다발성 외상 후 횡문근융해증 환자에서의 손상초기 급성신부전의 예측인자

문중범,이강현,황성오,이진웅,한병근,최승옥,강성준 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Acute renal failure(ARF) is a serious complication of rhabdomyolysis after multiple trauma, and may increase morbidity and mortality. The aim of this study was to elucidate predicting factors for the development of ARF induced by rhabdomyolysis at an early stage of multiple trauma. Methods: This prospective, observational study was conducted at the emergency department of a level I trauma center. Patients with acute multiple trauma, whose plasma levels of creatine phosphokinase(CPK) were higher than 1,000 IU, were included in this study. We excluded patients with any history of myocardial infarction, stroke, underlying renal disease, and/or infectious disease. We collected clinical and laboratory data including age, heart rate, mean arterial blood pressure, injury severity score, serum myoglobin, lactic dehydrogenase, creating phosphokinase, and base excess. Collected data were compared between patients who had ARF and patients who did not have ARF. Results: Eighty-eight patients were enrolled in this study. Eighteen patients(20.5%) developed ARF. The injury severity score(ISS)(p=0.001), the base excess(p<0.001), CPK(p=0.003), and myoglobin(p<0.001) were higher in patients with ARF than in patient without ARF. Logistic regression analysis revealed that early predictors for ARF were high ISS, high base excess, high CPK, and high myoglobin. Conclusion: We could identify early predicting factors for acute renal failure induced by rhabdomyolysis, these factors included ISS, serum CPK and myoglobin, and base excess in the arterial blood gas analysis performed at the emergency department.

2차병원에서의 소아과 환자의 응급실 및 외래 이용에 관한 연구

김진희,배진호,전진호,문정웅 인제대학교 2006 仁濟醫學 Vol.27 No.-

Objectives : To analyze the characteristics of the pediatric patients who visited the emergency room and outpatient department of secondary hospital in order to properly guide pediatric patients to use emergency room and raise the efficiency Methods : The authors investigated and analyzed sex, age, visit day, visit time, length of stay, hospitalization and diagnostic entities of the pediatric patients who visited the emergency room and outpatient department of Wallace Memorial Baptist Hospital from January 2003 to December 2005 in a retroactive approach with their medical records. Results : For the three years, the number of total patients who visited the emergency room was 56,051 and among them, the number of pediatric patients was 7,490 (13.4%). The age group of 1 to 2 years was the largest with 2,488 (33.2%). The male to female ratio was 1.34:1. Sunday was the day of the week that the largest number of patienst visited with 2,375 (31.7%) and nearly half (48.4%) of the patients visited the emergency room during the weekend. The time when the most patient visited the emergency room was between 8 pm to 12 am. Regarding the length of stay, the highest number of patients (65.0%) stayed in the emergency room for on hour or less, and the average length of visit was 1.5 hours, which was rather short. Most patients (68.8%) left the hospital after taking simple physical examination and procedure(prescription). The most frequent diagnoses for the pediatric patients who visited the emergency room were acute pharyngitis (26.0%), acute gastroenteritis (20.7%), fever (6.6%). During the same period, the total number of pediatric patients who visited the outpatient department was 125,513. The age group of 3 to 5 was the largest with 36,041 (28.7%). The male to female ratio was 1.34:1. 6.0% of total outpatients required treatment in a hospital. Most frequent diagnoses of the outpatients were asthma (24.4%), pneumonia (12.0%), vaccination (8.7%), febrile convulsion (8.4%), acute pharyngitis (6.6%), acute gastroenteritis (5.8%). Conclusion : It is considered that a large number of pediatric patients still have used emergency room for treatment of simple and mild diseases instead of visiting outpatient department and/or primary hospital. Thus further efforts are required to properly guide pediatric patients to use emergency room and to raise the efficiency of their use.

의대생의 스트레스에 영향을 미치는 요인 분석

전진용,김상아,문동석,강동원,박웅섭 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Background : Generally, it is well known that medical students have lots of stress because they have many classes of which the courses are much different from those of non-medical students. So, this study was designed for the purpose of evaluating the influencing factors on medical students' stress. Method : This study was carried out with the data of 69 students in premedical course and 66 students in medical course, who answered the survey by Kwandong Medical College, Department of Preventive Medicine and Public Health in June, 1999, The independent variables are the general characteristics, the characteristics related with study, the state of health, the activity for free time. The amount of stress is measured by Korean-translated BEPSI (Brief Encounter Psychosocial Instrument). Result : The multiple recession and logistic analysis show that the grade influence the significant difference of the stress level of the students in premedical course. The entrance age, average selfstudy time, hobby and religion influence the significant difference of the stress level of the students in medical course. The grade, avercage self-studying time and smoking habits influence the signifiant difference of the stress level of the medical students. Conclusion : This result will be used for the management of the stress level of the medical students' that influences their study.

Expression of growth hormone/insulin-like growth factor axis genes in olive flounder (Paralichthys olivaceus) fed a diet with partial replacement of dietary fish meal

Jin-Sung Moon,Dae Han Oh,Su-Jin Park,Jin-Song Seo,Dong-Uk Kim,Seong-Hwan Moon,Hung Sik Park,Sang-Gu Lim,Kang-Woong Kim,Bong-Joo Lee,Sang-Woo Hur,Hyeong-Jun Lee,Taek Jeong Nam,Youn Hee Choi 한국수산과학회 양식분과 2019 한국수산과학회 양식분과 학술대회 Vol.2019 No.5

Predictive Factors for Differentiating Gastrointestinal Stromal Tumors from Leiomyomas Based on Endoscopic Ultrasonography Findings in Patients with Gastric Subepithelial Tumors: A Multicenter Retrospective Study

Sun Moon Kim,Eun Young Kim,Jin Woong Cho,Seong Woo Jeon,Ji Hyun Kim,Tae Hyeon Kim,Jeong Seop Moon,Jin-Oh Kim,Research Group for Endoscopic Ultrasound of the Korean Society of Gastrointestinal Endoscop 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6

Background/Aims: The utility of endoscopic ultrasonography (EUS) for differentiating gastrointestinal stromal tumors (GISTs)and leiomyomas of the stomach is not well known. We aimed to evaluate the ability of EUS for differentiating gastric GISTs andleiomyomas. Methods: We retrospectively reviewed the medical records of patients with histopathologically proven GISTs (n=274) andleiomyomas (n=87). In two consensus meetings, the inter-observer variability in the EUS image analysis was reduced. Using logisticregression analyses, we selected predictive factors and constructed a predictive model and nomogram for differentiating GISTs fromleiomyomas. A receiver operating characteristic (ROC) curve analysis was performed to measure the discrimination performance inthe development and internal validation sets. Results: Multivariate analysis identified heterogeneity (odds ratio [OR], 9.48), non-cardia (OR, 19.11), and older age (OR, 1.06)as independent predictors of GISTs. The areas under the ROC curve of the predictive model using age, sex, and four EUS factors(homogeneity, location, anechoic spaces, and dimpling or ulcer) were 0.916 (sensitivity, 0.908; specificity, 0.793) and 0.904 (sensitivity,0.908; specificity, 0.782) in the development and internal validation sets, respectively. Conclusions: The predictive model and nomogram using age, sex and homogeneity, tumor location, presence of anechoic spaces, andpresence of dimpling or ulcer on EUS may facilitate differentiation between GISTs and leiomyomas.

MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer

( Ji Woong Son ),( Young Jin Kim ),( Hyun Min Cho ),( Soo Young Lee ),( Jin Sung Jang ),( Jin Eun Choi ),( Jung Uee Lee ),( Min Gyu Kang ),( Yu Mi Lee ),( Sun Jung Kwon ),( Eu Gene Choi ),( Moon Jun N 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5

Background: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer development and progression by regulating the expression of proto-oncogenes or tumor suppressor genes. In this study, we investigated miRNA expression profiles in Korean patients with non-small cell lung cancer (NSCLC). Methods: We performed miRNA microarray analysis containing 60∼65 bp oligonucleotide probes representing human 318 miRNAs and validated the results of the microarray with Northern blot analysis or quantitative RT-PCR. Next, we examined the correlation between miRNA expression and the target gene transcriptional profile using a human whole-genome-expression microarray. Results: We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding non-malignant lung tissues. We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding nonmalignant lung tissues. Thirteen of the 35 differentially expressed miRNAs were newly identified in the present study. Of the 35 miRNAs, 2 (miR-371 and miR-210) were over-expressed in lung cancers, and 33 miRNAs, including miR-145, were under-expressed in lung cancers. miR-99b expression consistently showed a negative correlation with FGFR3 expression. Conclusion: Albeit a small number of patients were examined, these results suggest that miRNA expression profiles in Korean lung cancers may be somewhat different from the expression profiles reported on lung cancers in Western populations. The findings suggest that miR-99b might be a tumor suppressor through its up-regulation of FGFR3.

GPU기반 Depth Map 회득을 위한 고속 병렬처리 기법

진문섭(Jin, Moon-Sub),최지윤(Choi, Ji-Yoon),추현곤(Choo, Hyon-Gon),김진웅(Kim, Jin-Woong),박종일(Park, Jong-Il) 한국방송·미디어공학회 2011 한국방송공학회 학술발표대회 논문집 Vol.2011 No.7

본 논문은 두 대의 카메라와 한 대의 프로젝터로 구성된 Pro-cam시스템을 이용하여, 출력된 패턴 영상을 카메라로 촬영하고 이를 기반으로 Depth Map을 계산하는 모듈의 실시간 처리를 위한 GPU기반 병렬처리 기법을 제안한다. 입력받은 영상으로부터 구조광의 패턴을 해석하고, Depth Map을 계산하기 위해서, Dynamic pattern decoding하는 과정은 프로젝터의 패턴영상과 촬영된 카메라 패턴영상 간의 관계를 반복적으로 비교하므로, 이를 GPU 프로그래밍을 이용하여 병렬 처리를 통해 고속화하였다. 결과적으로 본 논문에서는 기존 CPU에서 수행했던 속도에 비해 약 18배정도 속도를 개선 할 수 있었다.

Photosynthesis Response and Yield with Soil Flooding in Soybean

Cho Jin-Woong,Lee Jung-Joon,Oh Young-Jin,Lee Mi-Ja,Park Moon-Soo,Lee Sang-Bok,Kim Soo-Dong 한국작물학회 2003 한국작물학회 학술발표대회 논문집 Vol.2003 No.-

Replacement techniques to reduce animal experiments in drug and nanoparticle development

Ik Sup Jin,Moon Sup Yoon,Chun‑Woong Park,Jin Tae Hong,Youn Bok Chung,Jin‑Seok Kim,Dae Hwan Shin 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.3

Background Animals have been used for the testing of new drugs and nanoparticles to determine their safety and effectiveness before application in humans. Numerous drugs and nanoparticles have been developed through animal tests, and development in medical nanotechnology is progressing rapidly. However, a good experiment requires many animals. The primary measures to reduce animal experiments include reducing the number of animals used in each experiment and replacing laboratory animals with inanimate, cellular, or inferior animals to reduce sacrifices. Area covered Developing nanoparticles using simulations rather than experiments may be another alternative. Instead of animals, human cells or animal-derived organs, tissues, or cells could be used in experiments. These methods allow rapid toxicity and efficacy testing at low cost. However, the disadvantage of these methods is that they cannot accurately replicate the complex interrelationships between human organs, biological reactions to specific routes of administration, or toxicity of substances resulting from metabolic processes. To overcome these shortcomings of in vitro tests, new technologies such as organoids and organ-on-chips are progressing. These can be used to quickly examine the efficacy of newly developed drugs and nanoparticles and can be useful in developing patient-tailored agents. Expert opinion These technologies offer some promise but it is still difficult to entirely replace animal experiments. However, the scope of methods to replace experimental animals is widening, suggesting the potential to refine, reduce, and ultimately replace animal testing.

Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model

Hyong Woo Moon,Jung Woo Park,Kyu Won Lee,Hyun Cheol Jeong,Jin Bong Choi,Sae Woong Choi,Woong Jin Bae,Hyuk Jin Cho,U-Syn Ha,Sung Hoo Hong,Jeong Ho Geum,Seong Bin Hong,Sae Woong Kim 대한남성과학회 2017 The World Journal of Men's Health Vol.35 No.1

Purpose: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. Materials and Methods: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined. Results: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis. Conclusions: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.