Inducing apoptpsis by the inhibition of c-myb in oral squamous carcinoma cell line, KB cell

Lee,Jung-Chang 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4

Oral squamous cell carcinoma (OSCC) is the most commonmalignancy and is a major cause of worldwide cancer mortality.The proto-oncogene c-myb plays an important role in regulationof cell growth and differentiation, and it is expressed at highlevels in hematopoietic cells and many other types of cancers.However, the function of c-myb is not well known in OSCC.The present study aimed to reveal the function of c-myb and totest the alternation of cell growth and signaling by c-myb inOSCC. In this study, c-myb and dominant-negatibe myb(DN-myb) were expressed in an adenovirus-mediated gene deliverysystem to KB cells. The over-expressed c-myb broughtincreased cellular proliferation compared with control cells.However, DN-myb infected KB cells showed significantreduction of cell growth and enhanced induction of apoptosis toactivate PARP and caspase 9. c-myb induced increase of IGF-I,-II and IGF-IR expressions while DN-myb down-regulatedthese expression. Activation of ERK and Akt/PKB pathwaywas shown only in c-myb transduced cells. These findingssuggest that the role of c-myb in cell growth of oral cancer cellsis partially mediated through the modulation of IGFs, ERK andAkt/PKB. From this results, DN-myb is strongly recommendedas a curable gene for the treatment of c-myb dependentmalignancies such as OSCC.

원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

청소년의 스마트폰 중독과 우울 및 불안과의 관계

김경은,김필송,민주연,박수경,신서인,이지은,정해인,조호정,최정원,최정인 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to investigate the relationships between the degree of smart phone addiction among adolescents and their depression and anxiety levels. Method: In this study, 379 high school students were selected using the convenient sampling method. The instruments used for this study were smart phone addiction measure, the CES-D (Center for Epidemiological Studies-Depression Scale), and the STAI (State-Trait Anxiety Inventory). Data were analyzed using the SPSS 20.0 program with descriptive statistics, t-test, ANOVA with Scheffe test, and Pearson’s correlation coefficient. Result: The mean score for smart phone addiction was 40.45±17.27, depression was 36.56±9.58, state anxiety was 44.00±9.61, and trait anxiety was 45.70±9.75. There were significant differences between the degree of smart phone addiction and the following variables: gender (t=-4.953, p<.001), hours of smart phone use per day (F=12.259, p<.001), types of frequently used features (F=3.485, p=.008), and satisfaction level for smart phone (F=5.18, p<.001). There were statistically significant relationships (p<.001) among degree of smart phone addiction, depression level, and state and trait anxiety levels. Conclusion: The results of this study suggested that there was a significant relationship between smart phone addiction and mental health, specifically, depression and anxiety among adolescents. Further research is needed to develop nursing strategies to provide care for adolescents who frequently utilize smart phones.

3-(Sbustitued phenyl)iminomethyl-2-oxo-1,2-dihydroquinoxaline류의 합성

鄭謚朱,金浩植 대구효성가톨릭대학교 1997 연구논문집 Vol.56 No.2

3-Methyl-2-oxo-1,2-dihydroguinoxaline(10), obtained by condensation of o-pheny-lenediamine with methyl pyruvate, was used as a starting material for the synthesis of Schiff bases containing the quinoxaline ring. the oxidation of compound 10 with substituted anilines provided 3-(substituted phenyl)iminomethyl-2-oxo-1,2-dihydroquinoxalines(12).

육우 비선호 부위를 활용한 육우햄의 품질특성

이주호, 최정석, 정준영, 최양일 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.3

This study was undertaken to compare the quality characteristics of dairy beef ham. Dairy beef hams were manufactured using non-preferred portion (top round). 5 treatments were prepared: T1(beef 50% + pork emulsion 50%), T2(beef 65%emulsion 35%), T3(beef 80%emulsion 20%), T4(beef 90%emulsion 10%), T5(beef 100%emulsion 0%). In chemical composition, dairy beef content increases, moisture content was increased, fat content was decreased. In the meat quality characteristics, T5 showed higher (p<0.05) water holding capacity value than the others. Dairy beef content increases, product loss and cooking loss were decreased. In hunter color, dairy beef content increases, redness was increased. In texture profile analysis, T4 and T5 were significantly higher than the others. As a result, dairy beef ham with 80~90% dairy beef and 10~20% pork emulsion has low fat content, high product yield and superior texture profile, which could be developed as a dairy beef hams using non-preferred portion.

공급 사슬 환경에서의 고객주문만족 시스템

장지홍,정호상,정봉주 연세대학교 산업기술연구소 2000 논문집 Vol.32 No.2

기업의 틀을 뛰어넘어 고객과 공급자까지 자사를 중심으로 통합하는 공급 사슬 환경에 있어서 고객 만족 수준을 향상시키는 것은 매우 중요하다. 고객 만족 수준을 높이기 위해서는 우선 정확한 수요예측을 통하여 주문에 대비해야 하며, 주문이 들어올 경우 고객에게 정확한 납기회신을 제공해야 한다. 물류, 정보, 자금 등의 흐름을 총괄하는 공급 사슬 환경의 특성상, 정확한 수요예측과 납기회신을 제공하기 위해서는 제품의 공급자, 고객을 포함한 공급 사슬내의 여러 파트너 들에 대한 종합적인 고려가 이루어져야 한다. 본 연구에서는 일반적인 공급 사슬 환경에서 사용 가능한 수요계획 시스템을 구축하는데 필요한 모델과, 고객의 주문에 대한 납기 제시를 위한 납기회신 알고리듬을 제시하고자 한다. : 공급사슬관리, 수요계획, 납기회신

한국인 만성 간 질환 환자에서 G형 간염 바이러스 감염의 유병률에 대한 연구

이진호,이한주,윤정환,이효석,김정룡 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.31 No.3

글로벌 SCM 환경에서의 통합 생산계획 모델에 관한 연구

정호상,송익수,정봉주 한국로지스틱스학회 2002 로지스틱스연구 Vol.10 No.1

본 논문은 글로벌 SCM(Supply Chain Management) 환경에서 생산 연계 비용의 최소화를 목적으로 하는 생산 계획 수립 알고리즘을 제안한다. 글로벌 SCM환경은 지역적으로 분리된 여러 개의 공장에서 각각 부분품 및 완제품의 생산이 이루어지는 환경이다. 이러한 환경에서 완제품의 주문량 또는 수요 예측량을 만족하지 위해 제품의 BOM(Bill-Of-Material) 구조를 고려하여 각 부분품의 생산계획량을 결정해야 한다. 각 공장에서는 제한된 생산 능력을 가지면, 특정 부분품 또는 완제품을 생산한다. 부분품의 생산은 특정 공정 시간을 가지며 완성된 부분품은 이후 공정을 위해 다른 공장으로의 이동시간을 갖는다. 본 논문의 목적은 공장의 생산능력을 만족시키면서 제품의 공장별 생산 비용, 재고 비용, 공장 간 물류 비용을 최소화 시키는 생산 계획을 수립하는 문제의 해를 구하는 것이다. 본 논문에서는 글로벌 SCM 네트워크를 정의하고, 주어진 네트워크의 생산 계획문제를 혼합 정수 계획법을 이용하여 모델링한다. 효과적으로 문제를 해결하기 위해 계산 시간면에서 효율적인 발견적 기법을 제안하고 실험을 통해 해법의 성능을 검증한다. This paper presents a production planning algorithm for minimizing the costs of production and distribution in Global SCM(Supply Chain Management) environments. In the Global SCM environment, the several local plants produce parts and products. In this environment, we have to decide the production volumes of both parts and products considering the BOM(Bill-Of-Material) structure to meet the fixed order quantity or forecasted demand quantity. Each plant produces the specified parts of product and has a certain production capacity. There exist a fixed production lead time to make products and transportation lead time to move parts to different plants for subsequent processes. The objective of this study is to solve the production planning problem, which minimizes the total costs of production, inventory, and transportation under constraints of production capacity. For this problem, the integrated production planning model was formulated as a mixed integer programming, and an efficient heuristic algorithms was proposed. The experimental investigation shows that the proposed heuristic generates quite good solutions at very low computation costs.

송아지고기 소시지와 시중에 판매되는 우육과 돈육 소시지 제품의 저장특성 비교

이주호, 최정석, 이현진, 정구용, 최양일 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1

This study was undertaken to compare the storage characteristics between veal sausage and commercial pork and beef sausages in Korean domestic market. We manufactured 3_types of sausages and purchased 2_types of sausages in the market: T1(B-company product), T2(O-company product) and we made T3(smoked veal sausage), T4(smoked veal sausage with pepper) and T5(cooked veal sausage) products. During 20 days of storage at 4oC, T5 showed significantly higher in TBA value and VBN value (p<0.05). But TBA and VBN values showed normal range in all products. T3, T4, and T5 showed higher total microbial count than T1 and T2 (p<0.05). According to the result, beef and pork sausages in the market showed different total microbial count and VBN values from those made in laboratory. This result could be come from the different additives used and manufacturing processes. However, all products can be stored up to 20 days in the cooler.

연속생산공정에서의 유도형 유전알고리즘을 이용한 인과형 예측모델에 관한 연구

정호상,정봉주 한국경영과학회 2000 經營 科學 Vol.17 No.2

This paper presents a causal forecasting model using gulded genetic algorithm in continuous manufacturing process. The guided genetic algorithm(GGA) is an extended genetic algorithm(GA) using penalty function and population diversity index to increase forecasting accuracy. GGA adds to the canonical GA the concept of a penalty function to avoid selecting the unproductive chromosomes and to make a proper searching direction. Also, GGA modifies the current population using the similarity of chromosomes to avoid falling into the trap of local optimal solution. For investigating GGA performance, we used a set of real data that was collected in local glass melting processes, and experimental results show the proposed model results in the better forecasting accuracy than linear regression model and canonical GA.