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      • 유아의 서열화 능력발달에 관한 연구

        유지은,김선혜 원광대학교 대학원 2008 論文集 Vol.41 No.-

        The purpose of this study was to analysis young children's seriation through an examination of the performance of 190 children aged 5 to 7. The collected data were analyzed by percentage, mean, standard deviation, x², correlation analysis. The instrument of this study were Lee Hyo Jeong 's(1986) seriation test material which modified Piaget's seriation test material and Lavatelli's seriation test material. The results of this study are as follows. First, there was a statistically signification difference among ages, SES and between girls and boys about an object which children don't like. Second, there was a statistically signification difference among ages, SES and between girls and boys about an object which children like. Third There is a statistically signification relationship between young children' seriation and representation ability.

      • DeSOx/DeNOx 효율 개선을 위한 펄스 코로나 방전하에서 기체미립자 전환반응의 적용

        김동주,최유리,김교선 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

        In this paper, we investigated the post-combustion removal of nitrogen oxide(N0?) and sulfur oxide(S0?) which is based on the gas to particle conversion process by the pulsed corona discharge. Under normal pressure, the pulsed corona discharge produces the energetic free electrons which dissociate gas molecules to form the active radicals. These radicals cause the chemical reactions that convert SO? and NO? into acid mists and these mists react with NH? to form solid particles. Those particles can be removed from the gas stream by conventional devices such as electrostatic precipitator or bag filter. The reactor geometry was coaxial with an inner wire discharge electrode and an outer ground electrode wrapped on a glass tube. The simulated flue gas with SO? and NO? by adding NH? and H?O in the gas stream. We also measured the rmoval efficiency of SO? and NO? in a cylinder type corona discharge reactor and obtained more than 90% of removal efficiency in these experimental conditions. The effects of process variables such as the inlet concentrations of SO?, NH? asnd H?O, residence time, pulse frequencies and applied voltages were investigated.

      • TPA로 야기된 HL-60 세포의 기질부착 저해작용을 이용한 Protein Kinase C 저해 생약의 탐색

        김선희,안종석,김삼용,유관희,안병준 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

        Thirty-five kinds of herbal drugs, believed to be active for treatment of tumors, were selected as the experimental materials for observing their effects on TPA-induced adherence of HL-60 cell and activity of protein kinase C. They were extracted with ethyl ether(E) and ethyl acetate(EA), methanol(M) in sequence. Among the extracts, Sophorae Flos(EA), Paeoniae Radix(EA), Equisetum hiemale(EA), Phellodendri Cortex(E, EA), Mori Cortex radicis(EA), Ferula assafoetida(E, EA), Sophora subprostrata(EA, M) and Cnidium monnieri(E) inhibited the TPA-in-duced adherence of HL-60 cell more than 50% and Sophorae Flos(E, EA, M), Paeoniae Radix(E, EA, M), Eguisetum hiemale(E), Phellodenri Cortex(E,H), Mori Cortex radicis(M), Ferula assafoetida(M), Sophora subprostrata(EA, M), Cnidium monnieri(M) and Artemisia argyi(M) showed inhibiting effects on the activity of protein kinase C more than 50%. The extracts showing good inhibiting effects on the adherence and enzyme activity were Sophorae Flos(EA), Paeoniae Radix(EA), Phellodendri Cortex(E), Sophora subsprostrate(EA) and Equisetum hiemale(EA).

      • 구성주의에 의한 수학 교수·학습의 과제

        김선유 晋州敎育大學校 科學敎育硏究所 1997 科學敎育硏究 Vol.23 No.-

        The purpose of this thesis is to study the basic principles of the constructivism, which can be the theoretical background of Open Education in preparation for 21century. The basic principles of constructivism are as follows; 1. The knowledge of mathematics is actively constructed by the cognitive subject 2. The knowledge of mathematics is constructed by the reflective thought thought and modified and refined by social interaction 3. The knowledge of mathematics deals with the individual interpretation of the emprical world, not the absolute or objective truth. There are various types of the constructivism classified by its basic principles, this study introduces the radical constructivism among them and also considers the conventional constructivism mode which is adaptable to the mathematics learning in the real classroom circumstances by modifying and supplementing the radical constructivism. Finally, this study considers the teaching and learning task of mathematics by the conventional constructivism.

      • 한국형 노인주거개발을 위한 이론적 고찰

        박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

        According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.

      • 조선대학병원에서 경험한 삼일열 말라리아의 임상적 고찰

        서영선,김양수,김태균,박유환,홍순표,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

        In the five years since 1993 Malaria has made a ceaseless attack on the native Koreans as an indigenously formed disease in addition to the imported one. This study was aimed at clinical symptoms and signs of Malaria which had occurred indigenously in Cheon-Nam. 18 cases were reviewed retrospectively in this study which was composed of 17 men and 1 woman. They were admitted to Chosun Hospital because of the indigenous Malaria in 1998. Fever and chill , the most frequent symptoms in early stages made a 100% occurrence followed by general myalgia(89%) and headache(83%). Physical examination of those admitted showed the splenomegaly most frequently in 61% of the patients. It took four to ten days to visit the hospital since the symptoms first occurred in the patients. Gametocytes among the Malarial life cycle were observed most commonly (91.3%) in the occurrence of the disease and the prestages of the life cycle as well. The hematologic abnormalities observed was Anemia(89%), Thrombocytopenia(61%), and Neutropenia(50%) in the order named. On the third hospital day since giving the standard Malarial drugs parasitemia decreased remarkably (1540/㎕ : Mean parasitic concentration) and 28th day of treatment no parasitemia were found. In conclusion the patients suffering from malaria in Cheon-Nam had been in an armistice area and the symptoms were so relatively mild that the responses to treatment were good and relapses occurred. But, it requires further epidemiologic survey and more concern about the indigenous Malaria.

      • 비정질 셀레늄 박막의 이상광전도 특성

        금채,이기선,허복회,김유배,이병주 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

        In the visible region of spectral distribution, the photoconductivity of long wavelength in amorphous Se thin films showed an increase but that of short wavelength showed a decrease. After the sample was illuminated with high intensity white light for three hours at low temperature, we observed that the magnitude of the photoconductivity depended only on the spectral composition of the incident light and the dark conductivity showed a strong dependence on the wavelength to which the sample had been exposed beforehand at 100 K, which is called an anomalous photoconductivity. We believe that the mercuries in amorphous selenium film have generated the long-life traps contributing to the anomalous photoconductivity of samples. The height of the barrier generated by the long life traps was 2.4 eV

      • SCISCIESCOPUS

        Chemoresponsiveness associated with canonical molecular changes in colorectal adenocarcinomas.

        Kim, Jin C,Roh, Seon A,Cho, Dong H,Kim, Tae W,Yoon, Sang N,Kim, Chan W,Yu, Chang S,Kim, Seon Y,Kim, Yong S Potamitis Press 2009 Anticancer research Vol.29 No.8

        <P>BACKGROUND: The canonical molecular changes in colorectal tumorigenesis were assessed for correlation with response to chemotherapy, in order to identify candidate markers. PATIENTS AND METHODS: In total, 156 patients received adjuvant postoperative fluoropyrimidine-based chemotherapy and 32 patients received oxaliplatin- or irinotecan-based chemotherapy following palliative surgery or for metastatic or recurrent colorectal tumors. Representative molecular changes in tumor tissues, including adenomatous polyposis coli (APC) gene, wingless-type MMTV integration site family (Wnt), mismatch repair (MMR), RAF, transforming growth factor (TGF)-beta, bone morphogenetic protein, and p53, had been previously determined, with an additional 42 patients included in this analysis. RESULTS: The disease-free survival period (mean+/-SEM) was significantly longer after fluoropyrimidine-based adjuvant chemotherapy in tumors with TGF-beta2 expression (42+/-1.4 vs. 21+/-4.7 months; p=0.005) and D18S46 loss of heterozygosity or microsatellite instability (45.7+/-1.5 vs. 40.5+/-1.4 months; p=0.048). In the metastatic settings, the high disease-control rate of oxaliplatin and irinotecan regimens correlated significantly with wild-type APC and intact MMR, respectively, relative to mutant APC and defective MMR (p=0.013, respectively). Interestingly, specific molecular steps of tumorigenensis were closely associated with particular toxicities. CONCLUSION: A subset of molecular changes occurring during colorectal tumorigenesis showed significant associations with therapeutic responses and toxicities to chemotherapy regimens, suggesting that these changes may be candidate predictors of chemoresponsiveness with further validation.</P>

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