for clinical use. This review summarizes some of the major pharmacological characteristics among the drugs.

항우울제와 연관약물의 약물상호작용

이민수,Lee, Min Soo 대한생물정신의학회 2000 생물정신의학 Vol.7 No.1

As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. This review provides a better understanding of drug-drug interactions often encountered in pharmacotherapy of depression. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In this review, emphasis is placed on antidepressant medications, how they are metabolized by the P450 system, and how they alter the metabolism of other drugs. When prescribing antidepressant medications, the clinician must consider the drug-drug interactions that are potentially problematic.

고위인지기능과 정신질환

이민수,김재진,Lee, Min-Soo,Kim, Jae-Jin 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

Higher cognitive functions refer to the highest level of human intellectual functioning, including concept formation, reasoning, and executive functions. The executive functions can be conceptualized as having four components : volition, planning, purposive action, and effective performance. Because higher cognitive functions represent the most advanced stages of intellectual development, they are often highly susceptible to the effects of brain injuries and mental disorders. The ability to perform effectively within the environment is determined in large part by an individual's adequacy in performing such higher-order functions. Especially executive functions are necessary for appropriate, socially responsible, and effectively self-serving adult conduct. Threfore, an assessment of the psychiatric patient's performance in these areas will provide useful diagnostic information, as well as information concerning social and vocational prognosis.

우세안과 비우세안의 망막신경섬유층 두께, 시신경유두 형태 비교

이민수,조경진,조우형,경성은,장무환.Min Soo Lee. MD. Kyong Jin Cho. MD. Woo Hyung Cho. MD. Sung Eun Kyung. MD. PhD.Moo Hwan Chang. MD. PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.5

Purpose: To investigate the comparison of retinal nerve fiber layer (RNFL) thickness and optic disc parameters measured by optical coherence tomography (Cirrus HD-OCT<sup>®) in dominant and non-dominant eyes. Methods: Seventy-one subjects without underlying ocular disease were recruited for the present study. Ocular dominance was determined using the hole-in-the-card test. Comprehensive standardized eye examinations were performed. Scans of the optic disc and RNFL were performed using OCT. Results: The mean intraocular pressure (IOP) of the dominant eye was higher than its counterpart (p = 0.025). No significant differences were observed in uncorrected visual acuity, refractive error and axial length between dominant and non-dominant eyes (p = 0.235, 0.180, 0.850). No RNFL and optic disc features were identified in the dominant from non-dominant eyes. Conclusions: Although dominant eyes tended to have higher IOP than non-dominant eyes, no consistent ocular structural differences between dominant and non-dominant eyes with the use of OCT were found.

기분부전장애에서 Moclobemide와 Amitriptyline의 치료 효과와 내약성 비교 연구

이민수,남종원,유승호,차지현,김용구,Lee, Min Soo,Nam, Jong Won,Ryu, Seung Ho,Cha, Ji Hyun,Kim, Yong Ku 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

Background : Since dysthymia begins in late childhood or adolescence and has a chronic course, long-term pharmacotherapy may be required. New generation antidepressant, moclobemide, with more acceptable side effect profiles, is effective in the treatment of dysthymia. The main objective of this study was to determine whether they exhibit comparable efficacy and tolerability in dysthymia to amitriptyline. Method and Materials : The efficacy and tolerability of the moclobemide and amitriptyline, were compared in a eight-week single-centre double-blind study in patients(n=37) with dysthymia using he HAMD-17, the Clinical Global Impression Scale(CGI), the Montgomery-Asberg Depression Rating Scale (MADRS), Efficacy Index-Therapeutic Index(EITE), 4-point Index Side Effect Scale(4-PISES), and Efficacy Index- Side Effect Scale(EISE). Results : A total of 37 patients entered the study, 19 were randomly assigned to the moclobemide group and 18 to be amitriptyline group. Demo-graphic and illness characteristics were similar in both groups. There were no significant difference between two groups at the total 17-HDRS score, the HAMD-17% improvement, the total MADRS score, CGI response, and the EITE. In the comparison of EISE between two groups, the scores of the moclobemide group were relatively lower than the amitriptylinen group in full treatment. And the differences were significant(moclobemide group $1.39{\pm}0.61$ ; amitriptyline group $2.00{\pm}0.85$, p<.001). At the 4-PISE, There was no serious or treatment threatening side effects. And there was no specific difference in side effects between two groups. The moclobemide group reported higher EIR scores than the amitriptyline group at every follow up day, but the differences were not significant. And, there was no significant differences in the scores of five HRQOL subcategories which is compared between two groups at every follow up days. Conclusions : In terms of 17-HDRS and MADRS, moclobemide and amitriptyline are equally effective at least in allevating dysthymic symptoms. But moclobemide tended to be less troubling and better tolerated than amitriptyline. Therefore, moclobemide treatment can be used as a safe, and higher satisfactory treatment strategy for the dysthymia.

정신분열병 환자에서 Cytochrome P450 2D6 유형에 따른 부작용에 대한 연구

이민수,남종원,Lee, Min Soo,Nam, Jong Won 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

The genetically determined CYP2D6 activity may be considered to be associated with antipsychotic induced extrapyramidal side effects with interindividual variation. Genetic polymorphism of CYP2D6 was determined by polymerase chain reaction(PCR) and MspI restriction fragment length polymorphisms(RFLP) for 194 schizophrenics. Subjects with a 334bp band were classified a1a1, those with 229bp and 105bp bands a2a2, and those with all three bands a1-a2. We did not identify schizophrenic subject with poor metabolizer. 194 schizophrenic patients previously treated neuroleptic medication, were assessed by Extrapyramidal Symptom Rating Scale(ESRS).The cases were composed of 33 akathisia, 47 parkinsonism, 21 tardive dyskinesia. These results are similar to the previous understanding that the poor metabolizer is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6 genotypes have maybe no association with schizophrenia and extrapyramidal side effects in Koreans.

삼풍 사고 생존자들에서 정신과적 증상의 심각도에 영향을 미치는 요인

이민수,차지현,곽동일,이준상,Lee, Min-Soo,Cha, Ji-Hyun,Kwak, Dong-Il,Lee, Joon-Sang 한국정신신체의학회 1996 정신신체의학 Vol.4 No.2

We studied the factors that would affect the severity of psychiatric symptoms of the Sampoong accident survivors. In this study, the analyzed factors are sex, age, marital status, educational level, loss of consciousness, witness of death, death of related person, duration until the rescue, duration of hospitalization, and psychiatric treatment after the accident. Although our study has some limitations, we found some factors that affect the severity of psychiatric symptoms after the severe traumatic accident.

중력금형주조에서 기공량에 미치는 경동속도 및 경동각도의 영향

이민수,김기영,김성우 ( Min Soo Lee,Ki Young Kim,Sung Woo Kim ) 한국주조공학회 1994 한국주조공학회지 Vol.14 No.4

Gas is prone to be entrapped in the casting resulting from the reaction of molten metal with mold coating material and resin hardened sand cores during filling in gravity diecasting of aluminum alloys with complex shape. Tilted pouring is known to be one of the method to eliminate the gas defect, in which tilting speed and angle are important as operation variables. Transparent water model was employed to observe the gas entrapment and liberation during pouring of complex shaped casting in this study. As a result, slow tilting combined with movable pouring ladle is recommended to evolute gas effectively in gravity diecasting.