지역교육과정 개발 모형설정을 위한 일연구

정성종,권요한 창원대학교 학생생활연구소 1995 학생생활연구 Vol.8 No.-

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

Incarcerated umbilical hernia with small bowel obstruction in a continuous ambulatory peritoneal dialysis patient

Yo-han Jeong,Jun-young Do,Mun-ju Hwang,Min-Jung Kim,Min Geun Gu,Byung-sam Park,Jung-eun Choi,Tae-woo Kim 영남대학교 의과대학 2014 Yeungnam University Journal of Medicine Vol.31 No.1

Patients treated with peritoneal dialysis have increased intra-abdominal pressure and a high prevalence of abdominal wall complications. Hernias can lead to significant morbidity in patients on peritoneal dialysis. Hernias are clinically important because of the risk of incarceration, strangulation and subsequent bowel obstruction, rupture, and peritonitis. In this paper, a case of incarcerated umbilical hernia with small bowel obstruction in a continuous ambulatory peritoneal dialysis (CAPD) patient is reported. The small bowel obstruction improved after herniorrhaphy, and the peritoneal dialysis was resumed 2 weeks after the herniorrhaphy. The patient had been undergoing CAPD without technical failure until the 2 months follow-up after the herniorrhaphy. This case shows that early detection of incarcerated umbilical hernia and herniorrhaphy can prevent resection of a strangulated small bowel so that it can remain on CAPD without post-operative technical failure. Umbilical hernias should be carefully observed and intestinal obstruction should be considered when a CAPD patient with an umbilical hernia has abdominal pain.

Incarcerated umbilical hernia with small bowel obstruction in a continuous ambulatory peritoneal dialysis patient

Jeong, Yo-Han,Do, Jun-Young,Hwang, Mun-Ju,Kim, Min-Jung,Gu, Min Geun,Park, Byung-Sam,Choi, Jung-Eun,Kim, Tae-Woo Yeungnam University College of Medicine 2014 Yeungnam University Journal of Medicine Vol.31 No.1

Patients treated with peritoneal dialysis have increased intra-abdominal pressure and a high prevalence of abdominal wall complications. Hernias can lead to significant morbidity in patients on peritoneal dialysis. Hernias are clinically important because of the risk of incarceration, strangulation and subsequent bowel obstruction, rupture, and peritonitis. In this paper, a case of incarcerated umbilical hernia with small bowel obstruction in a continuous ambulatory peritoneal dialysis (CAPD) patient is reported. The small bowel obstruction improved after herniorrhaphy, and the peritoneal dialysis was resumed 2 weeks after the herniorrhaphy. The patient had been undergoing CAPD without technical failure until the 2 months follow-up after the herniorrhaphy. This case shows that early detection of incarcerated umbilical hernia and herniorrhaphy can prevent resection of a strangulated small bowel so that it can remain on CAPD without post-operative technical failure. Umbilical hernias should be carefully observed and intestinal obstruction should be considered when a CAPD patient with an umbilical hernia has abdominal pain.

Is There Any Difference of Microorganism Between Past and Present in Acute Cholangitic Patients?

( Yo Han Jeong ),( Kyeong Ok Kim ),( Jay Song ),( Si Hyung Lee ),( Tae Nyeun Kim ),( Ho Chan Lee ),( Sung Bum Kim ),( Jae Hyun Park ),( Kook Hyun Kim ),( Byung Ik Jang ),( Se Hoon Sohn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Recently, antibiotics resistant microorganism, particularly extended- spectrum beta-lactamase (ESBL)-producing organisms have been increased. Theaim of this study was to analyze the change of microorganism and origin of infection between past (2000-2006, group A) and present (2007-2013, group B) in patients with acute cholangitis. Methods: Of the acute cholangitic patients from Jan 2000 to Dec 2013, a systemic review of 896 patients having positive blood and/or bile culture (293 in group A vs. 603 in group B) was conducted retrospectively. They were further classifi ed into the two subgroups: community- and hospital-acquired infection. Bile culture was obtained via ENBD catheter. Results: In blood culture, the most common microorganism was E.coli [43.3% vs 41.8%] between group A and B. ESBL-producing E.coli was significantly higher in group B [13.6% vs 6.2%, p= 0.001]. The numbers of patients with bile culture-positive were 123 in group A and 196 in group B. In bile culture, the most common pathogen was E.coli [58.5% vs 45.4%] between group A and B. ESBL-producing E.coli was signifi cantly higher in group B [22.4% vs 4.8%, p=0.001]. The numbers of patients with community-acquired infection was higher than hospital-acquired infection (71.9% vs 28.9%, respectively). In community-acquired infection, ESBL-producing E.coli was signifi cantly higher in group B both in the blood culture [11.2% vs 5.6%, p=0.021] and in the bile culture [6.4% vs 2.3%, p=0.025]. In hospital-acquired infection, ESBL-producing E.coli was signifi cantly higher in group B both in the blood culture [19% vs 8.0%, p=0.028] and in the bile culture [9.2% vs 1.3%, p=0.023]. Conclusions: The numbers of ESBL-producing E.coli has been increased recently. The physicians must keep in mind that ESBL-producing E.coli is the causative pathogen in patients with acute cholangitis, irrespective of whether community or hospital-acquired infection.

Efficacy and Safety of Tunneled Hemodialysis Catheter Insertion without Fluoroscopy by Nephrologists (초)

( Yo Han Jeong ),( Seok Hui Kang ),( Mun Ju Hwang ),( Jung Min Park ),( Kyu Hyang Cho ),( Jong Won Park ),( Kyung Woo Yoon ),( Jun Young Do ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Rubrofusarin-6-β-gentiobioside inhibits lipid accumulation and weight gain by regulating AMPK/mTOR signaling

Han, Yo-Han,Kee, Ji-Ye,Park, Seong-Hwan,Mun, Jeong-Geon,Jeon, Hee-Dong,Park, Jinbong,Zou, Qin-Peng,Liu, Xiang-Qian,Hong, Seung-Heon Elsevier 2019 Phytomedicine Vol.62 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Although rubrofusarin-6-β-gentiobioside (RFG), which is a component of <I>Cassiae tora</I> seed, could likely regulate hyperlipidemia, its anti-obesity effect and related mechanism have not been elucidated.</P> <P><B>Purpose</B></P> <P>The aim of this study was to examine whether RFG can ameliorate obesity and the mechanism of lipid accumulation regulated by RFG.</P> <P><B>Study design</B></P> <P>In <I>in vitro</I> experiments, we confirmed the anti-adipogenic effect of RFG using 3T3-L1 cells and human adipose mesenchymal stem cells (hAMSCs). To confirm the anti-obesity effect, High-Fat Diet (HFD)-induced obese mice were selected as a model.</P> <P><B>Methods</B></P> <P>We investigated anti-adipogenic effects of RFG using MTS assay, Oil Red O Staining, real-time RT-PCR, western blot analysis, and immunofluorescence staining. The anti-obesity effect of RFG was confirmed in HFD-induced mice model using hematoxylin and eosin staining and serum analysis.</P> <P><B>Results</B></P> <P>RFG inhibited lipid accumulation in 3T3-L1 cells and hAMSCs by reducing expression of mammalian targets of rapamycin (mTOR), peroxisome proliferator-activated receptor (PPAR)γ, and CCAAT-enhancer binding protein (C/EBP)α. RFG phosphorylated AMP-activated protein kinase (AMPK) in a liver kinase B (LKB) 1-independent manner. Moreover, the anti-adipogenic effect of RFG was blocked by AMPK inhibitor. These results suggest that RFG inhibits lipid accumulation via AMPK signaling. Furthermore, RFG reduced the body weight, size of epididymal white adipose tissue (eWAT), and fatty liver in the mice. RFG also suppressed levels of adipogenic factors PPARγ, C/EBPα, FAS, LPL, and aP2) by activating AMPK in the eWAT and liver.</P> <P><B>Conclusion</B></P> <P>RFG can ameliorate obesity, and thus, could be used as a therapeutic agent for treating obesity.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Anti-obesity effects of Arctii Fructus (Arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice

Han, Yo-Han,Kee, Ji-Ye,Kim, Dae-Seung,Park, Jinbong,Jeong, Mi-Young,Mun, Jung-Geon,Park, Sung-Joo,Lee, Jong-Hyun,Um, Jae-Young,Hong, Seung-Heon The Royal Society of Chemistry 2016 Food & Function Vol.7 No.12

<P>Arctii Fructus is traditionally used in oriental pharmacies as an anti-inflammatory medicine. Although several studies have shown its anti-inflammatory effects, there have been no reports on its use in obesity related studies. In this study, the anti-obesity effect of Arctii Fructus was investigated in high-fat diet (HFD)-induced obese mice, and the effect was confirmed in white and primary cultured brown adipocytes. Arctii Fructus inhibited weight gain and reduced the mass of white adipose tissue in HFD-induced obese mice. Serum levels of triglyceride and LDL-cholesterol were reduced, and HDL-cholesterol was increased in the Arctii Fructus treated group. In 3T3-L1 cells, a water extract (WAF) and 70% EtOH extract (EtAF) of Arctii Fructus significantly inhibited adipogenesis and suppressed the expression of proliferator-activated receptor gamma and CCAAT/enhancer-binding protein alpha. In particular, EtAF activated the phosphorylation of AMP-activated protein kinase. On the other hand, uncoupling protein 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha, known as brown adipocytes specific genes, were increased in primary cultured brown adipocytes by WAF and EtAF. This study shows that Arctii Fructus prevents the development of obesity through the inhibition of white adipocyte differentiation and activation of brown adipocyte differentiation which suggests that Arctii Fructus could be an effective therapeutic for treating or preventing obesity.</P>

<i>Artemisia asiatica</i> ethanol extract exhibits anti-photoaging activity

Jeong, Deok,Lee, Jongsung,Jeong, Seong-Gu,Hong, Yo Han,Yoo, Sulgi,Han, Sang Yun,Kim, Ji Hye,Kim, Sunggyu,Kim, Jin Sic,Chung, Young Soo,Kim, Jong-Hoon,Yi, Young-Su,Cho, Jae Youl Elsevier 2018 Journal of Ethnopharmacology Vol.220 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Artemisia asiatica</I> Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies.</P> <P><B>Aim of the study</B></P> <P>In this study, traditionally known skin-protective activity of <I>Artemisia asiatica</I> Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells.</P> <P><B>Materials and methods</B></P> <P>Effects of Aa-EE on cell viability, photocytotoxicity, and expression of matrix metalloproteinases (MMPs), cyclooxygenase (COX)-2, and moisturizing factors were measured in B16F10, HEK293, NIH3T3, and HaCaT cells under untreated and ultraviolet B (UVB)-irradiation conditions. Anti-melanogenic effect of Aa-EE was also examined by measuring both melanin content in B16F10 cells and tyrosinase activity. Anti-photoaging mechanism of Aa-EE was explored by determining the activation levels of signaling molecules by immunoblotting analysis.</P> <P><B>Results</B></P> <P>Aa-EE protected HaCaT cells from UVB irradiation-induced death. Aa-EE increased the expression of a type 1 pro-collagen gene and decreased the expression of matrix metalloproteinases, and COX-2 in NIH3T3 cells induced by UVB. Aa-EE increased the expression of transglutamase-1, hyaluronic acid synthase (HAS)-2, and HAS-3 in HaCaT cells and decreased the production of melanin in α-melanocyte-stimulating hormone-stimulated B16F10 cells by suppressing tyrosinase activity and the expression of tyrosinase, microphthalmia-associated transcription factor, tyrosinase-related protein (TRP)-1 and TRP-2.</P> <P><B>Conclusion</B></P> <P>The results suggest that Aa-EE could be skin-protective remedy with anti-photoaging, anti-apoptotic, skin remodeling, moisturizing, and anti-melanogenesis properties.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Poster Session : PS 0916 ; Lower GI Tract : Clinical Features and Risk Factors of Complication in Patients with Acute Diverticulitis

( Yo Han Jeong ),( Kyeng Ok Kim ),( Kook Hyun Kim ),( Si Hyung Lee ),( Byung Ik Jang ),( Tae Nyeun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The adoption of a western lifestyle in Asian countries may result in a higher prevalence of diverticulosis. Approximately 20% of all patients with diverticula develop acute diverticulitis. The aims of the present study were to evaluate the clinical feature of acute diverticulitis and analyze the risk factors of complications. Methods: The medical records of 228 patients who were hospitalized due to acute diverticulitis between January 2008 and June 2014 were reviewed, retrospectively. The patients baseline characteristics, clinical symptoms, treatment and complications were assessed. Results: Mean age of the patients was 54.76 ± 17.53 years and male to female ratio was 138 to 90 . Recurrent attack was noted in 47 patient (20.6%). The most common symptom was abdominal pain(92.1%), fever (50%) and bloating(46.5%). Right colon involvement was more common(74.1%). Complication was noted in 54 patients(23.7%). The most common complication was abscess formation(9.6%) and perforation occurred in 7%. Abscess formation was treated by percutaneous drainage catheter insertion and colon perforation was treated by surgery. During the follow up period, 29 patient(12.7%) experienced recurrent attack of diverticulitis. Previous history of diverticulitis is not related with complication occurrence. Patients older than 60 years more frequently developed complications during hospitalization ( P=0.047, odds ratio : 1.857). Especillay, the frequency of perforation was high (P=0.02, odds ratio : 6.22). The risk factors for complication include older age than sixty, shock and fever. Conclusion: The most common symptom of acute diverticulitis is abdominal pain, fever and bloating. The right sided diverticulitis is dominant. Complications rate was 23.7%. The risk factor of complication include older age than sixty ,shock and fever. Therefore, we should pay particular attention to the patients who have these risk factors about occurrence of complications.