Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists

Yingmei Wang,Shiqian Zhang,Lihui Wei,Zhongqiu Lin,Xinyu Wang,Jianliu Wang,Keqin Hua,Manhua Cu,Jiandong Wang,Shixuan Wang,Wen Di,Yudong Wang,Ruifang An,Mingrong Xi,Ruixia Guo,Qi Zhou,Xing Xie,Fengxia X 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratorysyndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk ofbeing infected with the coronavirus and are more likely to develop severe complications, ascompared to the general population. The increasing spread of COVID-19 presents challengesfor the clinical care of patients with gynecological malignancies. Concerted efforts should beput into managing gynecological malignancies in an orderly manner by strictly implementingthe measures that are specifically developed for controlling the spread of COVID-19. We havedrafted Recommendations on Management of Gynecological Malignancies during the COVID-19 Pandemicbased on our experience on controlling COVID-19 pandemic in China. We recommendthat patients with gynecological malignancies should be managed in hierarchical andindividualized manners in combination with local conditions related to COVID-19. Medicalcare decision should be balanced between controlling COVID-19 pandemic spread and timelydiagnosis and treatment for gynecologic oncology patients.

Mechanism of gastrointestinal adaptability and antioxidant function of infant-derived Lactobacillus plantarum BF_15 through genomics

Xinyu Wang,Na Zhang,Dongyao Li,Miaoshu Wang,Chen Li,Hongtao Tian 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.11

Lactobacillus plantarum is an essential probiotic in the human gastrointestinal tract. L. plantarum BF_15, a functional probiotic isolated from the feces of breast-fed infants, has been reported in many in vitro and in vivo studies with strong gastrointestinal adaptability and outstanding anti-oxidative activities. Therefore, the whole genome of L. plantarum BF_15 was sequenced. Several genes, encoding the gastrointestinal adaptability-related proteins, were identified, including genes related to gastrointestinal environment-induced stress resistance, adhesive performance, and ability to transport and metabolize resistant starch and oligosaccharides. Genes related to alleviating oxidative stress were also found. Further functional verification was carried out by RT-qPCR on the 10 and 12 key adhesion and antioxidant genes. Overall, this study might provide a critical basis for L. plantarum BF_15 as a potential candidate for probiotics.

Comparison of Clinical and Radiographic Outcomes Between Transforaminal Endoscopic Lumbar Discectomy and Microdiscectomy: A Follow-up Exceeding 5 Years

Xinyu Yang,Shijun Zhang,Junxiao Su,Sai Guo,Yakubu Ibrahim,Kai Zhang,Yonghao Tian,Lianlei Wang,Suomao Yuan,Xinyu Liu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: To compare the long-term clinical and radiographic outcomes of transforaminal endoscopic lumbar discectomy (TELD) versus microdiscectomy (MD). Methods: The data of 154 patients with lumbar disc herniation (LDH) who underwent TELD (n = 89) or MD (n = 65) were retrospectively analyzed. The patients’ clinical outcomes were evaluated using visual analogue scales for leg and low back pain, the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index (ODI). The evolution of radiographic manifestations was observed during follow-up. Potential risk factors for a poor clinical outcome were investigated. Results: During a mean follow-up of 5.5 years (range, 5–7 years), the recurrence rate was 4.49% in the TELD group and 1.54% in the MD group. All scores significantly improved from preoperatively to postoperatively in both groups (p < 0.01). The improvement in the ODI and JOA scores was significantly greater in the TELD than MD group (p < 0.05). Forty-seven patients (52.8%) in the TELD group and 32 (49.2%) in the MD group had Modic changes before surgery, most of which showed no changes at the last follow-up. The degeneration grades of 292 discs (71.0%) were unchanged at the last follow-up, while 86 (20.9%) showed improvement, mostly at the upper adjacent segment. No significant difference was observed in the intervertebral height index or paraspinal muscle-disc ratio. Conclusion: Both TELD and MD provide generally satisfactory long-term clinical outcomes for patients with LDH. TELD can be used as a reliable alternative to MD with less surgical trauma. Modic type II changes, decreased preoperative intervertebral height, and a high body mass index are predictors of a poor prognosis. Objective: To compare the long-term clinical and radiographic outcomes of transforaminal endoscopic lumbar discectomy (TELD) versus microdiscectomy (MD). Methods: The data of 154 patients with lumbar disc herniation (LDH) who underwent TELD (n = 89) or MD (n = 65) were retrospectively analyzed. The patients’ clinical outcomes were evaluated using visual analogue scales for leg and low back pain, the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index (ODI). The evolution of radiographic manifestations was observed during follow-up. Potential risk factors for a poor clinical outcome were investigated. Results: During a mean follow-up of 5.5 years (range, 5–7 years), the recurrence rate was 4.49% in the TELD group and 1.54% in the MD group. All scores significantly improved from preoperatively to postoperatively in both groups (p < 0.01). The improvement in the ODI and JOA scores was significantly greater in the TELD than MD group (p < 0.05). Forty-seven patients (52.8%) in the TELD group and 32 (49.2%) in the MD group had Modic changes before surgery, most of which showed no changes at the last follow-up. The degeneration grades of 292 discs (71.0%) were unchanged at the last follow-up, while 86 (20.9%) showed improvement, mostly at the upper adjacent segment. No significant difference was observed in the intervertebral height index or paraspinal muscle-disc ratio.

Surface oxidation of PAN‑based ultrahigh modulus carbon fibers (UHMCFs) and its effect on the properties of UHMCF/EP composites

Xinyu Wang,Xin Qian,Yonggang Zhang,Xuefei Wang,Shulin Song,Cheng Zhang 한국탄소학회 2021 Carbon Letters Vol.31 No.3

In this study, nitric acid oxidation with varied treatment temperature and time was conducted on the surfaces of polyacrylonitrile- based ultrahigh modulus carbon fibers. Scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy and surface tension/dynamic contact angle instruments were used to investigate changes in surface topography and chemical functionality before and after surface treatment. Results showed that the nitric acid oxidation of ultrahigh modulus carbon fibers resulted in decreases in the values of the crystallite thickness Lc and graphitization degree. Meanwhile, increased treating temperature and time made the decreases more obviously. The surfaces of ultrahigh modulus carbon fibers became much more activity and functionality after surface oxidation, e.g., the total surface energy of oxidized samples at 80 °C for 1 h increased by 27.7% compared with untreated fibers. Effects of surface nitric acid oxidation on the mechanical properties of ultrahigh modulus carbon fibers and its reinforced epoxy composites were also researched. Significant decreases happened to the tensile modulus of fibers due to decreased Lc value after the nitric acid oxidation. However, surface treatment had little effect on the tensile strength even as the treating temperature and processing time increased. The highest interfacial shear strength of ultrahigh modulus carbon fibers/epoxy composites increased by 25.7% after the nitric acid oxidation. In the final, surface oxidative mechanism of ultrahigh modulus carbon fibers in the nitric acid oxidation was studied. Different trends of the tensile strength and tensile modulus of fibers in the nitric acid oxidation resulted from the typical skin–core structure.

Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse

Xinyu Wan,Xiaomin Yang,Fan Yang,Tianyi Wang,Lixia Ding,Lili Song,Yan Miao,Xiang Wang,Yani Ma,Chengjuan Luo,Jingyan Tang,Longjun Gu,Jing Chen,Yanjing Tang,Jun Lu,Benshang Li 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.

A comparative analysis of Chinese writings in English and the translation of ChatGPT

WANG XINYUE,Liu, Cuilin 한국언어과학회 2023 한국언어과학회 학술대회 Vol.2023 No.08

Goal-oriented multi-collision source algorithm for discrete ordinates transport calculation

Xinyu Wang,Bin Zhang,Yixue Chen 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

Discretization errors are extremely challenging conundrums of discrete ordinates calculations for radiation transport problems with void regions. In previous work, we have presented a multi-collision source method (MCS) to overcome discretization errors, but the efficiency needs to be improved. This paper proposes a goal-oriented algorithm for the MCS method to adaptively determine the partitioning of the geometry and dynamically change the angular quadrature in remaining iterations. The importance factor based on the adjoint transport calculation obtains the response function to get a problem-dependent, goal-oriented spatial decomposition. The difference in the scalar fluxes from one high-order quadrature set to a lower one provides the error estimation as a driving force behind the dynamic quadrature. The goal-oriented algorithm allows optimizing by using ray-tracing technology or high-order quadrature sets in the first few iterations and arranging the integration order of the remaining iterations from high to low. The algorithm has been implemented in the 3D transport code ARES and was tested on the Kobayashi benchmarks. The numerical results show a reduction in computation time on these problems for the same desired level of accuracy as compared to the standard ARES code, and it has clear advantages over the traditional MCS method in solving radiation transport problems with reflective boundary conditions

Xylazole inhibits NO-cGMP pathway in fetal rat nerve cells

Xinyu Wang,Yue Wu,Lin Liu,Hui Bai,Zhiheng Zhang,Mingchao Zhao,Tianwen Ma,Xiaopeng Song,Lina Jia,Liangyu Lv,Yue Yu,Xinyu Xu,Hong Chen,Li Gao 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1

Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 μg/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.

Backstepping Synchronous Control of Simplified Supersonic Missile

Xinyu Wang 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.12

A new kind of novel control method which is named backstepping synchronous control is firstly proposed in this paper. It is a kind of method that can applied in any general system as widely as PID control, variable structure control and any other control method. Synchronization was most frequently used in secure communication and else in the past, but here its concept was successfully used to construct a new control method. It is similar to model referenced adaptive control but it is still different from that. An auxiliary system with several virtual synchronous inputs and a real input is constructed to cope the uncertainties of original system. The synchronous inputs are designed to realize the synchronization between auxiliary system and original system. Since the real input is designed according to the auxiliary system without uncertainty by using backstepping method, so it is easy to design. Because the synchronous input is decoupling so it is easy to cope with uncertainties. In this paper, simplified supersonic missile system was taken as an example to show the design process and stability analysis of the new method. Also, it was compared with traditional PID control and backstepping control method. At last, detailed numerical simulations were done to testify the effectiveness of the proposed method.

Exploiting the Routing Efficiency for DMesh Networks

Xinyu Wang,Tingting Han,Haikuo Liu 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.6

A rising horizon in on-chip interconnection is the design of high-radix routers as the ever increasing pin bandwidth. Compared to mesh, DMesh introduces many crossing physical channels, and effectively lower down the diameter and average distance, which directly influence performance of the overall chip. However, the original algorithm DXY could not efficiently make use of physical channels, as it always prefers to use the crossing links. In this paper, we present a novel deadlock-free and livelock-free routing algorithm based on DMesh network in order to make better use of different channels. Moreover, the new scheme can be used to both wormhole and virtual-cut-through switched networks. Extensive simulation results validate the effectiveness of novel proposed routing scheme as compared to the original DXY routing, originally proposed for DMesh networks.