http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jung-Yong Wang (검색결과 265 건)
- 무료
- 기관 내 무료
- 유료
-
-
정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여
신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1
In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.
-
지익성,왕성근,신석철,이선우,황선희,신용재,김정란,배경도 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
In order to determine the frequency of physical illness in schizophrenia, 107 schizophrenics were assessed with physical exam and routine laboratoy test. The results were as follows 1) Among the total number of 107 schizophrenics, 31 had the physical illness(29%), and among the schizophrenics with physical illness, female outnumbered male at the rate of 17:14. 2) There was no difference between schizophrenics with physical illness and schizophrenics without physical illness in demographic characteristics. 3) Classification of physical illness were disease of skin 7 (22.6%), musculoskeletal system 5(16. 1%), ENT(ear nose throat) 3(9.7%), endocrine system 3(9.7%), circulatory system 2(6.5%), respiratory system 2(6.5%), digestive system 1(3.2%), genitourinary system 1(3.2%), infection 1(3. 2%), eye 1(3.2%) respectively Authors suggest that physical exam and routine laboratory test should be done for all hospitalized psychiatric patients
-
-
( Wang Yong Choi ),( Woo Jin Chung ),( Si Hyun Bae ),( Do Seon Song ),( Myeong Jun Song ),( Young Seok Kim ),( Hyung Joon Yim ),( Young Kul Jung ),( Sang Jun Suh ),( Jun Yong Park ),( Do Young Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The treatment responses of advanced hepatocellular carcinoma( HCC) with portal vein tumor thrombosis(PVTT) were not acceptable and treatment modalities were limited. So, we compared effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy( HAIC). Methods: We prospectively collected data of 58 advanced HCC with PVTT patients whose Child-Turcotte-Pugh(CTP) score range 5 to 7 in 6 university hospitals from January 2013 to Oct 2015. Each twenty nine patients were treated with sorafenib or HAIC. Results: 1. The mean age was 60.2±8.4 years old and 89.7% of the patients were male. Causes of HCC were HBV (67.3%), HCV (8.6%), alcohol (19.0%) and others (5.2%). CTP class A was 89.7%, modified Union for International Cancer Control (mUICC) stage IVa was 63.8%, tumor diameter >10cm was 55.2%, multiple tumor was 60.3%, infiltrative type was 56.9%, main PVTT was 63.8%, median AFP value was 240.4 ng/ml. 2. 29 patients were enrolled to each groups. Baseline characteristics( sex, mean age, cause of HCC, mUICC stage, size of tumor, number of tumor, type of tumor(nodular, massive, infiltrative, diffuse), location of PVTT(main, main+branch, branch). CTP class, median value of AFP) has no significant difference between two groups. 3. The objective response rate was 38.1% in HAIC and 4.5% in sorafenib group (p=0.003). In univariate analysis, treatment modality, main portal vein invasion, objective response, massive tumor type were significant prognostic factors of overall survival (p=0.012, 0.046, 0.011, 0.041) and treatment modality, tumor number, massive tumor type were significant prognostic factors of time to progress (p=0.004, 0.043, <0.01). In multivariate analysis, objective response was a significant prognostic factor of overall survival (p=0.048) and treatment modality was a significant prognostic factor of time to progress (p=0.016). 4. Major complications were neutropenia (6.9%, more than grade 3) and catheter-related complication (3.4%) in HAIC group, hand-foot syndrome (20.7%) and diarrhea (3.4%) in sorafenib group. Conclusions: For treatment of advanced HCC with PVTT patient, HAIC can be a valuable treatment modality like as sorafenib and more large size of study is needed.
-
-
( Hyo Jung Cho ),( Ji Sun Namc ),( Jae Keun Kim ),( Jei Hee Leeb ),( Bohyun Kim ),( Hee Jung Wang ),( Bong Wan Kim ),( Jung-dong Lee ),( Dae Yong Kang ),( Ji Hyun Kim ),( Yang Min Jae ),( Jae Chul Hwa 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aim: We aimed to evaluate prognostic implication of circulating microRNA (miR)-21, 26a, and 29a in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection or radiofrequency ablation (RFA) for curative treatment. Methods: A total of 120 patients with hepatitis B virus (HBV)-related HCC who underwent surgical resection (n=63) or RFA (n=57) were included. Expression levels of miR-21, 26a, and 29a in pretreatment plasma were assessed by fold change of Ct values acquired by quantitative real-time polymerase chain reaction. Several clinical variables and pretreatment circulating miRs were analyzed for identifying prognostic markers by using Kaplan-Meier analysis and Cox regression analysis. Results: Univariate analysis showed that age, low albumin level, low platelet count and advanced tumor stage (modified UICC stage III, IV), low miR-26a (Hazard ratio [HR]=1.72; 95% confidence interval [CI]=1.04-2.83; P=0.035) and low miR-29a (HR=1.75; 95% CI=1.04-2.94; P=0.035) were identified as independent risk factors of poor disease-free survival (DFS). In the analysis of liver transplantation (LT)-free survival, all of low miR-21, miR-26a and miR-29a were associated with poor LT-free survival in univariate analysis. However, multivariate Cox regression analysis revealed that low miR-26a (HR=3.41; 95% CI=1.32-8.82; P=0.011) and low miR-29a (HR=2.75; 95% CI=1.10-6.85; P=0.030), low platelet count and advanced tumor stage were significantly associated with poor LT-free survival. Circulating miR-21 was not significantly associated with both DFS and LT-free survival in multivariate analysis, even though miR-21 was positively correlated with tumor size and tumor stage. Correlation analysis showed remarkable correlation between circulating miR-26a and miR-29a (Spearman’s rho = 0.734, P<0.001). Conclusion: Pretreatment levels of circulating miR-26a and miR-29a were independent prognostic markers for predicting poor DFS and LT-free survival in patients with HBV-related HCC who underwent hepatic resection or RFA.
-
왕정원(Jung Won Wang),정찬기(Chan Gi Jung),심관용(Gwan Yong Sim) 한국지방교육경영학회 2020 지방교육경영 Vol.23 No.1
대학진학은 우리나라에서 신분상승의 수단으로 여겨져 높은 대학진학률을 보이고 있다. 이에 대학 입학정책은 민감한 국민적 관심사이며, 정부는 대학정책에 지속적인 어려움을 겪어왔고 대학입시정책의 잦은 변화를 야기해왔다. 이러한 대학 입학전형의 변화는 대학들이 우수 인재 확보에 많은 노력을 기울이게 하고 있다. 우수 인재들을 확보한 대학의 효과성을 확인할 수 있는 지표 중 하나는 취업률로 확인할 수 있다. 본 연구는 대학들이 대학 입학전형에 따라 우수인재를 확보하였을 때, 개인배경, 대학에서의 경험, 교수학습만족도, 대학지원제도 만족도 등이 취업에 미치는 영향에 대해 분석하였다. 연구 결과, 수시전형으로 들어온 학생보다 수능위주전형으로 들어온 학생이 취업해 있는 경우의 비율이 높았다. 교수학습만족도 특성에서는 교수진의 능력 및 열의가 유의한 영향을 미친 것으로 나타났다. 대학서비스 부분에서는 학생에 대한 진로관련 상담 및 지원제도가 좋을수록 취업할 확률이 높은 것으로 나타났다. 졸업평점의 경우 평점이 높을수록 취업할 확률이 낮은 것으로 결과 값이 도출되었으나, 그 차이는 퍼센트로 나타났다. 개인특성 중 유의한 결과를 보인 것으로는 부모의 학력이 높을수록 그렇지 않은 집단에 비해 취업할 확률이 낮은 것으로 나타났다. 개인의 대학특성에서의 유의한 결과는 지방권 대학들이 수도권보다, 사립대학이 국·공립대학들에 비해 취업할 확률이 높은 것으로 나타났다. 대학계열 별로는 인문계열에 비해 사회계열, 예체능계열, 의학계열이 높은 것으로 나타났다. College admission is considered a means of raising one's status in Korea, so it has a high college entrance rate. The university admission policy has been a sensitive national concern, and the government has suffered continuous difficulties in university policy and has caused frequent changes in college admission policy. This change in college admission is causing universities to put a lot of effort into securing talented people. One of the indicators for the effectiveness of universities with outstanding talent is the employment rate. This study analyzed the influence of university on employment, such as college admission transfer, personal background, experience in university, satisfaction with teaching experience, and satisfaction with college application system. As a result, students who entered the college entrance exam were 0.657 times lower than those who entered the college entrance exam at a significant level of 0.01 in terms of the impact of employment. Among the variables for teaching satisfaction, the faculty's ability and enthusiasm were found to be 0.919 times lower than those for those who did not at a significant level of 0.05 level. Among college application system satisfaction, career counseling and support systems were found to be 1.217 times more likely to be employed than those who did not have the support system at a significant level of 0.01 level. Among college environment satisfaction, education support facilities are 0.926 times less likely to get a job than those that are not at a significant level. Students with high graduation grades were 0.995 times less likely to get a job at a significant level of 0.01 than those who did not. Statistically significant individual characteristics have shown that the higher the parents' educational background, the more adverse the chances of getting a job.As a result of school location and university type, the local area was more likely to get a job than the metropolitan area. Private universities are more likely to get jobs than national and public universities. In the major category, the social and medical sectors were less likely to get a job than the humanities, while the arts and physical education classes were higher.
-
정원줄기세포의 이종간 이식을 위한 효율적인 수여(Recipient) 생쥐 생산 기법 개발
김기중 ( Ki Jung Kim ),임한 ( Han Lim ),왕종현 ( Jong Hyun Wang ),김병각 ( Byung Gak Kim ),이용안 ( Yong An Lee ),김방진 ( Bang Jin Kim ),김용희 ( Yong Hee Kim ),홍영호 ( Yeong Ho Hong ),김근배 ( Geun Bae Kim ),류범용 ( Buom Yong 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.1s
Spermatogonial xenotransplantation assay provides access to the several species germline and has been used in experimental animal models to study stem cell biology and germline development. To make the xenotransplantation technology more extensively accessible, it is require development of recipient preparation protocols. Therefore, we propose an optimal method for preparation of athymic nude recipient with busulfan treatment. To investigate the optimal concentration of busulfan treatment, athymic nude mice (6~8 weeks old) were intraperitoneally injected with different concentrations of busulfan (0, 15, 25, 35 and 45 mg/kg). 6~8 weeks after busulfan treatment, testicular weight was significantly lower in 45 mg/kg treated group than the other groups. And the percentage of spermatogenic tubule was significantly reduced in 45 mg/kg of busulfan treated recipient testis. Also we compared the gene expression level of sertoli-cell-derived growth factor, glial-cell-line-derived neurotrophic factor (GDNF) as a potential measure of niche function. Relative to the other experimental groups, 45 mg/kg busulfan treated recipient testis showed higher GDNF expression. Next, to find out the appropriate time to transplantation after treated with busulfan (45 mg/kg), the rat testicular donor cells were transplanted into recipient testis at 2, 4, 6 and 8 weeks after treated with busulfan. Analysis of recipient mice revealed that transplantation of donor cells on 6 weeks after busulfan treatment was the most effective time to support high level of donor stem cell engraftment. In this study, we provide an optimum experimental condition for preparation of recipient mouse model system for xenotransplantation. Also, our data could contribute to recipient preparation in other species.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
