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Xiaodong Wang,Xingguo Liu1,Boqiang Qin,Zhaojun Gu,Hao Xu,Hao Zhu,Guofeng Cheng,Huang Liu 한국생태학회 2015 Journal of Ecology and Environment Vol.38 No.3
In order to understand the mechanisms of conversion between different algal dominance, an experiment was performed in a greenhouse from 22 June to 10 July 2011. The experiment included a treatment group subjected to three instances of nutrient enrichment and a control with no nutrient enrichment. The initial water was dominated by Ankistrodesmus of Chlorophyta. The average water temperature at 08:30 h and 14:00 h during the experiment was 31.6°C and 34.6°C, respec¬tively. The results showed that the total nitrogen (TN), total phosphorus (TP), dissolved total nitrogen (DTN), dissolved total phosphorus (DTP), and soluble reactive phosphorus (SRP) concentrations in the treatment were significantly higher than in the control (P < 0.05). However, the TN/TP and DTN/DTP in the control was higher than in the treatment (P < 0.05). The dominant algae in the control did not change during the experiment, while the dominant algae in the treat¬ment switched to Planktothrix of Cyanophyta on day 9. The chlorophyll a (Chl-a), wet weight of all algae, wet weight of Cyanophyta, and percentage of Cyanophyta in the control were all significantly lower than in the treatment (P < 0.05). Amounts of zooplankton, especially rotifers, were present at the end of the experimental period. The density of rotifers between the control and treatment was not significantly different (P > 0.05), while the copepod density in the treatment was higher than in the control (P < 0.05). We conclude that green algae dominance quickly switches to cyanobacteria dominance after nutrient enrichment in a greenhouse with elevated temperature
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Wang, Xiaodong,Liu, Xingguo,Qin, Boqiang,Gu, Zhaojun,Wu, Zongfan,Xu, Hao,Zhu, Hao,Cheng, Guofeng,Liu, Huang The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.3
In order to understand the mechanisms of conversion between different algal dominance, an experiment was performed in a greenhouse from 22 June to 10 July 2011. The experiment included a treatment group subjected to three instances of nutrient enrichment and a control with no nutrient enrichment. The initial water was dominated by Ankistrodesmus of Chlorophyta. The average water temperature at 08:30 h and 14:00 h during the experiment was $31.6^{\circ}C$ and $34.6^{\circ}C$, respectively. The results showed that the total nitrogen (TN), total phosphorus (TP), dissolved total nitrogen (DTN), dissolved total phosphorus (DTP), and soluble reactive phosphorus (SRP) concentrations in the treatment were significantly higher than in the control (P < 0.05). However, the TN/TP and DTN/DTP in the control was higher than in the treatment (P < 0.05). The dominant algae in the control did not change during the experiment, while the dominant algae in the treatment switched to Planktothrix of Cyanophyta on day 9. The chlorophyll a (Chl-a), wet weight of all algae, wet weight of Cyanophyta, and percentage of Cyanophyta in the control were all significantly lower than in the treatment (P < 0.05). Amounts of zooplankton, especially rotifers, were present at the end of the experimental period. The density of rotifers between the control and treatment was not significantly different (P > 0.05), while the copepod density in the treatment was higher than in the control (P < 0.05). We conclude that green algae dominance quickly switches to cyanobacteria dominance after nutrient enrichment in a greenhouse with elevated temperature.
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Tensile performances of single-lap countersunk composite joints with metallic bushing
Xiaoquan Cheng,Xiaoyuan Du,Kun Chen,Maosheng Shu,Xiaodong Liu,Gang Chen 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.3
Tensile tests were carried out on the single-lap countersunk composite joints with metallic bushing, and the load-displacement curves, strains and damage morphologies around the bolt hole were measured. A 3D progressive damage finite element model (FEM) was established in ABAQUS/Standard and verified by experimental results. Based on the validated model, tensile performances of the joints were investigated, including damage mechanism analysis of the laminate and the effect discussion of bushing thickness, tightening torque, interference fit size and etc. The results show that metallic bushing can improve ultimate bearing load of the joints. The stress distribution and initial damages caused by assembly around the laminate hole are little affected by bushing thickness. Appropriate tightening torque and interference fit size can improve tensile performances of the joint.
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Multiparametric Magnetic Resonance Imaging Characteristics of Prostate Tuberculosis
Yue Cheng,Lixiang Huang,Xiaodong Zhang,Qian Ji,Wen Shen 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
To describe the multiparametric magnetic resonance imaging (MRI) appearance of prostate tuberculosis. Six patients with prostate tuberculosis were analyzed retrospectively. The mean age of the patients was 60.5 years (range, 48–67 years). The mean prostate specific antigen concentration was 6.62 ng/mL (range, 0.54–14.57 ng/mL). All patients underwent a multiparametric MRI examination. The histopathological results were obtained from biopsies in four men and from transurethral resection of the prostate in two men after the MRI examination. Nodular (33%, 2/6 patients) and diffuse lesions (67%, 4/6 patients) were seen on MRI. The nodular lesions were featured by extremely low signal intensity (similar to that of muscle) on T2-weighted imaging (T2WI). The T2WI signal intensity of the diffuse lesions was low but higher than that of muscle, which showed high signal intensity on diffusion weighted imaging and low signal intensity on an apparent diffusion coefficient map. MR spectroscopic imaging of this type showed a normal-like spectrum. Abscesses were found in one patient with the nodular type and in one with the diffuse type. The appearance of prostate tuberculosis on MRI can be separated into multiple nodular and diffuse types. Multiparametric MRI may offer useful information for diagnosing prostate tuberculosis.
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Yali Gong,Xiaodong Shen,Guangtao Huang,Cheng Zhang,Xiaoqiang Luo,Supeng Yin,Jing Wang,Fuquan Hu,Yizhi Peng,Ming Li 한국미생물학회 2016 The journal of microbiology Vol.54 No.8
Acinetobacter baumannii is an important opportunistic pathogen that causes severe nosocomial infections, especially in intensive care units (ICUs). Over the past decades, an everincreasing number of hospital outbreaks caused by A. baumannii have been reported worldwide. However, little attention has been directed toward the relationship between A. baumannii isolates from the ward environment and patients in the burn ICU. In this study, 88 A. baumannii isolates (26 from the ward environment and 62 from patients) were collected from the burn ICU of the Southwest Hospital in Chongqing, China, from July through December 2013. Antimicrobial susceptibility testing results showed that drug resistance was more severe in isolates from patients than from the ward environment, with all of the patient isolates being fully resistant to 10 out of 19 antimicrobials tested. Isolations from both the ward environment and patients possessed the β-lactamase genes blaOXA-51, blaOXA-23, blaAmpC, blaVIM, and blaPER. Using pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST), these isolates could be clustered into 4 major PFGE types and 4 main sequence types (ST368, ST369, ST195, and ST191) among which, ST368 was the dominant genotype. Epidemiologic and molecular typing data also revealed that a small-scale outbreak of A. baumannii infection was underway in the burn ICU of our hospital during the sampling period. These results suggest that dissemination of β-lactamase genes in the burn ICU might be closely associated with the high-level resistance of A. baumannii, and the ICU environment places these patients at a high risk for nosocomial infection. Cross-contamination should be an important concern in clinical activities to reduce hospital acquired infections caused by A. baumannii.
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Shen Wei,Yuan Lebin,Cheng Fei,Wu Zhao,Li Xiaodong 한국유전학회 2024 Genes & Genomics Vol.46 No.1
Background Previous studies indicate that the splicing process, regulated by the cellular machinery of tumors (spliceosome), undergoes alterations, leading to oncogenic splicing events associated with the progression of tumors towards aggressiveness. However, the role of serine/arginine-rich splicing factor 7 (SRSF7) in hepatocellular carcinoma (HCC) and the tumor microenvironment (TME) remains unclear. Methods This study was aimed to explore the role and clinical significance of SRSF7 in HCC. By conducting functional analysis and gene set enrichment analysis, it was discovered that SRSF7 contributes to multiple pathways associated with immune response and tumor advancement. Further experiments verified that silencing of SRSF7 obviously inhibits progression of HCC. Results Aberrant expression of SRSF7, which were referred as an independent prognostic risk factor, effectively predicts the prognosis of patients with HCC. Functional and gene enrichment analyses revealed that SRSF7 is linked with multiple immune and tumor progression-related pathways, including the B cell receptor signaling pathway, positive regulation of leukocyte and immunoglobulin receptor binding cell activation, nuclear division, membrane invagination, cell cycle, as well as mTOR signaling pathway. Furthermore, increased SRSF7 expression was associated with tumor-infiltrating inflammatory cells (CD4+, monocytes/macrophages, CD8 + and endothelial). Additionally, multiple immune checkpoint genes were markedly positively related to SRSF7. The efficiency of SRSF7 in predicting immunomodulator and chemokine responses were also assessed in microenvironment. Moreover, in vitro analyses demonstrated that knockdown of SRSF7 suppressed the malignant evolution of HCC possibly by deactivating the PI3K/AKT/mTOR signaling. Conclusion The role of SRSF7 in the tumor microenvironment has been successfully assessed. It may be a valid bio-index for predicting the HCC prognosis, thereby guiding individualized immunotherapy for cancer. Background Previous studies indicate that the splicing process, regulated by the cellular machinery of tumors (spliceosome), undergoes alterations, leading to oncogenic splicing events associated with the progression of tumors towards aggressiveness. However, the role of serine/arginine-rich splicing factor 7 (SRSF7) in hepatocellular carcinoma (HCC) and the tumor microenvironment (TME) remains unclear. Methods This study was aimed to explore the role and clinical significance of SRSF7 in HCC. By conducting functional analysis and gene set enrichment analysis, it was discovered that SRSF7 contributes to multiple pathways associated with immune response and tumor advancement. Further experiments verified that silencing of SRSF7 obviously inhibits progression of HCC. Results Aberrant expression of SRSF7, which were referred as an independent prognostic risk factor, effectively predicts the prognosis of patients with HCC. Functional and gene enrichment analyses revealed that SRSF7 is linked with multiple immune and tumor progression-related pathways, including the B cell receptor signaling pathway, positive regulation of leukocyte and immunoglobulin receptor binding cell activation, nuclear division, membrane invagination, cell cycle, as well as mTOR signaling pathway. Furthermore, increased SRSF7 expression was associated with tumor-infiltrating inflammatory cells (CD4+, monocytes/macrophages, CD8 + and endothelial). Additionally, multiple immune checkpoint genes were markedly positively related to SRSF7. The efficiency of SRSF7 in predicting immunomodulator and chemokine responses were also assessed in microenvironment. Moreover, in vitro analyses demonstrated that knockdown of SRSF7 suppressed the malignant evolution of HCC possibly by deactivating the PI3K/AKT/mTOR signaling. Conclusion The role of SRSF7 in the tumor microenvironment has been successfully assessed. It may be a valid bio-index for predicting the HCC prognosis, thereby guiding individualized immunotherapy for cancer.
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Chuanmin Zhang,Ran Huo,Xiaodong Wang,Junying Zhang,Jue Cheng,Ling Shi 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
To improve the corrosion resistance and glossiness offlaky aluminum pigments in waterborne coatings, aflaky aluminum pigment was encapsulated with poly(methylhydrosiloxane) (PMHS) as an anti-corrosionfilm by in-situ polymerization, and its chemical composition was characterized by Fourier-transforminfrared and X-ray photoelectron spectroscopy, and its morphology and microstructure was identified byscanning and transmission electron microcopy. Furthermore, its anticorrosive performance wasconfirmed by Zeta potential measurement and electrochemical impedance spectroscopy. Theencapsulatedflaky aluminum pigment not only exhibits excellent corrosion resistance but also showsan improved thermal stability due to the fabrication of a PMHS-based organosiliconfilm on the surface ofaluminumflakes. Most of all, the original glossiness and brightness could be maintained for thewaterborne coatingfilm after the encapsulatedflaky aluminum pigment was incorporated, indicating agreat application potential in waterborne coatings, water-based paints, printing inks, spray-freematerials and any more. This work provides a new strategy for design and fabrication of high corrosionresistantand high glossy aluminum pigments.
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Lai Xiongming,Huang Ju,Zhang Yong,Wang Cheng,Zhang Xiaodong 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.5
As for complex engineering structures, their single deterministic solutions need to be calculated with the help of computation-intensive finite element software, and the corresponding computation time always lasts very long. When referring to robust design optimization of complex engineering structures, the above expensive job should be repeatedly carried out for a considerable amount of time during the full optimization process. Hence, such repetitive jobs may be difficult to complete for most engineering applications. Aiming at this problem, the paper proposes a general methodology for reliability-based robust design optimization (RBRDO). Firstly, the improved formulation of the RBRDO problem is proposed based on the conventional RBRDO form, and the original probabilistic constraint functions in the improved formulation are changed into the deterministic ones by means of employing the performance measure approach (PMA). Secondly, the above-mentioned improved RBRDO problem is approximately replaced by a new sequence of approximate suboptimizations. For each suboptimization, its original PMA functions are replaced by the approximate explicit form only concerning the deterministic design variables rather than random variables. In this way, each suboptimization is deterministic. Furthermore, the trust-region method is adopted to ensure that the new sequence of suboptimization converge to the original improved RBRDO problem. Lastly, a test problem and three applications are adopted to demonstrate the effectiveness and efficiency of the above-proposed methods.PACS(optional, as per journal): 75.40.-s; 71.20.LP
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The management of hydatidiform mole with lung nodule: a retrospective analysis in 53 patients
Xiao Li,Yaping Xu,Yuanyuan Liu,Xiaodong Cheng,Xinyu Wang,Weiguo Lu,Xing Xie 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2
Objective: To investigate the significance of lung nodule in hydatidiform mole, we retrospectively compared the clinical outcomes of those patients treated with different strategies. Methods: The patients were divided into three groups: chemotherapy immediately once lung nodule was detected (group 1, n=17), delayed chemotherapy until human chorionic gonadotrophin (hCG) level met the diagnostic criteria for gestational trophoblastic neoplasia (GTN) (group 2, n=18), and hCG surveillance alone until hCG level was normalized spontaneously (group 3, n=18). The clinical parameters of these patients were collected and analyzed. Results: Totally 53 (4.0%) patients were included from 1,323 cases with molar pregnancy during past 16 years. Among them, the diameters of lung nodules were 0.3–2.5 cm. Chemotherapy cycles for achieving hCG normalization and the failure rate of first-line chemotherapy in group 1 were significantly increased than that in group 2 (5 vs. 3 cycles, p=0.000, 58.8% vs. 11.1%, p=0.005). The hCG level of all 18 cases in group 3 was normalized spontaneously within 6 months. Of those, lung nodules of 9 patients disappeared spontaneously, accounting for 25% (9/36) of patients who initially selected observation. The proportion of single nodule in group 3 was significantly higher than that in group 2 (10/18 vs. 2/18, p=0.012). Conclusion: Our results suggest that lung nodule alone is not an adequate indication of chemotherapy in molar pregnancy. hCG surveillance is safe for patients with lung nodule, especially with single nodule, as long as their hCG levels do not meet International Federation of Gynecology and Obstetrics diagnostic criteria for GTN.
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Ran Chu,Penglin Liu,Jingying Chen,Xiaodong Cheng,Kezhen Li,Yanci Che,Jianliu Wang,Li Li,Xi Zhang,Shu Yao,Li Song,Ying Zhao,Changzhen Huang,Ying Xue,Xiyu Pan,Junting Li,Zhongshao Chen,Jie Jiang,Beihua 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2
Objective: To evaluate the impact of bleomycin/etoposide/cisplatin (BEP) and paclitaxel/carboplatin (PC) chemotherapy regimens on the fertility and prognostic outcomes in malignant ovarian germ cell tumor (MOGCT) patients who underwent fertility-sparing surgery (FSS). Methods: A propensity score matching algorithm was performed between the BEP and PC groups. The χ2 test and the Kaplan-Meier method were used to compare the fertility outcome, disease-free survival (DFS) and overall survival (OS). The Cox proportional hazards regression analysis was used to identify risk factor of DFS. Results: We included 213 patients, 185 (86.9%) underwent BEP chemotherapy, and 28 (13.1%) underwent PC chemotherapy. The median age was 22 years (range, 8–44 years), and the median follow-up period was 63 months (range, 2–191 months). Fifty-one (29.3%) patients had a pregnancy plan, and 35 (85.4%) delivered successfully. In the before and after propensity score matching cohorts, there were no significant differences in spontaneous abortion, selective termination of pregnancy, during-pregnancy status, and live birth between the BEP and PC groups (p>0.05). Fourteen (6.6%) patients experienced recurrence, including 11 (5.9%) in the BEP group and 3 (10.7%) in the PC group. Four (1.9%) patients in the BEP group died. Kaplan-Meier analysis revealed no significant differences in DFS (p=0.328) and OS (p=0.446) between the BEP and PC groups, and the same survival results were observed in the after matching cohort. Conclusion: The PC regimen is as safe as the BEP regimen for MOGCT patients with fertility preservation treatment, and no differences were observed in fertility and clinical prognosis.
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