http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
Akira Kikuchi,Shosei Kishida,Hideki Yamamoto 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.1
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays im-portant roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic β-catenin and then the accumulated β-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-trans-lational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of β-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.
Design of Seismic Isolated Tall Building with High Aspect-Ratio
Kikuchi, Takeshi,Takeuchi, Toru,Fujimori, Satoru,Wada, Akira Council on Tall Building and Urban Habitat Korea 2014 International journal of high-rise buildings Vol.3 No.1
When seismic isolation system is applied to high aspect-ratio (height/wide-ratio) steel structures, there are several problems to be taken into consideration. One is lifting up tensile force on the isolation bearing by overturning moment caused by earthquake. Another is securing building stiffness to produce seismic isolation effects. Under these conditions, this paper reports the structural design of high-rise research building in the campus of Tokyo Institute of Technology. With the stepping-up system for the corner bearings, the narrow sides of single span framework are designed to concentrate the dead load as counter-weight for the tensile reaction under earthquake. Also we adopted concrete in-filled steel column and Mega-Bracing system covering four layers on north & south framework to secure the horizontal stiffness of the building.
Hikomitsu Kikuchi,Nguyen Thi Tinh Y,Yutaka Fujii,Akira Matsuo,Koichi Kindo 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
Orthorombic Cu5(PO4)3(OH)4 (pseudomalachite) is a layered compound. Each Cu-O layer in thiscompound is separated by PO4 tetrahedra. The spin network in the bc-plane of a pseudomlachite iscomposed of triangles and pentagons, which will induce the spin frustration effect. This network maybe a new type of geometrically frustrated spin lattice. Magnetic susceptibility, specific heat, highfield magnetization measurements are used to study the magnetic properties of Cu5(PO4)3(OH)4 innatural mineral samples. Magnetic ordering is observed at around 4.2 K. The spin entropy changeat the transition temperature is about one-fifth times smaller than that expected for a usual longrangeorder. A 1/5 magnetization plateau is observed in the high-field magnetization curve. Theplateau is explained based on a simple model in which the spin network is assumed to be composedof chain, dimer and monomer units.
Cho, Seungchan,Kikuchi, Keiko,Kawasaki, Akira,Kwon, Hansang,Kim, Yangdo IOP Pub 2012 Nanotechnology Vol.23 No.31
<P>Multi-walled carbon nanotube (MWCNT) reinforced copper (Cu) matrix composites, which exhibit chromium (Cr) carbide nanostructures at the MWCNT/Cu interface, were prepared through a carbide formation using CuCr alloy powder. The fully densified and oriented MWCNTs dispersed throughout the composites were prepared using spark plasma sintering (SPS) followed by hot extrusion. The tensile strengths of the MWCNT/CuCr composites increased with increasing MWCNTs content, while the tensile strength of MWCNT/Cu composite decreased from that of monolithic Cu. The enhanced tensile strength of the MWCNT/CuCr composites is a result of possible load-transfer mechanisms of the interfacial Cr carbide nanostructures. The multi-wall failure of MWCNTs observed in the fracture surface of the MWCNT/CuCr composites indicates an improvement in the load-bearing capacity of the MWCNTs. This result shows that the Cr carbide nanostructures effectively transferred the tensile load to the MWCNTs during fracture through carbide nanostructure formation in the MWCNT/Cu composite. </P>
Cho, Seungchan,Okayasu, Rin,Kikuchi, Keiko,Choi, Moonhee,Park, Jehong,Jo, Ilguk,Lee, Sang-Bok,Kwon, Hansang,Kim, Yangdo,Miyazaki, Takamichi,Kawasaki, Akira Elsevier 2019 Scripta materialia Vol.159 No.-
<P><B>Abstract</B></P> <P>We successfully fabricated a controllable intragranular pore containing hydroxyapatite (HA) by the combination of an electric current assisted sintering and pre-heat treatment process. The microstructure and mechanical properties of the sintered HA bulk with and without intragranular pores were investigated in this study. Fully densified HA fabricated by the combination of an electric assisted sintering and pre-heat treatment process showed extremely superior mechanical properties. Meanwhile, hierarchically structured porous HA consisting of nanosized intragranular pores without macropores in the grain boundary showed dramatically decreased elastic modulus by different fracture mechanism compared with fully densified HA.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Technical Improvement Using a Three-Dimensional Video System for Laparoscopic Partial Nephrectomy
Komatsuda, Akari,Matsumoto, Kazuhiro,Miyajima, Akira,Kaneko, Gou,Mizuno, Ryuichi,Kikuchi, Eiji,Oya, Mototsugu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Laparoscopic partial nephrectomy is one of the major surgical techniques for small renal masses. However, it is difficult to manage cutting and suturing procedures within acceptable time periods. To overcome this difficulty, we applied a three-dimensional (3D) video system with laparoscopic partial nephrectomy, and evaluated its utility. Materials and Methods: We retrospectively enrolled 31 patients who underwent laparoscopic partial nephrectomy between November 2009 and June 2014. A conventional two-dimensional (2D) video system was used in 20 patients, and a 3D video system in 11. Patient characteristics and video system type (2D or 3D) were recorded, and correlations with perioperative outcomes were analyzed. Results: Mean age of the patients was $55.8{\pm}12.4$, mean body mass index was $25.7{\pm}3.9kg/m^2$, mean tumor size was $2.0{\pm}0.8cm$, mean R.E.N.A.L nephrometry score was $6.9{\pm}1.9$, and clinical stage was T1a in all patients. There were no significant differences in operative time (p=0.348), pneumoperitoneum time (p=0.322), cutting time (p=0.493), estimated blood loss (p=0.335), and Clavien grade of >II complication rate (p=0.719) between the two groups. However, warm ischemic time was significantly shorter in the 3D group than the 2D group (16.1 min vs. 21.2min, p=0.021), which resulted from short suturing time (9.1 min vs. 15.2 min, p=0.008). No open conversion occurred in either group. Conclusions: A 3D video system allows the shortening of warm ischemic time in laparoscopic partial nephrectomy and thus may be useful in improving the procedure.
Lymphadenectomy issues in endometrial cancer
Yosuke Konno,Hiroshi Asano,Ayumi Shikama,Daisuke Aoki,Michihiro Tanikawa,Akinori Oki,Koji Horie,Akira Mitsuhashi,Akira Kikuchi,Hideki Tokunaga,Yasuhisa Terao,Toyomi Satoh,Kimio Ushijima,Mitsuya Ishika 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objectives: This review aims to introduce preoperative scoring systems to predict lymphnode metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role oflymphadenectomy for endometrial cancer. Methods: We summarized previous reports on the preoperative prediction models forLNM and evaluated their validity to omit lymphadenectomy in our recent cohorts. Next, wecompared characteristics of two ongoing lymphadenectomy trials (JCOG1412, ECLAT) toexamine the survival benefit of lymphadenectomy in endometrial cancer, and described thedetails of JCOG1412. Results: Lymphadenectomy has been omitted for 64 endometrial cancer patients who met low risk criteria to omit lymphadenectomy using our scoring system (LNM score) and no lymphaticfailure has been observed. Other two models also produced comparable results. Two randomizedphase III trials to evaluate survival benefit of lymphadenectomy are ongoing for endometrialcancer. JCOG1412 compares pelvic lymphadenectomy alone with pelvic and para-aorticlymphadenectomy to evaluate the therapeutic role of para-aortic lymphadenectomy for patients atrisk of LNM. For quality assurance of lymphadenectomy, we defined several regulations, includinglower limit of the number of resected nodes, and submission of photos of dissected area toevaluate thoroughness of lymphadenectomy in the protocol. The latest monitoring report showedthat the quality of lymphadenectomy has been well-controlled in JCOG1412. Conclusion: Our strategy seems reasonable to omit lymphadenectomy and could begeneralized in clinical practice. JCOG1412 is a high-quality lymphadenectomy trial in terms ofthe quality of surgical procedures, which would draw the bona-fide conclusions regarding thetherapeutic role of lymphadenectomy for endometrial cancer.
Suzuki Yugo,Ochiai Yorinari,Hosoi Atsuko,Okamura Takayuki,Hayasaka Junnosuke,Mitsunaga Yutaka,Tanaka Masami,Odagiri Hiroyuki,Nomura Kosuke,Yamashita Satoshi,Matsui Akira,Kikuchi Daisuke,Ohashi Kenichi 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1
Background/Aims: Asymptomatic esophageal eosinophilia (aEE) is considered to be a potential precursor of eosinophilic esophagitis (EoE). However, there are few clinical parameters that can be used to evaluate the disease. Therefore, we aimed to clarify the factors involved in the symptoms of EoE by examining the clinicopathological differences between aEE and EoE. Methods: We reviewed 41 patients with esophageal eosinophilia who underwent endoscopic ultrasonography and high-resolution manometry. They were divided into the aEE group (n=16) and the EoE group (n=25) using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease score. The patients’ clinicopathological findings were collected and examined. Results: The median Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease score was 3.0 in the aEE group and 10.0 in the EoE group. There was no significant difference in patient characteristics, endoscopic findings and pathological findings. The cutoff value for wall thickening was 3.13 mm for the total esophageal wall thickness and 2.30 mm for the thickness from the surface to the muscular layer (total esophageal wall thickness: 84.0% sensitivity, 75.0% specificity; thickness from the surface to the muscular layer: 84.0% sensitivity, 68.7% specificity). The high-resolution manometry study was abnormal in seven patients (43.8%) in the aEE group and in 12 (48.0%) in the EoE group. The contractile front velocity was slower in the EoE group (p=0.026). Conclusions: The esophageal wall thickening in the lower portion of the esophagus is an important clinical factors related to the symptoms in patients with EoE.