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The CONTIN algorithm and its application to determine the size distribution of microgel suspensions
Scotti, A.,Liu, W.,Hyatt, J. S.,Herman, E. S.,Choi, H. S.,Kim, J. W.,Lyon, L. A.,Gasser, U.,Fernandez-Nieves, A. American Institute of Physics 2015 The Journal of chemical physics Vol.142 No.23
<P>We review a powerful regularization method, known as CONTIN, for obtaining the size distribution of colloidal suspensions from dynamic light scattering data. We show that together with the so-called L-curve criterion for selecting the optimal regularization parameter, the method correctly describes the average size and size distribution of microgel suspensions independently characterized using small-angle neutron scattering. In contrast, we find that when using the default regularization process, where the regularizer is selected via the 'probability to reject' method, the results are not as satisfactory.</P>
Stricturing Crohn's disease: what is the role of endoscopic stenting? A systematic review
Giorgia Burrelli Scotti,Roberto Lorenzetti,Annalisa Aratari,Antonietta Lamazza,Enrico Fiori,Claudio Papi,Stefano Festa 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.6
Background/Aims: Endoscopic stenting for stricturing Crohn’s disease (CD) is an emerging treatment that achieves more persistentdilatation of the stricture over time than endoscopic balloon dilatation (EBD). We aimed to explore the efficacy and safety of stentingfor the treatment of CD strictures. Methods: A systematic electronic literature search was performed (PROSPERO; no. CRD42022308033). The primary outcomes weretechnical success, efficacy, complication rate, and the need for further interventions due to reobstruction. The outcomes of partiallycovered self-expanding metal stents (PCSEMS) with scheduled retrieval after seven days were also analyzed. Results: Eleven eligible studies were included in the review. Overall, 173 patients with CD were included in this study. Mean percentageof technical success was 95% (range, 80%–100%), short-term efficacy was 100% in all studies, and long-term efficacy was 56% (range,25%–90%). In patients with a scheduled PCSEMS retrieval, the long-term efficacy was 76% (range, 59%–90%), the mean complicationrate was 35% (range, 15%–57%), and the major complication rate was 11% (range, 0%–29%). Conclusions: Endoscopic stenting with scheduled PCSEMS retrieval may be considered a feasible second-line treatment for short CDstrictures to postpone surgery. However, larger head-to-head prospective studies are needed to understand the role of stenting as an al-ternative or additional treatment to EBD in CD.
BACH: Grand challenge on breast cancer histology images
Aresta, Guilherme,Araú,jo, Teresa,Kwok, Scotty,Chennamsetty, Sai Saketh,Safwan, Mohammed,Alex, Varghese,Marami, Bahram,Prastawa, Marcel,Chan, Monica,Donovan, Michael,Fernandez, Gerardo,Zeineh, J Elsevier 2019 Medical image analysis Vol.56 No.-
<P><B>Abstract</B></P> <P>Breast cancer is the most common invasive cancer in women, affecting more than 10% of women worldwide. Microscopic analysis of a biopsy remains one of the most important methods to diagnose the type of breast cancer. This requires specialized analysis by pathologists, in a task that i) is highly time- and cost-consuming and ii) often leads to nonconsensual results. The relevance and potential of automatic classification algorithms using hematoxylin-eosin stained histopathological images has already been demonstrated, but the reported results are still sub-optimal for clinical use. With the goal of advancing the state-of-the-art in automatic classification, the Grand Challenge on BreAst Cancer Histology images (BACH) was organized in conjunction with the 15th International Conference on Image Analysis and Recognition (ICIAR 2018). BACH aimed at the classification and localization of clinically relevant histopathological classes in microscopy and whole-slide images from a large annotated dataset, specifically compiled and made publicly available for the challenge. Following a positive response from the scientific community, a total of 64 submissions, out of 677 registrations, effectively entered the competition. The submitted algorithms improved the state-of-the-art in automatic classification of breast cancer with microscopy images to an accuracy of 87%. Convolutional neuronal networks were the most successful methodology in the BACH challenge. Detailed analysis of the collective results allowed the identification of remaining challenges in the field and recommendations for future developments. The BACH dataset remains publicly available as to promote further improvements to the field of automatic classification in digital pathology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The BACH challenge was organized to push forward methods for automatic classification of breast cancer biopsies using clinical hematoxylin-eosin stained histopathological images. </LI> <LI> A large public dataset, composed of 400 microscopy images and 30 whole-slide images, was specifically compiled for the BACH challenge. </LI> <LI> A total of 64 methods were submitted, out of 677 registration, and a detailed comparative analysis was carried out for the methods with higher accuracy scores. </LI> <LI> Several submitted algorithms performed better than the state-of-the-art in terms of accuracy (top score of 87%). </LI> <LI> Convolutional neural networks dominated the submissions, and was the method of choice in the algorithm that won the challenge. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jinan Corinne Banna,Marla Reicks,Carolyn Gunther,Rickelle Richards,Christine Bruhn,Mary Cluskey,Siew Sun Wong,Scottie Misner,Nobuko Hongu,N Paul Johnston 대한지역사회영양학회 2016 Nutrition Research and Practice Vol.10 No.4
BACKGROUND/OBJECTIVES: Setting healthful beverage expectations, making calcium-rich foods and beverages (CRF/B) available, and role modeling are parenting practices promoting calcium intake among early adolescents. This study aimed to evaluate emotion-based messages designed to motivate parents of early adolescents to perform these practices. SUBJECTS/METHODS: Emotion-based messages were developed for each parenting practice and tested in 35 parents from 5 states. Findings were used to modify messages and develop a survey administered via Amazon MechanicalTurk to a convenience sample of Asian (n = 166) and Hispanic (n = 184) parents of children 10-13 years. Main outcome measures were message comprehension, motivation, relevance, acceptability, and novelty. Engagement in the parenting practices was also assessed. RESULTS: Message comprehension was acceptable for the majority of parents. Most also agreed that messages were motivational (setting healthful beverage expectations (69.0%), making CRF/B available (67.4%), and role modeling (80.0%)), relevant and acceptable. About 30-50% indicated they had not seen the information before. Many parents indicated they were already engaging in the practices (> 70%). No racial/ethnic differences were observed for responses to messages or engaging in parenting practices. CONCLUSIONS: Results indicate that emotion-based messages designed to motivate parents to engage in parenting practices that promote calcium intake among early adolescents were motivating, relevant, and acceptable.
Banna, Jinan Corinne,Reicks, Marla,Gunther, Carolyn,Richards, Rickelle,Bruhn, Christine,Cluskey, Mary,Wong, Siew Sun,Misner, Scottie,Hongu, Nobuko,Johnston, N Paul The Korean Nutrition Society 2016 Nutrition Research and Practice Vol.10 No.4
BACKGROUND/OBJECTIVES: Setting healthful beverage expectations, making calcium-rich foods and beverages (CRF/B) available, and role modeling are parenting practices promoting calcium intake among early adolescents. This study aimed to evaluate emotion-based messages designed to motivate parents of early adolescents to perform these practices. SUBJECTS/METHODS: Emotion-based messages were developed for each parenting practice and tested in 35 parents from 5 states. Findings were used to modify messages and develop a survey administered via Amazon MechanicalTurk to a convenience sample of Asian (n = 166) and Hispanic (n = 184) parents of children 10-13 years. Main outcome measures were message comprehension, motivation, relevance, acceptability, and novelty. Engagement in the parenting practices was also assessed. RESULTS: Message comprehension was acceptable for the majority of parents. Most also agreed that messages were motivational (setting healthful beverage expectations (69.0%), making CRF/B available (67.4%), and role modeling (80.0%)), relevant and acceptable. About 30-50% indicated they had not seen the information before. Many parents indicated they were already engaging in the practices (> 70%). No racial/ethnic differences were observed for responses to messages or engaging in parenting practices. CONCLUSIONS: Results indicate that emotion-based messages designed to motivate parents to engage in parenting practices that promote calcium intake among early adolescents were motivating, relevant, and acceptable.