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- 저자 : Shikama, T. (검색결과 10 건)
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Harunobu Matsumoto,Mototsugu Shimokawa,Kaei Nasu,Ayumi Shikama,Takaya Shiozaki,Masayuki Futagami,Kentaro Kai,Hiroaki Nagano,Taisuke Mori,Mitsutake Yano,Norihiro Sugino,Etsuko Fujimoto,Norihito Yoshiok 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6
Objective: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. Methods: At medical institutions participating in the Kansai Clinical Oncology Group/Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. Results: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. Conclusion: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.
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( Masayuki Kitagawa ),( Jiro Akiba ),( Yukihiro Shikama ),( Ikuro Ohta ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Advanced glycation end products such as carboxymethyl-lysine are produced by a nonenzymatic reaction between proteins and sugar in patients with long-term hyperglycemia. Advanced glycation end products in the matrix of the walls of small blood vessels are thought to have an effect on the development of diabetic complication. We hypothesized that plasma levels of caroxymethyl-lysine were re- flected by the severity of diabetic neuropathy. Methods: 1) Patients: The 84 patients with type 2 diabetes mellitus (mean age 61.8±9.5 years, duration of diabetes 12.4±8.6, mean HbA1c 7.7±1.4%) were included. 2) Carboxymethl-lysine: The plasma levels of carboxymethyl-lysine were measured by ELISA method. 3) Motor Nerve Conduction Velocity: We measured motor nerve conduction velocity of tibial nerve as marker of the severity of diabetic neuropathy. 4) Statistical Analyses: Correlation was assessed by linear regression analysis and multiple regression analysis using Stat View 5 for Macintosh. Results: In 53 type 2 diabetic patients with normal renal function (serum creatinine <1.0 mg/dl), we measured motor nerve conduction velocity of tibial nerve, and at the same time, we measured plasma levels of carboxymethyl-lysine. Motor nerve conduction velocity was correlated negatively with plasma levels of carboxymethyl-lysine in 25 male patients (r = 0.228, p = 0.29), but motor nerve conduction velocity was significantly correlated with plasma levels of carboxymethyl-lysine in 28 female patients (r =-0.632, p < 0.0003). Multiple regression analysis revealed an in dependent influence of plasma levels of carboxmethyl-lysine on motor nerve conduction velocity of tibial nerve in 28 female patients (r² = 0.375, p < 0.05). Conclusions: Our data suggests that plasma levels of carboxymethyl-lysine may be one of the etiology of diabetic neuropathy in female diabetic patients. We presumed this result is concerned with female lipid peroxidation of carboxymethyl-lysine.
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Jae-Hwan Kim,Shinji Nagata,강창룡,Tatsuo Shikama 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.3
To investigate the effects of ion irradiation for improving the performance of a fuel cell, specimens were irradiated with Ar+ion beams at total fluences of 0, 1×1017and 5×1017ions/cm2. After the ion-beam pro-cessing, measurements of the hydrogen concentration at the near-surface and of the electrical conductivity of the specimens, along with scanning electron microscopy observations, showed that the increase in oxy-gen vacancies formed due to irradiation contributed not only to an increase in hydrogen concentration on the surface but to an improvement in proton conductivity. These results suggest that this method is effec-tive for improving the proton conductivity in proton-conducting Y-doped BaCeO3-δ. Additionally, unit fuel cells were fabricated using the Y-doped BaCeO3-δs irradiated by the ion beam with different fluences. It was observed from their I-V and I-P curves, that with the increase in Ar+fluence, both the current density and power density were improved.
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Lymphadenectomy issues in endometrial cancer
Yosuke Konno,Hiroshi Asano,Ayumi Shikama,Daisuke Aoki,Michihiro Tanikawa,Akinori Oki,Koji Horie,Akira Mitsuhashi,Akira Kikuchi,Hideki Tokunaga,Yasuhisa Terao,Toyomi Satoh,Kimio Ushijima,Mitsuya Ishika 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objectives: This review aims to introduce preoperative scoring systems to predict lymphnode metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role oflymphadenectomy for endometrial cancer. Methods: We summarized previous reports on the preoperative prediction models forLNM and evaluated their validity to omit lymphadenectomy in our recent cohorts. Next, wecompared characteristics of two ongoing lymphadenectomy trials (JCOG1412, ECLAT) toexamine the survival benefit of lymphadenectomy in endometrial cancer, and described thedetails of JCOG1412. Results: Lymphadenectomy has been omitted for 64 endometrial cancer patients who met low risk criteria to omit lymphadenectomy using our scoring system (LNM score) and no lymphaticfailure has been observed. Other two models also produced comparable results. Two randomizedphase III trials to evaluate survival benefit of lymphadenectomy are ongoing for endometrialcancer. JCOG1412 compares pelvic lymphadenectomy alone with pelvic and para-aorticlymphadenectomy to evaluate the therapeutic role of para-aortic lymphadenectomy for patients atrisk of LNM. For quality assurance of lymphadenectomy, we defined several regulations, includinglower limit of the number of resected nodes, and submission of photos of dissected area toevaluate thoroughness of lymphadenectomy in the protocol. The latest monitoring report showedthat the quality of lymphadenectomy has been well-controlled in JCOG1412. Conclusion: Our strategy seems reasonable to omit lymphadenectomy and could begeneralized in clinical practice. JCOG1412 is a high-quality lymphadenectomy trial in terms ofthe quality of surgical procedures, which would draw the bona-fide conclusions regarding thetherapeutic role of lymphadenectomy for endometrial cancer.
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( Masayuki Kitagawa ),( Jiro Akiba ),( Yukihiro Shikama ),( Ikuro Ohta ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It is thought that there is close relation in glucose metabolism and brain damage. It is presumed that brain damage is caused for hypoglycemia. A limbic system exists in the inside of the cerebral cortex. It has been reported that limbic system atrophy tends to receive damage with hypoglycemia. We evaluated brain MR imaging changes of limbic system in a patient with type 2 diabetes mellitus with hypoglycemia. This case was considered to be a precious case when considering the relevance of glucose metabolism and brain damage. Case Report: The patient was 86-year-old female diagnosed with type 2 diabetes mellitus 20 years ago. She was brought to the emergency department in our hospital due to consciousness disturbance. In the emergency room, the blood glucose level was 16 mg/dl, and consciousness disorder was not recovered although intravenous injection of glucose was performed. It was presumed that the badness of a general state and unsuitable use of the oral hypoglycemic agent caused unstable glycemic control. Evaluation of change of brain MRI was made for 98 days. Results: Evaluation of change of brain MRI was made for 98 days. The appearance of limbic system atrophy was observed. Limbic system atrophy advanced gradually. It was thought that this case was a precious case in which picture change of the limbic system was able to be caught. Conclusions: It is presumed that hypoglycemia brings about activation of a glutamic acid receptor, and causes oxidant stress, and it is presumed that they make brain damage induce. Also in this case, we thought the damage of the limbic system was based on hypoglycemia. This case was considered to be a precious case when considering the relevance of glucose metabolism and brain damage.
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Competition between Magnetic Ordering and Random Spin Freezing in Dy2PtS3
Dexin Li,Tomoo Yamamura,Yoshiya Homma,Kunio Yubuta,Tatsuo Shikama,Dai Aoki,Shigeki Nimori,Yoshinori Haga 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
We report the results for ac and dc susceptibility, magnetization, magnetic relaxation, specific heatand electrical resistivity measurements on a well annealed ternary intermetallic compound Dy2PtSi3. An unusual magnetic phase transition with an apparent ferromagnetic nature was observed at TC= 5.6 K. At temperatures below TC, however, Dy2PtSi3 showed a metastable magnetic behaviorcharacteristic of a typical cluster glass. The classification of Dy2PtSi3 as a large magnetic cluster(extended short-range ferromagnetic ordered) system with competition between magnetic orderingand random spin freezing seems appropriate.
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Naoki Nakamura,Osamu Takahashi,Minobu Kamo,Shogo Hatanaka,Haruna Endo,Norifumi Mizuno,Naoto Shikama,Mami Ogita,Kenji Sekiguchi 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: The purpose of this study was to quantify the targetcoverage, homogeneity, and robustness of the dose distributionsagainst geometrical uncertainties associated with fourwhole breast radiotherapy techniques. Methods: The study wasbased on the planning-computed tomography-datasets of 20patients who underwent whole breast radiotherapy. A total offour treatment plans (wedge, field-in-field [FIF], hybrid intensitymodulatedradiotherapy [IMRT], and full IMRT) were created foreach patient. The hybrid IMRT plans comprised two opposedtangential open beams plus two IMRT beams. Setup errors weresimulated by moving the beam isocenters by 5 mm in the anterioror posterior direction. Results: With the original plan, thewedge technique yielded a high volume receiving ≥107% of theprescription dose (V107; 7.5%±4.2%), whereas the other threetechniques yielded excellent target coverage and homogeneity. A 5 mm anterior displacement caused a large and significant increasein the V107 (+5.2%±4.1%, p<0.01) with the FIF plan, butnot with the hybrid IMRT (+0.4%±1.2%, p=0.11) or full IMRT(+0.7%±1.8%, p=0.10) plan. A 5-mm posterior displacementcaused a large decrease in the V95 with the hybrid IMRT (-2.5%±3.7%, p<0.01) and full IMRT (-4.3%±5.1%, p<0.01) plans, butnot with the FIF plan (+0.1%±0.7%, p=0.74). The decrease inV95 was significantly smaller with the hybrid IMRT plan than withthe full IMRT plan (p<0.01). Conclusion: The FIF, hybrid IMRT,and full IMRT plans offered excellent target coverage and homogeneity. Hybrid IMRT provided better robustness against geometricaluncertainties than full IMRT, whereas FIF provided comparablerobustness to that of hybrid IMRT
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Kan Yonemori,Keiichi Fujiwara,Kosei Hasegawa,Mayu Yunokawa,Kimio Ushijima,Shiro Suzuki,Ayumi Shikama,Shinichiro Minobe,Tomoka Usami,김재원,김병기,Peng-Hui Wang,Ting-Chang Chang,Keiko Yamamoto,Shirong Han,Jo 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2
Objective: In the global phase 3 Study 309/KEYNOTE-775 (NCT03517449) at the first interimanalysis, lenvatinib+pembrolizumab significantly improved progression-free sur vival (PFS),overall sur vival (OS), and objective response rate (ORR) versus treatment of physician’schoice chemotherapy (TPC) in patients with previously treated advanced/recurrentendometrial cancer (EC). This explorator y analysis evaluated outcomes in patients enrolledin East Asia at the time of prespecified final analysis. Methods: Women ≥18 years with histologically confirmed advanced, recurrent, or metastaticEC with progressive disease after 1 platinum-based chemotherapy (2 if 1 given in neoadjuvant/adjuvant setting) were enrolled. Patients were randomized 1:1 to lenvatinib 20 mg orallyonce daily plus pembrolizumab 200 mg intravenously ever y 3 weeks (≤35 cycles) or TPC(doxorubicin or paclitaxel). Primar y endpoints were PFS per RECIST v1.1 by blindedindependent central review and OS. No alpha was assigned for this subgroup analysis. Results: Among 155 East Asian patients (lenvatinib+pembrolizumab, n=77; TPC, n=78),median follow-up time (data cutoff: March 1, 2022) was 34.3 (range, 25.1–43.0) months. Hazard ratios (HRs) with 95% confidence inter vals (CIs) for PFS (lenvatinib+pembrolizumabvs. TPC) were 0.74 (0.49–1.10) and 0.64 (0.44–0.94) in the mismatch repair proficient(pMMR) and all-comer populations, respectively. HRs (95% CI) for OS were 0.68 (0.45–1.02)and 0.61 (0.41–0.90), respectively. ORRs were 36% with lenvatinib+pembrolizumab and 22%with TPC (pMMR) and 39% and 21%, respectively (all-comers). Treatment-related adverseevents occurred in 97% and 96% (grade 3–5, 74% and 72%), respectively. Conclusion: Lenvatinib+pembrolizumab provided clinically meaningful benefit withmanageable safety compared with TPC, supporting its use in East Asian patients withpreviously treated advanced/recurrent EC. Trial Registration: ClinicalTrials.gov Identifier: NCT03517449
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