Dance motion generation by recombination of body parts from motion source

Lee, Minho,Lee, Kyogu,Lee, Mihee,Park, Jaeheung Springer-Verlag 2018 INTELLIGENT SERVICE ROBOTICS Vol.11 No.2

<P>In this paper, we propose an approach to synthesize new dance routines by combining body part motions from a human motion database. The proposed approach aims to provide a movement source to allow robots or animation characters to perform improvised dances to music, and also to inspire choreographers with the provided movements. Based on the observation that some body parts perform more appropriately than other body parts during dance performances, a correlation analysis of music and motion is conducted to identify the expressive body parts. We then combine the body part movement sources to create a new motion, which differs from all sources in the database. The generated performances are evaluated by a user questionnaire assessment, and the results are discussed to understand what is important in generating more appealing dance routines.</P>

Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus

( Mihee Hong ),( Hee Yeon Kim ),( Hannah Seok ),( Chang Dong Yeo ),( Young Soo Kim ),( Jae Yen Song ),( Young Bok Lee ),( Dong-hee Lee ),( Jae-im Lee ),( Tae-kyu Lee ),( Hyo-suk Ahn ),( Yoon Ho Ko ),( 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.5

Background/Aims: This study examined prevalence and risk factors of peri­odontitis in representative samples of Korean adults, with and without diabetes mellitus (DM). Methods: Data from the 2012 Korean National Health and Nutritional Exam­ination Survey were analyzed. A total of 4,477 adults (≥ 30 years old) were selected from 8,057 individuals who completed a nutrition survey, a self-reported general health behavior questionnaire, an oral examination, an oral hygiene behaviors survey, and laboratory tests. DM was defined as a fasting plasma glucose ≥ 126 mg/dL, or self-reported diagnosed diabetes, or current use of oral hypoglyce­mic agents and/or insulin. The community periodontal index was used to as­sess periodontitis status and comparisons between the periodontitis and the non-periodontitis group, were performed, according to the presence of DM. Risk factors for periodontitis in adults with DM and without DM were evaluated by multiple logistic regression analysis. Results: The prevalence of periodontitis was significantly higher in adults with DM (43.7%) than in those without DM (25%, p < 0.001). In adults without DM, risk factors for periodontitis were older age, male, urban habitation, waist cir­cumference, smoking, oral pain, and less frequent tooth brushing. Significant risk factors for periodontitis in adults with DM were the smoking, oral pain, and not-using an oral hygiene product. Conclusions: Adults with DM have an increased risk of periodontitis than those without DM. Current smoking and oral pain increase this risk. Using an oral hy­giene product can reduce risk of periodontal disease in adults with DM.

New Insight into Ni-Rich Layered Structure for Next-Generation Li Rechargeable Batteries

Lee, Wontae,Muhammad, Shoaib,Kim, Taewhan,Kim, Hyunchul,Lee, Eunkang,Jeong, Mihee,Son, Suhan,Ryou, Jae-Hyun,Yoon, Won-Sub Wiley (John WileySons) 2018 Advanced Energy Materials Vol.8 No.4

Least squares sieve estimation of mixture distributions with boundary effects

Mihee Lee,Ling Wang,Haipeng Shen,Peter Hall,Guang Guo,J.S. Marron 한국통계학회 2015 Journal of the Korean Statistical Society Vol.44 No.2

In this study, we propose two types of sieve estimators, based on least squares (LS), for probability distributions that are mixtures of a finite number of discrete atoms and a continuous distribution under the framework of measurement error models. This research is motivated by the maximum likelihood (ML) sieve estimator developed in Lee et al. (2013). We obtain two types of LS sieve estimators through minimizing the distance between the empirical distribution/characteristic functions and the model distribution/characteristic functions. The LS estimators outperform the ML sieve estimator in several aspects: (1) they need much less computational time; (2) they give smaller integrated mean squared error; (3) the characteristic function based LS estimator is more robust against mis-specification of the error distribution. We also use roughness penalization to improve the smoothness of the resulting estimators and reduce the estimation variance. As an application of our proposed LS estimators, we use the Framingham Heart Study data to investigate the distribution of genetic effects on body mass index. Finally asymptotic properties of the LS estimators are investigated.

Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel

Lee, Ho-Joon,Son, Myung Jin,Ahn, Jiwon,Oh, Soo Jin,Lee, Mihee,Kim, Ansoon,Jeung, Yun-Ji,Kim, Han-Gyeul,Won, Misun,Lim, Jung Hwa,Kim, Nam-Soon,Jung, Cho-Rock,Chung, Kyung-Sook Elsevier 2017 Acta Biomaterialia: structure-property-function re Vol.64 No.-

<P><B>Abstract</B></P> <P>Current <I>in vitro</I> liver models provide three-dimensional (3-D) microenvironments in combination with tissue engineering technology and can perform more accurate <I>in vivo</I> mimicry than two-dimensional models. However, a human cell-based, functionally mature liver model is still desired, which would provide an alternative to animal experiments and resolve low-prediction issues on species differences. Here, we prepared hybrid hydrogels of varying elasticity and compared them with a normal liver, to develop a more mature liver model that preserves liver properties <I>in vitro</I>. We encapsulated HepaRG cells, either alone or with supporting cells, in a biodegradable hybrid hydrogel. The elastic modulus of the 3D liver dynamically changed during culture due to the combined effects of prolonged degradation of hydrogel and extracellular matrix formation provided by the supporting cells. As a result, when the elastic modulus of the 3D liver model converges close to that of the <I>in vivo</I> liver (≅ 2.3 to 5.9 kPa), both phenotypic and functional maturation of the 3D liver were realized, while hepatic gene expression, albumin secretion, cytochrome p450-3A4 activity, and drug metabolism were enhanced. Finally, the 3D liver model was expanded to applications with embryonic stem cell-derived hepatocytes and primary human hepatocytes, and it supported prolonged hepatocyte survival and functionality in long-term culture. Our model represents critical progress in developing a biomimetic liver system to simulate liver tissue remodeling, and provides a versatile platform in drug development and disease modeling, ranging from physiology to pathology.</P> <P><B>Statement of Significance</B></P> <P>We provide a functionally improved 3D liver model that recapitulates <I>in vivo</I> liver stiffness. We have experimentally addressed the issues of orchestrated effects of mechanical compliance, controlled matrix formation by stromal cells in conjunction with hepatic differentiation, and functional maturation of hepatocytes in a dynamic 3D microenvironment. Our model represents critical progress in developing a biomimetic liver system to simulate liver tissue remodeling, and provides a versatile platform in drug development and disease modeling, ranging from physiology to pathology. Additionally, recent advances in the stem-cell technologies have made the development of 3D organoid possible, and thus, our study also provides further contribution to the development of physiologically relevant stem-cell-based 3D tissues that provide an elasticity-based predefined biomimetic 3D microenvironment.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes

Lee, Kyung-Mi,Kang, Jung Hoon,Yun, Mihee,Lee, Seong-Beom Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.1

<P><B>Abstract</B></P> <P>Quercetin, a polyphenol, belongs to a class of flavonoids that exerts anti-inflammatory effects. Interleukin (IL)-18 is a member of the IL-1 family cytokine that regulates immune responses and is implicated in various inflammatory skin diseases. Absent in melanoma 2 (AIM2) is a cytosolic double-stranded (ds) DNA sensor that recognizes the dsDNA of a microbial or host origin. Binding of dsDNA to AIM2 simulates caspase-1-dependent inflammasome activity, which leads to the production of IL-1β and IL-18. Increased levels of AIM2 have been observed in patients with inflammatory skin diseases. In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-γ-primed human keratinocytes. Treatment with 5 and 10 μM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-γ priming and before poly (dA:dT)-induced AIM2 activation. In addition, treatment with Quercetin at 10 μM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-γ-primed keratinocytes. These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed keratinocytes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pre-treatment with Quercetin inhibited poly(dA:dT)-induced IL-18 secretion in IFN-γ-primed keratinocytes. </LI> <LI> Pre-treatment with Quercetin inhibited expression of AIM2 and pro-caspase-1 in poly(dA:dT)-treated and IFN-γ–primed keratinocytes. </LI> <LI> Pre-treatment with Quercetin inhibited the JAK2/STAT1 pathway in poly(dA:dT)-treated and IFN-γ–primed keratinocytes. </LI> </UL> </P>

Cooperative control system of the floating cranes for the dual lifting

Mihee Nam,Jinbeom Kim,Jaechang Lee,Daekyung Kim,Donghyuk Lee,이장명 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.1

This paper proposes a dual lifting and its cooperative control system with two different kinds of floating cranes. The Mega-erection and Gigaerection in the ship building are used to handle heavier and wider blocks and modules as ships and off-shore platforms are enlarged. However, there is no equipment to handle such Tera-blocks. In order to overcome the limit on performance of existing floating cranes, the dual lifting is proposed in this research. In the dual lifting, two floating cranes are well-coordinated to add up the lift capabilities of both cranes without any loss such that virtually a single crane is lifting, maneuvering and unloading. Two main constraints for the dual lifting are as follows: First, two barges of floating cranes should be constrained as a rigid body not to cause a relative motion between two barges and main hooks of the two cranes should be controlled as main hooks of a single crane. In order words, it is necessary to develop the cooperative control of two floating cranes in order to sustain a center of gravity of the module and minimize the tilting angle during the lifting and unloading by the two floating cranes. Two floating cranes are handled as a master-slave system. The master crane is able to gather information about all working conditions and make a decision to control the individual hook speed, which communicates the slave crane by TCP/IP. The developed control system has been embedded in the real floating crane systems and the dual lifting has been demonstrated five times at SHI shipyard in 2015. The moving angles of the lifting module are analyzed and verified to be suitable for hoisting control. It is verified that the dual lifting can be applied for many heavier and wider blocks and modules to shorten the construction time of ships and off-shore platforms.

Depletion of Janus kinase-2 promotes neuronal differentiation of mouse embryonic stem cells

Mihee Oh,Sun Young Kim,Jeong-Su Byun,Seonha Lee,Won-Kon Kim,Kyoung-Jin Oh,Eun-Woo Lee,Kwang-Hee Bae,이상철,Baek-Soo Han 생화학분자생물학회 2021 BMB Reports Vol.54 No.12

Janus kinase 2 (JAK2), a non-receptor tyrosine kinase, is a criticalcomponent of cytokine and growth factor signaling pathwaysregulating hematopoietic cell proliferation. JAK2 mutations areassociated with multiple myeloproliferative neoplasms. Althoughphysiological and pathological functions of JAK2 in hematopoietictissues are well-known, such functions of JAK2 in thenervous system are not well studied yet. The present study demonstratedthat JAK2 could negatively regulate neuronal differentiationof mouse embryonic stem cells (ESCs). Depletion ofJAK2 stimulated neuronal differentiation of mouse ESCs andactivated glycogen synthase kinase 3ꞵ, Fyn, and cyclin-dependentkinase 5. Knockdown of JAK2 resulted in accumulation of GTPboundRac1, a Rho GTPase implicated in the regulation of cytoskeletaldynamics. These findings suggest that JAK2 might negativelyregulate neuronal differentiation by suppressing the GSK-3β/Fyn/CDK5 signaling pathway responsible for morphological maturation.

The prognostic impact of reduced variant burden in elderly patients with acute myeloid leukemia treated with decitabine

Mihee Kim,TaeHyung Kim,Seo-Yeon Ahn,Jun Hyung Lee,Ju Heon Park,Myung-Geun Shin,Sung-Hoon Jung,Ga-Young Song,Deok-Hwan Yang,Je-Jung Lee,Seung Hyun Choi,Mi Yeon Kim,Jae-Sook Ahn,Hyeoung-Joon Kim,Dennis 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.4

Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy. Methods: A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We analyzed the dynamics of variant allele frequency (VAF) in 49 available follow-up samples after the fourth cycle of decitabine. The 58.6% VAF clearance (Δ, [VAF at diagnosis − VAF at follow-up] × 100 / VAF at diagnosis) was the optimal cut-off for predicting overall survival (OS). Results: The overall response rate was 34.1% (eight patients with complete remission [CR], six of CR with incomplete hematologic recovery, 22 with partial responses, and six with morphologic leukemia-free status). Responders (n = 42) had significantly better OS compared with non-responders (n = 42) (median, 15.3 months vs. 6.5 months; p < 0.001). Of the 49 patients available for follow-up targeted NGS analysis, 44 had trackable gene mutations. The median OS of patients with ΔVAF ≥ 58.6% (n=24) was significantly better than that of patients with ΔVAF < 58.6% (n = 19) (20.5 months vs. 9.8 months, p = 0.010). Moreover, responders with ΔVAF ≥ 58.6% (n = 20) had a significantly longer median OS compared with responders with VAF < 58.6% (n = 11) (22.5 months vs. 9.8 months, p = 0.004). Conclusions: This study suggested that combining ΔVAF ≥ 58.6%, a molecular response, with morphologic and hematologic responses can more accurately predict OS in elderly AML patients after decitabine therapy.

Source Analysis and Effective Control of a COVID-19 Outbreak in a University Teaching Hospital during a Period of Increasing Community Prevalence of COVID-19

Lee Unhee,김성은,Lee Seung Yeob,Wi Hang Nam,Choi Okja,Park Ji-Won,Kim Dahee,Kim You Jung,Shin Hwa Young,Kim Mihee,Kim Eun Ji,Kang Seung-Ji,Jung Sook-In,Park Kyung-Hwa 대한의학회 2021 Journal of Korean medical science Vol.36 No.24

Background: South Korea has been experiencing a third wave of coronavirus disease 2019 (COVID-19) since mid-November 2020. Our hospital in Gwangju metropolitan city experienced a healthcare-associated COVID-19 outbreak early in the third wave. The first confirmed COVID-19 patient was a symptomatic neurosurgery resident with high mobility throughout the hospital. We analyzed the transmission routes of nosocomial COVID-19 and discussed infection control strategies. Methods: We retrospectively analyzed the severe acute respiratory syndrome coronavirus 2 reverse transcription-polymerase chain reaction (RT-PCR) testing results according to time point and evaluated transmission routes. Results: Since COVID-19 was first confirmed in a healthcare worker (HCW) on 11/13/2020, we performed RT-PCR tests for all patients and caregivers and four complete enumeration surveys for all HCWs. We detected three clusters of nosocomial spread and several sporadic cases. The first cluster originated from the community outbreak spot, where an asymptomatic HCW visited, which led to a total of 22 cases. The second cluster, which included patient-to-patient transmission, originated from a COVID-19 positive caregiver before diagnosis and the third cluster involved a radiologist and a banker. We took measures to isolate Building 1 of the hospital for 17 days and controlled the outbreak during a period of increasing community COVID-19 prevalence. Universal screening of all inpatients upon admission and resident caregivers was made mandatory and hospital-related employees are now screened monthly. Conclusion: Infection control strategies to prevent the nosocomial transmission of emerging infectious diseases must correspond with community disease prevalence. Our data reinforce the importance of multi-time point surveillance of asymptomatic HCWs and routine surveillance of patients and caregivers during an epidemic.