RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
        • 원문제공처
        • 등재정보
        • 학술지명
        • 주제분류
        • 발행연도
        • 작성언어
        • 저자

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        Serial values for hematologic and biochemical analysis after myocardial infarction in rats

        ( Mi Jin Lee ), ( Hyun Jin Tae ), ( Ying Hua Li ), ( Do Hyeon Yu ), ( In Ae Han ), ( Seok Won Lee ), ( Dong Choon Ahn ), ( In Shik Kim ), ( Jin Ho Park ) 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.2

        To diagnose acute myocardial infarction(MI), many cardiac markers have been used in hematologic and biochemical analysis, and many studies have been published for hema-tologic and biochemical analysis associated with human acute MI. However, after occurrence of acute MI, the serial investigation for values in hematologic and bioche-mical analysis including chronic MI has rarely been performed. To observe the change of the serial values in hematologic and biochemical analysis, we induced artificial MI. The left main descending artery(LMDA) of the left coronary artery was ligated during the progression(day 1, 3, 5, 7, 14 and 30) of MI. Total 66 Sprague-Dawley rats were divided into the sham group(n=24, thoracotomy without LMDA ligation) and the experimental(MI) group(n=42, with LMDA ligation). And all individual in each group was sacrified at day 1, 3, 5, 7, 14 and 30 for the hematologic and biochemical analysis. In comparison of hematologic analysis between the sham and MI groups, the mean values of red blood cell(RBCs), hemoglobin and hematocrit(HCT) showed a steady increase. In biochemical analysis, the mean values of glucose, choles-terol, total creatine kinase(CK) and isoenzyme MB, and lactate dehydrogenase(LDH) were increased in all MI groups compared with the sham groups. The results of this study suggest that early hematologic and biochemical mean values occurred after acute MI are similar to those of human acute MI. In conclusion, we could observe the alterations and serial values in hematologic and biochemical analysis to the extent of chronic status after acute MI.

      • SCOPUSKCI등재

        Alterations of Proteins in Artificially Induced Chronic Myocardial Infarction in Rats

        Mi-Jin,Lee,Hyun-Jin,Tae,Do-Hyeon,Yu,Ying-Hua,Li,Jong-Hyun,Lee,Ji-Seon,Yoon,Seok-Won,Lee,In-Shik,Kim,Jin-Ho,Park 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.3

        We investigated the changes of protein in chronic MI which was occurred with long-term ischemia, without reperfusion. Sprague Dawley (SD) rats were divided into the sham group and the experimental groups (MI groups). The sham group was treated only thoracotomy without ligation for left main descending artery (LMDA) of left coronary artery (LCA), and the experimental groups (MI7d, ligation of LMDA for 7 days and MI30d, ligation of LMDA for 30 days) were conducted an artificial chronic MI. The change of proteins according to passage of times was compared and analyzed on first and second dimension (1 and 2D) sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. Among total 46 spots expressed differentially in the sham group versus MI7d and MI30d groups on 2D gel, we selected proteins that the volume of spot was increased in the MI7d and MI30d groups compared with the sham group. After that, the proteins were identified through liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis. In result, we could obtain many proteins as follows; albumin, glucose regulated protein 58 KDa, similar to tripartite motif protein 50, ubiquinol-cytochrome c reductase core protein Ⅱ, sarcomeric mitochondrial creatine kinase, ATP synthetase alpha chain (mitochondrial precursor) and creatine kinase. In conclusion, we suggest many changed proteins shown at chronic ischemia after artificial MI and consider that these proteins play an important role in the function of heart after MI.

      • KCI등재

        Serial values for hematologic and biochemical analysis after myocardial infarction in rats

        Lee,,Mi-Jin,Tae,,Hyun-Jin,Li,,Ying-Hua,Yu,,Do-Hyeon,Han,,In-Ae,Lee,,Seok-Won,Ahn,,Dong-Choon,Kim,,In-Shik,Park,,Jin-Ho The Korean Society of Veterinary Service 2008 韓國家畜衛生學會誌 Vol.31 No.2

        To diagnose acute myocardial infarction (MI), many cardiac markers have been used in hematologic and biochemical analysis, and many studies have been published for hematologic and biochemical analysis associated with human acute MI. However, after occurrence of acute MI, the serial investigation for values in hematologic and biochemical analysis including chronic MI has rarely been performed. To observe the change of the serial values in hematologic and biochemical analysis, we induced artificial MI. The left main descending artery (LMDA) of the left coronary artery was ligated during the progression (day 1, 3, 5, 7, 14 and 30) of MI. Total 66 Sprague-Dawley rats were divided into the sham group (n=24, thoracotomy without LMDA ligation) and the experimental (MI) group (n=42, with LMDA ligation). And all individual in each group was sacrified at day 1, 3, 5, 7, 14 and 30 for the hematologic and biochemical analysis. In comparison of hematologic analysis between the sham and MI groups, the mean values of red blood cell (RBCs), hemoglobin and hematocrit (HCT) showed a steady increase. In biochemical analysis, the mean values of glucose, cholesterol, total creatine kinase (CK) and isoenzyme MB, and lactate dehydrogenase (LDH) were increased in all MI groups compared with the sham groups. The results of this study suggest that early hematologic and biochemical mean values occurred after acute MI are similar to those of human acute MI. In conclusion, we could observe the alterations and serial values in hematologic and biochemical analysis to the extent of chronic status after acute MI.

      • KCI등재

        조선조 首尾吟體 창작현황 및 창작방식에 대하여

        이미진,Lee,Mi-jin 대동한문학회 2015 大東漢文學 Vol.43 No.-

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        본고는 <한국문집총간>을 대상으로 조선조 首尾吟體를 창작한 문인 현황을 파악하고 그 구체적인 작법을 확인하는 것을 목표로 한다. 수미음체는 첫 구와 마지막 구를 반복사용하는 것을 기본 원칙으로 하는 詩體의 일종으로 대개 雜體詩의 하나로 인식된다. 宋 邵雍(1011~1077)이 중국 문단에 이를 처음으로 선보인 뒤로 중국에서 뿐만 아니라 조선 문단에서도 적지않 은 문인들이 그의 시에 차운하거나 새로이 모방하였는데, 그 중 대표적인 인물로 尤庵 宋時烈 및 過齋 金正默 등 몇몇의 특정 인물이 거질의 연작시를 창작하였고, 그 외 私淑齋 姜希孟, 息山 李萬敷가 다수의 수미음체를 남 긴 사실을 확인하였다. 수미음체의 작법은 일률적이지 않았는데 기본형을 비롯해 창작양상에 있어 크게 세 가지로 구분할 수 있다. 첫째, 소옹이 그러했듯 첫 구와 마지막 구를 동일하게 처리하는 경우로써 대부분의 작품이이 방식을 준수하였다. 여기에는 소옹의 수미음체에서 구사한 싯구 일부를 그대로 차용하는가하 면, 작가 임의로 새로운 싯구를 중복 처리한 경우가 있다. 둘째, 매편 首聯 첫 구와 尾聯 첫 구에 각각 동일한 싯구를 삽입하는 경우로써 두 편 이상의 작품을 지을 때라야 구사 가능한 방식이 그것이다. 세 번째, 첫 구 첫 단어와 마지막 구 마지막 단어를 동일하게 처리함으로써 首尾一貫의 형식을 약식 으로 처리하였는데, 이 경우 ‘君恩'을 삽입하였다. 수미음체는 처음과 마지막 구의 반복을 통해 시인이 전달하고자 하는 의미를 강조하고 이에 따른 운율을 형성하였으며, 주제 강화 및 시적 정서의 완결성을 기하여 작품의 구조적 완결성을 확보하였다. 이러한 작법은 근・현 대로 이어져 首尾相關, 首尾雙關, 首尾相應이라는 작법의 하나로 계승되어, 예컨대 김소월(1902~1934)의 <엄마야 누나야>・<진달래꽃>・<산유 화>, 유치환(1908~1967)의 <울릉도>, 조지훈(1920~1968)의 <승무>, 신동엽(1930~1969)의 <산에 언덕에> 등의 작품에서 수미상관의 기법이 준용되었다. 이렇듯 宋代 邵雍에 의해 시작된 이래 오랜 세월 문인들의 작시에 종종 활용되었던 수미음체는 조선조에 수용되어 현대에까지 계승되었으 니, 조선조 수미음체 창작과 현대시의 수미상관(수미상응)의 작법의 연관성 을 고려하여 詩作法의 史的 발달과정을 탐구해보는 것은 의미있는 작업이 되리라 생각한다. This study aims to identify the current status of literary writers who had created Su-Mi-Eum-Che in Joseon Dynasty through <Korean Literary Collections> and find their specific writing techniques. Su-Mi-Eum-Che is a kind of poetry whose basic principle is to repeat the first line and the last line and typically recognized as one of the Jap-Che poetries. Since Song So-Ong(1011~1077) introduced this to the Chinese literary world, not a few literary writers borrowed or imitated such a line to their own poetry in Joseon as well as in China. The representative figures are Uam Song Si-Yeol, Gwajae Kim Jung-Muk and some others who created serial poetries and additionally Sasukjae Gang Hee-Maeng and Siksan Lee Man-Bu who left multiple works of Su-Mi-Eum-Che.The writing techniques of Su-Mi-Eum-Che were not uniform and can be classified into three categories including basic form in terms of creative writing aspects. The first category is the case that the first line and the last line were treated in the same way as So-Ong did. Most of the works followed this category. Sometimes, some of the lines described in So-Ong's Su-Mi-Eum-Che were borrowed as they were, but other times, new lines were overlapped on writer's own discretion. Second, this category is the case that the same line was inserted into the first line of the first stanza (1stand 2nd line in a style of Chinese verse) and the last line of the last stanza (7th and 8th line in a style of Chinese verse) for every poem. This is available only if more than two works are created. Third, this category is the case that the first word of the first line and the last word of the last line were treated in the same way: the form of Su-Mi-Il-Gwan(consistent beginning and end). In this case, the word ‘royal benevolence (favor of lord)' was inserted. Su-Mi-Eum-Che emphasized the meaning that a poet aimed to convey through the repetition of the first and the last line and accordingly formed a rhythm and reinforced subject and raised completion of poetic feeling to obtain structural completion of works. This writing technique was succeeded to one of these writing techniques: Su-Mi-Sang-Gwan, Su-Mi-Ssang-Gwan, and Su-Mi-Sang-Eung in modern times. For example, Su-Mi-Sang-Gwan techniques were applied into Kim So-Wol(1902~1934)'s <HEY MOM HEY SIS>・<Azalea>・<Wild Flowers>, Yu Chi-Hwan (1908~1967)'s <Ulleungdo>, Jo Ji-Hun(1920~1968)'s <Dance in Buddhist Attire>, and Shin Dong-Yeop(1930~1969)'s <In the Mountaisn and Hills>. Like this, the Su-Mi-Eum-Che that had often been used in literary writers' poems for long years since its beginning by So-Ong in Song period was accepted in Joseon period and succeeded to this modern times. Therefore, it seems to become a significant work to explore the historical development process of poetics by taking into account of the association between the creation of Su-Mi-Eum-Che in Joseon period and the writing technique of Su-Mi-Sang-Gwan(Su-Mi-Sang-Eung) in modern poems.

      • SCOPUSKCI등재

        Effects of sperm insemination on the final meiotic maturation of mouse oocytes arrested at metaphase I after in vitro maturation

        Yoon,,Jeong,Juhn,,Kyoung-Mi,Yoon,,San-Hyun,Ko,,Yong,Lim,,Jin-Ho The Korean Society for Reproductive Medicine 2017 Clinical and Experimental Reproductive Medicine Vol.44 No.1

        Objective: The aims of this study were to investigate whether fertilization could induce the resumption of meiosis in mouse oocytes arrested at metaphase I (MI) after in vitro maturation (IVM), and to investigate the effect of $Ca^{2+}$ chelator treatment at the time of fertilization on the transition from MI to metaphase II (MII). Methods: MII-stage and arrested MI-stage mouse oocytes after IVM were fertilized, and then embryonic development was monitored. Blastocysts from each group were transferred into 2.5 days post-coitum pseudo-pregnant ICR mice. MI oocytes after IVM were treated with a $Ca^{2+}$ chelator to investigate the effect of $Ca^{2+}$ oscillations on their maturation. Results: As insemination time increased, the number of oocytes in the MI group that reached the MII stage also increased. The blastocyst rates and total cell numbers in the MII group were significantly higher than in the MI group. No pregnancy occurred in the MI group, but 10 pregnancies were achieved (10 of 12) in the MII group. The proportion of MI oocytes that matured to MII oocytes after fertilization was significantly higher in the non-treated group than in the $Ca^{2+}$ chelator-treated group. Conclusion: The findings that a higher proportion of MI-arrested oocytes progressed to MII after fertilization and that the MI-to-MII transition was blocked by $Ca^{2+}$ chelator treatments before fertilization indicate that the maturation of MI oocytes to MII oocytes is associated with intracellular $Ca^{2+}$ oscillations driven by fertilization.

      • Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

        Seo,,Hee-Won,Kim,,Eun-Jin,Na,,Hyelin,Lee,,Mi-Ock Elsevier 2009 FEBS letters Vol.583 No.1

        <P><B>Abstract</B></P><P>The interplay between hypoxia-inducible factor-1α (HIF-1α) and histone deacetylase (HDACs) have been well studied; however, the mechanism of cross-talk is unclear. Here, we investigated the roles of HDAC4 and HDAC5 in the regulation of HIF-1α function and its associated mechanisms. HDAC4 and HDAC5 enhanced transactivation by HIF-1α without stabilizing HIF-1α. HDAC4 and HDAC5 physically associated with HIF-1α through the inhibitory domain (ID) that is the binding site for factor inhibiting HIF-1 (FIH-1). In the presence of these HDACs, binding of HIF-1α to FIH-1 decreased, whereas binding to p300 increased. These results indicate that HDAC4 and HDAC5 increase the transactivation function of HIF-1α by promoting dissociation of HIF-1α from FIH-1 and association with p300.</P><P><B>Structured summary:</B></P><P>MINT-6802187:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>FIH1</I> (uniprotkb:Q9NWT6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802058:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>pull down</I> (MI:0096)</P><P>MINT-6802021:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802036:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802102:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>pull down</I> (MI:0096)</P><P>MINT-6802121, MINT-6802156:</P><P><I>P300</I> (uniprotkb:Q09472) <I>physically interacts</I> (MI:0218) with <I>HIF1 alpha</I> (uniprotkb:Q16665) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P>

      • Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression

        Yoo,,Jung-Yoon,Choi,,Kyung-Chul,Kang,,HeeBum,Kim,,Young,Jun,Lee,,Jeongmin,Jun,,Woo,Jin,Kim,,Mi-Jeong,Lee,,Yoo-Hyun,Lee,,Ok-Hee,Yoon,,Ho-Geun Elsevier 2010 FEBS letters Vol.584 No.11

        <P><B>Abstract</B></P><P>This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.</P><P><B>Structured summary</B></P><P>MINT-7719975: <I>L3MBTL2</I> (uniprotkb:Q969R5) and <I>HDAC3</I> (uniprotkb:O15379) <I>colocalize</I> (MI:0403) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7719941, MINT-7719921: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>binds</I> (MI:0407) to <I>HDAC3</I> (uniprotkb:O15379) by <I>pull down</I> (MI:0096)</P><P>MINT-7719991: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-7719958: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>physically interacts</I> (MI:0915) with <I>HDAC3</I> (uniprotkb:O15379) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7719897: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>two hybrid</I> (MI:0018)</P>

      • SCIESCOPUSKCI등재

        Original Article : Enhanced Anti-Cancer Effect of Snake Venom Activated NK Cells on Lung Cancer Cells by Inactivation of NF-kB

        ( Jin Tae Hong ), ( Pushpa Saranya Kollipara ), ( Do Hee Won ), ( Chul Ju Hwang ), ( Yu Yeon Jung ), ( Heui Seoung Yoon ), ( Mi Hee Park ), ( Min Jong Song ), ( Ho Sueb Song ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2

        In the present study, we investigated anti-cancer effect of snake venom activated NK cells (NK-92MI) in lung cancer cell lines. Weused snake venom (4 mg/ml) treated NK-92MI cells to co-culture with lung cancer cells. There was a further decrease in cancer cellgrowth up to 65% and 70% in A549 and NCI-H460 cell lines respectively, whereas 30-40% was decreased in cancer cell growthby snake venom or NK-92MI alone treatment. We further found that the expression of various apoptotic proteins such as that Bax,and cleaved caspase-3 as well as the expression of various death receptor proteins like DR3, DR4 and Fas was also further increased. Moreover, consistent with cancer cell growth inhibition, the DNA binding activity of NF-kB was also further inhibited aftertreatment of snake venom activated NK-92MI cells. Thus, the present data showed that activated NK cells could further inhibitlung cancer cell growth.

      • KCI등재

        Effects of Plant Growth regulators on Rapid in vitro Propagation of Camptotheca acuminata from Axillary Buds

        Seung-Mi,Kang,Ji-Yun,Min,Dong-Jin,Park,Mi-Jin,Jeong,Hyun-Jin,Song,Chang-Mi,Heo,Hyun-Shik,Moon,Jong-Gab,Kim,Chandrakant,S.,Karigar,Myung-Suk,Choi 경상대학교 농업생명과학연구원 2011 농업생명과학연구 Vol.45 No.1

        An efficient method for the rapid micropropagation of Camptotheca acuminata from axillary buds was established by application of various plant growth regulators. Among various cytokinins, 0.5 mg L-1 BA showed the best performance on shoot multiplication, number average multiple shoots up to 10.8. The propagated shoot cuttings in vitro were elongated on NN basal medium without plant growth regulators. The secondary multiple shoots were induced at the site of initially induced buds. Rooting was induced directly near the base of the shoot on half-strength NN medium containing 0.5 mg L-1 of IBA, whereas high concentration of 1.0 mg L-1 IBA could induce callus at the base of the shoot. The camptothecin content, anticancer compound of the micropropagated plants was contained in various tissues. Camptothecin contents were 1.8 and 2.5 mg g-1 dry weight in stems from propagated in vitro and mother plant, respectively. This result may be used to develop strategies for large-scale propagation of elite C. acuminata trees.

      • SCIESCOPUSKCI등재

        Co-culture with NK-92MI cells enhanced the anti-cancer effect of bee venom on NSCLC cells by inactivation of NF-${\kappa}B$

        Kollipara,,Pushpa,Saranya,Kim,,Jung,Hyun,Won,,Dohee,Lee,,Sang,Min,Sung,,Ha,Chang,Chang,,Hyun,Sok,Lee,,Kang,Tae,Lee,,Kang,Sik,Park,,Mi,Hee,Song,,Min,Jong,Song,,Ho,Sueb,Hong,,Jin,Tae 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

        In the present study we experimented on a multimodal therapeutic approach, such as combining chemotherapy agent (Bee venom) with cellular (NK-92MI) immunotherapy. Previously bee venom has been found to show anti-cancer effect in various cancer cell lines. In lung cancer cells bee venom showed an $IC^{50}$ value of $3{\mu}g/ml$ in both cell lines. The co-culture of NK-92MI cell lines with lung cancer cells also show a decrease in viability upto 50 % at 48 h time point. Hence we used bee venom treated NK-92MI cells to co-culture with NSCLC cells and found that there is a further decrease in cell viability upto 70 and 75 % in A549 and NCI-H460 cell lines respectively. We further investigated the expression of various apoptotic and anti-apoptotic proteins and found that Bax, cleaved caspase-3 and -8 were increasing where as Bcl-2 and cIAP-2 was decreasing. The expression of various death receptor proteins like DR3, DR6 and Fas was also increasing. Concomitantly the expression of various death receptor ligands (TNFalpha, Apo3L and FasL) was also increasing of NK-92MI cells after co-culture. Further the DNA binding activity and luciferase activity of NF-${\kappa}B$ was also inhibited after co-culture with bee venom treated NK-92MI cell lines. The knock down of death receptors with si-RNA has reversed the decrease in cell viability and NF-${\kappa}B$ activity after co-culture with bee venom treated NK-92MI cells. Thus this new approach can enhance the anti-cancer effect of bee venom at a much lower concentration.

      맨 위로 스크롤 이동