만성경과의 폐렴을 동반한 기관지결석증 1례

황석순,이헌영,전석구,남계윤,전영준 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

Broncholithiasis has been recognized in medicall literature for centuries. Because of the relative infrequency, broncholithiasis has often been neglecteed in the differential deagnosis of bronchial obstruction. In this case, we could remove the broncholith obstructing the right middle lobar bronchus with the fiberoptic bronchoscope in a 37-year old man without any complications and the complete resolution of the pneumonia was followed.

회분식 반응기에서 무수말레인산과 알킬메타크릴레이트의 공중합속도론

설수덕,황준호,김남석 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

Radical copolymerization of maleic anhydride with methylmethacrylate, ethyl methacrylate was carried out in a Batch reactor. Solvent and initiator used were n,n-dimethylformamide and AIBN, repectavely. Reaction volume was 500 litters, polymerization time 10 hours and polymerization temperature 60∼80℃. The copolymerization conversions were analyzed by FT-IR, EA, GPC, and confirmed by measuring the solid weights of copplymers obtained after evaporating solvent. The monomer reactivity ratio were determined by the Kelen-T ds method.

무수말레인산과 메틸메타크릴레이트의 공중합 및 열분해속도에 관한 연구

설수덕,김남석,황준호 東亞大學校 大學院 1997 大學院論文集 Vol.22 No.-

Radical copolymerization of maleic anhydride with methylmethacrylate was carried out in a Batch reactor. Solvent and initiator used were n,n-dimethylformamide and AIBN, respectively. Reaction volume was 500 litters, polymerization time 6 hours and polymerization temperature 60~90℃. The copolymerization conversions were analyzed by FT-IR, UV, viscometer, and confirmed by measuring the solid weights of copymers obtained after evaporating solvent. The monomer reactivity ratios were determined by the Kelen T?d?s method.

적응제어 개념을 이용한 GP-PID 제어기에 관한 연구

김종만,설남오,이재석,황인갑 전주대학교 공학연구소 1997 전주대학교 공학기술종합연구소 학술논문집 Vol.3 No.1

New Adaptive PID controller which has the same structure as a generalized predictive control is proposed. The proposed controller can perform better that the conventional PID controller because it includes intrinsic delay-time compensator. The PID tuning parameters and delay-time compensator are calculated by equating the two degrees of freedom PID to a linear form of GPC. The proposed controller is combined with a supervisor for safe start and self-tuning. The proposed controller has been tested for various numerical models and an experimental stirred tank heater. As a result, the proposed controller has a satisfactory performance for variable delay as well as stochastic disturbance and the characteritics of the real time- process control.

근관 전색재의 방사선 불투과성에 관한 비교연구

김태민,김서경,황인남,황윤찬,강병철,윤숙자,이재서,오원만 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

This study was performed to assess the radiopacity of a variety of root canal sealers according to the Specification concerning root canal sealers. Ten materials including Tubli-Seal™, Kerr Pulp Canal Sealer™, AH 26^(R), AH plus^(R), AH plus jet™, Ad seal™, Sealapex™, NOGENOU™, ZOB seal™, Epiphany™, and dentin were evaluated in this study. In the first part. densitometric reading of an each step of aluminum step wedge on occlusal film was performed at different voltage and exposure time. In the second part, ten specimens were radiographed simultaneously with an aluminum step wedges on the occlusal films under decided condition. The mean radiographic density values of the materials were transformed into radiopacity expressed equivalent thickness of aluminum (mm Al). The following results were obtained 1 Among the various conditions, the appropriate voltage and exposure time that meet the requirement density was 60 kVp at 0.2 s 2 All of the materials had greater radiopacity than 3 mm Al requirement of ANSI/ADA specification No. 57 (2000) and ISO No. 6876 (2001) standards. 3 The radiopacity of materials increased as thickness of materials increased. 4 The mm Al value of each specimen at 1mm in thickness has a significant difference in the statistics. It suggests that root canal sealers have a sufficient radiopacity that meet the requirement. 다양한 근관전색제는 방사선 사진상 주위 해부학적 구조와 구별될 만한 방사선 불투과성을 나타내야 한다 따라서 이런 물질들이 근관에 충전될 때의 방사선 불투과성 정도를 평가해야 할 필요성이 대두되고 있다. 본 실험에서는 다양한 근관전색제들의 방사선 불투과성을 평가하고자, 방사선 노출조건에 따른 aluminium step wedge에 대한 광학 밀도를 알아보고, 그 중 적절한 노출조건을 선택하여 수종의 근관 전색재의 방사선 불투과성 정도를 알루미늄 두께로 환산하여 비교해 보고자 한다. 방사선 불투과성의 기준을 위해 11개의 step으로 구성된 aluminum step wedge을 사용하여, 60kVP, 70kVp관전압 상태에서 각각 0.2, 0.3, 0.4초 그리고 0.2, 0.3, 0.33초의 꼭 노출시간으로 교합필름상에서 방사선 촬영후 적절한 노출 조건을 구하였다. 직경 5mm 각각의 두께 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 mm인 10종 (Tubli-Seal™, Kerr pulp Canal Sealer™, AH26^(R), AHplus^(R), AH plus jet starter kit™, Ad seal™, Sealapex™, Nogenol root canal sealer™, ZOB seal™, Epiphany™)의 근관전색재 시편을 각 재료와 두께당 10개씩 제작한 후, 동일한 두께의 상아질 시편, aluminum step wedge와 함께 정해진 노출시간에 따라 방사선 촬영을 하였다. 모든 필름은 자동현상기로 현상하였다. 시편의 방사선 흑화도를 densitometer로 5회 반복 측정 후, 평균값을 구하여 알루미눔 두께로 환산하였다.얻어진 정보를 분석하여 다음의 결과를 얻었다. 1 관전압 60 kVp에서 노출시간 0.2, 0.3, 0.4초, 70 kVp에서 0.2, 0.3, 0.33초로 변화를 주어 방사선 촬영을 하였을 때 흑화도가 ISO No. 6876 규격에 가장 적합한 것은 60 kVP, 0.2초 일 경우였다. 2 측정된 근관 전색제의 방사선 불투과성은 2.29 mm Al (N0GEN0L)로부터 13.69 mm Al (AH Plus jet)까지 다양하게 나타났으나, 모두 ANSI/ADA specification (2000) 또는 ISO No. 6876 (2001) 규격이 제시한 최소한 3mm Al 이상의 방사선 불투과성을 지녀야 한다는 기준에 적합하였다. 3 재료의 두께가 증가할수록 방사선 불투과성은 증가하지만, 정비례하지는 않았다. 4 각 실험재료의 1 mm 두께의 시편에 대한 mm Al값들은 통계적으로 유의한 차이가 있었다. 이상의 결과는 본 실험에 사용된 수종의 근관 전색재는 모든 규격에 적합한 방사선 불투과성을 가지고 있음을 시사한다.

Profile^(Ⓡ), ProTaper™ 및 K^(3TM) Ni-Ti파일의 과기구 조작이 치근단공 변위에 미치는 영향

양현,양인석,황윤찬,황인남,윤숙자,김원재,오원만 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.2

본 연구는 ProFile, ProTaper 및 K^(3)를 이용하여 과잉 기구 조작에 의해 근관 성형 시 근관의 만곡형태와 Ni-Ti 파일의 종류에 따라 치근단공이 어떻게 변위 되는지를 비교 분석하고자 시행되었다. 본 실험에서는 레진모형근관으로 J자와 S자의 근관 형태가 재현된 ENDO-TRAINING BLOC을 사용하였다. 근관 성형 기구로는 ProFile^(®), ProTaper™, K^(3TM)를 사용하였다. 총 60개의 레진모형근관을 사용하였으며, 사용된 레진모형근관 및 Ni-Ti 파일의 종류에 따라 10개씩 6개의 군으로 나누어 근관성형을 시행하였다. 근관 성형 전·후 이미지를 Image-analyzing microscope 100X를 이용하여 얻고 Photoshop 7.0 프로그램을 이용하여 중첩하였다. 이미지 분석 프로그램을 이용하여 근관 성형 전·후 치근단공의 중심으로부터의 직경 변화량과 면적을 측정한 결과 만곡된 근관의 성형시 치근단공이 주로 만곡의 외측으로 변위됨을 나타내며 ProFile이 ProTaper나 K^(3) 보다 통계적으로 유의성이 있게 작은 변화량을 나타내어 근관성형시 바람직한 기구임을 시사한다. This study was done to evaluate transportation of the apical foramen after 0.5 mm overinstrumentation by ProFile, ProTaper and K^(3) in simulated resin root canal. Sixty simulated resin root canal with a curvature of J and S-shape were divided into two groups. Each group consisted of three subgroups with 10 blocks according to the instruments used: ProFile^(®), ProTaper™, and K^(3TM). Simulated resin root canal was prepared by ProFile, ProTaper and K^(3) with 300 rpm by the crown-down preparation technique. Pre- and post-instrumentation apical foramen images were overlapped and recorded with Image-analyzing microscope 100X (Camcope, Sometech Inc, Korea). The amounts of difference in width and dimension on overlapped images were measured after reference points were determined by Image Analysis program (Image-Pro^(®) Express, Media Cybernetic, USA). Data were analyzed using Kruskal-Wallis and Mann-Whitney U-test. The results suggest that ProFile showed significantly less canal transportation and maintained original apical foramen shape better than K^(3) and ProTaper.

도.토기의 과학적 분석-경상남도 도요지 출토 토기편을 중심으로

홍종욱,조남철,황진주,문환석,Hong, Jong-Ouk,Cho, Nam-Chul,Hwang, Jin-Ju,Moon, Whan-Suk 국립문화재연구소 2001 保存科學硏究 Vol.22 No.-

The scientific analysis and provenance study of potteries excavated from kiln site at Gyeongsang Nam-do were carried out using XRD, ICP-AES and NAA. We can summary the following Result :1. As a result of XRD analysis, it showed that soft potteries consisted of quartz, feldspar and clay minerals while hard potteries consisted of high temperature crystals such as mullite, tridymite, cristobalite.In case of firing temperature which are determined by XRD, potteries consisted of quartz, feldspar and clay mineral had very low firing temperature. While potteries having only cristobalite ranged above $1200^{\circ}C$.2. As a result of correlation analysis using trace element, the selected characteristic elements which was able to distinguish from each kiln site was Sm, Cs, Sc, Eu, Hf.3. Discriminant analytical showed that each kiln site were classified into 4-gruops;Kimhaeci Daesungdong, Hamangun Myosari, Changyounggun Yochori and one group mixed KimhaeciGuosandong, Kimhaeci Samgyeri. This suggests that there are no correlations between the raw materials used in each kiln sites except Kimhaeci Guosandong, Kimhaeci Samgyeri.

Genetic Polymorphisms of p53 Tumor Suppressor Gene in Korean Population

Hwang, Hye Suk,Hwang, Jung Hee,Shin, Sang Hee,Kim, Hyun Sup,Kim, Nam Keun,Kim, Se Jae,Chung, Ki Wha 공주대학교 자원재활용 신소재 연구센터 2002 센터사업 성과집 Vol.- No.1

Mutations in the p53 tumor suppressor gene are frequently found in many different forms of human cancers, the majority of which are missense mutations which alter the DNA-binding property and transcriptional activity of the product. In the present study, three p53 restriction fragment length polymorphisms(BstUI RFLP in exon 4, MspI RFLP in intron 6 and TaqI RFLP in exon 6) were examined in 154 controlled studies and 57 patients with cerical cancer from the Korean population. The A1 allele frequencies of BstUI and MspI RELPs in controlled studies were 0.395 and 0.029, respectively. The TaqI RELP sites (codon 213 polymorphism) were, however, monomorphic in the Korean population. The genotype distributions of BstUI and MspI polymorphic sites between control and patient groups well agreed upon with the Hardy-Weinberg equilibrium(BstUI RFLP: x^2 = 1.468, p=0.480; MspI RFLP: x^2 = 0.209, p= 0.647), which suggested that three RFLPs have no relevance to the susceptibility of cervical cancer development. This study showed that the allele frequencies of BstUI and MspI RFLPs in Korean populations are significantly different from other ethnic populations. Thus, it seems that the p53 polymorphisms are useful for the studies of human population genetics and anthropology.

Thr-6Pro missense mutation in human lysosomal acid lipase (LAL) gene in patients with familial hypercholesterolemia in Korea

Hwang, Hye-Suk,Hwang, Jung-Hee,Kim, Hyun-Sup,Kim, Nam-Keun,Kim, Se-Jae,Lee, Chung-Choo,Chung, Ki-Wha Korean Society of Medical Genetics 1998 대한의학유전학회지 Vol.2 No.2

Lysosomal acid lipase (LAL) plays a central role in the intracellular degradation of neutral lipids derived from plasma lipoproteins. In this study, we investigated the missense mutation within exon 2 of human LAL gene changing of codon -6 of prepeptide from threonine to proline. The Thr-6Pro mutation was detected by the HaeIII restriction fragment length polymorphism (RFLP) and single-strand conformation polymorphism (SSCP). We analyzed the mutation in subjects with 221 unrelated randomly selected control samples and 86 patients with familial hypercholesterolemia (FH) in Korea. We observed that mutation is present with high frequency in Korea compared to other populations studied previously. The frequency of PP homozygote in the FH group was observed considerably higher than that of control. However, there was no significant difference of genotype frequency between two groups. These results, together with the fact that plasma lipids and lipoproteins levels between genotypes showed no statistical difference, suggest that the Thr-6Pro mutation in the LAL gene may have no association with the increased risk of FH development.

흰쥐의 뇌조직에서 Protease Inhibitor Nexin - 1 과 N - Methylpurine - DNA Glycosylase 유전자 발현연구

김남근(Nam Keun Kim),황태선(Tae Sun Hwang),김남일(Nam Il Kim),강원석(Won Suk Kang),안정용(Jung Yong Ahn),오도연(Do Yeun Oh),황성규(Seong Gyu Hwang),김병성(Byung Sung Kim),고정재(Jung Jae Ko),(Ki Wha Chung) 한국유전학회 2001 Genes & Genomics Vol.23 No.4

Protease nexin-1(PN-1) is a potent thrombin inhibitor that is identical to the glia-derived neurite promoting factor or glia-derived nexin. It also plays a role in regulating proteolytic activity of plasminogen activator(PA) system. PN-1 is known to be involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. The multifunctional mammalian N-methylpurine-DNA glycosylase(MPG) is responsible for the DNA repair of alkylating damages. In this study, we examined regional differences of PN-1 and MPG transcript in the adult rat brain. Results show a widespread but heterogeneous patterns of expression. These analyses revealed distinct spatial PN-1 and MPG expression patterns in thalamus, olfactory bulb, midbrain, cerebellum, hippocampus, basal ganglia, septal area, spinal cord, pons, cerebral cortex, pituitary gland and medulla oblongata. Interestingly, PN-1 and MPG expressions were found in all tested brain regions with about two-fold differences(p>0.05). The differential regulation of PN-1 and MPG expression across different regions of the rat brain suggests multiple roles in tissue homeostasis and DNA damages.