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        관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

        한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

        Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

      • 유한요소법에 의한 영구자석 전동기의 정특성 해석

        오연호,한성진,주수원 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.2

        There are increasing needs for high performance small motors using permanent magnets. In this paper, the static characteristics of pm dc motor has been analyzed by finite element method. In the air gap, magnet flux densities due to only field magnet have been calculated, and the effect of armature reaction has been investigated. For torque calculation two dimensional F.E.A. with the integration of Maxwell stress tensor has been applied and show good agreement with experimental result.

      • 噴霧法에 依한 硫化亞鉛 薄膜의 電場發光 調査

        손연규,윤지홍,권태향,한광수,이자현 안동대학교 기초과학연구소 1991 基礎科學 硏究論文集 Vol.2 No.1

        The study of Electroluminescence has been begun with that the two Germans, B. Gudden & R. W. Pohl in 1920 examined the remaining lights by dint of adding Electric Field at the fluorescent substance, and from 1952 the study became brisk, in 1960 made a peak, and afterward it was diminished. The above facts were appeared through H. E. Ivey`s investigation. The cause was it that the light-efficiency and the brightness were very pessimistic, though the beginning of EL-Study was given in the development of illumination. In 1950, however, with the initiative that C. W. Jerome of Sylvania Co. deviced and announced EL-Lamp, EL-Fluorescent substances were embed and merchandised as EL-Panels, and after a while it was applied to EL-Lamps, Expression Apparatuses, Light Amplifier, Logic Circuit and so on, with which the use frequency got high, and it has been developed as a promising Electronic Industry. But in our country, considering the various conditions, in order to find out the possibility of EL-Production within the home country, Impurity was introduced to ZnS powder, EL of ZnS : Cu, Cl & ZnS : Cu, Mn, Cl could be manufactured, and surveying the Voltage Characteristics, the Frequency Characteristics, and the Spectral Response of the manufactured things, the fundamental technique-problems about the composition of ZnS powder, the introduction of impurity, the formation of thin-thickness, and the construction of Cell, etc were solved gradually. 1. The quantity of Cu must commonly be more one order than in the use of Photoluminescence, as a whole 10(-3)gm,atm/mole ZnS is fitted, and Mn suitable in about 10 times of Cu. 2. Yellow color must dope Cu as well as Mn, when the quantity of Cu fixed to a certain amount, in case that the quantity of Mn is decreased, it be turned into Yellow color, if it is increased, it be taken Orange color. 3. In vacuum flowing HzS gas and baking at the moment, it is said that EL of which brightness is high, but in the air we can secure ZnS : Cu, Cl EL. only. 4. In referring to the conditions 1, 2, 3, I can infer that EL-manufacture if possible in our country.

      • KCI등재

        Ultrasound-Guided Core Needle Biopsy Techniques for Intermediate or Low Suspicion Thyroid Nodules: Which Method is Effective for Diagnosis?

        Soo Yeon Hahn,Jung Hee Shin,Young Lyun Oh,박고운 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.10

        Objective: To retrospectively compare the diagnostic performances of two different ultrasound (US)-guided core needle biopsy (CNB) techniques for intermediate or low suspicion thyroid nodules. Materials and Methods: Between August 2015 and December 2016, two different biopsy techniques were alternatively applied for 248 consecutive thyroid nodules, of which, 140 intermediate or low suspicion thyroid nodules were included in this study. In the first technique, two specimens included nodular tissue, nodular margin, and surrounding normal parenchyma (i.e., marginal target). In the second technique, two specimens were obtained from two different target areas, one for the marginal target and another for the intranodular target. The diagnostic performances of the two techniques to predict neoplasm and malignancy were compared. Results: CNB was performed on 80 intermediate or low suspicion nodules (57.1%) using the first technique and on 60 (42.9%) using the second technique. The accuracy of the first technique for predicting neoplasm or malignancy was significantly higher than that of the second technique (100% vs. 93.3%, p = 0.032 for predicting neoplasm; 88.8% vs. 75.0%, p = 0.033 for predicting malignancy). The negative predictive value of the first technique for predicting malignancy was also significantly higher than that of the second technique (87.5% vs. 72.7%, p = 0.035). Conclusion: For intermediate or low suspicion thyroid nodules, US-guided CNB to obtain two specimens with marginal targets is more effective for diagnosing neoplasm or malignancy than is CNB for respective marginal and intranodular targets.

      • KCI등재

        Symbolic Values of Fur in Fashion Since 1990s -An Analysis under the Theories of Fetishism-

        ( Soo Yeon Hahn ),( Sook Hi Yang ) 한국패션비즈니스학회 2001 패션 비즈니스 Vol.5 No.5

        Fur is conceived as a material signifier, not only with its commodity value as luxury goods but also as its symbolic value as objects invested by one`s libidinal desire. In this study, complex meanings of fur as multi-layered signs of political and sexual power focusing on fetishism shall be explored, especially on the spectacle fetishism acted by mass media during the anti-fur movement in the 1980s. In conjuction herewith, a highlight shall also be made to the symbolic value in fashion design since 1990s. In this study, first, as a theoretical investigation, fetishism, that has been traditionally considered only as sexual fetishism in fashion discourse will be explored in socio-economic level. Second, in historical context, how the meanings and values of fur have become realized in various cultural spaces, such as literature, art, film and finally, fashion will be viewed. In fashion, fur is a product of desire and power influenced by commodity fetishism as well as sexual fetishism. During the anti-fur movement, mass media has developed the concept of spectacle fetishism. Fur is a sign of animal-victim, and fur-clad women is viewed with images full of imperialsm, sexism and racism, thus act as derisive spectacles of consumerism. Since 1990s as a reflection on anti-fur movement, fetishistic characteristics, which challenge traditional operation method, are expressed by disguise, parody, and returning to the nature. First, fur as disguise is intended to hide sexually perverse, decadent characteristics and expensiveness of fur by texturing or patterning techniques. Second, fur as parody uses fake fur or dyed fur in order to satirize erotically and ethnographically fetishized meanings of fur. Third, aboriginal design of fur is adapted to use symbolic values outside the West, which can potentially mobilize antagonistic oppositions out of their fetishistic regimes. In conclusion, fur as sign of female sexuality and its libidinal profits of exchange, has significant symbolic values expressed in fashion.

      • KCI등재
      • KCI등재
      • KCI등재

        보문 : 패션 커뮤니케이션 매체로서의 패션 전시에 관한 연구-2012 노라 노 <라 비 엥 로즈> 전시 사례를 중심으로-

        한수연 ( Soo Yeon Hahn ) 한국의류학회 2012 한국의류학회지 Vol.36 No.9

        Fashion exhibitions in museums and galleries is a form of fashion communication media. This thesis examines the messages, objects, and space of fashion exhibitions as fashion communication media as well as analyzes the method of fashion communication. This thesis first provides a theoretical study on fashion exhibition and conducts a case study of the 2012 Nora Noh Retro Exhibition La Vie en Rose (2012/5/23-6/2, Horim GNB Gallery, Seoul), dedicated to the first Korean female fashion designer. The message of the exhibition was the fashion philosophy and the fashion style of the designer as well as the intention of the curator. The objects presented were the dresses kept by the loyal customers of the brand, and the homage items by designers of present generation. The space designs of the exhibition were the layout and total coordination of the opening event. The methods of fashion communication for the fashion exhibition, in the case of the La Vie en Rose exhibition, were communicated (1) from the past to the present, (2) from designers to celebrities and (3) from the designer to the celebrity and the viewers. From the past to the present, the designer`s style throughout the 60 years of her fashion career is conveyed to the present generation fashion people, in the form of homage designs and collaboration works. From designers to celebrities, her fashion philosophy was delivered in the form of movie and stage costumes. Some present generation celebrities tried reinterpretations of the garment. From the designer to the celebrity and the viewers of the exhibition, the intention of the curator and the designer were individualized and internalized by the viewers.

      • KCI등재
      • KCI등재

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