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이윤주(Yun-Ju Lee),임태범(Tae-Beom Lim),김경원(Kyung-Won Kim),문재원(Jae-Won Moon),이석필(Seok-Pil Lee) 한국멀티미디어학회 2010 한국멀티미디어학회 학술발표논문집 Vol.2010 No.2
홈 네트워크 상에서 다양한 디지털 기기들 간에 멀티미디어 콘텐츠를 공유/연동하는데 있어, IPTV환경에서 응용프로그램을 비디오, 오디오, 그리고 이미지 파일과 같이 공유/연동할 수 있도록 하는 방법을 제안하고 사용자의 편의성을 증진시키고 시청 환경이 서로 다른 디지털 기기에 동시 적용 가능하며 다양한 시청 환경에 최적화된 사용자 인터페이스를 제공하도록 한다.
간세포암과 하대정맥 막성폐쇄의 치료 후 호전된 백혈구파괴혈관염 1예
이준엽 ( Jun Yeob Lee1 ),이주원 ( Ju Won Lee1 ),이진욱 ( Jin Wook Lee ),박현준 ( Hyun Joon Park ),장국환 ( Gook Hwan Jang ),김다정 ( Da Jung Kim ),김선민 ( Sun Min Kim ),한병훈 ( Byung Hoon Han ),정규식 ( Gyoo Sik Jung ),김근태 ( 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5
저자들은 하지 자색반과 고환 통증으로 내원한 알코올성 간경화증 환자에서 LCV의 원인 감별하는 과정에서 HCC와 하대정맥 막성폐쇄를 진단하고 이에 대한 치료 후 LCV의 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Vasculitis is a heterogeneous group of diseases that destroy blood vessel walls by inflammation. Approximately half of vasculitis cases are idiopathic, but sometimes associated with genetic factors, medicines, chronic infection, autoimmune diseases, and malignancies. Although the mechanism remains unclear, vasculitis secondary to malignancy, also known as paraneoplastic vasculitis, has been reported. It is generally associated with hematologic malignancies rather than solid malignancies and commonly presents as leukocytoclastic vasculitis or polyarteritis nodosa. We experienced a case of leukocytoclastic vasculitis in a patient with hepatocellular carcinoma and membranous obstruction of the inferior vena cava. Here, we report this case with a brief review of literature. (J Rheum Dis 2015;22:322-326)
국경아,김주원,이호영,Kook, Kyungnk-A,Kim, Ju-Won,Lee, Ho-Young 대한음성학회 2005 말소리 Vol.53 No.-
A Study of N-Insertion Preferences in KoreanKyung-A Kook, Ju-Won Kim, Ho-Young LeeSince n-insertion is not an obligatory process in Korean, it is necessary to investigate what factors influence n-insertion preferences and whether n-insertion preferences have been changed over time. To find answers to these questions, an n-insertion preference test using a questionnaire was conducted. 183 words were selected for this test and 167 subjects participated in the test. The results of this test show that the n-insertion preferences were influenced by the speakers' age, the number and structure of the syllable, word class, phonetic environments, and familiarity. It is suggested that the results of this test should be incorporated into the Principles of Standard Pronunciation and in the Grand Dictionary of Standard Korean.
저령차전자탕(猪苓車前子湯)의 기원(基源), 변천과정(變遷過程) 및 구조원리(構成原理)
권오원,김배수,이지원,신승원,이의주,Kwon, Oh-Won,Kim, Bae-Su,Lee, Ji-Won,Shin, Seung-Won,Lee, Eui-Ju 사상체질의학회 2016 사상체질의학회지 Vol.28 No.2
Objectives This paper investigates the origin, the progressive changes and the constructive principles of Jeoryoungchajeonja-tang(猪苓車前子湯).Methods Jeoryoungchajeonja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including 『Sanghannon(傷寒論)』, 『Keumkuaeyoryak(金匱要略)』, 『Donguibogam(東醫寶鑑)』, 『Donguisusebowon‧Sasangchobongwon(東醫壽世保元‧四象草本卷)』, 『Donguisusebowon‧Gabogubon(東醫壽世保元‧甲午舊本)』, 『Donguisusebowon‧Sinchukbon(東醫壽世保元‧辛丑本)』Results and Conclusions 1) The origin of Jeoryoungchajeonja-tang is discovered in the prescriptions for Lee-su(利水), that is, Jeoryoung-tang(猪苓湯). 2) Ohryoung-san(五苓散) introduced in 『Donguisusebowon‧Sasangchobongwon(東醫壽世保元‧四象草本卷)』progressively transformed into Shihosaryoung-san(柴胡四苓散)(『Donguisusebowon‧Gabogubon(東醫壽世保元 ‧甲午舊本)』) and ultimately into Jeoryoungchajeonja-tang(『Donguisusebowon‧Sinchukbon(東醫壽世保元‧辛丑本)』), a prescription appropriate for usage in the Mangeum symptomatology(亡陰證). 3) The Jeoryoungchajeonja-tang is composed of 10 herbs. Of these, Notopterygium incisum Ting(羌活), Aralia cordata Thunb.(獨活), Schizonepeta tenuifolia Briq.(荊芥), Saposhnikovia divaricata Schischk.(防風) make the Pyoeum(表陰) drop, and Anemarrhena asphodeloides Bge.(知母), Gypsum fibrosum(石膏) scatter the uihwa(胃火), and Poria cocos Wolf.(茯苓), Alisma canaliculatum(澤瀉), Polyporus umbellatus Fr.(猪苓), Plantago asiatica L.(車前子) facilitate urination.
소음인(少陰人) 태음병(太陰病) 심하비증(心下?證)의 병증약리(病證藥理) 고찰
서영광,이지원,이준희,최원철,이의주,고병희,Seo, Young-Kwang,Lee, Ji-Won,Lee, Jun-Hee,Choi, Won-Cheol,Lee, Eui-Ju,Kho, Byung-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3
1. Objective: Gastric Stuffiness (心下?證) in the Soeumin Taeeum symptomatology (少陰人 太陰病) in Sasang Constitutional Medicine shows an interesting evolutionary process. Originally found in the texts of Sanghanlun (傷寒論), the perspectives regarding the symptoms of Gastric Stuffiness were expanded by many medical scholars and Lee Jema. To comprehend the Jema's concept of Taeeum symptomatology and utilize his prescription clinically, it deserves to study on the Gastric Stuffiness in Donguisuseowon (東醫壽世保元). 2. Methods: Many texts including Sanghanlun (傷寒論) and Dongeuibogam (東醫寶鑑) were reviewed in order to track the evolutionary process concerning the symptoms of Gastric Stuffiness. Also, Lee Jema's works including the different versions of Donguisuseowon (東醫壽世保元) were reviewed to examine the development of Lee's concepts regarding the Gastric Stuffiness in the Soeumin Taeeum symptomatology. 3. Results and Conclusions: 1) Most of the previous concepts on Gastric Stuffiness were generally similar to those found in Sanghanlun, especially in that they addressed Yang deficiency of the middle triple energizeer as the central pathogenic process. 2) Lee Jema's views on the epigastric discomfort in the Soeumin Taeeum symptomatology evoloved over time and culminated in the finalized pathology and therapeutics appearing in his last work, the Shinchuk version of Donguisuseowon (東醫壽世保元). 3) 4 kinds of prescription which invented by Lee Jema to treat the Gastric Stuffiness in the Soeumin Taeeum symptomatology can be matched to the prescription of Sanghanlun respectively. However through evolutionary process of Jema's prescriptions, the indication of them expanded: not only to treat Gastric Stuffiness but to diverse symptoms of Soeumin.
Family Origin Names and Haplotypes of Y - DNA in Korean Population
Kim, Jong Soon,Kim, Yung Jin,Ahn, Gwang Sook,Lee, Ju Won,You, Sun Ah 한국유전학회 1996 Genes & Genomics Vol.18 No.4
The use of restriction fragment length polymorphisms (RFLPs) has been proposed for the construction of a human genetic linkage map and also become a powerful tool in human population genetics. Human Y-chromosome which is haploid and paternally inherited is valuable for investigating male-mediated gene flow and for complement maternally based studies of mtDNA. We have studied 166 samples from 4 kinds of family origin names such as Kyungju Kim, Kimhae Kim, Chunju Lee and Milyang Park based on the 49aTaq 1 polymorphisms, and a total of 25 haplotypes were observed. The B, F, and I bands is observed in all haplotypes and haplotype showing A3, B, D2, D3, F, and I bands is common haplotype except for Chunju Lee. The result obtained are summarized as follows.
Lee, Mi-Hwa,Kim, Ji-Young,Ju, Hyun-Yang,Lee, Ju-Young,Roh, Sang-Keun,Gu, Bon-Seong,Kim, Min-Ho,Han, Sang-Min,Kim, Hong-Sik,Choi, Won-Chul The Society of Korean Medicine 2003 대한한의학회지 Vol.24 No.4
So-Hap-Hyang-Won, a traditional oriental medicine used in the treatment of stroke patients, was examined for its ability to reverse the cell damage caused by lipid peroxidation products and oxidative stress in bovine aortic endothelial cells (BAEC). The effects of herbal medicine on cell proliferation and recovery of oxidative damaged situation were studied in BAEC, which was considered an appropriate in vitro model for stroke resulting from various vascular diseases prevalent in advanced age. In a clinical study of stroke patients, So-Hap-Hyang-Won appeared to improve considerably arm and leg movements as well as consciousness disturbance condition, compared with other traditional medicines used for stroke. When BAEC were treated with extracts of the lyophilized herbal medicines, only that of So-Hap-Hyang-Won stimulated cell proliferation and showed no toxicity even at high concentrations. In studies of BAEC treated with extracts of the lyophilized material of the 14 components of So-Hap-Hyang-Won, only the extract of Foeniculi Fructus stimulated cell growth at all concentrations tested. Moreover, when cells were treated with Foeniculi Fructus (10 and 100 mg/ml) extract after prior exposure to t-BHP ($l0\mu\textrm{M}$) or HNE ($0.2\mu\textrm{M}$), lipid peroxidation products which are known to be involved in aging and vascular diseases, or after the exposure to SIN-l ($500\mu\textrm{M}$), which generates nitric oxide (NO) and other reactive oxygen species, there was substantial recovery from the oxidative damage, presumably due to the radical-scavenging effect of Foeniculi Fructus extract. Foeniculi Fructus not only showed stimulatory effects on cell growth and cell damage repair in BAEC, but also appeared to show the most anti-aging activity among all the herbal components of So-Hap-Hyang-Won.
Secondary Sphere Formation Enhances the Functionality of Cardiac Progenitor Cells
Cho, Hyun-Jai,Lee, Ho-Jae,Youn, Seock-Won,Koh, Seok-Jin,Won, Joo-Yun,Chung, Yeon-Ju,Cho, Hyun-Ju,Yoon, Chang-Hwan,Lee, Sae-Won,Lee, Eun Ju,Kwon, Yoo-Wook,Lee, Hae-Young,Lee, Sang Hun,Ho, Won-Kyung,Par Elsevier 2012 MOLECULAR THERAPY Vol.20 No.9
( Won-ju Kima ),( Ja-hyun Koo ),( Hyun-jung Cho ),( Jae-ung Lee ),( Ji Yun Kim ),( Sohee Lee ),( Jong Hoon Kim ),( Mi Seon Ohe Minah Suh ),( Eui-cheol Shin ),( Joo Yeon Ko ),( Myung Hyun Sohn ),최제민 ( 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
Background: Atopic dermatitis and psoriasis are the most common chronic inflammatory skin diseases. However, there are high unmet medical needs with limitations for transcutaneous drug development due to the skin barrier. Objective: We aimed to identify a novel transdermal delivery peptide and develop a transcutaneously applicable immune modulatory protein by targeting cytokine signaling in atopic dermatitis and psoriasis. Methods: We generated reporter proteins conjugated with a human-originated transdermal delivery peptide, AP and analyzed intracellular delivery efficiency in mouse or human skin cells and tissues. Especially, we utilized multi-photon confocal microscopy for visualizing the localized proteins. We also generated a recombinant therapeutic protein, AP-rPTP, which is conjugated with AP and phosphatase domain of TC-PTP targeting multiple STATs. Immune modulatory function of AP-rPTP was confirmed in splenocytes upon cytokine stimulation and TcR stimulation. Finally, we confirmed in vivo efficacy of AP-rPTP in OXA-induced acute dermatitis, OVA-induced chronic dermatitis, and imiquimod-induced psoriasis models. Results: AP-conjugated reporter proteins exhibited significant intracellular transduction efficacy in keratinocytes, fibroblasts, and immune cells. In addition, transcutaneous administration of AP-dTomato showed significant localization into the dermis and epidermis in mouse skin. AP-rPTP could inhibit pSTAT1, pSTAT3, and pSTAT6 in splenocytes and also regulate T cell activation and proliferation. Transcutaneous paper-patch of AP-rPTP protein significantly ameliorated ear thickness, tissue inflammation, and cytokine expression in allergy- as well as psoriasis-like dermatitis models. Conclusion: We identified a 9 amino acid-long novel transdermal delivery peptide and suggest the feasibility of utilizing AP for transcutaneous biologic drug development such as AP-rPTP as a novel immune modulatory drug candidate for dermatitis.