Structural and Functional Neural Alterations in Internet Addiction: A Study Protocol for Systematic Review and Meta-Analysis

Jun-Li Liu,Jing-Ting Sun,Hui-Lin Hu,Hao-Yuan Wang,Yun-Xi Kang,Tian-Qi Chen,Zhu-Hong Chen,Yu-Xuan Shang,Yu-Ting Li,Bo Hu,Rui Liu 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1

A growing number of neuroimaging studies have revealed abnormal brain structural and functional alterations in subjects with internet addiction (IA), however, with conflicting conclusions. We plan to conduct a systematic review and meta-analysis on the studies of voxelbased morphometry (VBM) and resting-state functional connectivity (rsFC), to reach a consolidated conclusion and point out the future direction in this field. A comprehensive search of rsFC and VBM studies of IA will be conducted in the PubMed, Cochrane Library, and Web of Science databases to retrieve studies published from the inception dates to August 2021. If the extracted data are feasible, activation likelihood estimation and seed-based d mapping methods will be used to meta-analyze the brain structural and functional changes in IA patients. This study will hopefully reach a consolidated conclusion on the impact of IA on human brain or point out the future direction in this field.

Influence of internal pores and graphene platelets on vibration of non-uniform functionally graded columns

Wen-qi Liu,Shan-jun Liu,Ming-yu Fan,Wei Tian,Ji-peng Wang,Vahid Tahouneh 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.35 No.2

This paper deals with free vibration analysis of non-uniform column resting on elastic foundations and subjected to follower force at its free end. The internal pores and graphene platelets (GPLs) are distributed in the matrix according to different patterns. The model is proposed with material parameters varying in the thickness of column to achieve graded distributions in both porosity and nanofillers. The elastic modulus of the nanocomposite is obtained by using Halpin-Tsai micromechanics model. The differential quadrature method as an efficient and accurate numerical approach is used to discretize the governing equations and to implement the boundary conditions. It is observed that the maximum vibration frequency obtained in the case of symmetric porosity and GPL distribution, while the minimum vibration frequency is obtained using uniform porosity distribution. Results show that for better understanding of mechanical behavior of nanocomposite column, it is crucial to consider porosities inside the material structure.

Effects of gas signaling molecule SO2 in cardiac functions of hyperthyroid rats

Yang Qi,Yang Ting,Liu Xing,Liu Shengquan,Liu Wei,Nie Liangui,Chu Chun,Yang Jun 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.2

Sulfur dioxide (SO2), a novel endogenous gas signaling molecule, is involved in the regulation of cardiac function. Exerting a key role in progression of hyperthyroidism-induced cardiomyopathy (HTC), myocardial fibrosis is mainly caused by myocardial apoptosis, leading to poor treatment outcomes and prognoses. This study aimed to investigate the effect of SO2 on the hyperthyroidism-induced myocardial fibrosis and the underlying regulatory mechanisms. Elisa, Masson staining, Western-Blot, transmission electron microscope, and immunofluorescence were employed to evaluate the myocardial interstitial collagen deposition, endoplasmic reticulum stress (ERS), apoptosis, changes in endogenous SO2, and Hippo pathways from in vitro and in vivo experiments. The study results indicated that the hyperthyroidism-induced myocardial fibrosis was accompanied by decreased cardiac function, and down-regulated ERS, apoptosis, and endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2 in cardiac myocytes. In contrast, exogenous SO2 donors improved cardiac function, reduced myocardial interstitial collagen deposition, up-regulated AAT1/2, antagonized ERS and apoptosis, and inhibited excessive activation of Hippo pathway in hyperthyroid rats. In conclusion, the results herein suggested that SO2 inhibited the overactivation of the Hippo pathway, antagonized ERS and apoptosis, and alleviated myocardial fibrosis in hyperthyroid rats. Therefore, this study was expected to identify intervention targets and new strategies for prevention and treatment of HTC.

Research progress and treatment of radiation enteritis and gut microbiota

Huiwen Ren(Huiwen Ren),Qi Wu(Qi Wu),Zhiqiang Sun(Zhiqiang Sun),Mingming Fang(Mingming Fang),Jun Liu(Jun Liu),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2

Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. Abdominal radiation causes changes in the composition of the flora and a decrease in its diversity, which is mainly manifested by a decrease in beneficial bacterial species such as Lactobacilli and Bifidobacteria. Intestinal dysbacteriosis aggravates radiation enteritis, weakens the function of the intestinal epithelial barrier, and promotes the expression of inflammatory factors, thereby aggravating the occurrence of enteritis. Given the role of the microbiome in radiation enteritis, we suggest that the gut microbiota may be a potential biomarker for the disease. Treatment methods such as probiotics, antibiotics, and fecal microbiota transplantation are ways to correct the microbiota and may be an effective way to prevent and treat radiation enteritis. Based on a review of the relevant literature, this paper reviews the mechanism and treatment of intestinal microbes in radiation enteritis.

Stabilization of Benchmark Under-actuated Systems via Saturated Controls

Jun Liu,Huawen Ye,Xianting Qi 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11

In this paper, we present controllers to stabilize benchmark under-actuated systems such as inertia wheel pendulum (IWP), cart-pole, cart-pendulum, overhead crane, VTOL aircraft, ball-and-beam, translational oscillations with a rotational actuator (TORA), and active magnetic bearing (AMB). The mentioned systems are transformed into the feedforward systems subject to uncertain gains, the nested-saturation controllers in an almost unified form are then designed. Due to the analysis mechanism of saturation reduction (checking the time-derivatives of boundary surfaces), the bounds of uncertain gains can always be determined in small domains. In turn, there is no need to treat in advance certain subsystems, and the fully-saturated controllers (rather than partially-saturated ones) can be taken as global stabilizers. Moreover, the explicit inequality conditions can always be summarized. In addition, for the relatively complicated systems such as the overhead crane system, a non-strict upper-triangular subsystem of the ball-and-beam system as well as the TORA system, special technical strategies are developed to treat the linear perturbation, the non-strict upper-triangular structure and an oscillator.

Time Domain Sensitivity of High-Speed VLSI Interconnects

Liu,Nelson,Nakhia,Michel S.,Zhang,Qi Jun 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1

An efficient method based on the Asymptotic Waveform Evaluation (AWE) technique, is described in this paper for time domain adjoint sensitivity analysis of VLSI interconnect networks that contain distributed elements. As a practical application, this method is applied to the case where the distributed elements can be modelled as lossless or lossy coupled transmission lines. Due to the recursive relationship between moments for interconnect networks, the conventional adjoint approach could not be applied directly Instead, we present an alternative approach to solve this problem by introducing the adjoint moments for distributed networks. The proposed technique is useful for identification of critical circuit elements and performance optimization of high speed VLSI designs. Examples and comparisons with sensitivity determined by perturbation are presented.

Vertical Distribution and Temporal Variation of Asian Dust Observed over Hefei, China by Using a Lidar

Jun Zhou,Anyuan Fan,Cha Hyungki,Dong Liu,Dukhyeon Kim,Fudi Qi,Guangyu Shi,Guming Yue 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

A Mie lidar has been used to make observations of Asian dust over Hefei (31.90 N, 117.16 E) in the every spring month since the year of 1998. This paper presents the main features of the vertical distribution and the temporal variation of the Asian dust extinction coefficient at a 532-nm wavelength during seven years. There were two kinds of vertical distributions of Asian dust extinction coefficients. One kind of distribution indicated that the Asian dust particles intruded into the local boundary layer, causing a very thick dust layer with depth of about 3 4 km. The other one showed that the Asian dust passed over Hefei area above the boundary layer. The aerosol extinction coefficients in the elevated dust layer within the middle troposphere from 3 to 6 km were unusually large. Seasonally averaged aerosol extinction coefficient profiles showed that larger aerosol extinction coefficients were observed in the altitude range from 1 km to 10 km in the springtime than in any other season.쯢

Effect of mixture ratio and accelerator on the mechanical strength of cement mortar for binder jet 3D printing

Liu, Jun-Xing(유준성),Li, Pei-Qi(리패기),Piao, Tai-Yan(퍄오 타이옌),Bae, Sung-Chul(배성철) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.1

Exploiting the antibacterial mechanism of phenazine substances from Lysobacter antibioticus 13-6 against Xanthomonas oryzae pv. oryzicola

Liu Qi,Yang Jun,Ahmed Waqar,Wan Xiaoyan,Wei Lanfang,Ji Guanghai 한국미생물학회 2022 The journal of microbiology Vol.60 No.5

Bacterial leaf streak caused by Xanthomonas oryzae pv. oryzicola (Xoc) is one of the most destructive diseases affecting rice production worldwide. In this study, we extracted and purified phenazine substances from the secondary metabolites of Lysobacter antibioticus 13-6. The bacteriostatic mechanism of phenazine substances against Xoc was investigated through physiological response and transcriptomic analysis. Results showed that phenazine substances affects the cell membrane permeability of Xoc, which causes cell swelling and deformation, blockage of flagellum synthesis, and imbalance of intracellular environment. The changes in intracellular environment affect the physiological and metabolic functions of Xoc, which reduces the formation of pathogenic factors and pathogenicity. Through transcriptomic analysis, we found that among differentially expressed genes, the expression of 595 genes was induced significantly (275 up-regulated and 320 down-regulated). In addition, we observed that phenazine substances affects three main functions of Xoc, i.e., transmembrane transporter activity, DNA-mediated transposition, and structural molecular activity. Phenazine substances also inhibits the potassium ion transport system that reduces Xoc resistance and induces the phosphate ion transport system to maintain the stability of the internal environment. Finally, we conclude that phenazine substances could retard cell growth and reduce the pathogenicity of Xoc by affecting cell structure and physiological metabolism. Altogether, our study highlights latest insights into the antibacterial mechanism of phenazine substances against Xoc and provides basic guidance to manage the incidence of bacterial leaf streak of rice.

Juvenile hormone-mediated reproduction induced by a sublethal concentration of imidacloprid in Cyrtorhinus lividipennis (Hemiptera: Miridae)

Jun Zhu,Yao Li,Ying-Ying Tang,Jian-Qi Liu,Yi-Yu Chen,Zhongxian LV,Fang Liu 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1

The Hemipteran predator, Cyrtorhinus lividipennis, feeds on the eggs and nymphs of rice planthoppers and leafhoppers. We previously demonstrated that sublethal concentrations of imidacloprid stimulated the reproduction of C. lividipennis. Considering the essential roles of juvenile hormone (JH) in insect reproduction, we speculated that sublethal concentrations of imidacloprid may stimulate the reproduction of C. lividipennis by regulating JH level. To test this, we cloned C. lividipennis JH acid methyl transferase (ClJHAMT) and JH esterase (ClJHE), which are responsible for JH biosynthesis and degradation genes, respectively. We then knocked down ClJHAMT by injecting dsRNA into C. lividipennis nymphs and found that emerging female adults exhibited 88.8% lower expression of the vitellogenin gene (ClVg) and the number of eggs was reduced by 41.5% as compared with controls. Silencing ClJHE increased ClVg mRNA expression by 275.0% but did not affect fecundity. A sublethal concentration of imidacloprid (LC 20 ) increased the JH titer in females by 35.3% and 60.6% at 24 and 48 h post-emergence, respectively. In treatments containing both imidacloprid and dsJHAMT, the silencing of CLJHAMT reduced the number of eggs produced by adult females by 21.4% as compared to the control (imidacloprid + dsGFP). Our results indicated that sublethal concentration of imidacloprid may induce C. lividipennis reproduction by upregulating JH level via JHAMT. The finding could provide valuable information for improved integration of C. lividipennis and insecticides in pest management.