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변은하,김상훈,김재민,박상학,김학열,박찬원 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Objective : Weight gain is one of the common side effects of antipsychotics and it has been known that the quality of life is decreased by weight gain. Therefbre the purpose of this study is to compare weight gain among the antipsychotics, which are frequently used in the clinical practice. Methods : We performed a retrospective chart review of 124 patients with schizophrenia who were treated at least 12 weeks with typical antipsychotics (chlorpromazine and halopehdol) or atypical antipsychotics (risperidone, olanzapine, and clozapine). They were divided into three groups as treated with chlorpromazine (N=44), with haloperidol (N=60), and with atypical antipsychotics (N=20) and body weight and Body Mass Index (BMI) were compared at O (Baseline), 8 and 12 week between the three groups. Additionally, we examined possible correlations of changes in body weight with baseline factors. Results : 1) Significant change in body weight and BMI were found during 12 weeks in all groups, received different kinds of antipsychotics but there were no significant differences between three groups. 2) Weight gain was prominent within 8 weeks in the treatment, but not significant after then in all the three groups. 3) Lower body weight in baseline was correlated with more weight gain with the treatment with antipsychotics. Conclusions: Antipsychotics were associated with weight gain in patients with schizophrenia, Particularly in the early stage of treatment. Therefore to increase the quality of life and improve the compliance of medication in treatment of schizophrenia and other psychotic disorder, we must choice medication which are consistent with a individuality
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요추간판탈출증에서 현미경 수술과 경피적 자동수핵제거술에 대한 비교연구
신원한,장재칠,주교성,김범태,최순관,변박장 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1
A retrospective study of operative results were carried out in a series of 164 patients who were performed microdiscectomy and 57 patients performed automated percutaneous lumbar discectomy (APLD) for herniated lumbar discs between January 1, 1990 and June 30, 1996 at the Department of Neurosurgery, Soonchunhyang University Hospital. The operative results were analysed, and the correlation between preoperative clinicoradiological factors and postoperative clinical results were statistically assessed. The major results were as follows : 1. Of 164 microdiscectomy cases, 102 were males and 62 were females, mean age was 42.4 years and incidence was the highest in the 5th decade, and of 57 APLD cases, 43 were male and 14 female, mean age was 32.2 years and incidence was the highest in the 3rd decade. 2. The preoperative symptoms and signs were lumbago(98.2%), radiating pain(96.3%), positive straight leg raising test(77.4%), motor weakness(27.4%), claudication(13.4%) & voiding difficulty(2.4%) in microdiscectomy cases, and lumbago(98.2%), radiating pain(98.2%), positive straight leg raising test(70.2%) & motor weakness(17.5%) in APLD cases. 3. Number of operated levels were performed 226 in microdiscectomy and 74 in APLD. The most commonly operated levels of two groups were L4-5 level. 4. Operative results 1) The overall success rates by Prolo's scale were 87.1% in microdiscectomy and 80.7% in APLD, respectively. 2) In younger age group (below 30 years) and in non-compensatory group, success rates were significantly higher in microdiscectomy. 3) As to protrusion and degeneration on MRI, clinical results of moderate protrusion and degeneration of discs in microdiscectomy were statistically significant, and those of mild protrusion and degeneration of discs in APLD were also statistically significant. 4) The most common cause of failure was inappropriate removal of disc material in microdiscectomy and sequestered discs in APLD. According to the above results, there were no differance in overall success rates between microdiscectomy and APLD. But clinical results seem to be influenced by the age, existence of compensation, and by the degree of protrusion and degeneration of discs as prognostic factors. If the selection of operative procedure between microdiscectomy and APLD for herniated lumbar disc is carefully done with clinical and radiologic findings of patients, good outcome might be achieved.
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장재혁,송치원,심병용,이동건,변재호,정정임,이교영,홍영선,신완식,김춘추,이경식 대한감염학회 2003 감염과 화학요법 Vol.35 No.3
저자들은 비호지킨씨 림프종 환자에서 항암 치료 후 질환의 진행성 병변과 감별을 요했던 우폐 중엽의 단발성 종괴를 흉강경하 생검으로 폐 효모균증을 확진하고 amphotericin B와 fluconazole로 치료한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Non-Hodgkin's lymphoma is monoclonal expansion of malignant B or T cells. The immunocompromised status in this disease is accompanied by many infections. The cryptococcosis, caused by Cryptococcus neoformans, frequently occurs in leukemia, Hodgkin's disease, sarcoidosis, diabetes mellitus, tuberculosis, and long-term steroid-using patients. Recent increasing incidence of fungal infection could be due to the spread of AIDS and transplantation. We experienced one patient with lung mass in Non-Hodgkin's lymphoma after three cycles of chemotherapy, which could not be discriminated from the newly developed lymphoma mass. Cryptococcus neoformans was isolated from the lung tissue obtained by thoracoscopic biopsy. Herein we report this case with brief review of pertinent literature.
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이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.
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尹忠沅,崔宇琮,尹錫玩,卞在權 全北大學校 1988 論文集 Vol.30 No.-
Jewellery & gems industry has been developed with the beginning of ancient human history as all the mankind have a fancy for precious metals and stones regardless of the times and nationality. Historically, Korean also had an excellent workmanship from the ancient era and shipped it, as a tribute, to the neighboring countries. However, our deposits of gold and silver had been almost dried up, especially owing to a lot of excavation during Japanese imperialist rule, And precious stones have not been discovered in Korea except a small quantity of crystal. Therefore, Korea cannot but depend on the processing industry of jewellery and germs by importing the unworked gold, diamond and other precious stones from overseas countries. By the way, recent overseas market of jewellery & germs is very extensive and the value added of the industry is much larger than other industries. So jewellery & gems processing industry is regarded as the most important field in the advanced countries. All the more, the industry is typical of labor-intensive one and is more suitable to the nations whose people are deft-handed. From those points, it is quite appropriate to Korea. Recognizing this facts, Korean government had set up a Jewellery & Gems Export Industry Park in Iri city ten years ago. The bonded industry park has much contributed to export promotion and regional economic development. But there are a lot of room for improvement if we would obtain the anticipated results. So we researchers have studied and analyzed the following points to find some ways for improving the Iri Jewellery & Gems Export Industry Park. ① the history of precious metals & gems industry in both overseas countries and Korea. ② international production status of unworked precious metals & stones, and structure of international trade. ③ business status of exporting companies in Iri Jewellery & Gems Export Industry park; general circumstances, exprot & import structure, employment policy, production & skill, purchasing materials (the unworked stones ) and marketing etc.
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송하원,변근주,양재성 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2
Fracture machines does work for concrete, provided that one uses a proper, nonlinear form of fracture mechanics in which a finite nonlinear zone at fracture front is being considered. The fracture process zone is a region ahead of a traction-free crack, in which two major mechanisms, microcraking and bridging, play important rules. The development of model of fracture process zone is most important to describe fracture phenomena in concrete. The toughness due to bridging is dominant compared to the toughness induced by the microcracking, so that the bridging is the dominant mechanism governing the fracture process of concrete. In this paper the bridging zone, which is a part of extended macrocrack with stresses transmitted by aggregates in concrete, is modelled by a Dugdale-Barenblatt type model with linear tension-softening curve. Finite element techniques are shown for implementation of the model for the analyses of crack growth in concrete.
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고재걸,민경덕,최종락,오대섭,권병규,변창진,여환진,정원우 경북대학교 과학교육연구소 1988 科學敎育硏究誌 Vol.12 No.-
The purpose of this study is to develop models and instruments for teaching and assessing scientific experiments and practices. General objectives for teaching and evaluating scientific experiments and practices in secondary schools were analyzed and categorized into three domains:they were inquiry skill, scientific thinking skill, and scientific attitude. The sub-categories for each domain were constructed, and specific objectives for each general objective were also stated in terms of behavioral objectives according to Mager's suggestion. The tables of specification (content×behavior) were developed in order to assist secondary school teachers to teach and evaluate scientific experiments in class. In addition, we introduced some useful assessment techniques which can be adopted to evaluating learning outcomes of each specific objective. The sample test items corresponding to each objective were listed for practical usage in class.
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