1,2-Benzisothiazol-3-one-1,1-Dioxide 유도체의 합성

정대일,정희철,변석인,이용균,박유미,최순규,한정태 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1

사카린 유도체는 제초제, 항독성, 살균제 등에 광범위하게 연구되어져 오고 있다. 새로운 농략 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-CI) 2와2cholromethy-1,2-benzisohizol-3-one1,1-dioxide 4를 합성하였다. 선도물질, amines, imidazoles, trones등과 반응시켜 다음과 같은 물질들을 얻었다. ; 3-cyclohexylamino-1,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1-dioxide 8, 3-(3-imidazol)-1,2-benzisothiazol-1,1-dioxide 10, 3-(2-methy-3-imidazol)-1,2-benzisothaizol-1,1-dioxide 12, 2-(3-imidazol)methy-1-1,2-benzisothiazol-3-one-1,1-dioxide 13, and 2-(-3-imidazol)methyl- 1,2-benzisothiazol-1,1-dioxide 14.

TiO₂를 이용한 아세틸렌, 프로필렌, 프로판 가스의 광촉매 산화반응

정대일,변석인,이도훈,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2002 硏究報告 Vol.25 No.1

Photocatalyzed degradation of acetylene, propylene, and propane gases were carried out over precoated titanium dioxide(anatase) illuminated UV light in a flow reactor. photocatalytic oxidation of acetylene, propylene, and propane gases respectively indicated high conversion rates (78.0%) to CO₂gas. And photocatalytic oxidation of three gases according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂gas showed.

人蔘이 卵巢摘出로 誘發된 흰쥐의 骨多孔症 예방에 미치는 효능

정국영,서부일,이은숙,변부형,신순식,박지하 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1

Objectives : The present study has been undertaken to investigate the effects of Ginseng Radix on prevention of osteoporosis in ovariectomized rats. Methods : In this experiment, the rats were ovariectomized. Rats were administered by 2 kinds of medicine, Estradiol, Ginseng Radix. The levels of bone mineral density, osteocalcin, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. Results : The levels of spinal bone mineral density was significantly increased in comparison with OVX group at 8 weeks in Ginseng Radix group. The levels of serum didn t show significant change in comparison with OVX group in Ginseng Radix group. The levels of urine deoxypyridinoline showed significant decrease in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial ash weight didn t show significant increase in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial phosphorus showed significant increase in comparison with OVX group in Ginseng Radix group. The levels of body weight didn t show significant changes in comparison with OVX group in Ginseng Radix group. The levels of uterus weight didn t show significant changes in comparison with OVX group in Ginseng Radix group. Conclusions : Reviewing these experimetal results, it appears that Ginseng Radix have efficacy on prevention of osteoporosis. And further study should be conducted to illustrate in depth the curing and prevention of osteoprosis.

젖소 말초혈액 림프구로부터 소백혈병 바이러스 배양 및 전자현미경적 관찰

윤순식,박중원,변재원,강문일,유한상,한홍율 韓國電子顯微鏡學會 2005 Applied microscopy Vol.35 No.1

국내 젖소의 54.2%가 BLV에 감염되어 있지만 현재까지 국내에서는 소백혈병 바이러스 (BLV) 입자를 확인한 연구 보고가 없기 때문에 BLV 항체 양성 소의 말초혈액림프구를 배양, BLV를 발현시켜 전자현미경으로 바이러스 입자를 검출하였고 배양조건에 따른 바이러스 발현율 및 발현 시간을 비교하였다. 검사 결과 전형적인 C-형 바이러스를 확인할 수 있었으며 BLV 단크론 항체를 이용한 면역염색결과 BLV 항원 양성으로 확인되었다. BLV 는 대부분 세포 외부에 분포하고 있었으며 세포질 막에서 생성, 발아되어 나오는 것도 관찰되었다. 전체 바이러스의 크기는 90~100 nm였으며 nucleocapsid는 40~60nm였다. 소태아혈청 (FBS)과 T- 및 B-림프구 분열촉진물질(mitogen)을 각각 첨가하여 배양한 결과 두 군 모두에서 BLV 발현이 확인되었다. Lipopolysaccharide 첨가군은 배양 12시간, Conconavalin A 첨가군은 배양 24시간에 각각 림프구의 10%에서 바이러스가 관찰되었다. 또한 FBS만 첨가한 군과 FBS와 mitogen을 모두 첨가하지 않은 군에서도 관찰되었으나 바이러스의 수는 적었다. 본 연구에서 확립된 BLV 배양 기법을 활용하면 BLV에 감염된 소 중 바이러스를 발현하는 소, 즉 전파능이 있는 개체를 찾아내어 우선적으로 도태할 수 있기 때문에 BLV 감염으로 인한 피해를 막는데 효과적으로 이용될 수 있을 것으로 사료된다. Many studies have been performed on the bovine leukemia virus (BLV) since bovine leukosis had been reported in 1968 in Korea. However, there was no report on the ultrastructural examination of BLV. An attempt to detect C-type viral particles in the cultured peripheral blood lymphocytes of Holstein-Friesian dairy cattle, was made to determine whether in vitro viral expression might be used as a reliable method to identify the cow which is likely to transmit BLV. In transmission electron microscopic (TEM) examination, the virus particles were found predominantly outside of the lymphocytes even though a few particles were also observed within the membrane bound cytoplasmic vacuoles. All of them were C-type particles consisting of a central, electron-dense core separated by a clear area from a limiting envelope with a unit membrane structure. Virus particles were easily detected in the lymphocyte which was cultured with medium supplemented with either T-lymphocyte mitogen (conconavalin A) or B-lymphocyte mitogen (lipopolysaccharide). Identical viral particles, although fewer, were also consistently present in the lymphocytes cultured with medium which was containing foetal bovine serum (FBS) only and which was containing neither FBS or mitogen. By contrast, no virus particle was detected in extensive examination of lymphocytes before culture. In conclusion, the BLV cultivation and detection methods established in this study could be used as a tool to identify and eliminate the cattle which can transmit the BLV.

Ti 클래드 강판 제조를 위한 저항 seam 접합 공정의 열전달 수치 해석

정순효,도정만,변지영 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.2

The electrical and thermal fields during a resistance seam welding process for the production of titanium-clad steel plates were numerically analyzed using a finite volume method. Effect of welding parameters such as welding speed, electric current, heating/cooling period, electrode/plate contact area, water cooling intensity, and thermal conductivity of electrode, on temperatures at the bonding layer and titanium surface were studied. With the increase of the water cooling intensity, welding speed, electrode/plate contact area, and thermal conductivity of electrode, temperatures at the bonding layer and titanium surface decreased, but they increased with increasing the heating/cooling period and electric current. Strong cooling, low welding speed, and the use of high thermal-conductivity electrodes were advantageous in preventing oxidation of titanium surface.

Bovine botulism outbreak associated with incidental consumption of presumably contaminated leftover food

( Jae Won Byun ),( Kyung Hyun Lee ),( Ha Young Kim ),( Soon Seek Yoon ),( Ji Youl Jung1 ),( Woo Seog Jeong1 ),( Jae Ku Oem ),( Jong Soo Lim ),( Myoung Heon Lee ),( You Chan Bae ) 한국예방수의학회(구 한국수의공중보건학회) 2013 예방수의학회지 Vol.37 No.1

Nine cattle among 18 in a native Korean herd died or were euthanized within 3 days. The affected cattle showed cowshed. The pigs and dogs had been fed leftover food originating from nearby restaurants, and the cattle could presumably reach the contaminated food in the pig troughs. Necropsy revealed a few chicken bones and red pepper pieces as well as large amounts of grain and rice straw hay mixed in the rumen. Botulism type D was isolated in the ruminal contents of one of the cattle. We speculated that the outbreak was associated with the cattle incidentally eating presumably contaminated leftover food from the pig trough.

Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder

Byun, Jung-Ick,Lee, Byeong Uk,Kim, Minah,Sunwoo, Jun-Sang,Lim, Jung-Ah,Moon, Jangsup,Lee, Soon-Tae,Jung, Keun-Hwa,Chu, Kon,Kim, Man-Ho,Jeong, Min Hee,Cha, Kwang Su,Choi, Jeong Woo,Kim, Kyung Hwan,Lee, Elsevier 2017 SLEEP MEDICINE Vol.38 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls.</P> <P><B>Methods</B></P> <P>We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects. Behavioral data and the mean P300 amplitude were compared between groups.</P> <P><B>Results</B></P> <P>No group difference was found for reaction time or accuracy, but a significant group effect was observed for the P300 amplitude. IRBD patients had reduced P300 amplitude (μV) than controls in both valid (IRBD: 0.53 ± 1.05 vs Controls: 1.61 ± 0.95; p = 0.008) and invalid (IRBD: 0.74 ± 0.99 vs Controls: 1.73 ± 0.86; p = 0.009) conditions. The P300 amplitude was correlated with Montreal cognitive assessment (MOCA) scores (r = 0.424, p = 0.024).</P> <P><B>Conclusion</B></P> <P>Reduced P300 amplitude during the Posner task provides electrophysiological evidence for subclinical visuospatial attention deficits in cognitively normal IRBD patients. The results of this study imply that cortical dysfunction is already present in patients with IRBD in their early disease stage.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IRBD with normal cognition had reduced P300 amplitude during Posner task. </LI> <LI> Reduced P300 in IRBD was independent of age, sex, depression, and autonomic function. </LI> <LI> The P300 amplitude correlated with MOCA scores. </LI> <LI> Cortical dysfunction may be present in early stage of IRBD. </LI> </UL> </P>

The Korean Society of Gastroenterology& SLDDS 2037 : Slide Session ; K-BP-27 : Pancreatobiliary ; Early Check Up CA 19-9 for Pancreatic Cancer Screening in New Onset Diabetic Patient

( Jung Wan Choe ),( Jae Seon Kim ),( Soon Young Hwang ),( Hyo Jung Kim ),( Moon Kyung Joo ),( Beom Jae Lee ),( Ji Hoon Kim ),( Jong Eun Yeon ),( Jong Jae Park ),( Kwan Soo Byun ),( Young Tae Bak ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Patients with diabetes have higher risk for pancreatic cancer and the risk is reported to be high in early period after diagnosis. We had reported the usefulness of CA 19-9 with the new onset (< 2yrs) diabetes as a screening test for pancreatic cancer. (KJS, abstract 251) This study was to evaluate the validity of CA 19-9 check soon after diagnosis of diabetes as a pancreatic cancer screening tool. Methods: We reviewed medical records of diabetes patients who were diagnosed fi rst time at our hospital from Jan.2004 to Jan.2013. Among them, 2385 patients who checked CA 19-9 were enrolled. We classifi ed groups according to the timing of CA 19-9 measurement; first group, checked CA 19-9 within 1 year after diagnosis of diabetes and second group checked within 1~2 year after diabetes diagnosis. Results: Of 2385 diabetes patients, 91 (3.8%) were diagnosed with pancreatic cancer. In fi rst group, 72 (4.1%) of 1739 diabetes patients developed pancreatic cancer and odd ratio of pancreatic cancer according to abnormal CA 19-9 was 13.7 (p<0.001). 10 of pancreatic cancer (4.4%) were detected in second group of 226 patients and odd ratio was 8.02 (p=0.002). But after 2 years, the odd ratio for pancreatic cancer had no statistically signifi cance. The incidences of pancreatic cancer in 1965 patients with new onset diabetes followed by checking CA 19-9 within 2 years and in 420 patients with diabetes established for more than 2 years were 82 (4.1%) and 9 (2.1%), respectively. The odd ratio of pancreatic cancer for abnormal CA 19-9 within 2 year following diabetes diagnosis was 12.5 (P<0.001) Conclusion: Early check up of CA 19-9 following new onset diabetes diagnosis is meaningful as a screening test for pancreatic cancer.

P124 : The efficacy and safety of cryo fat reduction in the treatment of pseudogynecomastia

( Jung Tae Park ),( Bori Kim ),( Sang Young Byun ),( Soon Hyo Kwon ),( Jung Won Shin ),( Kyoung Chan Park ),( Jung Im Na ),( Chang Hun Huh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Options for the treatment of pseudogynecomastia, a condition of enlarged male breast primarily due to the accumulation of adipose tissue, have been limited, including weight reduction and surgical liposuction. Cryo fat reduction provides noninvasive, selective, localized subcutaneous adipocyte destruction without epidermal or dermal injury by inducing adipocyte apoptosis. Objectives: This study was designed to evaluate the efficacy of cryo fat reduction in the treatment of pseudogynecomastia. Methods: In this prospective, 28-week trial, 12 male patients with psudogynecomastia were treated with cryo fat reduction twice bimonthly. Efficacy was determined by breast circumference measurement, ultrasonographic measurement of subcutaneous layer thickness, physician’s global photographic assessment, and patient’s satisfaction at baseline at week 4, week 8, week 16 and week 28. Safety was evaluated by questionnaire at each visit. Results: For the 11 subjects completing the trial, breast circumference and thickness of fat layer determined by ultasonography significantly improved at week 8, andgradually reduced until week 28. Physician’s photographic assessment and patient’s satisfaction showed significant improvement at each visit. No adverse event was observed except transient pain immediately after the treatment and bruise at the treated site. Conclusion: Cryo fat reduction is a safe and effective therapeutic option of the treatment of pseudogynecomastia.

Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea

Byun, Jung-Ick,Lee, Soon-Tae,Jung, Keun-Hwa,Sunwoo, Jun-Sang,Moon, Jangsup,Kim, Tae-Joon,Lim, Jung-Ah,Kim, Soyun,Kim, Do-Yong,Han, Su-Hyun,Jang, Hyemin,Suh, Hong Il,Cho, A-Hyun,Kim, Dong Wook,Shin, Ju Elsevier 2016 Journal of neuroimmunology Vol.293 No.-

<P><B>Abstract</B></P> <P>We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Among 1699 patients with encephalopathy of unknown etiology, autoantibody was identified in 6.12%. </LI> <LI> Autoimmune encephalopathy comprised a significant portion of idiopathic cases. </LI> <LI> Anti-NMDA receptor antibody was the most common autoantibody in age under 40. </LI> <LI> Anti-LGI1 antibody was the most common autoantibody in age 40 and over. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>