Protective Effect of Baicalin Against Carbon Tetrachloride–Induced Acute Hepatic Injury in Mice

Park, Sang-Won,Lee, Chan-Ho,Kim, Yeong Shik,Kang, Sam Sik,Jeon, Su Jin,Son, Kun Ho,Lee, Sun-Mee The Japanese Pharmacological Society 2008 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.106 No.1

<P>This study examined the effects of baicalin, a bioactive flavonoid isolated from <I>Scutellariae Radix</I>, on carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl<SUB>4</SUB> and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl<SUB>4</SUB> treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl<SUB>4</SUB>-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-α were markedly increased by the CCl<SUB>4</SUB> treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl<SUB>4</SUB> treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl<SUB>4</SUB>, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.</P>

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

내담즙성 유산균의 분리 및 특성에 관한 연구

박종인,정호권,김승곤 서울保健大學 1991 論文集 Vol.11 No.1

개에서 발생한 신우신염 증례

유건우,이선희,임수정,박형진,김태신,송은식,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 6 years old Schunauzer dog (7.2kg, intact female) with history of hematuria for two days was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Complete blood cell count showed no significant abnormalities and serum chemistry profile showed increased phosphate profile. On urinanalysis, there was evidence of bacterial infection. On ultrasonographic evaluation, irregular renal contour and increased echogenecity, pelvic and uretral dilation, and thickening of urinary bladder wall were observed. Based on these finding, the dog was diagnosed as pyelonephritis. The dog was treated with antibiotics based on antimicrobial susceptibility test results, then successfully resolved after 8 weeks of treatment.

河川水質解析에서 BFGS 技法에 의한 最適反應係數의 決定

朴在弘,金相浩,韓健淵 경북대학교 산업기술연구소 1995 産業技術硏究誌 Vol.23 No.-

QUAL2E model was applied to assess the water quality variations for the downstream of the Han River. The varied flow analysis is performed in the reach of Paldang dam to Indogyo considering the effect of Jamsil submerged weir. A sensitivity analysis was made to determine the significant reaction coefficients and an optimization technique by BFGS method was used to estimate them. The calibration and verification were performed by using observed water quality data for the Han River. The calculated pollutant concentrations showed good agreements with the observed. The predictions of water quality in the river were made for the various discharge conditions and wastewater treatment alternatives.

Zn₁-xFexSe의 고유결함에 관한 연구

박남천,송재홍,채건식,오재근,김영국,손인호 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-

We studied the native defects of dilute magnetic semiconductors Zn₁-xFexSe epilayer by using SAW device. The energy gap of Zn₁-xFexSe for each epilayer(x=0.0213, 0.0915) was 2.57eV, 2.74eV at room temperature (294K). The trap level for x=0.0213, 0.0915 were calculated by measuring Transverse Acoustoelectric Voltage(TAV). Also we can calculated cross section.

Titanium isopropoxide의 가수분해에 의한 TiO₂ Power 합성

박찬웅,명중재,김호건 漢陽大學校 基礎科學硏究所 1995 基礎科學論文集 Vol.14 No.-

Isopropanol 내에서 titanium isopropoxide의 가수분해반응속도를 자외선분광법에 의하여 측정하였다. H₂O 농도 및 온도의 변화에 따른 반응속도상수를 Guggenheim method로 계산하였다. 이 실험 결과 titanium isopropoxide의 가수분해반응은 이분자 반응이 ?? mechanism 으로 관여하는 것으로 추정되었다. 또한 titanium isopropoxide의 가수분해에 의한 TiO₂ 분말합성에 있어서 pH 및 온도영향을 연구하였다. 합성된 분말과 소결체에 대하여 SEM, XRD, IR 및 입도분석을 통하여 characterization 하였다. TiO₂분말 합성결과 pH가 높을수록, 또한 반응온도가 높을수록 반응시간이 짧아졌으나, 낮은 온도에서 반응시킬 경우에 입자의 agglomeration이 적어짐을 알았다. 생성된 입자는 비정질의 gel 상태였으며, 소결시킨 후는 rutile, 또는 rutile과 anatase의 혼합물인 titanium dioxide인 것으로 나타났다. 소결하기 전의 TiO₂ 분말의 IR분석에서는 -OH, -CH₃ 등 유기물 그룹의 흡수 피크가 나타났으나 소결한 후의 시료에서는 그러한 피크가 나타나지 않았다. Rates of hydrolysis of titanium isopropoxide in isopropanol were investigated by UV spectroscopy. The change of reaction rate according to temperature and concentration of H₂O was calculated by Guggenheim method. From these results, it could be estimated that the hydrolysis of titanium isopropoxide was ?? mechanism involving both of titanium isopropoxide and H₂O. pH and temperature dependence of TiO₂ powder preparation were also investigated. Particle sizes and size distributions of dried powders were determined using size distribution analysis and SEM(scaning electron microscope), and the crystal phases in dried powder and in sintered powder were analyzed using powder XRD method. The reaction rate of TiO₂ powder preparation was faster at higher temperature and higher pH, however more agglomeration of particles occured at high temperature. The phase of dried powders was noncrystalline gel state but the sintering of the powder at 800℃ changed its phase to crystalline rutile or anatase. Absorption peaks of organic group such as -OH, -CH₃ in IR spectra of dried powder disappeared after sintering.

限界狀態 設計法에 의한 鐵筋콘트리트 二方向 슬라브의 最的設計

朴文浩,韓健淵 慶北大學校 1983 論文集 Vol.35 No.-

This study attempts to optimize reinforced concrete two way slabs with each spanning condition, based on the concept of ultimate limit state and of serviceability limit state. The variable adoped in this mathematical model consist of design variables including sectional sizes and reinforcement areas per unit width of middle strips and column slrips of slab. The cost function is taken as the objective function in the formulation optimal problem. A number of constraint equations involving flexural stress, reinforcement ratio, deflection and side limit is derived in accordance with BSI cp110 requirements on the basis of limit state design theory. Both objective function and constraints equation derived into terms of design variables and analysis variables generally become high degree nonlinear programming problems. Optimal algorithm that can optimize a structure synthetically earring on both analysis and design of a slab with each spanning condition. The developed algorithm is directly applied to two adjacent edges discontinuous slab, one long edge discontinuous slab, one short edge discontinuous slab and interior panel slab in order to assure validity of the algorithm and the possibility to optimize reinforced two way slabs. From this research it is found that the althorithm developed in this study is applicable to optimization of reinforced two way slabs and it converges to a optimal solution with 2 to 3 iterations regardless of initial variables. The results shows that an economical design can be possible when campared with conventional designs.

社會科學方法論의 知的成長과 現象學

朴瑾浩 동국대학교 행정대학원 1987 행정논집 Vol.16 No.-

ZnSe의 광전압효과

박남천,채건식,김영국,설정식,손인호 慶南大學校 附設 基礎科學硏究所 1997 硏究論文集 Vol.10 No.-

We have measured the energy gap in ZnSe as a function of temperature by Laser-Generaeted Photocharge Voltage Spectroscopy(PVS). Trap levels were calculated quasi equibrium, peak shape, initial rise methods. And We have measured the Photocharge Voltage as a function of temperature with varing heating rate. The trapping cross-section of ZnSe was calculated by the methods of Grossweiner.