The ERCC1 C118T Polymorphism Predicts Clinical Outcomes of Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Meta-analysis Based on 22 Studies

Qian, Ying-Ying,Liu, Xin-You,Wu, Qian,Song, Xian,Chen, Xiao-Feng,Liu, Yi-Qian,Pei, Dong,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1) C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, the conclusions are conflicting. Therefore, we performed the present meta-analysis to determine the precise role of the ERCC1 C118T polymorphism in this clinical situation and help optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were used to estimate objective response and oxaliplatin-induced toxicity, with hazard ratios (HRs) with 95%CIs for progression-free survival (PFS) and overall survival (OS). Results: A total of 22 studies including 2,846 CRC patients were eligible in the analysis. Overall, no significant correlation was found between the ERCC1 C118T polymorphism and objective response to oxaliplatin-based chemotherapy, in all patients or in the Asian and Caucasian subgroups. However, the pooled analysis showed that the PFS and OS were significantly shorter in patients who carried T/T or T/C genotypes of ERCC1 C118T as compared to the C/C genotype. On stratified analysis by ethnicity, the ERCC1 118T allele was associated with a favorable prognosis in Caucasians (PFS, HR=0.58, 95%CI: 0.24-1.44; OS, HR=0.38, 95%CI: 0.22-0.64) but an unfavorable prognosis in Asians (PFS, HR=2.49, 95%CI: 1.87-3.33; OS, HR=2.63, 95%CI: 1.87-3.69) based on a dominant model. In addition, we failed to find a statistically significant impact of ERCC1 C118T polymorphism on oxaliplatin-induced toxicity. Conclusions: The ERCC1 C118T polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

A study on the modified Hough algorithm for image processing in weld seam tracking

Qian-Qian Wu,이종표,박민호,진병주,김도형,박철균,김일수 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.11

Nowadays, automatic Gas metal arc (GMA) welding is receiving a growing attention for its fast production speed and wide-rangingversatility. Furthermore, automatic and robotic welding systems are urgently needed for general application, which depends on the realizationof auto-weld seam tracking. Seam tracking system allows for not only robot or machine trajectory shifts, but also adaptive controlto change weld bead formation, making further improvement on the weld quality. Based on the laser vision system, this study aims fordevelopment of an image processing by the modified Hough algorithm which applied for seam tracking system in GMA welding. Toachieve this objective, image features in the procedure of welding processing were discussed and specially treated. Algorithms in theimage processing were investigated to maximize the processing effect based on the modified Hough algorithm, which was quite costefficientin line detection. Quantitative evaluations of the used algorithm were set up to acquire optimal image processing algorithm. Finally, a common image processing method was employed to verify efficiency of proposed image processing and extract the weldinglocation in a shorten time for industrial application. It can be concluded the detected feature points and centerlines proved that this algorithmcan be used for automatic GMA welding process as well as industrial applications.

A Study on Development of the Optimal Neural Network in GMA Welding Process

Wu, Qian Qian,Lee, Ji Hye,Lee, Jong Pyo,Park, Min Ho,Kim, Young Su,Kim, Ill Soo Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.936 No.-

<P>Gas Metal Arc (GMA) welding is considered as a multi-parameter process that it’s hard to find optimal parameters for good welding. To overcome the problem, an artificial neural network based on the backpropagation algorithm was built to realize the relationships between process parameters and welding quality as output parameter. In this study, Mahalanobis Distance (MD) was employed to evaluate the availability of a given welding parameters which was proved to performance well in multivariate statistics. Input parameters such as welding current and arc voltage were chosen due to their significant influence on the welding quality. To improve the precision of given parameters’ evaluation, neural networks with different configurations were verified. The analyses on the measured and predicted MD by the proposed neural network were conducted. The proposed neural network based on the error backpropogation algorithm was proved to have high reliability to evaluate process parameters, which further makes it available in on-line monitoring system.</P>

Preparation and Characterization of Acid and Pepsin-soluble Collagens from Scales of Croceine and Redlip Croakers

Qian-Qian Wu,Tao Li,Bin Wang,Guo-Fang Ding 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6

Acid-soluble (ASC) and pepsin-soluble collagen (PSC) from scales of croceine croaker (ASCPC and PSC-PC) and redlip croaker (ASC-PP and PSC-PP) were prepared with yields of 0.37±0.08% (ASCPC), 1.09±0.23% (PSC-PC), 0.42±0.09% (ASC-PP), and 1.14±0.30% (PSC-PP) (dry scale basis). Gly (347.1- 359.8 residues/1,000 residues) was the major amino acid. Contents of imino acid were between 189.4 and 192.9 residues/1,000 residues in all 4 collagens. ASC-PC and ASC-PP were type I collagens. Differences in subunit components between ASC and PSC were observed. Denaturation temperature values of ASC-PC, ASC-PP, PSC-PC, and PSC-PP were 30.7, 30.1, 27.5, and 26.6℃, respectively. All 4 collagens were soluble at pH 1-4. Values declined when NaCl concentrations exceeded 2%. Freeze-dried collagens showed loose, fibrous, and porous structures. The 4 scale collagens can be alternatives to collagen from terrestrial animals for applications in functional food, cosmetic, and biomedical industries.

New indoles from the roots of Brassica rapa ssp. campestris

Wu, Qian,Bang, Myun-Ho,Lee, Dae-Young,Cho, Jin-Gyeong,Jeong, Rak-Hun,Shrestha, Sabina,Lee, Kyung-Tae,Chung, Hae-Gon,Ahn, Eun-Mi,Baek, Nam-In Springer-Verlag 2012 Chemistry of natural compounds Vol.48 No.2

A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation

Qian Wu,백남인,Jin-Gyeong Cho,유기현,정태숙,박지해,Su-Yeon Kim,Ji-Hyun Kang,정인식,최명숙,이경태,Hae-Gon Chung,방면호 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.4

Brassica rapa ssp. campestris (Brassicaceae) isa conical, deep purple, edible root vegetable commonlyknown as a turnip. We initiated phytochemical and pharmacologicalstudies to search for biological active compoundsfrom the roots of B. rapa ssp. campestris. Weisolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2,4-dione, named brassicaphenanthrene A (3) alongwith two known diarylheptanoid compounds, 6-paradol (1)and trans-6-shogaol (2), through the repeated silica gel(SiO2), octadecyl silica gel, and Sephadex LH-20 columnchromatography. The chemical structures of the compoundswere determined by spectroscopic data analyses includingnuclear magnetic resonance, mass spectrometry, ultravioletspectroscopy, and infra-red spectroscopy. All compoundsexhibited high inhibitory activity against the growth ofhuman cancer lines, HCT-116, MCF-7, and HeLa, with IC50values ranging from 15.0 to 35.0 lM and against LDL-oxidationwith IC50 values ranging from 2.9 to 7.1 lM.

All Sky Camera and Fabry-Perot Interferometer Observations in the Northern Polar Cap

Wu Qian,Killeen Timothy L.,Solomon Stanley C.,McEwen Donald J.,Guo, Weiji Korea Institute of Ocean ScienceTechnology 2002 Ocean and Polar Research Vol.24 No.3

We report all sky camera and Fabry-Perot interferometer (FPI) observations of mesospheric gravity waves and a 12-hour wave at Resolute $(75^{\circ}N)$ and a joint observation of 10-hour wave with Eureka $(80^{\circ}N)$. All sky camera observations showed a low occurrence of mesosphere gravity waves during equinoxes, which is similar to the mid-latitude region. A slightly higher occurrence near solstice appears to indicate that gravity waves are not filtered out by the neutral wind in the winter. The FPI observation of a 12-hour wave showed amplitude variations from day to day. The phase of the wave is mostly stable and consistent with the GSWM prediction in the winter. The phase shifts with season as predicted by the GSWM. Four events of the 12-hour wave were found in spring with amplitudes larger than the GSW predictions. The FPls at Resolute and Eureka also observed a wave with period close to 10 hours. The 10-hour wave maybe the result of the non-linear interaction between the semi-diurnal tide and the quasi-two day wave. Further studies are under way. Overall, the combined Resolute and Eureka observation have revealed some new fractures about the mesospheric gravity wave, tidal wave, and other oscillations.

Incidence and Mortality of Female Breast Cancer in Jiangsu, China

Wu, Li-Zhu,Han, Ren-Qiang,Zhou, Jin-Yi,Yang, Jie,Dong, Mei-Hua,Qian, Yun,Wu, Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Objectives: The aim of this study was to describe and analyze the incidence and mortality of female breast cancer in Jiangsu Province of China. Methods: Incidence and mortality data for female breast cancer and corresponding population statistics from eligible cancer registries in Jiangsu from 2006 to 2010 were collected and analyzed. Crude rates, age-specific rates and age-standardized rates of incidence and mortality were calculated, and annual present changes (APCs) were estimated to describe the time trends. Results: From 2006 to 2010, 11,013 new cases and 3,068 deaths of female breast cancer were identified in selected cancer registry areas of Jiangsu. The annual average crude incidence and age-standardized incidence by world population (ASW) were 25.2/ and 17.9/100,000 respectively. The annual average crude and ASW for mortality rates were 7.03/ and 4.81/100,000. The incidence was higher in urban areas than that in rural areas, and this was consistent in all age groups. No significant difference was observed in mortality between urban and rural areas. Two peaks were observed when looking at age-specific rates, one at 50-59 years and another at over 85 years. During the 5 years, incidence and mortality increased with APCs of 4.47% and 6.89%, respectively. Compared to the national level, Jiangsu is an area with relatively low risk of female breast cancer. Conclusion: Breast cancer has become a main public health problem among Chinese females. More prevention and control activities should be conducted to reduce the burden of this disease, even in relatively low risk areas like Jiangsu.

중국 가족기업의 지배구조가 경영성과에 미치는 영향: 상장된 제조업인 가족기업 대상으로

QIAN WU,남영호 글로벌경영학회 2018 글로벌경영학회 학술대회 발표논문집 Vol.2018 No.1

본 연구는 가족의 지배구조, 기업의 지배구조와 경영성과 간의 관계를 살펴보는 게 본 논문의 목적이다. 가족기업은 가족과 기업의 근간이므로 일반기업과 다른 가족목표도 갖고 있으며, 가족 기업의 지배구조는 일반기업과의 차이가 될 수도 있다. 본 연구에서 가족기업의 지배구조는 기업의 지배구조와 가족의 지배구조를 나누어 경영성과에 대한 관계를 고찰하였다. 본 연구는 위의 연구목적을 달성하기 위해, 상해·심천증권거래소 사이트와 CSMAR(国泰安) 금융데이터베이스를 통해 중국에서 A주 상장된 가족기업에 관한 데이터를 수집하였다. 우리 잘 알다시피 중국은 제조업 강한 국가이며, 2016년도에 A주 상장된 가족기업 수가 1022개인데 제조업에 속한 가족기업이 700개 넘게 나왔다. 그러므로 본 연구는 A주 상장된 제조업에 속한 가족기업 대상으로 연구하였다. 그 중 ST 기업, PT기업, 자료를 수집하지 못 하는 기업을 제외해서 704개 기업을 최종적으로 정하였다. 그리고 가설을 검증하기 위한 실증분석은 SPSS18.0을 사용하여 실시하였다. 연구결과, 기업의 지배구조인 이사회 규모와 사외이사 수는 기업의 매출액과 당기순이익에 유의한 정(+)의 영향을 끼쳤다. 또한 가족의 지배구조인 경영지배권은 기업의 매출액과 당기순이익에 유의한 정(+)의 영향을 끼쳤지만, 가족의 지배구조인 소유권은 기업의 매출액과 당기순이익에 부 (-)의 영향을 끼쳤다는 것을 검증하였다. 결론적으로, 가족기업에서 이사회와 사외이사의 감시 기능을 잘 수행할 수 있도록 제도나 관리 이년 등 측면에서 많이 발전하게 된다고 보일 수 있다. 또한 가족은 기업에 대한 경영지배권이 높을수록 경영성과를 증가할 수 있었다. 그러나 가족의 소유권이 높아지면 경영성과가 상대적으로 하락한다는 것을 활인할 수 있다. 왜냐하면 오너가 기업의 발전뿐만 아니라 가족목표도 가지고 있다. 그러므로 가족의 발전을 위하여 기업의 단기적인 재무성과를 포기할 가능성도 있기 때문이다.

关于贵州发展乡村旅游的几点思考

Wu Qian,이숙영,정건섭 한국비교정부학회 2008 한국비교정부학보 Vol.12 No.1

The domestic and international growth of rural tourism is remarkable and it continues to grow steadily. The characteristic of rural and ecological tourism is very different from mass tourism. This paper focuses on the entry point for the development of Guizhou rural tourism in China. First of all, we analyze the advantages of the rural tourism development in Guizhou. Secondly, we descript the existing problems of development. Finally, we made the countermeasures and suggestions with the development of rural tourism in Guizhou; i.e., they are supporting the sound system, improving the level of service value, improving the developing environmental requirements, and brewing the culture of brand equity. In order to achieve rural tourism efficiently, attention and supports by central and local governments are required and local community participation is needed. The domestic and international growth of rural tourism is remarkable and it continues to grow steadily. The characteristic of rural and ecological tourism is very different from mass tourism. This paper focuses on the entry point for the development of Guizhou rural tourism in China. First of all, we analyze the advantages of the rural tourism development in Guizhou. Secondly, we descript the existing problems of development. Finally, we made the countermeasures and suggestions with the development of rural tourism in Guizhou; i.e., they are supporting the sound system, improving the level of service value, improving the developing environmental requirements, and brewing the culture of brand equity. In order to achieve rural tourism efficiently, attention and supports by central and local governments are required and local community participation is needed.