The ERCC1 C118T Polymorphism Predicts Clinical Outcomes of Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Meta-analysis Based on 22 Studies

Qian, Ying-Ying,Liu, Xin-You,Wu, Qian,Song, Xian,Chen, Xiao-Feng,Liu, Yi-Qian,Pei, Dong,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1) C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, the conclusions are conflicting. Therefore, we performed the present meta-analysis to determine the precise role of the ERCC1 C118T polymorphism in this clinical situation and help optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were used to estimate objective response and oxaliplatin-induced toxicity, with hazard ratios (HRs) with 95%CIs for progression-free survival (PFS) and overall survival (OS). Results: A total of 22 studies including 2,846 CRC patients were eligible in the analysis. Overall, no significant correlation was found between the ERCC1 C118T polymorphism and objective response to oxaliplatin-based chemotherapy, in all patients or in the Asian and Caucasian subgroups. However, the pooled analysis showed that the PFS and OS were significantly shorter in patients who carried T/T or T/C genotypes of ERCC1 C118T as compared to the C/C genotype. On stratified analysis by ethnicity, the ERCC1 118T allele was associated with a favorable prognosis in Caucasians (PFS, HR=0.58, 95%CI: 0.24-1.44; OS, HR=0.38, 95%CI: 0.22-0.64) but an unfavorable prognosis in Asians (PFS, HR=2.49, 95%CI: 1.87-3.33; OS, HR=2.63, 95%CI: 1.87-3.69) based on a dominant model. In addition, we failed to find a statistically significant impact of ERCC1 C118T polymorphism on oxaliplatin-induced toxicity. Conclusions: The ERCC1 C118T polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

A study on the modified Hough algorithm for image processing in weld seam tracking

Qian-Qian Wu,이종표,박민호,진병주,김도형,박철균,김일수 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.11

Nowadays, automatic Gas metal arc (GMA) welding is receiving a growing attention for its fast production speed and wide-rangingversatility. Furthermore, automatic and robotic welding systems are urgently needed for general application, which depends on the realizationof auto-weld seam tracking. Seam tracking system allows for not only robot or machine trajectory shifts, but also adaptive controlto change weld bead formation, making further improvement on the weld quality. Based on the laser vision system, this study aims fordevelopment of an image processing by the modified Hough algorithm which applied for seam tracking system in GMA welding. Toachieve this objective, image features in the procedure of welding processing were discussed and specially treated. Algorithms in theimage processing were investigated to maximize the processing effect based on the modified Hough algorithm, which was quite costefficientin line detection. Quantitative evaluations of the used algorithm were set up to acquire optimal image processing algorithm. Finally, a common image processing method was employed to verify efficiency of proposed image processing and extract the weldinglocation in a shorten time for industrial application. It can be concluded the detected feature points and centerlines proved that this algorithmcan be used for automatic GMA welding process as well as industrial applications.

A Study on Development of the Optimal Neural Network in GMA Welding Process

Wu, Qian Qian,Lee, Ji Hye,Lee, Jong Pyo,Park, Min Ho,Kim, Young Su,Kim, Ill Soo Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.936 No.-

<P>Gas Metal Arc (GMA) welding is considered as a multi-parameter process that it’s hard to find optimal parameters for good welding. To overcome the problem, an artificial neural network based on the backpropagation algorithm was built to realize the relationships between process parameters and welding quality as output parameter. In this study, Mahalanobis Distance (MD) was employed to evaluate the availability of a given welding parameters which was proved to performance well in multivariate statistics. Input parameters such as welding current and arc voltage were chosen due to their significant influence on the welding quality. To improve the precision of given parameters’ evaluation, neural networks with different configurations were verified. The analyses on the measured and predicted MD by the proposed neural network were conducted. The proposed neural network based on the error backpropogation algorithm was proved to have high reliability to evaluate process parameters, which further makes it available in on-line monitoring system.</P>

Preparation and Characterization of Acid and Pepsin-soluble Collagens from Scales of Croceine and Redlip Croakers

Qian-Qian Wu,Tao Li,Bin Wang,Guo-Fang Ding 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6

Acid-soluble (ASC) and pepsin-soluble collagen (PSC) from scales of croceine croaker (ASCPC and PSC-PC) and redlip croaker (ASC-PP and PSC-PP) were prepared with yields of 0.37±0.08% (ASCPC), 1.09±0.23% (PSC-PC), 0.42±0.09% (ASC-PP), and 1.14±0.30% (PSC-PP) (dry scale basis). Gly (347.1- 359.8 residues/1,000 residues) was the major amino acid. Contents of imino acid were between 189.4 and 192.9 residues/1,000 residues in all 4 collagens. ASC-PC and ASC-PP were type I collagens. Differences in subunit components between ASC and PSC were observed. Denaturation temperature values of ASC-PC, ASC-PP, PSC-PC, and PSC-PP were 30.7, 30.1, 27.5, and 26.6℃, respectively. All 4 collagens were soluble at pH 1-4. Values declined when NaCl concentrations exceeded 2%. Freeze-dried collagens showed loose, fibrous, and porous structures. The 4 scale collagens can be alternatives to collagen from terrestrial animals for applications in functional food, cosmetic, and biomedical industries.

Incidence and Mortality of Female Breast Cancer in Jiangsu, China

Wu, Li-Zhu,Han, Ren-Qiang,Zhou, Jin-Yi,Yang, Jie,Dong, Mei-Hua,Qian, Yun,Wu, Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Objectives: The aim of this study was to describe and analyze the incidence and mortality of female breast cancer in Jiangsu Province of China. Methods: Incidence and mortality data for female breast cancer and corresponding population statistics from eligible cancer registries in Jiangsu from 2006 to 2010 were collected and analyzed. Crude rates, age-specific rates and age-standardized rates of incidence and mortality were calculated, and annual present changes (APCs) were estimated to describe the time trends. Results: From 2006 to 2010, 11,013 new cases and 3,068 deaths of female breast cancer were identified in selected cancer registry areas of Jiangsu. The annual average crude incidence and age-standardized incidence by world population (ASW) were 25.2/ and 17.9/100,000 respectively. The annual average crude and ASW for mortality rates were 7.03/ and 4.81/100,000. The incidence was higher in urban areas than that in rural areas, and this was consistent in all age groups. No significant difference was observed in mortality between urban and rural areas. Two peaks were observed when looking at age-specific rates, one at 50-59 years and another at over 85 years. During the 5 years, incidence and mortality increased with APCs of 4.47% and 6.89%, respectively. Compared to the national level, Jiangsu is an area with relatively low risk of female breast cancer. Conclusion: Breast cancer has become a main public health problem among Chinese females. More prevention and control activities should be conducted to reduce the burden of this disease, even in relatively low risk areas like Jiangsu.

Stigma and Efficacy of Zhizhu Kuanzhong Capsules Versus Doxepin in the Treatment of Refractory Functional Dyspepsia: A Randomized Controlled Trial

Qian-Qian Wang,Li Cheng,Bi-Yu Wu,Hong-Yi Qiu,Ping Xu,Bo Wang,Xiu-Juan Yan,Sheng-Liang Chen 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.3

Background/AimsStigma related with antidepressants is prevalent in patients with functional dyspepsia. It affects medication compliance and efficacy. Herbal medicine acquired a deep-rooted cultural identity in relieving dyspeptic symptoms in Asians. The research was designed to compare the effectiveness of Zhizhu Kuanzhong capsules (ZZKZ) versus doxepin hydrochloride (doxepin) on alleviating stigma and medication nonadherence among patients with refractory FD (rFD). MethodsPatients with rFD from February 2021 to February 2022 were randomly allocated to receive either doxepin (n = 56) or ZZKZ (n = 57) combined with omeprazole for 4 weeks. Medication possession ratio (MPR), the disease- and medication-associated stigma were analyzed. The scales were utilized to assess dyspeptic symptoms (Leeds Dyspepsia Questionnaire) and psychological conditions (Generalized Anxiety Disorder Questionnaire and Patient Health Questionnaire). ResultsThe MPR values for ZZKZ were significantly higher than those for doxepin (P < 0.001). The stigma scores decreased in ZZKZ group while increased in doxepin group compared to baseline after treatment. The proportion of patients showing ZZKZ-associated stigma was significantly lower than doxepin-associated stigma (P < 0.001). The MPR values were negatively correlated with post-treatment stigma scores in both groups (P < 0.001). Dyspeptic symptoms and psychological condition were improved in both groups after treatment, with no significant difference on post-treatment Leeds Dyspepsia Questionnaire, Generalized Anxiety Disorder Questionnaire, or Patient Health Questionnaire scores between 2 groups. ConclusionZZKZ is superior to doxepin in alleviating stigma and medication non-adherence, with comparable efficacy in improving dyspeptic symptoms and psychological condition of patients with rFD.

Thermospheric Wind Observation and Simulation during the Nov 4, 2021 Geomagnetic Storm Event

Qian Wu,Dong Lin,Wenbin Wang,William Ward 한국우주과학회 2022 Journal of Astronomy and Space Sciences Vol.39 No.3

Thermospheric wind observations from high to mid latitudes are compared with the newly developed Multiscale Atmosphere Geospace Environment (MAGE) model for the Nov 3–4 geomagnetic storm. The observation and simulation comparison shows a very good agreement and is better at high latitudes in general. We were able to identify a thermospheric poleward wind reduction possibly linked to a northward turning of the Interplanetary Magnetic Field (IMF) at ~22 UT on Nov 3 and an enhancement of the poleward wind to a southward turning near 10 UT on Nov 4 at high latitudes. An IMF southward turning may have led to an enhancement of equatorward winds at Boulder, Colorado near midnight. Simultaneous occurrence of aurora may be associated with an IMF By turning negative. The MAGE model wind simulations are consistent with observations in these cases. The results show the model can be a very useful tool to further study the magnetosphere and ionosphere coupling on short time scales.

Thermospheric Wind Observation and Simulation during the Nov 4, 2021 Geomagnetic Storm Event

Wu, Qian,Lin, Dong,Wang, Wenbin,Ward, William The Korean Space Science Society 2022 Journal of astronomy and space sciences Vol.39 No.3

Thermospheric wind observations from high to mid latitudes are compared with the newly developed Multiscale Atmosphere Geospace Environment (MAGE) model for the Nov 3-4 geomagnetic storm. The observation and simulation comparison shows a very good agreement and is better at high latitudes in general. We were able to identify a thermospheric poleward wind reduction possibly linked to a northward turning of the Interplanetary Magnetic Field (IMF) at ~22 UT on Nov 3 and an enhancement of the poleward wind to a southward turning near 10 UT on Nov 4 at high latitudes. An IMF southward turning may have led to an enhancement of equatorward winds at Boulder, Colorado near midnight. Simultaneous occurrence of aurora may be associated with an IMF By turning negative. The MAGE model wind simulations are consistent with observations in these cases. The results show the model can be a very useful tool to further study the magnetosphere and ionosphere coupling on short time scales.

Soybean GmAOC3 promotes plant resistance to the common cutworm by increasing the expression of genes involved in resistance and volatile substance emission in transgenic tobaccos

Qian Wu,Hui Wang,Juanjuan Wu,Dagang Wang,Yongli Wang,Lei Zhang,Zhiping Huang,Deyue Yu 한국식물학회 2015 Journal of Plant Biology Vol.58 No.4

The evaluation and use of endogenous soybean genes is an effective strategy to minimize the yield losses caused by insects. Allene oxide cyclase (AOC) catalyzes the most important step in the biosynthesis of jasmonate (JA), which plays a crucial role in plant defense against insects. In this study, the role of GmAOC3 in plant insect resistance was evaluated. Real-time PCR results indicate that GmAOC3 was uniquely and rapidly activated and attained peak expression in leaves after attack by the common cutworm (CCW). In insect bioassays, transgenic lines overexpressing GmAOC3 were significantly less damaged than wild-type plants, and the relative growth rate of CCW fed with leaves from transgenic lines was significantly lower than that of CCW fed with leaves from wild-type plants. Electron microscopy revealed that the density of leaf trichomes in transgenic lines overexpressing GmAOC3 was greater than that in wild-type tobacco. Several physiological and morphological indicators, including JA, phenolic content and the relative expression levels of the putrescine N-methyltransferase (PMT) and proteinase inhibitor (PI) genes, phenylalanine ammonia lyase (PAL) activity and volatile substances, increased in the transgenic plants overexpressing GmAOC3. Our findings indicate that GmAOC3 plays an important role in soybean resistance to CCW and can be used as a resource for plant breeding.

중국 가족기업의 지배구조가 경영성과에 미치는 영향: 상장된 제조업인 가족기업 대상으로

QIAN WU,남영호 글로벌경영학회 2018 글로벌경영학회 학술대회 발표논문집 Vol.2018 No.1

본 연구는 가족의 지배구조, 기업의 지배구조와 경영성과 간의 관계를 살펴보는 게 본 논문의 목적이다. 가족기업은 가족과 기업의 근간이므로 일반기업과 다른 가족목표도 갖고 있으며, 가족 기업의 지배구조는 일반기업과의 차이가 될 수도 있다. 본 연구에서 가족기업의 지배구조는 기업의 지배구조와 가족의 지배구조를 나누어 경영성과에 대한 관계를 고찰하였다. 본 연구는 위의 연구목적을 달성하기 위해, 상해·심천증권거래소 사이트와 CSMAR(国泰安) 금융데이터베이스를 통해 중국에서 A주 상장된 가족기업에 관한 데이터를 수집하였다. 우리 잘 알다시피 중국은 제조업 강한 국가이며, 2016년도에 A주 상장된 가족기업 수가 1022개인데 제조업에 속한 가족기업이 700개 넘게 나왔다. 그러므로 본 연구는 A주 상장된 제조업에 속한 가족기업 대상으로 연구하였다. 그 중 ST 기업, PT기업, 자료를 수집하지 못 하는 기업을 제외해서 704개 기업을 최종적으로 정하였다. 그리고 가설을 검증하기 위한 실증분석은 SPSS18.0을 사용하여 실시하였다. 연구결과, 기업의 지배구조인 이사회 규모와 사외이사 수는 기업의 매출액과 당기순이익에 유의한 정(+)의 영향을 끼쳤다. 또한 가족의 지배구조인 경영지배권은 기업의 매출액과 당기순이익에 유의한 정(+)의 영향을 끼쳤지만, 가족의 지배구조인 소유권은 기업의 매출액과 당기순이익에 부 (-)의 영향을 끼쳤다는 것을 검증하였다. 결론적으로, 가족기업에서 이사회와 사외이사의 감시 기능을 잘 수행할 수 있도록 제도나 관리 이년 등 측면에서 많이 발전하게 된다고 보일 수 있다. 또한 가족은 기업에 대한 경영지배권이 높을수록 경영성과를 증가할 수 있었다. 그러나 가족의 소유권이 높아지면 경영성과가 상대적으로 하락한다는 것을 활인할 수 있다. 왜냐하면 오너가 기업의 발전뿐만 아니라 가족목표도 가지고 있다. 그러므로 가족의 발전을 위하여 기업의 단기적인 재무성과를 포기할 가능성도 있기 때문이다.