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황인조,한근혁,최형욱,김동술,김신도 경희대학교 환경연구소 2001 環境硏究 論文集 Vol.10 No.-
The various existing situations like overpopulation, urbanization, industrialization, and heavy traffic volume in the Seoul metropolitan area have led to the air pollution problem, traffic problem, and increase in opportunities of residing underground place. So, recently in Korea, the residents using underground working place have been of great concerns on indoor air pollutants such as HCHO, radon, particulate matter, carbon monoxide. However, the studies on indoor air pollution have been not extensively conducted in Korea. Indoor radon is an odorless, colorless, tasteless, invisible, inert, and naturally occurring radioactive gas. And it has been known as one of the notorious carcinogens. The purpose of this study was to survey the concentration variations of radon in the subway stations located Seoul metropolitan area. Total of 216 subway stations were surveyed by the continuous radon monitors from Mar. 2001 to Jun. 2001. The study showed that average radon levels of concourses in each line were 1.51, 1.45, 1.51, 1.23, 1.28, 1.37, 1.12, 1.28 pCi/L and those of platforms in each line were 2.09, 1.43, 1.37, 1.67, 1.44, 1.54, 1.40, 1.22 pCi/L, respectively. The study results showed that the average radon concentrations were 1.19 pCi/L in outdoor, 1.34 pCi/L in concourse, and 1.52 pCi/L in platform, respectively.
Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예
남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.
Shin, Wook-Geun,Testa, Mauro,Kim, Hak Soo,Jeong, Jong Hwi,Lee, Se Byeong,Kim, Yeon-Joo,Min, Chul Hee IOP 2017 Physics in medicine & biology Vol.62 No.19
<P>For the independent validation of treatment plans, we developed a fully automated Monte Carlo (MC)-based patient dose calculation system with the tool for particle simulation (TOPAS) and proton therapy machine installed at the National Cancer Center in Korea to enable routine and automatic dose recalculation for each patient. The proton beam nozzle was modeled with TOPAS to simulate the therapeutic beam, and MC commissioning was performed by comparing percent depth dose with the measurement. The beam set-up based on the prescribed beam range and modulation width was automated by modifying the vendor-specific method. The CT phantom was modeled based on the DICOM CT files with TOPAS-built-in function, and an in-house-developed C++ code directly imports the CT files for positioning the CT phantom, RT-plan file for simulating the treatment plan, and RT-structure file for applying the Hounsfield unit (HU) assignment, respectively. The developed system was validated by comparing the dose distributions with those calculated by the treatment planning system (TPS) for a lung phantom and two patient cases of abdomen and internal mammary node. The results of the beam commissioning were in good agreement of up to 0.8 mm<SUP>2</SUP> <img ALIGN='MIDDLE' ALT='${\rm g}^{-1}$ ' SRC='http://ej.iop.org/images/0031-9155/62/19/7598/pmbaa8663ieqn001.gif'/> for B8 option in both of the beam range and the modulation width of the spread-out Bragg peaks. The beam set-up technique can predict the range and modulation width with an accuracy of 0.06% and 0.51%, respectively, with respect to the prescribed range and modulation in arbitrary points of B5 option (128.3, 132.0, and 141.2 mm<SUP>2</SUP> <img ALIGN='MIDDLE' ALT='${\rm g}^{-1}$ ' SRC='http://ej.iop.org/images/0031-9155/62/19/7598/pmbaa8663ieqn002.gif'/> of range). The dose distributions showed higher than 99% passing rate for the 3D gamma index (3 mm distance to agreement and 3% dose difference) between the MC simulations and the clinical TPS in the target volume. However, in the normal tissues, less favorable agreements were obtained for the radiation treatment planning with the lung phantom and internal mammary node cases. The discrepancies might come from the limitations of the clinical TPS, which is the inaccurate dose calculation algorithm for the scattering effect, in the range compensator and inhomogeneous material. Moreover, the steep slope of the compensator, conversion of the HU values to the human phantom, and the dose calculation algorithm for the HU assignment also could be reasons of the discrepancies. The current study could be used for the independent dose validation of treatment plans including high inhomogeneities, the steep compensator, and riskiness such as lung, head & neck cases. According to the treatment policy, the dose discrepancies predicted with MC could be used for the acceptance decision of the original treatment plan.</P>
Shin, Myung-Geun,Levin, Barbara C.,Kim, Hyeoung-Joon,Kim, Hye-Ran,Lee, Il-Kwon,Cho, Duck,Jung Kee, Seung,Shin, Jong-Hee,Suh, Soon-Pal,Ryang, Dong-Wook WILEY-VCH Verlag 2006 Electrophoresis Vol.27 No.7
<P>The length heteroplasmies in the hypervariable (HV) regions of mitochondrial DNA (mtDNA) from blood cells were examined in 57 healthy Korean donors. Interestingly, all the healthy Korean subjects displayed length heteroplasmies in both the HV1 and HV2 regions. Closer examination of the HV2 length heteroplasmies indicated that most of these donors (84%) exhibited a minimal 303–315 homopolymeric C (poly-C) tract frameshift of 1 bp (mixture of one major and minor mtDNA type). Sixteen percent of the donors however had poly-C tract frameshifts of 2 bp or more. The donor group with major length variants (two or more frameshifts) had about a two-fold decrease in mtDNA copy number compared with the group exhibiting only a 1 bp frameshift. This result supports the possibility that a severe frameshift in the 303–315 poly-C tract may also cause the impairment of mtDNA replication in hematopoietic tissue.</P>
Shin, Wook-Geun,Lee, Hyun-Cheol,Choi, Chang-Il,Park, Chang Soo,Kim, Hong-Suk,Min, Chul Hee Elsevier 2015 Applied radiation and isotopes Vol.101 No.-
<P><B>Abstract</B></P> <P>Nuisance and false alarms due to naturally occurring radioactive material (NORM) are major problems facing radiation portal monitors (RPMs) for the screening of illicit radioactive materials in airports and ports. Based on energy-weighted counts, we suggest an algorithm that distinguishes radioactive nuclides with a plastic scintillation detector that has poor energy resolution. Our simulation study, using a Monte Carlo method, demonstrated that man-made radionuclides can be separated from NORM by using a conventional RPM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Radiation portal monitor using plastic scintillator was modeled and the energy spectra of six radionuclides were assessed. </LI> <LI> Energy-weighted algorithm which enables radionuclide analysis with plastic scintillator was suggested and evaluated. </LI> <LI> The cases of moving and shielding effect were evaluated and simultaneous radionuclide identification was carried out. </LI> <LI> Analysis of the simulated spectra with suggested method shows clear results to enable the radionuclide identification. </LI> </UL> </P>
Shin Wook-Geun,Lee Sung Young,진형민,Kim Jeongho,Kang Seonghee,Kim Jung-in,정성문 대한방사선방어학회 2022 방사선방어학회지 Vol.47 No.3
Background: The hemi-body electron beam irradiation (HBIe–) technique has been proposed for the treatment of mycosis fungoides. It spares healthy skin using an electron shield. However, shielding electrons is complicated owing to electron scattering effects. In this study, we devel- oped a thimble-like head bolus shield that surrounds the patient’s entire head to prevent irradia- tion of the head during HBIe–. Materials and Methods: The feasibility of a thimble-like head bolus shield was evaluated using a simplified Geant4 Monte Carlo (MC) simulation. Subsequently, the head bolus was manufac- tured using a three-dimensional (3D) printed mold and Ecoflex 00-30 silicone. The fabricated head bolus was experimentally validated by measuring the dose to the Rando phantom using a metal-oxide-semiconductor field-effect transistor (MOSFET) detector with clinical configura- tion of HBIe–. Results and Discussion: The thimble-like head bolus reduced the electron fluence by 2% com- pared with that without a shield in the MC simulations. In addition, an improvement in fluence degradation outside the head shield was observed. In the experimental validation using the in- house-developed bolus shield, this head bolus reduced the electron dose to approximately 2.5% of the prescribed dose. Conclusion: A thimble-like head bolus shield for the HBIe– technique was developed and vali- dated in this study. This bolus effectively spares healthy skin without underdosage in the region of the target skin in HBIe–.